Search Results for neuroblastoma

OLFACTORY NEUROBLASTOMA Figure 1-134 OLFACTORY NEUROBLASTOMA A: Grossly, this olfactory neuroblastoma (ONB) is a glistening, whitetan mass below the epithelium. (Courtesy of Dr. K. Magliocca, Atlanta, GA) B: A polypoid tissue fragment contains numerous lobules of tumor separated More about this image found in OLFACTORY NEUROBLASTOMA A: Grossly, this olfactory neuroblastoma (ONB) is ...

OLFACTORY NEUROBLASTOMA Figure 1-141 OLFACTORY NEUROBLASTOMA A: A silver impregnation Grimelius stain highlights the cytoplasmic neurosecretory granules. (Courtesy of Dr. L. Grimelius, Stockholm, Sweden) B: S-100 protein reacts with the peripheral supporting sustentacular cells. C,D More about this image found in OLFACTORY NEUROBLASTOMA A: A silver impregnation Grimelius stain highlight...

OLFACTORY NEUROBLASTOMA Figure 1-136 OLFACTORY NEUROBLASTOMA A syncytium of small round blue cells cuffs the central neural fibrillar matrix. More about this image found in OLFACTORY NEUROBLASTOMA A syncytium of small round blue cells cuffs the ce...

OLFACTORY NEUROBLASTOMA Figure 1-138 OLFACTORY NEUROBLASTOMA A: A Homer Wright pseudorosette shows neural matrix surrounded by a wreath of neoplastic cells. B: A true rosette with gland-like lumen (black arrow) in a high-grade tumor. C: Several true rosettes with lumina are noted. More about this image found in OLFACTORY NEUROBLASTOMA A: A Homer Wright pseudorosette shows neural matri...

OLFACTORY NEUROBLASTOMA Figure 1-135 OLFACTORY NEUROBLASTOMA A–C: The neoplastic cells of ONB are generally small (A), with scant to lightly staining cytoplasm (B), occasionally showing spindling or irregular outlines (C). D: An “in situ” or intraepithelial growth may be seen (black arrow More about this image found in OLFACTORY NEUROBLASTOMA A–C: The neoplastic cells of ONB are generally sma...

OLFACTORY NEUROBLASTOMA Figure 1-139 OLFACTORY NEUROBLASTOMA A: Calcification and tumor necrosis (black arrow) are seen in intermediate- and high-grade tumors. B: There is focal gangliocytic (black arrow) differentiation. C: Metastatic breast carcinoma is identified (white arrows) within More about this image found in OLFACTORY NEUROBLASTOMA A: Calcification and tumor necrosis (black arrow) ...

OLFACTORY NEUROBLASTOMA Figure 1-133 OLFACTORY NEUROBLASTOMA A: Sagittal CT shows a mass at the cribriform plate (white arrow) of the ethmoid sinus, although without any intracranial extension. B: A coronal T2-weighted MRI shows a “dumbbell”-shaped mass, with intracranial and intranasal growth More about this image found in OLFACTORY NEUROBLASTOMA A: Sagittal CT shows a mass at the cribriform plat...

OLFACTORY NEUROBLASTOMA Figure 1-137 OLFACTORY NEUROBLASTOMA The appearance of the nuclei changes over the arc of tumor differentiation, with low-grade tumors showing round and regular nuclei large nuclei with small nucleoli in grade 2 tumors (B), more nuclear variation and differences in shape More about this image found in OLFACTORY NEUROBLASTOMA The appearance of the nuclei changes over the arc ...

OLFACTORY NEUROBLASTOMA Figure 1-140 OLFACTORY NEUROBLASTOMA A,B: Grading ONB is based on several factors. No pleomorphism, small cell size, and abundant neural matrix in a grade 1 tumor (A); slight tumor cell spindling with small nucleoli, but no increased mitoses and lymphoid tissue More about this image found in OLFACTORY NEUROBLASTOMA A,B: Grading ONB is based on several factors. No p...

OLFACTORY CARCINOMA Figure 1-44 OLFACTORY CARCINOMA A: The tumor has a nested configuration similar to olfactory neuroblastoma. B: However, it exhibits overt epithelial differentiation, here in the form of ciliated eosinophilic glands. More about this image found in OLFACTORY CARCINOMA A: The tumor has a nested configuration similar to olf...

OLFACTORY CARCINOMA Figure 1-45 OLFACTORY CARCINOMA A,B: Synaptophysin (A) and INSM1 (B) are positive. C: S-100 protein stains in a distinctly sustentacular pattern. D: Pancytokeratin is far more diffuse than is acceptable for olfactory neuroblastoma, however. More about this image found in OLFACTORY CARCINOMA A,B: Synaptophysin (A) and INSM1 (B) are positive. C:...

ANATOMIC DISTRIBUTION OF NEUROBLASTOMA Figure 11-2 ANATOMIC DISTRIBUTION OF NEUROBLASTOMA The adrenal gland is the most frequent primary location of neuroblastoma (NB), followed by other locations in the abdomen. (Table 56-1 from Brodeur GM, Castleberry RP. Neuroblastoma. In: Pizzo PA, Poplack More about this image found in ANATOMIC DISTRIBUTION OF NEUROBLASTOMA The adrenal gland is the most frequ...

DISTRIBUTION OF NEUROBLASTOMA BY SEX AND STAGE OVER AGE Figure 11-1 DISTRIBUTION OF NEUROBLASTOMA BY SEX AND STAGE OVER AGE Nearly 90 percent of patients are below 5 years of age at diagnosis. The left side of each pair of columns represents male patients and the right side of each pair More about this image found in DISTRIBUTION OF NEUROBLASTOMA BY SEX AND STAGE OVER AGE Nearly 90 percent ...

MRI SCAN OF METASTASIZED ABDOMINAL NEUROBLASTOMA Figure 11-4 MRI SCAN OF METASTASIZED ABDOMINAL NEUROBLASTOMA More about this image found in MRI SCAN OF METASTASIZED ABDOMINAL NEUROBLASTOMA

ANAPLASTIC NEUROBLASTOMA Figure 11-15 ANAPLASTIC NEUROBLASTOMA The tumor cells have pleomorphic, hyperchromatic nuclei. More about this image found in ANAPLASTIC NEUROBLASTOMA The tumor cells have pleomorphic, hyperchromatic ...