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neuroendocrine

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Images
Published: 01 December 2024
PHEOCHROMOCYTOMA: NEUROENDOCRINE MARKERS Figure 8-37 PHEOCHROMOCYTOMA: NEUROENDOCRINE MARKERS The tumor cells express nuclear INSM1 (A), cytoplasmic synaptophysin (B), and cytoplasmic chromogranin A (C). These biomarkers indicate that this is a neuroendocrine neoplasm but are not specific for phe... More about this image found in PHEOCHROMOCYTOMA: NEUROENDOCRINE MARKERS The tumor cells express nuclear I...
Images
Published: 01 December 2024
PHEOCHROMOCYTOMA Figure 8-22 PHEOCHROMOCYTOMA The tumor cells are round and regular, with abundant cytoplasm, resembling cells of an epithelial neuroendocrine tumor. More about this image found in PHEOCHROMOCYTOMA The tumor cells are round and regular, with abundant cyto...
Images
Published: 01 December 2024
ECTOPIC ACTH SYNDROME Figure 3-11 ECTOPIC ACTH SYNDROME Diffuse ACTH-dependent adrenocortical hyperplasia from an adrenal metastasis of an ACTH-secreting lung neuroendocrine tumor. More about this image found in ECTOPIC ACTH SYNDROME Diffuse ACTH-dependent adrenocortical hyperplasia fr...
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Published: 01 December 2024
PHEOCHROMOCYTOMA IN A PATIENT WITH MEN1 Figure 10-7 PHEOCHROMOCYTOMA IN A PATIENT WITH MEN1 This adrenal pheochromocytoma was identified at the time of surgery for a pancreatic neuroendocrine tumor in a patient with a history of multi-glandular parathyroid disease. While the tumor has no specific... More about this image found in PHEOCHROMOCYTOMA IN A PATIENT WITH MEN1 This adrenal pheochromocytoma was ...
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Published: 01 December 2024
ECTOPIC ACTH SYNDROME Figure 3-6 ECTOPIC ACTH SYNDROME Transverse sections of adrenal glands surgically resected from a patient with ectopic ACTH syndrome due to a bronchial neuroendocrine tumor. The tumor had remained occult for several years. The right adrenal gland weighed 12 g and the left 11... More about this image found in ECTOPIC ACTH SYNDROME Transverse sections of adrenal glands surgically res...
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Published: 01 December 2024
NORMAL PERITHYROIDAL PARAGANGLION Figure 9-10 NORMAL PERITHYROIDAL PARAGANGLION A: This paraganglion, discovered incidentally in peri-thyroidal soft tissue in an adult patient with a multinodular goiter, is architecturally similar to the carotid body in figure 9-7 . The intimate association of n... More about this image found in NORMAL PERITHYROIDAL PARAGANGLION A: This paraganglion, discovered inciden...
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Published: 01 December 2024
NORMAL ABDOMINAL PARAGANGLION Figure 9-5 NORMAL ABDOMINAL PARAGANGLION A: Low magnification shows proximity of this paraganglion to adjacent developing ganglia, adrenal gland, and kidney in a mid-second trimester fetus. B: Higher magnification of paraganglion in a mid-second trimester fetus. Thi... More about this image found in NORMAL ABDOMINAL PARAGANGLION A: Low magnification shows proximity of this...
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Published: 01 December 2024
MESENTERIC PARAGANGLIOMA Figure 9-14 MESENTERIC PARAGANGLIOMA A: This paraganglioma composed of basophilic and clear cells was incidentally discovered in an asymptomatic patient with no other tumors. Fat invasion, poorly defined irregular cell nests, and diffuse growth are putative risk factors f... More about this image found in MESENTERIC PARAGANGLIOMA A: This paraganglioma composed of basophilic and ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...DEVELOPMENT, ANATOMY, AND FUNCTION OF NORMAL PARAGANGLIA Paraganglia are neuroendocrine organs associated with paraxial sympathetic nerves and branches of the glossopharyngeal and vagus nerves in the head and neck. In the late 19th century, the anatomist Alfred Kohn proposed...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... extra-adrenal) 2 Neurofibroma and MPNST a Ocular manifestations including Lisch nodules and optic gliomas Café-aulait spots Duodenal neuroendocrine tumor Renal, liver, and epididymal cysts VHL 3p25.5 VHL (von Hippel-Lindau disease) Adrenal and extra-adrenal 1 Clear cell...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., since it is evident that this distinction is not currently possible or reliable. Instead, as with other neuroendocrine tumors, these neoplasms are all considered to have malignant potential, and those that do give rise to metastasis are classified as “metastatic.” Moreover, with increasing awareness...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... of the neuroendocrine cells comprising the medulla to respond to trans-synaptic signals from preganglionic sympathetic nerves by exocytosis of presynthesized pools of catecholamines stored in secretory granules ( 15 ). The clearance of catecholamines within the blood is also rapid, and epinephrine and norepinephrine...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... source should include the neck (to detect potential medullary thyroid carcinoma), the thorax (for thymic or pulmonary neuroendocrine tumors), the abdomen (where pancreatic neuroendocrine tumors are the most common source of ectopic ACTH), and the pelvis. The use of Ga68-dotate positron emission...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...) MEN1 Primary macronodular adrenal disease, adenoma, carcinoma <2% Parathyroid hyperplasia/adenoma, pituitary tumors, foregut neuroendocrine tumors Familial adenomatous polyposis (FAP) APC Adenoma, primary macronodular adrenal disease and carcinoma <1% Colon carcinoma, duodenal...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... with alimentary tract ganglioneuromatosis-lipomatosis, adrenal myelolipomas, pancreatic telangiectasia, and multinodular goiter has been reported as having a possible neuroendocrine syndrome ( 21 ). There is usually no relationship to anemia or other hematopoietic abnormalities ( 16 ), although some patients...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... recent World Health Organization (WHO) classification of endocrine and neuroendocrine tumors ( 1 ). Adrenal cortical nodular diseases are classified according to defined macroscopic and microscopic criteria, and the presence or absence of a particular endocrine syndrome ( 2 ). They may...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... with myxoid stromal change or fibrosis. In rare cases, there is a serpiginous arrangement of cells as might be seen in neuroendocrine tumors. Another architectural pattern is a nesting or alveolar arrangement of cells, which is usually not predominant and blends with the trabecular arrangement noted above...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... immunohistochemical panel but pathologists should be aware of this potential pitfall ( 38 ). Synaptophysin is expressed in both lesions, and the distinction should rely instead on other neuroendocrine (i.e., INSM1, chromogranin A) and adrenal cortical (SF1, Melan-A) markers. PEComa may arise in the adrenal gland...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
.... Furlan   A , Dyachuk   V , Kastriti   ME , et al . Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla . Science   2017 ; 357 : eaal3753 . 8. Lumb   R , Tata   M , Xu   X , et al . Neuropilins guide preganglionic sympathetic axons...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... association and diagnosis. The pathology of JCV infection and PML is discussed in chapter 3 (viral infections of the central nervous system). Merkel cell carcinoma is a highly aggressive primary neuroendocrine carcinoma of the skin. On macroscopy, lesions are often fleshy to tan nodules and can show...