NON-NEOPLASTIC ACINAR CELLS Figure 9-30 NON-NEOPLASTIC ACINAR CELLS These are non-neoplastic acinar cells (H&E stain). More

NON-NEOPLASTIC ISLET CELLS AND PANCREATIC NEUROENDOCRINE TUMOR Figure 12-60 NON-NEOPLASTIC ISLET CELLS AND PANCREATIC NEUROENDOCRINE TUMOR Left: Non-neoplastic islet cells are identified in an aspirate from histologically confirmed autoimmune pancreatitis. Right: Plasmacytoid cells in a well-dif... More

NON-NEOPLASTIC ACINAR CELLS Figure 12-64 NON-NEOPLASTIC ACINAR CELLS Non-neoplastic acinar cells have smaller nuclei, gran ular cytoplasm, and lobular architecture compared to neuroendocrine tumors (H&E stain). More

ACINAR EPITHELIAL CELLS Figure 1-11 ACINAR EPITHELIAL CELLS Aspirate smears of non-neoplastic acinar cells demonstrate a fairly cohesive grape-like clustering architecture, with stroma and single rosettes, some single cells, and a few stripped epithelial nuclei (direct smear; Papanicolaou). More

CYTOLOGY OF NON-NEOPLASTIC GASTROINTESTINAL EPITHELIUM Figure 6-38 CYTOLOGY OF NON-NEOPLASTIC GASTROINTESTINAL EPITHELIUM Left: Duodenal epithelium contains regularly spaced goblet cells. Right: Gastric epithelium has mucin cytoplasm and uniformly spaced, bland nuclei (both: hematoxylin and eosi... More

CHRONIC PANCREATITIS Figure 7-48 CHRONIC PANCREATITIS Reactive duct with non-neoplastic epithelium. The epithelium is uniform without atypia. More

NON-NEOPLASTIC ACINAR CELLS AND ACINAR CELL CARCINOMA Figure 9-28 NON-NEOPLASTIC ACINAR CELLS AND ACINAR CELL CARCINOMA Neoplastic acinar cells have hyperchromatic chromatin and high nuclear: cytoplasmic ratio (left). On the right, cytoplasmic granularity is decreased in acinar cell carcinoma and... More

PANCREATIC NEUROENDOCRINE TUMOR Figure 12-39 PANCREATIC NEUROENDOCRINE TUMOR Entrapped non-neoplastic ductules within a PanNET. The ductular epithelium has eosinophilic cytoplasm (left) and is closely associated with the neoplastic cells (right). More

SOLITARY FIBROUS TUMOR Figure 13-23 SOLITARY FIBROUS TUMOR Nuclear immunolabeling for STAT6. The non-neoplastic pancreatic parenchyma (right) does not label. More

NON-HODGKIN LYMPHOMA Figure 13-36 NON-HODGKIN LYMPHOMA Left: Grossly, the lymphoma forms a solid, homogeneous fleshy tan mass similar to its appearance outside the pancreas. The lymphoma in this case compresses the bile duct. Right: Multinodular involvement of the pancreatic body and tail may re... More

ACINAR CELL CARCINOMA Figure 9-27 ACINAR CELL CARCINOMA Neoplastic acinar cell clusters appear more hyperchromatic than non-neoplastic acinar cells because of the increased nuclear to cytoplasmic ratio (left). The vaguely lobulated architecture of acinar cell carcinoma is more disorganized and cr... More

SQUAMOCOLUMNAR JUNCTION (SCJ) AND NON-SCJ–RELATED PRECURSORS IN THE CERVIX Figure 1-4 SQUAMOCOLUMNAR JUNCTION (SCJ) AND NON-SCJ–RELATED PRECURSORS IN THE CERVIX SCJ-associated high-grade squamous intraepithelial lesion (A). SCJ-associated adenocarcinoma in situ (B), and isolated adenocarcinoma in... More

CROHN DISEASE Figure 5-99 CROHN DISEASE A non-necrotizing granuloma with central multinucleated giant cells is present in the superficial dermis. More

PANCREATIC NEUROENDOCRINE TUMOR Figure 12-53 PANCREATIC NEUROENDOCRINE TUMOR Scattered cells immunolabel for glucagon in this non-functioning PanNET. More

ISLET AGGREGATION Figure 15-67 ISLET AGGREGATION Immunolabeling for insulin shows pseudoinfiltration of fat tissue by non-neoplastic islets. More

SOLID PSEUDOPAPILLARY NEOPLASM Figure 11-16 SOLID PSEUDOPAPILLARY NEOPLASM So-called blood lakes at the inter face with the non-neoplastic pancreas. More

ACINAR CELL NODULE Figure 1-21 ACINAR CELL NODULE Acinar cell nodules are defined as aggregates of enlarged non-neoplastic acinar cells that are distinguished from the surrounding acinar cells by the pale tinctorial staining qualities of the cytoplasm. More

INTRADUCTAL TUBULOPAPILLARY NEOPLASM Figure 6-55 INTRADUCTAL TUBULOPAPILLARY NEOPLASM Left: Back-to-back tubular glands form a nodular tumor mass nearly filling a dilated duct. Right: A rim of residual non-neoplastic ductal epithelium surrounds the periphery of an intraductal tumor nodule. More

SOLID PSEUDOPAPILLARY NEOPLASM Figure 11-15 SOLID PSEUDOPAPILLARY NEOPLASM A: The interface with the adjacent pancreas is often infiltrative, but there is no stromal reaction to the neoplasm. B: Islands of tumor are surrounded by pancreatic parenchyma, where the neoplastic cells resemble islets.... More