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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Combined melanocytic nevi are benign melanocytic proliferations that display two (or more) histopathologic nevus phenotypes within the same clinical lesion. Their relevance lies in the fact that they may both clinically and histopathologically be confused with melanoma. In some combined...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Congenital melanocytic nevus (CMN) is a melanocytic nevus that is present at birth ( Table 2-1 ) ( 1 ). Nevi developing or becoming clinically apparent within the first 2 years of life share similar histopathologic features, and are called tardive CMN or congenital-like...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Acquired melanocytic nevi are benign melanocytic neoplasms not present at birth. They develop during childhood, adolescence, or any time during adulthood. The annotations “common,” “ordinary,” “conventional,” or “banal” refer to the spectrum of acquired nevi most frequently encountered...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... and atypia and Clark nevus, although the latter term is not entirely synonymous because its historic microscopic definition does not require cytologic atypia. While there is consensus that dysplastic nevi are significant as clinical and histologic simulants of melanoma, their biology and prognostic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...The category of nevi of special site is useful to address unusual or atypical histopathologic features of melanocytic nevi that tend to be associated with various anatomic sites ( 1 – 4 ). It is relevant for pathologists to be aware of the spectrum of site-related atypical features...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...This chapter addresses the histopathologic changes associated with persistent melanocytic nevi presenting with repigmentation after prior surgery and nevi changing in response to nonsurgical mechanical trauma or biochemical injury, such as effects from cancer treatment. Knowledge of the effects...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...SPITZ NEVI Definition. The eponym “Spitz” honors Sophie Spitz who in 1948 published observations on the relatively favorable clinical course of children diagnosed with melanoma compared to adults with melanoma ( 1 ). Over time, it became apparent that most of the lesions previously classified...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... and dendritic melanocytes with variable amounts of finely granular melanin pigment. The melanocytes are typically confined to the dermis and/or subcutis, with no associated intraepidermal or intrafollicular tumor component. BN shares with most other nevi immunoreactivity for MART1/Melan-A, SOX10, and tyrosinase...
Images
Published: 01 February 2024
ACQUIRED MELANOCYTIC NEVI WITH MINOR ARCHITECTURAL DISORDER Figure 3-23 ACQUIRED MELANOCYTIC NEVI WITH MINOR ARCHITECTURAL DISORDER A: The lesion is small and circumscribed. It displays minor asymmetry. B: This compound nevus has a shoulder, but lacks other features of a dysplastic nevus. More about this image found in ACQUIRED MELANOCYTIC NEVI WITH MINOR ARCHITECTURAL DISORDER A: The lesion ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... for pediatric melanoma include large or giant congenital melanocytic nevi, an atypical nevus phenotype, freckles, history of sunburns, neurocutaneous melanosis, and a prior history of cancer, xeroderma pigmentosum, or immunosuppression ( 4 – 8 ). Excessive exposure to ultraviolet light, from indoor/artificial...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...). In contrast to many other nevi, apart from blue nevi, diffuse staining with HMB-45 is commonly seen in DPN. Most DPNs show a distinct pattern of staining for beta-catenin and cyclin D1 ( 8 , 9 ). In common melanocytic nevi, expression of beta-catenin and cyclin D1 is restricted to superficial dermal...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... surrounded by collarettes of thin rete ridges (“puffy shirt sign”) Nuclear atypia Mitoses Differential Diagnosis Mitotically active nevus Nevus with unusual/atypical features Ancillary Tests Immunohistochemistry: Most nevoid melanomas express PRAME; most nevi are negative...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-11
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... sporadically ( 5 ). Zembowicz et al. ( 4 ) noted that both animal-type melanomas and epithelioid blue nevi showed overlapping histopathologic features and proposed the term pigmented epithelioid melanocytoma to encompass both tumors, and to define an entity with the potential to involve regional lymph nodes...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... sensitivity ( 22 ). Similar limitations in test sensitivity apply to contemporary gene expression arrays ( 23 ). DIFFERENTIAL DIAGNOSIS DM poses a significant diagnostic pitfall for pathologists ( 24 ). It may be confused with desmoplastic nevi or benign fibrosing nonmelanocytic lesions, such as a scar...
Images
Published: 01 February 2024
ATYPICAL SPITZ TUMOR Figure 7-22 ATYPICAL SPITZ TUMOR A: The tumor is larger and extends more deeply than most Spitz nevi. There is limited maturation. B: The tumor cells display spitzoid features and nuclear atypia. More about this image found in ATYPICAL SPITZ TUMOR A: The tumor is larger and extends more deeply than m...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of SSMs ( 9 ). Diffuse PRAME expression is very rare in melanocytic nevi and can therefore be used as an ancillary tool for the distinction of nevi from melanoma. MOLECULAR GENETIC FINDINGS BRAF V600E mutations are the most common driver mutation of SSM, found in more than 50 percent of cases...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., or hemangioma. Pigmented nodular melanomas may be confused with pigmented basal cell carcinoma, seborrheic keratosis, melanocytic nevi, or metastatic melanoma. Attention to the dermoscopic findings may help in the recognition of nodular melanoma, such as the presence of abnormal vascular structures ( fig. 15-1C...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... nevi and present as a flesh-colored, erythematous, brown or black papule, plaque, or nodule. Large tumors may be ulcerated. The clinical impression may be broad, ranging from pyogenic granuloma or fibroma to nevus or melanoma. Spitz and spitzoid melanomas tend to occur in younger patients, but the age...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... heterogeneous group of pigmented melanomas with significant interobserver variability as to whether a tumor has blue nevus-like features or not. This chapter focuses on melanomas related to blue nevi, either by documentation of a shared molecular pathway or strong evidence indicating that the melanoma is most...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... There is associated marked solar elastosis. Although in its classic form a LM is characterized by a predominance of solitary units of melanocytes, junctional nests may be found in variable proportions ( Table 13-1 ). When junctional nests are present, they tend to be small. In contrast to melanocytic nevi, junctional...
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