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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-15
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
...A variety of non-neoplastic processes can mimic solid and cystic pancreatic neoplasms at the clinical, radiographic, gross, and microscopic levels ( Table 15-1 ) ( 1 , 2 ). Recognition of the key diagnostic features of these non-neoplastic lesions is important for the clinical management...
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<span class="search-highlight">NON</span>-NEOPLASTIC ACINAR CELLS  These are <span class="search-highlight">non</span>-neoplastic acinar cells (H&amp;E...
Published: 01 March 2023
NON-NEOPLASTIC ACINAR CELLS Figure 9-30 NON-NEOPLASTIC ACINAR CELLS These are non-neoplastic acinar cells (H&E stain). More
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<span class="search-highlight">NON</span>-NEOPLASTIC ISLET CELLS AND PANCREATIC NEUROENDOCRINE TUMOR  Left: <span class="search-highlight">Non</span>-n...
Published: 01 March 2023
NON-NEOPLASTIC ISLET CELLS AND PANCREATIC NEUROENDOCRINE TUMOR Figure 12-60 NON-NEOPLASTIC ISLET CELLS AND PANCREATIC NEUROENDOCRINE TUMOR Left: Non-neoplastic islet cells are identified in an aspirate from histologically confirmed autoimmune pancreatitis. Right: Plasmacytoid cells in a well-dif... More
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<span class="search-highlight">NON</span>-NEOPLASTIC ACINAR CELLS  <span class="search-highlight">Non</span>-neoplastic acinar cells have smaller nucle...
Published: 01 March 2023
NON-NEOPLASTIC ACINAR CELLS Figure 12-64 NON-NEOPLASTIC ACINAR CELLS Non-neoplastic acinar cells have smaller nuclei, gran ular cytoplasm, and lobular architecture compared to neuroendocrine tumors (H&E stain). More
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ACINAR EPITHELIAL CELLS  Aspirate smears of <span class="search-highlight">non</span>-neoplastic acinar cells dem...
Published: 01 March 2023
ACINAR EPITHELIAL CELLS Figure 1-11 ACINAR EPITHELIAL CELLS Aspirate smears of non-neoplastic acinar cells demonstrate a fairly cohesive grape-like clustering architecture, with stroma and single rosettes, some single cells, and a few stripped epithelial nuclei (direct smear; Papanicolaou). More
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CYTOLOGY OF <span class="search-highlight">NON</span>-NEOPLASTIC GASTROINTESTINAL EPITHELIUM  Left: Duodenal epit...
Published: 01 March 2023
CYTOLOGY OF NON-NEOPLASTIC GASTROINTESTINAL EPITHELIUM Figure 6-38 CYTOLOGY OF NON-NEOPLASTIC GASTROINTESTINAL EPITHELIUM Left: Duodenal epithelium contains regularly spaced goblet cells. Right: Gastric epithelium has mucin cytoplasm and uniformly spaced, bland nuclei (both: hematoxylin and eosi... More
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CHRONIC PANCREATITIS  Reactive duct with <span class="search-highlight">non</span>-neoplastic epithelium. The epi...
Published: 01 March 2023
CHRONIC PANCREATITIS Figure 7-48 CHRONIC PANCREATITIS Reactive duct with non-neoplastic epithelium. The epithelium is uniform without atypia. More
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<span class="search-highlight">NON</span>-NEOPLASTIC ACINAR CELLS AND ACINAR CELL CARCINOMA  Neoplastic acinar ce...
Published: 01 March 2023
NON-NEOPLASTIC ACINAR CELLS AND ACINAR CELL CARCINOMA Figure 9-28 NON-NEOPLASTIC ACINAR CELLS AND ACINAR CELL CARCINOMA Neoplastic acinar cells have hyperchromatic chromatin and high nuclear: cytoplasmic ratio (left). On the right, cytoplasmic granularity is decreased in acinar cell carcinoma and... More
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PANCREATIC NEUROENDOCRINE TUMOR  Entrapped <span class="search-highlight">non</span>-neoplastic ductules within a...
Published: 01 March 2023
PANCREATIC NEUROENDOCRINE TUMOR Figure 12-39 PANCREATIC NEUROENDOCRINE TUMOR Entrapped non-neoplastic ductules within a PanNET. The ductular epithelium has eosinophilic cytoplasm (left) and is closely associated with the neoplastic cells (right). More
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SOLITARY FIBROUS TUMOR  Nuclear immunolabeling for STAT6. The <span class="search-highlight">non</span>-neoplasti...
Published: 01 March 2023
SOLITARY FIBROUS TUMOR Figure 13-23 SOLITARY FIBROUS TUMOR Nuclear immunolabeling for STAT6. The non-neoplastic pancreatic parenchyma (right) does not label. More
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<span class="search-highlight">NON</span>-HODGKIN LYMPHOMA  Left: Grossly, the lymphoma forms a solid, homogeneou...
Published: 01 March 2023
NON-HODGKIN LYMPHOMA Figure 13-36 NON-HODGKIN LYMPHOMA Left: Grossly, the lymphoma forms a solid, homogeneous fleshy tan mass similar to its appearance outside the pancreas. The lymphoma in this case compresses the bile duct. Right: Multinodular involvement of the pancreatic body and tail may re... More
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ACINAR CELL CARCINOMA  Neoplastic acinar cell clusters appear more hyperchr...
Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-27 ACINAR CELL CARCINOMA Neoplastic acinar cell clusters appear more hyperchromatic than non-neoplastic acinar cells because of the increased nuclear to cytoplasmic ratio (left). The vaguely lobulated architecture of acinar cell carcinoma is more disorganized and cr... More
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SQUAMOCOLUMNAR JUNCTION (SCJ) AND <span class="search-highlight">NON</span>-SCJ–RELATED PRECURSORS IN THE CERVIX ...
Published: 01 February 2023
SQUAMOCOLUMNAR JUNCTION (SCJ) AND NON-SCJ–RELATED PRECURSORS IN THE CERVIX Figure 1-4 SQUAMOCOLUMNAR JUNCTION (SCJ) AND NON-SCJ–RELATED PRECURSORS IN THE CERVIX SCJ-associated high-grade squamous intraepithelial lesion (A). SCJ-associated adenocarcinoma in situ (B), and isolated adenocarcinoma in... More
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CROHN DISEASE  A <span class="search-highlight">non</span>-necrotizing granuloma with central multinucleated gian...
Published: 01 February 2023
CROHN DISEASE Figure 5-99 CROHN DISEASE A non-necrotizing granuloma with central multinucleated giant cells is present in the superficial dermis. More
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PANCREATIC NEUROENDOCRINE TUMOR  Scattered cells immunolabel for glucagon i...
Published: 01 March 2023
PANCREATIC NEUROENDOCRINE TUMOR Figure 12-53 PANCREATIC NEUROENDOCRINE TUMOR Scattered cells immunolabel for glucagon in this non-functioning PanNET. More
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ISLET AGGREGATION  Immunolabeling for insulin shows pseudoinfiltration of f...
Published: 01 March 2023
ISLET AGGREGATION Figure 15-67 ISLET AGGREGATION Immunolabeling for insulin shows pseudoinfiltration of fat tissue by non-neoplastic islets. More
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SOLID PSEUDOPAPILLARY NEOPLASM  So-called blood lakes at the inter face wit...
Published: 01 March 2023
SOLID PSEUDOPAPILLARY NEOPLASM Figure 11-16 SOLID PSEUDOPAPILLARY NEOPLASM So-called blood lakes at the inter face with the non-neoplastic pancreas. More
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ACINAR CELL NODULE  Acinar cell nodules are defined as aggregates of enlarg...
Published: 01 March 2023
ACINAR CELL NODULE Figure 1-21 ACINAR CELL NODULE Acinar cell nodules are defined as aggregates of enlarged non-neoplastic acinar cells that are distinguished from the surrounding acinar cells by the pale tinctorial staining qualities of the cytoplasm. More
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INTRADUCTAL TUBULOPAPILLARY NEOPLASM  Left: Back-to-back tubular glands for...
Published: 01 March 2023
INTRADUCTAL TUBULOPAPILLARY NEOPLASM Figure 6-55 INTRADUCTAL TUBULOPAPILLARY NEOPLASM Left: Back-to-back tubular glands form a nodular tumor mass nearly filling a dilated duct. Right: A rim of residual non-neoplastic ductal epithelium surrounds the periphery of an intraductal tumor nodule. More
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SOLID PSEUDOPAPILLARY NEOPLASM  A: The interface with the adjacent pancreas...
Published: 01 March 2023
SOLID PSEUDOPAPILLARY NEOPLASM Figure 11-15 SOLID PSEUDOPAPILLARY NEOPLASM A: The interface with the adjacent pancreas is often infiltrative, but there is no stromal reaction to the neoplasm. B: Islands of tumor are surrounded by pancreatic parenchyma, where the neoplastic cells resemble islets.... More