GATA3 IN NORMAL ADRENAL MEDULLA Figure 1-51 GATA3 IN NORMAL ADRENAL MEDULLA GATA3 is expressed in normal and neoplastic adrenal medulla and extra-adrenal paraganglia but not adrenal cortex. It is a valuable marker for diagnosis but is widely ex pressed in various tissues and must be considered in... More about this image found in GATA3 IN NORMAL ADRENAL MEDULLA GATA3 is expressed in normal and neoplasti...

BODY AND HEAD OF NORMAL ADRENAL GLAND Figure 1-23 BODY AND HEAD OF NORMAL ADRENAL GLAND In this transverse section, the medullary compartment appears dull gray in contrast to the bright yellow cortex. Partial to complete cuffs of cortex are present around the central adrenal vein and its tributar... More about this image found in BODY AND HEAD OF NORMAL ADRENAL GLAND In this transverse section, the medu...

EXTRUSION OF CORTICAL TISSUE THROUGH THE CAPSULE OF NORMAL ADRENAL GLAND Figure 1-28 EXTRUSION OF CORTICAL TISSUE THROUGH THE CAPSULE OF NORMAL ADRENAL GLAND A: Extracapsular perivascular extrusion of cortical cells. B: Nodular protrusion of cortical cells still partly covered by attenuated caps... More about this image found in EXTRUSION OF CORTICAL TISSUE THROUGH THE CAPSULE OF NORMAL ADRENAL GLAND A...

Ki-67 STAIN Figure 1-32 Ki-67 STAIN Ki-67 staining is relatively sparse in the unstressed normal adult adrenal gland, with the greatest amount of staining in the outer part of the zona fasciculata. Rare stained cells are present in the zona reticularis, which is highlighted by the intrinsic brown... More about this image found in Ki-67 STAIN Ki-67 staining is relatively sparse in the unstressed normal a...

ARTIFACTUAL FISSURE FORMATION IN A NORMAL ADRENAL GLAND Figure 1-34 ARTIFACTUAL FISSURE FORMATION IN A NORMAL ADRENAL GLAND Autolysis at a plane roughly between cortex and medulla can create the appearance of an empty sac. More about this image found in ARTIFACTUAL FISSURE FORMATION IN A NORMAL ADRENAL GLAND Autolysis at a pla...

FAT CELL METAPLASIA Figure 1-35 FAT CELL METAPLASIA Normal adrenal cortex in an adult shows patchy areas with confluent lipid vacuoles and some individual cells resembling mature adipocytes. This has been referred to as lipomatous metaplasia. More about this image found in FAT CELL METAPLASIA Normal adrenal cortex in an adult shows patchy areas w...

NORMAL ADRENAL MEDULLA IN AN ADULT Figure 1-39 NORMAL ADRENAL MEDULLA IN AN ADULT Well-preserved chromaffin cells are arranged in nests and anastomosing short cords. The cells vary in size, with some larger or smaller than the zona reticularis cells at top left. A few cells have moderately conspi... More about this image found in NORMAL ADRENAL MEDULLA IN AN ADULT Well-preserved chromaffin cells are arr...

INTRACYTOPLASMIC HYALINE GLOBULES IN NORMAL ADRENAL MEDULLA Figure 1-40 INTRACYTOPLASMIC HYALINE GLOBULES IN NORMAL ADRENAL MEDULLA Globules are present in several chromaffin cells. A few cells contain numerous small globules. More about this image found in INTRACYTOPLASMIC HYALINE GLOBULES IN NORMAL ADRENAL MEDULLA Globules are p...

VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA Figure 1-44 VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA The figure shows a single VIP-expressing neuron, a myelinated nerve containing VIP-positive axons (arrow), and branching VIP-positive terminal fibers between chr... More about this image found in VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA The figure s...

DISTINCTIVE ARCHITECTURE OF THE CENTRAL VEIN IN NORMAL ADRENAL GLAND Figure 1-45 DISTINCTIVE ARCHITECTURE OF THE CENTRAL VEIN IN NORMAL ADRENAL GLAND Distinctive arcades of interrupted smooth muscle form the wall of the central adrenal vein and its tributaries. The vein is surrounded by chromaffi... More about this image found in DISTINCTIVE ARCHITECTURE OF THE CENTRAL VEIN IN NORMAL ADRENAL GLAND Disti...

PROTRUSION OF NORMAL CORTICAL CELLS INTO THE LUMEN OF THE CENTRAL VEIN Figure 1-46 PROTRUSION OF NORMAL CORTICAL CELLS INTO THE LUMEN OF THE CENTRAL VEIN Where smooth muscle is deficient, chromaffin or cortical cells may come into close proximity with the vascular space and can form intravascular... More about this image found in PROTRUSION OF NORMAL CORTICAL CELLS INTO THE LUMEN OF THE CENTRAL VEIN Whe...

STEROIDOGENIC FACTOR 1 (SF1) IN NORMAL ADRENAL CORTEX Figure 1-50 STEROIDOGENIC FACTOR 1 (SF1) IN NORMAL ADRENAL CORTEX SF1 controls the development of steroidogenic cells in the adrenal cortex and gonads, and distinguishes adrenal cortex from medulla. More about this image found in STEROIDOGENIC FACTOR 1 (SF1) IN NORMAL ADRENAL CORTEX SF1 controls the dev...

INHIBIN EXPRESSION IN NORMAL ADRENAL GLAND Figure 1-52 INHIBIN EXPRESSION IN NORMAL ADRENAL GLAND Inhibin is expressed in the adrenal cortex in a variable and often patchy distribution, suggesting an association with different functional states. The greatest expression is in the zona reticularis,... More about this image found in INHIBIN EXPRESSION IN NORMAL ADRENAL GLAND Inhibin is expressed in the adr...

MELAN-A IN NORMAL ADRENAL GLAND Figure 1-53 MELAN-A IN NORMAL ADRENAL GLAND Melan-A is expressed throughout the cortex but staining tends to be most intense in the zona glomerulosa (negative medulla at bottom of field). More about this image found in MELAN-A IN NORMAL ADRENAL GLAND Melan-A is expressed throughout the cortex...

CALRETININ IN NORMAL ADRENAL GLAND Figure 1-54 CALRETININ IN NORMAL ADRENAL GLAND Calretinin typically shows diffuse strong expression throughout the cortex (negative medulla at bottom of field). More about this image found in CALRETININ IN NORMAL ADRENAL GLAND Calretinin typically shows diffuse stro...

SYNAPTOPHYSIN IN NORMAL ADRENAL GLAND Figure 1-55 SYNAPTOPHYSIN IN NORMAL ADRENAL GLAND A: Synaptophysin expression is shown in a patchy distribution in the zona fasciculata. This contrasts with diffuse strong staining in the adrenal medulla at bottom of the field. B: Strong but variable express... More about this image found in SYNAPTOPHYSIN IN NORMAL ADRENAL GLAND A: Synaptophysin expression is shown...

CHROMOGRANIN A IN NORMAL ADRENAL GLAND Figure 1-56 CHROMOGRANIN A IN NORMAL ADRENAL GLAND Chromaffin cells in the adrenal medulla characteristically show diffuse, intense immunoreactivity for chromogranin A. There is no staining in the adrenal cortex or in perivascular cuffs of cortical tissue wi... More about this image found in CHROMOGRANIN A IN NORMAL ADRENAL GLAND Chromaffin cells in the adrenal med...

ETIOLOGY OF NONIATROGENIC ACTH-DEPENDENT CUSHING SYNDROME Figure 3-2 ETIOLOGY OF NONIATROGENIC ACTH-DEPENDENT CUSHING SYNDROME Normal hypothalamic-pituitary-adrenal axis (upper left), pituitary-dependent Cushing disease (upper right), and ectopic ACTH syndrome. More about this image found in ETIOLOGY OF NONIATROGENIC ACTH-DEPENDENT CUSHING SYNDROME Normal hypothala...

NORMAL ABDOMINAL PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS Figure 9-3 NORMAL ABDOMINAL PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS A: Normal paraganglia (arrows) in close proximity to lymph nodes. In a patient with a hereditary paraganglioma syndrome, this anatomic rel... More about this image found in NORMAL ABDOMINAL PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS ...

ABDOMINAL PARAGANGLIA AND ADJACENT DEVELOPING ADRENAL GLAND Figure 9-4 ABDOMINAL PARAGANGLIA AND ADJACENT DEVELOPING ADRENAL GLAND A: Normal paraganglia are fully formed before the adrenal medulla exists. This adrenal gland shows only provisional cortex and a small cluster of primitive adrenal me... More about this image found in ABDOMINAL PARAGANGLIA AND ADJACENT DEVELOPING ADRENAL GLAND A: Normal para...