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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-15
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... tumor type, grade, size, number of foci of invasive carcinoma, presence or absence of DCIS and lymphovascular space invasion, margin status, lymph node status, and results of ER, PR, and HER2 studies (usually from the prior core needle biopsy specimen) ( 19 ). Analogous to the process of determining...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch48
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...CYSTIC TUMOR OF THE ATRIOVENTRICULAR NODE: MAGNETIC RESONANCE IMAGING Figure 48-1 CYSTIC TUMOR OF THE ATRIOVENTRICULAR NODE: MAGNETIC RESONANCE IMAGING Although these rests are usually diagnosed initially at autopsy, cardiac imaging may detect them during life. A cardiac magnetic resonance image...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-14
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...In patients with breast cancer, axillary lymph nodes are excised and processed for pathologic examination as part of the cancer staging process. Microscopic evaluation to assess for the presence, or absence, of metastasis is key to informing treatment planning, and determines patient prognosis...
Images
SPITZOID MELANOMA (OF CHILDHOOD)  A: Shave biopsy of an ulcerated tumor.  B...
Published: 01 February 2024
SPITZOID MELANOMA (OF CHILDHOOD) Figure 19-4 SPITZOID MELANOMA (OF CHILDHOOD) A: Shave biopsy of an ulcerated tumor. B: The tumor cells display severe nuclear atypia. The tumor was associated with homozygous deletions of p16 (not shown). C: Metastatic melanoma in the regional lymph node. More about this image found in SPITZOID MELANOMA (OF CHILDHOOD) A: Shave biopsy of an ulcerated tumor. B...
Images
SPITZOID MELANOMA (OF CHILDHOOD)  A: The tumor is densely cellular with lac...
Published: 01 February 2024
SPITZOID MELANOMA (OF CHILDHOOD) Figure 19-6 SPITZOID MELANOMA (OF CHILDHOOD) A: The tumor is densely cellular with lack of maturation and tongue-like projections at the base. B: The tumor is composed of fusiform melanocytes, many of which are in mitosis. C: Tumor cells are present in the subca... More about this image found in SPITZOID MELANOMA (OF CHILDHOOD) A: The tumor is densely cellular with lac...
Images
SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS  A: Symmetric silhouette of a...
Published: 01 February 2024
SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS Figure 19-2 SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS A: Symmetric silhouette of a compound pigmented spindle and epithelioid cell neoplasm in a young adult. There are clefts between junctional nests and adjacent hyperplastic epidermis. B: A few ... More about this image found in SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS A: Symmetric silhouette of a...
Images
MELANOMA WITH PLEXIFORM GROWTH  A: Asymmetric silhouette of a melanoma with...
Published: 01 February 2024
MELANOMA WITH PLEXIFORM GROWTH Figure 21-3 MELANOMA WITH PLEXIFORM GROWTH A: Asymmetric silhouette of a melanoma with conventional features in its superficial portion and a deep pigmented plexiform invasive tumor component. B: The superficial part of the tumor contains atypical cells in the epid... More about this image found in MELANOMA WITH PLEXIFORM GROWTH A: Asymmetric silhouette of a melanoma with...
Images
EXTRACAPSULAR EXTENSION  In addition to a macrometastasis of the lymph <span class="search-highlight">node</span>...
Published: 01 January 2024
EXTRACAPSULAR EXTENSION Figure 14-2 EXTRACAPSULAR EXTENSION In addition to a macrometastasis of the lymph node, nests of tumor cells are seen extending beyond the lymph node capsule into the perinodal adipose tissue. More about this image found in EXTRACAPSULAR EXTENSION In addition to a macrometastasis of the lymph node...
Images
METASTATIC CARCINOMA  In this low-power image, the lymph <span class="search-highlight">node</span> is seen to be...
Published: 01 January 2024
METASTATIC CARCINOMA Figure 14-4 METASTATIC CARCINOMA In this low-power image, the lymph node is seen to be completely replaced by metastatic carcinoma. The stromal reaction and nested growth pattern allow for easy identification. The extent of involvement constitutes a macrometastasis. More about this image found in METASTATIC CARCINOMA In this low-power image, the lymph node is seen to be...
Images
SENTINEL LYMPH <span class="search-highlight">NODE</span> STATUS POSTNEOADJUVANT SYSTEMIC CHEMOTHERAPY  A: At int...
Published: 01 January 2024
SENTINEL LYMPH NODE STATUS POSTNEOADJUVANT SYSTEMIC CHEMOTHERAPY Figure 14-10 SENTINEL LYMPH NODE STATUS POSTNEOADJUVANT SYSTEMIC CHEMOTHERAPY A: At intermediate power, this lymph node is replaced by fibrosis characteristic of treatment effect. Careful examination in the areas of fibrosis reveals... More about this image found in SENTINEL LYMPH NODE STATUS POSTNEOADJUVANT SYSTEMIC CHEMOTHERAPY A: At int...
Images
BENIGN SQUAMOUS INCLUSION  A: Low power demonstrates a lymph <span class="search-highlight">node</span> with squa...
Published: 01 January 2024
BENIGN SQUAMOUS INCLUSION Figure 14-17 BENIGN SQUAMOUS INCLUSION A: Low power demonstrates a lymph node with squamous-lined epithelial cysts. B: At higher power, keratinaceous debris within the cyst is easily appreciated. More about this image found in BENIGN SQUAMOUS INCLUSION A: Low power demonstrates a lymph node with squa...
Images
SUPERFICIAL SPREADING MELANOMA ARISING IN ASSOCIATION WITH A NEVUS  A: Asym...
Published: 01 February 2024
SUPERFICIAL SPREADING MELANOMA ARISING IN ASSOCIATION WITH A NEVUS Figure 20-1 SUPERFICIAL SPREADING MELANOMA ARISING IN ASSOCIATION WITH A NEVUS A: Asymmetric silhouette of the lesion of a teenager shows an ulcerated nodular growth on the right side and a plaque lesion of a compound nevus on the left. B: Compound melanocytic nevus with bland cytologic features. C: In situ and invasive melanoma are characterized by architectural disorder and nuclear atypia. D: The primary invasive melanoma contains sheets of atypical melanocytes, some of which are in mitosis. E: Metastatic melanoma in the sentinel lymph node. F: The tumor cells homogenously express BRAF V600E. More about this image found in SUPERFICIAL SPREADING MELANOMA ARISING IN ASSOCIATION WITH A NEVUS A: Asym...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... melanoma in the sentinel lymph node. F: The tumor cells homogenously express BRAF V600E. PRIMARY DE NOVO PEDIATRIC MELANOMA Figure 20-2 PRIMARY DE NOVO PEDIATRIC MELANOMA A: Ulcerated pigmented melanoma from a child with no associated nevus remnant. B: Sheets of tumor cells are present...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... was in the regional lymph node draining the site of this tumor 6 years after its removal. SPITZ MELANOMA WITH ALK FUSION Figure 19-3 SPITZ MELANOMA WITH ALK FUSION A: The silhouette of the tumor shows an expansile nodular growth with sheets of tumor cells and an area of necrosis (arrow). B...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-23
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... factors of primary cutaneous melanomas; prognostic issues related to lymph nodes and distant sites are not discussed. Clinical Parameters A number of clinical parameters affect the outcome of patients, such as old age, male gender, head and neck location, immune suppression, and co-morbidities ( 1...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-11
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... sporadically ( 5 ). Zembowicz et al. ( 4 ) noted that both animal-type melanomas and epithelioid blue nevi showed overlapping histopathologic features and proposed the term pigmented epithelioid melanocytoma to encompass both tumors, and to define an entity with the potential to involve regional lymph nodes...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...  Most often elderly Caucasians  Most often head and neck  Papule, nodule, indurated plaque with or without pigmentation  May have been present for several years  Tendency for local recurrence  Low probability for involvement of regional lymph nodes for pure tumors Histopathology...
Images
BIOPSY CLIP SITE  In this scanning magnification image, a positive lymph no...
Published: 01 January 2024
BIOPSY CLIP SITE Figure 14-3 BIOPSY CLIP SITE In this scanning magnification image, a positive lymph node is seen on the left, and on the right is histologic evidence of the biopsy clip site, which must be identified and documented in any case in which preoperative lymph node sampling has occurre... More about this image found in BIOPSY CLIP SITE In this scanning magnification image, a positive lymph no...
Images
NEVUS CELL AGGREGATE  A: At low power, a nest of epithelial-appearing cells...
Published: 01 January 2024
NEVUS CELL AGGREGATE Figure 14-12 NEVUS CELL AGGREGATE A: At low power, a nest of epithelial-appearing cells is identified in the lymph node capsule. B: At higher power, the cells appear to have relatively abundant pale pink cytoplasm, indistinct cell borders, and small oval nuclei. One cell is ... More about this image found in NEVUS CELL AGGREGATE A: At low power, a nest of epithelial-appearing cells...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... the primary tumor is the treatment of choice for primary blue melanomas. The value of sentinel lymph node biopsies for patients with blue melanomas is not known. When evaluating sentinel lymph nodes of patients with a primary melanoma associated with a blue nevus, the possibility of a nodal blue nevus should...