... are primary breast carcinomas. Typical primary tumor types include lymphoma, rhabdomyosarcoma, medulloblastoma, neuroblastoma, medullary carcinoma of the thyroid gland, and Ewing sarcoma/primitive neuroectodermal tumor ( 33 ). Alveolar rhabdomyosarcoma appears to have a particular propensity to metastasize...

... of the developing embryo. The immature tissue can be mixed with mature tissues. Most immature tissues are immature neuroectodermal tissue, which contains rosettes and tubules ( fig. 13-5 ), cellular foci of glia showing mitoses, and sometimes areas resembling neuroblastoma or glioblastoma. Neuroepithelium...

... tumor, medulloepithelioma, chondromesenchymal hamartoma, pituitary blastoma, pineoblastoma, anaplastic sarcoma of kidney, medulloblastoma, DICER1 sarcoma, and neuroblastoma ( 43 ). By 10 years of age, about 5 percent of carriers develop the first neoplasm, while at 50 years, 19 percent of carriers have...

... the gynecologic tract. Ovarian peripheral PNETs are histologically indistinguishable from PNET/Ewing sarcoma, show diffuse expression of CD99, and have a EWSR1-FLI1 gene fusion ( 111 ). Central type PNETs ( 112 ) resemble neuroblastoma, ependymoblastoma, or medulloblastoma. The correct diagnosis involves...

...: a case report . Surg Case Rep   2021 ; 7 : 35 . 32. Zhang   J , Liu   Y , Bao   P , Wang   Y , Zhang   Y . Rare coexistence of metastatic neuroblastoma of liver and solid pseudo papillary tumor of pancreas: case report and literature review . J Cancer Res Ther   2013 ; 9 : 308...

..., hemihypertrophy, adrenal cytomegaly, and an increased risk of embryonal neoplasms including Wilms tumor, hepatoblastoma, neuroblastoma, and rhabdomyosarcoma ( 30 ). BWS is caused by an assortment of epigenetic and genetic alterations that impact a highly imprinted region on chromosome 11p. This region includes...

... neuroendocrine tumors in the esophagus ( 499 ), small bowel ( 500 ), kidney, and other sites can also produce VIP. VIP-producing neurogenic neoplasms have also been designated VIPomas; these include ganglioneuromas, ganglioneuroblastomas, neuroblastomas, and paragangliomas that usually arise...

... secretory granules ( 72 ). Chromogranin may not always show significant immunoreactivity in Merkel cell carcinoma, neuroblastoma, small cell lung carcinoma, prolactinoma, or hindgut neuroendocrine tumors ( 72 , 78 ). Staining may vary in intensity among cells: chromogranin A stains parathyroid chief cells...

... infancy. Nodules range in diameter from 60 µm to 400 µm, and may be confused with small neuroblastomas ( 1 , 9 ). Gross Anatomy The adrenal glands are located in the retroperitoneum, superior and slightly anterior and medial to the kidney ( fig. 4-1 ). At birth, the adrenal glands together weigh about 8...

... are irregular and vesicular, with prominent nucleoli. There was complete loss of SMARCA4 (BRG1 antibody) and diffuse nuclear SOX2 expression in the tumor cells (not shown). In the pediatric population, neuroblastoma ( 8 ) and Wilms tumor ( 21 , 22 ) are the most frequent nonhematopoietic secondary tumors...

..., in the paratesticular area: rhabdomyosarcoma, malignant lymphoma, retinal anlage tumor (melanotic neuroectodermal tumor of infancy), neuroblastoma, and Ewing sarcoma. Embryonal rhabdomyosarcoma usually occurs at a younger age (mean age, 6.6 years). It lacks the tightly nested arrangement that is frequent in DRCT, often...

... carcinoma 3-4 Miscellaneous 1-2  Neuroblastoma  Ewing sarcoma/primitive neuro-ectodermal tumor (PNET)  Synovial sarcoma  Angiomyolipoma  Lymphoma  Other rare neoplasms Table 1-3 THREE MAIN CONGENITAL SYNDROMES ASSOCIATED WITH NEPHROBLASTOMA ^a Syndrome...

... by S-100 protein immunostaining. Occasional bizarre nuclei, such as seen in other neuroendocrine neoplasms, may be present. Rare examples of composite paraganglioma-ganglioneuroma and paraganglioma with neuroblastoma-like foci have been described ( 711 – 713 ). Mitotic figures are variable. Vascular...

... a systematic workup using immunohistochemistry and molecular analysis. Table 11-2 DIFFERENTIAL DIAGNOSIS OF MALIGNANT SMALL ROUND CELL TUMORS IN BONE Ewing sarcoma Rhabdomyosarcoma Neuroblastoma (metastasis) Non-Hodgkin lymphoma/leukemia Small cell osteosarcoma Mesenchymal chondrosarcoma...

...-macrocystic subtype of renal cell carcinoma that is associated with the tuberous sclerosis complex ( 365 , 381 ), and is considered its sporadic counterpart. Some cases previously reported as “oncocytoid renal cell carcinoma after neuroblastoma” also have proven to be this entity ( 378 ). Gross Findings...

... are neuroblastoma and rhabdomyosarcoma. Clinical Features . The skeleton is one of the most common sites for metastatic disease. Most patients with metastatic disease to bone have a known primary. Sometimes the metastasis is the presenting finding, causing pain or pathologic fracture without a known primary. In one...

... ). Neuroblastoma may present with bony metastases but its tumor cells are pear-shaped or carrot-shaped, with denser chromatin than lymphoma; they may form rosettes. Myeloid sarcomas composed of primitive cells with scant cytoplasm can mimic lymphoblastic lymphoma. Myeloid sarcomas with a component...

... by osteosarcoma ( 115 ). Affected patients are often in the second decade of life at the time of the diagnosis of osteosarcoma. The underlying conditions include myelodysplastic syndrome, acute leukemia, neuroblastoma, and sickle cell disease ( 115 – 117 ). The patients often have a history of myeloablative total...