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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... association and diagnosis. The pathology of JCV infection and PML is discussed in chapter 3 (viral infections of the central nervous system). Merkel cell carcinoma is a highly aggressive primary neuroendocrine carcinoma of the skin. On macroscopy, lesions are often fleshy to tan nodules and can show...
Images
Published: 01 January 2024
INVASIVE CARCINOMA WITH NEUROENDOCRINE FEATURES Figure 8-21 INVASIVE CARCINOMA WITH NEUROENDOCRINE FEATURES A: On H&E stain, this tumor is characterized by solid sheets of tumor cells with intermediate-grade nuclei that have even chromatin. B: High-power image better demonstrates the nuclear... More about this image found in INVASIVE CARCINOMA WITH NEUROENDOCRINE FEATURES A: On H&E stain, this ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... cell cytologic features, simulating a primitive small round cell sarcoma or neuroendocrine carcinoma ( 4 , 5 ). Mitotic figures and apoptotic bodies are common in small cell melanoma. A diagnostic error is unlikely if there is associated melanoma in situ, but there is potential for confusion...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with an adenocarcinoma or signet ring cell lymphoma. Sheets or lobules of small round tumor cells may mimic lymphoma, small round cell sarcoma, or neuroendocrine carcinoma. Dissociation of tumor cells may lead to a pattern mimicking angiosarcoma. Some metastatic melanomas show a prominent myxoid stromal reaction as seen...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
.... Invasive carcinoma with neuroendocrine differentiation is restricted to those tumors with demonstrated neuroendocrine differentiation, usually by immunohistochemistry ( fig. 8-21 ), but which do not fit the strict diagnostic criteria for neuroendocrine tumor or neuroendocrine carcinoma (see later...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-03
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... neuroendocrine markers, such as chromogranin, synaptophysin, and CD56 highlight the epithelial cells. However, the presence of endocrine differentiation has no clinical significance. The most important differential diagnostic consideration for DCIS with endocrine differentiation is UDH (see above discussion...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-07
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... have a more spindle-shaped morphology and nuclei are ovoid rather than round ( fig. 7-26 ). Neuroendocrine differentiation may be present, demonstrated with synaptophysin or chromogranin immunostains ( 27 , 28 ). Extracellular mucin production may also be seen, and care must be taken to exclude...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch10
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... . One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States . J Clin Oncol 2008 ; 26 : 3063 - 72 . 32. Patel C , Mathur M , Escarcega RO , Bove AA . Carcinoid heart disease: current...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch41
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... A , Bartoloni G , Tessitore E , Carney JA , Papotti M . Cytokeratin profile and neuroendocrine cells in the glandular component of cardiac myxoma . Virchows Arch 2003 ; 443 : 618 - 24 . 77. Miller DV , Tazelaar HD , Handy JR , Young DA , Hernandez JC...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch52
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... lymph node metastases . Int J Gynecol Cancer 2006 ; 16 : 914 - 6 . 30. Minicucci MF , Zornoff LA , Okoshi MP , et al . Heart failure due to right ventricular metastatic neuroendocrine tumor . Int J Cardiol 2008 ; 126 : e25 - 6 . 31. Bowman AR , Siegel RJ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch43
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... that inhibit mTOR function therefore are promising therapeutics for cardiac rhabdomyomas in TSC patients ( 25 ). Everolimus has been approved by the Food and Drug Administration for pancreatic progressive neuroendocrine tumors, tuberous sclerosis-associated inoperable subependymal giant cell astrocytoma (SEGA...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch09
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... connective tissues a bluish-black color, termed ochronosis, including the heart valves and coronary arteries ( fig. 9-31 ). It is also seen in the sternum, intervertebral discs, skin, and cartilage. Active secretory products of low-grade neuroendocrine tumors and vasoactive amines found in drugs may...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch21
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... in chapter 23 . This section focuses on some of the prototypical paraneoplastic effects that occur in the heart. Pheochromocytoma. Pheochromocytomas are rare neuroendocrine neoplasms of the adrenal medulla that may incite cardiac injury by the secretion of catecholamines. Symptoms of a pheochromocytoma...
Images
Published: 01 August 2023
SMALL CELL CARCINOMA OF NEUROENDOCRINE TYPE Figure 7-29 SMALL CELL CARCINOMA OF NEUROENDOCRINE TYPE Unlike undifferentiated carcinoma, this tumor shows nuclear molding, neuroendocrine-type chromatin and conspicuous apoptosis. More about this image found in SMALL CELL CARCINOMA OF NEUROENDOCRINE TYPE Unlike undifferentiated carcin...
Images
Published: 01 August 2023
GOBLET CELL ADENOCARCINOMA METASTATIC TO THE OVARY Figure 15-4 GOBLET CELL ADENOCARCINOMA METASTATIC TO THE OVARY Left: At low power, the tumor resembles a signet ring cell carcinoma. Right: At high power, neuroendocrine granules are seen (arrowheads). More about this image found in GOBLET CELL ADENOCARCINOMA METASTATIC TO THE OVARY Left: At low power, the...
Images
Published: 01 August 2023
EPENDYMOMA OF BROAD LIGAMENT Figure 16-39 EPENDYMOMA OF BROAD LIGAMENT The low-power appearance sometimes recalls a neuroendocrine tumor (A) or an endometrioid neoplasm (B), but the presence of ependymal pseudorosettes (C) should raise the possibility of ependymoma. This diagnostic impression can... More about this image found in EPENDYMOMA OF BROAD LIGAMENT The low-power appearance sometimes recalls a ...
Images
Published: 01 August 2023
CARCINOMA METASTATIC TO FALLOPIAN TUBE Figure 16-30 CARCINOMA METASTATIC TO FALLOPIAN TUBE A: Lobular carcinoma of breast. B: Colorectal adenocarcinoma with an intraepithelial and invasive profile. C: Signet ring cell carcinoma of stomach. D: Well-differentiated neuroendocrine carcinoma (carci... More about this image found in CARCINOMA METASTATIC TO FALLOPIAN TUBE A: Lobular carcinoma of breast. B:...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-12
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
...Table 12-1 WORLD HEALTH ORGANIZATION (WHO) CLASSIFICATION OF PANCREATIC NEUROENDOCRINE NEOPLASMS a Differentiation Terminology Mitoses per 2 mm2 Ki-67 Index b Well differentiated NET c G1 <2 <3% NET G2 2 - 20 3 - 20% NET...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-07
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... eosinophilic or oxyphilic cytoplasm may on occasion demonstrate hepatoid differentiation ( 43 , 44 ), which can be confirmed with immunohistochemical stains. Rare examples are admixed with yolk sac tumor ( 45 ), small ( 46 ) or large cell neuroendocrine ( 47 , 48 ) carcinoma, undifferentiated carcinoma ( 49...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-14
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
...- and dedifferentiated carcinomas. Small Cell Neuroendocrine Carcinoma (SCNEC). These are high grade neuroendocrine tumors, resembling small cell neuroendocrine carcinomas of the lung. They show nuclear molding, and are positive for synaptophysin and/or chromogranin. Undifferentiated carcinomas are typically...
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