EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Figure 8-8 EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Lymph node with architectural distortion (A) with focal capsular permeation by lymphoid cells (top), a polymorphic mononuclear infiltrate (B) with associated plasma cells (C) and focal mitotic activity (cen... More about this image found in EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Lymph node with architectural dist...

MULTICENTRIC CASTLEMAN DISEASE AND KAPOSI SARCOMA Figure 8-24 MULTICENTRIC CASTLEMAN DISEASE AND KAPOSI SARCOMA Lymph node in patient with HIV where there is HHV8-associated Kaposi sarcoma (A) and Castleman disease (B). More about this image found in MULTICENTRIC CASTLEMAN DISEASE AND KAPOSI SARCOMA Lymph node in patient wi...

PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL) Figure 9-2 PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL) A: The lymph node has irregularly shaped reactive follicles. B: PGL lymph node follicle in center with macrophage phagocytosis and apoptotic debris. C: HIVp24 stains HIV virus in follicular dend... More about this image found in PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL) A: The lymph node has irregul...

MESENTERIC LYMPH NODE INFECTION BY Y. PSEUDOTUBERCULOSIS Figure 13-13 MESENTERIC LYMPH NODE INFECTION BY Y. PSEUDOTUBERCULOSIS A–C: There is a mixture of granulomatous and suppurative inflammation, the latter often identified centrally in the granulomatous foci. More about this image found in MESENTERIC LYMPH NODE INFECTION BY Y. PSEUDOTUBERCULOSIS ...

WHIPPLE DISEASE Figure 13-38 WHIPPLE DISEASE A,B: Mesenteric lymph node with foamy macrophage infiltration and isolated small granulomas. More about this image found in WHIPPLE DISEASE A,B: Mesenteric lymph node with foamy macrophage infiltrat...

INHALATION ANTHRAX Figure 14-11 INHALATION ANTHRAX A mediastinal lymph node shows prominent hemorrhage (A) and associated neutrophil infiltration (B), also involving the perinodal fat. Parietal pleural biopsy (C) in a patient with inhalation anthrax shows edema, vasculitis, and associated hemorrh... More about this image found in INHALATION ANTHRAX A mediastinal lymph node shows prominent hemorrhage (A)...

LYMPH NODE INVOLVEMENT IN TULAREMIA Figure 17-9 LYMPH NODE INVOLVEMENT IN TULAREMIA High-power view of a necrotizing granuloma with suppurative inflammation and necrosis surrounded by histiocytes. (Courtesy of the CDC IDPB) More about this image found in LYMPH NODE INVOLVEMENT IN TULAREMIA High-power view of a necrotizing granu...

LYMPH NODE INVOLVEMENT IN TULAREMIA Figure 17-10 LYMPH NODE INVOLVEMENT IN TULAREMIA Confirmatory immunohistochemistry highlights F. tularensis organisms at low power (A) and high power (B). (Courtesy of the CDC IDPB) More about this image found in LYMPH NODE INVOLVEMENT IN TULAREMIA Confirmatory immunohistochemistry high...

SECONDARY SYPHILIS INVOLVING A LYMPH NODE Figure 18-7 SECONDARY SYPHILIS INVOLVING A LYMPH NODE Endothelial cell swelling, plasma cell infiltration (A), and early granuloma formation (B). More about this image found in SECONDARY SYPHILIS INVOLVING A LYMPH NODE Endothelial cell swelling, plasm...

LYMPHOGRANULOMA VENEREUM Figure 18-16 LYMPHOGRANULOMA VENEREUM Low-power appearance of lymph node involvement demonstrates characteristic geographic to stellate necrosis, surrounding palisaded epithelioid cells, and a paucity of multinucleated giant cells. (Courtesy of the AFIP Archives) More about this image found in LYMPHOGRANULOMA VENEREUM Low-power appearance of lymph node involvement de...

INHALATION ANTHRAX Figure 14-10 INHALATION ANTHRAX At autopsy there is an enlarged, edematous black mediastinal lymph node (center). (Courtesy of the CDC IDPB) More about this image found in INHALATION ANTHRAX At autopsy there is an enlarged, edematous black medias...

TYPHOID FEVER Figure 13-17 TYPHOID FEVER A: Base of a cecal ulcer shows the characteristic predominance of histiocytes in the inflammatory infiltrate. B: The histiocytes (Mallory cells), which are also found in draining lymph nodes, have granular cytoplasm due to phagocytosis of necrotic debris ... More about this image found in TYPHOID FEVER A: Base of a cecal ulcer shows the characteristic predominan...

C. TRACHOMATIS INFECTIONS Figure 18-12 C. TRACHOMATIS INFECTIONS A: Eyelid with early stage of trachoma (A), shows a typically granular conjunctiva due to the presence of multiple lymphoid follicles. (Courtesy of the CDC PHIL) B: Lymphogranuloma venereum (LGV) demonstrating draining lymph nodes. (Courtesy of Dr. M. Gaviria, Pontifica Bolivariana University, Medellín, Colombia) More about this image found in C. TRACHOMATIS INFECTIONS A: Eyelid with early stage of t...

BRUCELLOSIS Figure 14-4 BRUCELLOSIS A: Brucellosis of the liver shows a small non-necrotizing granuloma. (Courtesy of Prof. S. Lucas, London, UK) B: Lymph node involvement shows extensive necrosis with surrounding histiocytes and scattered granulomas. C: Brucella spp organisms are highlighted by a modified Steiner silver stain. (Case courtesy of Dr. B. Pritt, Mayo Clinic, Rochester, MN) More about this image found in BRUCELLOSIS A: Brucellosis of the liver shows a small non-necrotizing gran...

HHV8-ASSOCIATED MULTICENTRIC CASTLEMAN DISEASE IN HIV PATIENT Figure 8-23 HHV8-ASSOCIATED MULTICENTRIC CASTLEMAN DISEASE IN HIV PATIENT A: An intra-abdominal lymph node shows an early germinal center and vascular hyalinization, surrounding concentric rims (“onion-skinning”) of lymphocytes and ass... More about this image found in HHV8-ASSOCIATED MULTICENTRIC CASTLEMAN DISEASE IN HIV PATIENT A: An intra-...

IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME (IRIS), MYCOBACTERIUM-AVIUM COMPLEX (MAC) Figure 9-29 IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME (IRIS), MYCOBACTERIUM-AVIUM COMPLEX (MAC) A: Mesenteric lymph node from a patient on HAART and anti-MAC drugs. Note the abundant macrophages and lymphocytes. B: Granuloma formation and T-cell infiltrate on CD4 immunohistochemical stain. C: Ziehl-Neelsen stain shows masses of fragmented acid-fast bacilli within macrophages. (Courtesy of the JPC) More about this image found in IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME (IRIS), MYCOBACTERIUM-A...