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Book Chapter
Oral Cavity
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
... is extremely rare, accounting for 0.5 to 1.0 percent of all melanomas ( 193 , 194 ). No specific etiology or pathogenesis is known. OMM is not related to preexisting mucosal nevi or physiologic pigmentation, and it is biologically distinct from cutaneous melanomas ( 195 , 196 ). OMM, unlike cutaneous melanoma...
Book Chapter
Congenital Melanocytic Nevi
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... in adulthood (small [<1.5 cm], medium [1.6-20 cm], large [20-40 cm], and giant [40-60 cm]) Satellite nevi and neurocutaneous melanosis may be present Histopathologic Findings Band-like architecture occupying the entire dermis Extension into reticular dermis or subcutis, occasionally fascia...
Book Chapter
Common Acquired Melanocytic Nevi
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., inflammation, desmoplasia, edema, hypervascularity, other) Ancillary Test Findings Immunohistochemistry Most ordinary nevi homogenously express SOX10 and S-100 protein Epithelioid cells are usually immunoreactive for Melan-A and tyrosinase Neurotized spindle melanocytes may only express...
Book Chapter
Dysplastic Melanocytic Nevi
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... . 3. Ackerman AB , Magana-Garcia M . Naming acquired melanocytic nevi: Unna’s, Miescher’s, Spitz’s, Clark’s . Am J Dermatopathol 1990 ; 12 : 193 - 209 . 4. Metcalf JS , Maize JC . Clark’s nevus . Semin Cutan Med Surg 1999 ; 18 : 43 - 6 . 5. Clark WH Jr...
Book Chapter
Melanocytic Nevi of Special Sites
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 5-1 CLINICAL AND PATHOLOGIC FEATURES OF ATYPICAL NEVI BY ANATOMIC SITE Anatomic Site Clinical Findings of Atypical Nevi Histologic Features of Atypical Nevi Acral Small, circumscribed with even color Parallel furrow, lattice-like, or fibrillar dermoscopic patterns Variable...
Book Chapter
Traumatized and Recurrent Melanocytic Nevi
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... Figure 6-10 NEVUS CHANGING UNDER IMMUNOTHERAPY Compound melanocytic nevus with features of partial regression. REFERENCES REFERENCES 1. Schoenfeld RJ , Pinkus H . The recurrence of nevi after incomplete removal . AMA Arch Derm 1958 ; 78 : 30 - 5 . 2. Cox AJ , Walton...
Book Chapter
Spitz Nevi, Spitz Melanocytomas, and Atypical Spitz Tumors
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... most Spitz nevi. There is limited maturation. B: The tumor cells display spitzoid features and nuclear atypia. SPITZ MELANOCYTOMA Figure 7-23 SPITZ MELANOCYTOMA A: Silhouette of a cellular tumor with extension into the deep dermis and deep bulbous growth. B: Nests of plump spindle and epithelioid...
Book Chapter
Blue Nevi and Dermal Melanocytoses
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... are present. REFERENCES REFERENCES 1. Murali R , McCarthy SW , Scolyer RA . Blue nevi and related lesions: a review highlighting atypical and newly described variants, distinguishing features and diagnostic pitfalls . Adv Anat Pathol 2009 ; 16 : 365 - 82 . 2. de la Fouchardiere...
Book Chapter
Combined Melanocytic Nevi/Melanocytomas
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 10-1 VARIANTS OF COMBINED NEVI Combined deep penetrating nevus Combined inverted type A nevus Combined blue nevus Combined spitzoid nevus a Combined desmoplastic nevus Combined neurotized nevus Combined balloon cell nevus Combined pigmented epithelioid...
Images
ACQUIRED MELANOCYTIC NEVI WITH MINOR ARCHITECTURAL DISORDER A: The lesion ...
Available to PurchasePublished: 01 February 2024
ACQUIRED MELANOCYTIC NEVI WITH MINOR ARCHITECTURAL DISORDER Figure 3-23 ACQUIRED MELANOCYTIC NEVI WITH MINOR ARCHITECTURAL DISORDER A: The lesion is small and circumscribed. It displays minor asymmetry. B: This compound nevus has a shoulder, but lacks other features of a dysplastic nevus. More about this image found in ACQUIRED MELANOCYTIC NEVI WITH MINOR ARCHITECTURAL DISORDER A: The lesion ...
Book Chapter
Pediatric Melanoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 20-1 FEATURES OF PEDIATRIC ADULT SUBTYPE MELANOMA Clinical Features Adolescents; rare in children Caucasian Nevus phenotype (large number of acquired melanocytic nevi) Microscopic Findings Superficial spreading Nodular Acral lentiginous (rare...
Book Chapter
Deep Penetrating Nevus
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... penetrating nevi . Nat Commun 2017 ; 8 : 644 . 9. de la Fouchardière A , Caillot C , Jacquemus J , et al . β-catenin nuclear expression discriminates deep penetrating nevi from other cutaneous melanocytic tumors . Virchows Arch 2019 ; 474 : 539 - 50 . 10. Bender RP...
Book Chapter
Nevoid Melanoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with unusual/atypical features Ancillary Tests Immunohistochemistry: Most nevoid melanomas express PRAME; most nevi are negative Molecular Genetic: Genomic aberrations are common (cytogenetic tests are often positive) NRAS mutations and noncoding mutations are common...
Book Chapter
Pigmented Epithelioid Melanocytoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-11
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... melanocytoma with chromosomal copy number alterations in 15q and 17q and a novel NTRK3-SCAPER gene fusion . J Cutan Pathol 2020 ; 47 : 70 - 5 . 12. Phadke PA , Zembowicz A . Blue nevi and related tumors . Surg Pathol Clin 2009 ; 2 : 483 - 96 . 13. Lim C , Murali R...
Images
ATYPICAL SPITZ TUMOR A: The tumor is larger and extends more deeply than m...
Available to PurchasePublished: 01 February 2024
ATYPICAL SPITZ TUMOR Figure 7-22 ATYPICAL SPITZ TUMOR A: The tumor is larger and extends more deeply than most Spitz nevi. There is limited maturation. B: The tumor cells display spitzoid features and nuclear atypia. More about this image found in ATYPICAL SPITZ TUMOR A: The tumor is larger and extends more deeply than m...
Book Chapter
Desmoplastic Melanoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... for the distinction of desmoplastic melanomas from sclerosing melanocytic nevi . J Cutan Pathol 2011 ; 38 : 329 - 34 . 23. Clarke LE , Pimentel JD , Zalaznick H , Wang L , Busam KJ . Gene expression signature as an ancillary method in the diagnosis of desmoplastic melanoma . Hum...
Book Chapter
Superficial Spreading Melanoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... GL , Parazzini F , Gallus S , La Vecchia C . Pigmentary traits, modalities of sun reaction, history of sunburns, and melanocytic nevi as risk factors for cutaneous malignant melanoma in the Italian population: results of a collaborative case-control study . Cancer 2000 ; 88...
Book Chapter
Nodular Melanoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... Pathologic Differential Diagnosis Various melanocytic nevi with nodular growth pattern Predominantly intradermal densely cellular nevus Cellular blue nevus Pigmented epithelioid melanocytoma Combined nevus with nodular growth Cellular and/or proliferative nodule associated...
Book Chapter
Spitzoid and Spitz Melanomas
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... , et al . Spitz nevi and Spitzoid melanomas: exome sequencing and comparison with conventional melanocytic nevi and melanomas . Mod Pathol 2017 ; 30 : 640 - 9 . 12. Gerami P , Scolyer RA , Xu X , et al . Risk assessment for atypical spitzoid melanocytic neoplasms using FISH...
Book Chapter
Blue Nevus-Related Melanoma
Available to PurchaseSeries: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... . Melanomas associated with blue nevi or mimicking cellular blue nevi: clinical, pathologic, and molecular study of 11 cases displaying a high frequency of GNA11 mutations, BAP1 expression loss, and a predilection for the scalp . Am J Surg Pathol 2016 ; 40 : 368 - 77 . 8. Gerami P...
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