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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-01
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
..., the large collecting ducts expand to form lactiferous sinuses, which terminate in cone-shaped ampullae before opening onto the nipple. MICROARCHITECTURE OF NORMAL ADULT FEMALE BREAST TISSUE Figure 1-1 MICROARCHITECTURE OF NORMAL ADULT FEMALE BREAST TISSUE A portion of an extralobular duct (arrow...
Images
EXCISION OF MELANOMA IN SITU  A: A rim of <span class="search-highlight">normal</span> skin is between the edge o...
Published: 01 February 2024
EXCISION OF MELANOMA IN SITU Figure 13-15 EXCISION OF MELANOMA IN SITU A: A rim of normal skin is between the edge of the melanoma in situ and the inked side margin (H&E stain). B: Immunostain for PRAME. C: The junctional melanoma cells display nuclear labeling for PRAME. More about this image found in EXCISION OF MELANOMA IN SITU A: A rim of normal skin is between the edge o...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-appendix01
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Appendix 1 . Abbreviations Appendix 2 . English Equivalents of Latin Terms Appendix 3 . Predicted Normal Heart Weight (g), from Formalin-Fixed Specimens, as a Function of Body Weight in 392 Women and 373 Men, 20 to 99 Years Old Appendix 4 . Predicted Normal Heart Height (g), from...
Images
SATELLITE METASTASIS  A: A small subcutaneous tumor nodule (arrow) is separ...
Published: 01 February 2024
SATELLITE METASTASIS Figure 22-2 SATELLITE METASTASIS A: A small subcutaneous tumor nodule (arrow) is separated from the primary tumor by normal adipose tissue. B: The nodule is composed of atypical tumor cells similar to the primary melanoma. More about this image found in SATELLITE METASTASIS A: A small subcutaneous tumor nodule (arrow) is separ...
Images
SUBUNGUAL MELANOMA IN SITU  A: There is a proliferation of solitary units o...
Published: 01 February 2024
SUBUNGUAL MELANOMA IN SITU Figure 14-13 SUBUNGUAL MELANOMA IN SITU A: There is a proliferation of solitary units of melanocytes involving the nail bed and nail matrix associated with focal lichenoid inflammation (*). B: The density of melanocytes is above normal, but overall relatively low. C: ... More about this image found in SUBUNGUAL MELANOMA IN SITU A: There is a proliferation of solitary units o...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-01
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... to be of small size and sharply circumscribed, but there are exceptions. Some vulvar lesions form large patches. Microscopically, solitary units of melanocytes are distributed at a normal or only slightly increased cell density. Melanotic macules are a common clinical presentation. They are benign and do...
Images
MICROARCHITECTURE OF <span class="search-highlight">NORMAL</span> ADULT FEMALE BREAST TISSUE  A portion of an ext...
Published: 01 January 2024
MICROARCHITECTURE OF NORMAL ADULT FEMALE BREAST TISSUE Figure 1-1 MICROARCHITECTURE OF NORMAL ADULT FEMALE BREAST TISSUE A portion of an extralobular duct (arrow), terminal duct, and lobules, in turn composed of acini, is seen. More about this image found in MICROARCHITECTURE OF NORMAL ADULT FEMALE BREAST TISSUE A portion of an ext...
Images
IMMUNOSTAIN FOR ESTROGEN RECEPTOR (ER)  In <span class="search-highlight">normal</span> lobules, the epithelial c...
Published: 01 January 2024
IMMUNOSTAIN FOR ESTROGEN RECEPTOR (ER) Figure 1-9 IMMUNOSTAIN FOR ESTROGEN RECEPTOR (ER) In normal lobules, the epithelial cells show variable nuclear expression with ER: some cells are negative, others demonstrate weak staining, and still others are strongly positive. More about this image found in IMMUNOSTAIN FOR ESTROGEN RECEPTOR (ER) In normal lobules, the epithelial c...
Images
NIPPLE DUCT PLICATIONS  On occasion, the anatomically <span class="search-highlight">normal</span> infoldings of ...
Published: 01 January 2024
NIPPLE DUCT PLICATIONS Figure 7-13 NIPPLE DUCT PLICATIONS On occasion, the anatomically normal infoldings of the nipple ducts can be sectioned in such a way that suggests intraductal papilloma. Careful attention to the location in the breast and recognition of any adjacent nipple ducts aid in app... More about this image found in NIPPLE DUCT PLICATIONS On occasion, the anatomically normal infoldings of ...
Images
INVASIVE LOBULAR CARCINOMA  The tumor cells infiltrate around <span class="search-highlight">normal</span> ducts ...
Published: 01 January 2024
INVASIVE LOBULAR CARCINOMA Figure 8-34 INVASIVE LOBULAR CARCINOMA The tumor cells infiltrate around normal ducts and lobules in a “targetoid” pattern; this feature is typical of invasive lobular carcinoma. More about this image found in INVASIVE LOBULAR CARCINOMA The tumor cells infiltrate around normal ducts ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... linear streaks, or diffuse pigmentation within scars. Microscopically, there are lentigo-like features: hyperpigmentation predominantly of basilar keratinocytes with a normal or slightly increased density of cytologically bland junctional melanocytes ( 18 ). Nevi Associated with Nonsurgical Trauma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... The separate melanocyte populations of a combined nevus tend to blend with each other or “respect” each other as well as adnexal structures. With a melanoma associated with a nevus there is an impression that the melanoma displaces, compresses, or overgrows the nevus remnant as well as normal skin structures...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... matrix associated with focal lichenoid inflammation (*). B: The density of melanocytes is above normal, but overall relatively low. C: The melanocytes have enlarged, hyperchromatic and irregularly shaped nuclei (arrows). In later stages of melanoma in situ, there is confluence of junctional melanocytes...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... , et al . Deep penetrating nevus-like borderline tumors: a unique subset of ambiguous melanocytic tumors with malignant potential and normal cytogenetics . Eur J Dermatol   2014 ; 24 : 594 - 602 . ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... penetrating nevus-like borderline tumors: a unique subset of ambiguous melanocytic tumors with malignant potential and normal cytogenetics . Eur J Dermatol   2014 ; 24 : 594 - 602 . 3. Hantschke   M , Mentzel   T , Kutzner   H . Follicular malignant melanoma: a variant of melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with conventional melanomas (confirmed BRAF, NRAS mutation or other molecular aberration not typical of Spitz), if their tumor has some spitzoid features. When a diagnosis of spitzoid or Spitz melanoma of childhood has been rendered, we recommend a full-thickness excision with a rim of normal skin...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... nodules found by microscopic review of a primary tumor resection are classified as “satellite metastases” ( fig. 22-2 ). SATELLITE METASTASIS Figure 22-2 SATELLITE METASTASIS A: A small subcutaneous tumor nodule (arrow) is separated from the primary tumor by normal adipose tissue. B: The nodule...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... and metastases (more than a decade after the excision of the primary tumor) and subsequent death from metastatic melanoma after two decades. The pattern of recurrence is variable, but metastases first to the liver (similar to uveal melanoma) are common. Surgical excision with a rim of normal tissue around...
Images
DUCTAL CARCINOMA IN SITU: PAGETOID GROWTH PATTERN  High-grade DCIS undermin...
Published: 01 January 2024
DUCTAL CARCINOMA IN SITU: PAGETOID GROWTH PATTERN Figure 3-25 DUCTAL CARCINOMA IN SITU: PAGETOID GROWTH PATTERN High-grade DCIS undermines an attenuated layer of residual normal epithelium with spindled nuclei. More about this image found in DUCTAL CARCINOMA IN SITU: PAGETOID GROWTH PATTERN High-grade DCIS undermin...
Images
MAMMARY HAMARTOMA  This excisional biopsy depicts a well-circumscribed mass...
Published: 01 January 2024
MAMMARY HAMARTOMA Figure 5-44 MAMMARY HAMARTOMA This excisional biopsy depicts a well-circumscribed mass of normal breast tissue, with admixed adipose tissue (border at top right of image). These features, in the context of a palpable or image-detected mass, are compatible with a mammary hamartom... More about this image found in MAMMARY HAMARTOMA This excisional biopsy depicts a well-circumscribed mass...