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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... cell nevi, but also blue nevi ( fig. 22-8 ). Metastatic melanoma simulating blue nevus has been reported for both cutaneous and ocular melanomas ( 12 , 13 ). The diagnosis of a nevoid melanoma metastasis mainly relies on clinical context (time course and location that fit with metastatic disease...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-01
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... mutation  Lentigines  ECG abnormality  Ocular hypertelorism  Pulmonic stenosis  Abnormality of genitalia  Retarded growth with skeletal abnormalities  Deafness LABIAL MELANOTIC MACULES Figure 1-8 LABIAL MELANOTIC MACULES Patient with Peutz-Jeghers syndrome. Hypermelanosis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...-Like Melanoma. On occasion, melanoma metastatic to the skin simulates the clinical and/or histopathologic appearance of a BN ( 41 ). Clinical context and attention to cytologic features are essential for the correct diagnosis. A prior history of cutaneous, mucosal, or ocular melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... syndrome, with risk for ocular melanoma, mesothelioma, renal cell carcinoma, and other neoplasms ( Table 10-2 ) ( 11 ). Microscopic features suggestive of a germline mutation include the presence of junctional nests with BAP1 loss and fatty metaplasia of dermal melanocytes. Some BAP1-inactivated nevi show...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... (cutaneous or ocular) melanoma, as well as pigmented melanotic schwannian neoplasms. Blue Melanoma versus Blue Nevus. Confusion between a melanoma and blue nevus is rare, but may occur, especially in the setting of a cellular blue nevus with atypical features (e.g., nuclear atypia, a few mitotic figures...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch31
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... dropout ( fig. 31-19 ). Definition.  Loeys-Dietz syndrome (LDS) is a connective tissue disorder similar to MFS with vascular, skeletal, craniofacial (bifid uvula, craniosynostosis, and hypertelorism), cutaneous, and ocular findings. The vascular manifestations, however, tend to be more aggressive...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch42
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... (sheet-like) calcification of the falx Minor Diagnostic Criteria  Cardiac or ovarian fibroma  Lymphomesenteric or pleural cysts  Childhood medulloblastoma  Cleft lip/palate  Macrocephaly  Bifid ribs or extra ribs  Polydactyly  Ocular anomalies (e.g., cataract, pigmentary...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch19
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... of mutation in the FBN1 gene. While individuals with MFS may have skeletal, ocular, and dermatologic manifestations, it is the cardiovascular abnormalities that constitute the primary cause of mortality. Among these, aortic complications are the most significant and include aortic dilatation...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch30
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
..., and ocular inflammation are common. The wheals on the skin are usually painful and often last more than 24 hours, unlike urticaria. Histologic confirmation by skin biopsy is necessary for distinction from urticaria ( 60 ). There is small vessel vasculitis of the kidney and lung in the form...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-5
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
...) those arising in acral skin (acral melanoma); 3) those arising from blue nevus or from giant congenital nevus; 4) ocular melanoma; 5) nodular, nevoid, and metastatic melanomas; and 6) mucosal melanoma ( 446a ). Vulvar and vaginal melanomas are mucosal melanomas. In this classification, some categories...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
10.55418/9781933477251-2
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
..., characteristic facies, and short stature ( 260 , 261 ). Velocardiofacial syndrome is an autosomal dominant disorder characterized by neonatal hypocalcemia, T-cell dysfunction, cleft palate, cardiac and ocular anomalies, and learning disabilities. Due to the numerous syndromic names to describe the phenotypic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
10.55418/9781933477251-3
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... antigen to T cells and resident dendritic cells, thereby serving to perpetuate if not initiate the pathologic process ( 506 – 509 ). TSHR antibodies and activated T cells also play an important role in the pathogenesis of Graves orbitopathy by activating retro-ocular fibroblast and adipocyte TSHR...
Images
SUBSTAGING OF T1 BLADDER CANCER BY DEPTH OF INVASION  A: The depth of strom...
Published: 01 November 2021
SUBSTAGING OF T1 BLADDER CANCER BY DEPTH OF INVASION Figure 3-60 SUBSTAGING OF T1 BLADDER CANCER BY DEPTH OF INVASION A: The depth of stromal invasion in the transurethral resection or biopsy specimen is measured from the basement membrane of the bladder mucosa to the deepest invasive cancer cell... More about this image found in SUBSTAGING OF T1 BLADDER CANCER BY DEPTH OF INVASION A: The depth of strom...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
10.55418/9781933477183-6
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... for adequacy. Etiology. Paucity of intrahepatic bile ducts is a pattern of injury, so there are many etiologies ( Table 6-2 ). One of the syndromic forms, Alagille syndrome, is associated with JAG1 mutations and other congenital abnormalities that include posterior embryotoxon (an ocular anatomic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
10.55418/9781933477183-10
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... delayed developmental milestones. Sensorineural deafness is almost always present, and patients may have ocular abnormalities. Facial dysmorphic features are less pronounced than in the neonatal-infantile group. These patients may develop renal calcium oxalate stones, adrenal insufficiency, and a rapid...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 9
Published: 01 November 2021
10.55418/9781933477176-3
ISBN-10: 1-933477-17-2
ISBN: 978-1-933477-17-6
... resection or biopsy specimen is measured from the basement membrane of the bladder mucosa to the deepest invasive cancer cells using an ocular micrometer, whether the lesion is flat (AI) or papillary (AII). When tissue fragments contain cancer without adjacent basement membrane or when the specimen...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 3
Published: 01 February 2021
10.55418/9781933477923-ch01
ISBN-10: 1-933477-92-X
ISBN: 978-1-933477-92-3
... (at center) containing the tumor. E: The calottes are further sectioned in a bread-loaf manner to achieve larger surface of tumor and ocular tissue for histopathologic evaluation. Here, segments were generated from one calotte. IRIDOCYCLECTOMY SPECIMENS Figure 1-9 IRIDOCYCLECTOMY SPECIMENS A: The tumor...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 3
Published: 01 February 2021
10.55418/9781933477923-ch07
ISBN-10: 1-933477-92-X
ISBN: 978-1-933477-92-3
... in MYC and BCL6 genes, compatible with a high-grade B-cell lymphoma with rearrangement of MYC and BCL6 genes (double-hit lymphoma). OCULAR ADNEXAL MUCOSA-ASSOCIATED LYMPHOID TISSUE (MALT) LYMPHOMA Figure 7-2 OCULAR ADNEXAL MUCOSA-ASSOCIATED LYMPHOID TISSUE (MALT) LYMPHOMA...
Book
Book Cover Image
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 3
Published: 01 February 2021
10.55418/9781933477923
ISBN-10: 1-933477-92-X
ISBN: 978-1-933477-92-3
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 7
Published: 01 September 2021
10.55418/9781933477121-3
ISBN-10: 1-933477-12-1
ISBN: 978-1-933477-12-1
..., and lower gastrointestinal tract are typically also affected ( 552 ). There is CNS (40 percent) and ocular (20 percent) involvement ( 553 – 555 ). Microscopic Findings . The appearance of JXG is varied and somewhat related to the age of the lesion biopsied. JXG histiocytes populate the dermis ( fig. 3-149...