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COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL <span class="search-highlight">NERVE</span> SHEATH TUMOR (MP...
Published: 01 December 2024
COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) Figure 8-58 COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) This tumor is composed of an admixture of pheochromocytoma with a highly cellular nerve sheath tumor (A–D). The pheochromocyt... More about this image found in COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MP...
Images
COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL <span class="search-highlight">NERVE</span> SHEATH TUMOR (MP...
Published: 01 December 2024
COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) Figure 8-58 COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) This tumor is composed of an admixture of pheochromocytoma with a highly cellular nerve sheath tumor (A–D). The pheochromocyt... More about this image found in COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MP...
Images
NORMAL PARAGANGLION WITHIN A GANGLION OF THE VAGUS <span class="search-highlight">NERVE</span>  The paraganglion ...
Published: 01 December 2024
NORMAL PARAGANGLION WITHIN A GANGLION OF THE VAGUS NERVE Figure 9-8 NORMAL PARAGANGLION WITHIN A GANGLION OF THE VAGUS NERVE The paraganglion contrasts with the neurons adjacent to it. More about this image found in NORMAL PARAGANGLION WITHIN A GANGLION OF THE VAGUS NERVE The paraganglion ...
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ECTOPIC PARATHYROID TISSUE WITHIN VAGUS <span class="search-highlight">NERVE</span>  Non-neoplastic ectopic parat...
Published: 01 December 2024
ECTOPIC PARATHYROID TISSUE WITHIN VAGUS NERVE Figure 9-9 ECTOPIC PARATHYROID TISSUE WITHIN VAGUS NERVE Non-neoplastic ectopic parathyroid tissue and parathyroid adenomas within the vagus, as in this example, are potentially mistaken for vagal paraganglia and paragangliomas. More about this image found in ECTOPIC PARATHYROID TISSUE WITHIN VAGUS NERVE Non-neoplastic ectopic parat...
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MALIGNANT PERIPHERAL <span class="search-highlight">NERVE</span> SHEATH TUMOR  Interlacing fascicles of spindle c...
Published: 01 December 2024
MALIGNANT PERIPHERAL NERVE SHEATH TUMOR Figure 12-17 MALIGNANT PERIPHERAL NERVE SHEATH TUMOR Interlacing fascicles of spindle cells and epithelioid cells are present beneath a small area of residual adrenal cortex. More about this image found in MALIGNANT PERIPHERAL NERVE SHEATH TUMOR Interlacing fascicles of spindle c...
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MALIGNANT TRANSFORMATION OF A GANGLIONEUROMA  This tumor first presented at...
Published: 01 December 2024
MALIGNANT TRANSFORMATION OF A GANGLIONEUROMA Figure 11-44 MALIGNANT TRANSFORMATION OF A GANGLIONEUROMA This tumor first presented at 13 months as an unresectable abdominal NB and was treated with abdominal mega-voltage irradiation. At age 17 years, the patient presented again with an abdominal tu... More about this image found in MALIGNANT TRANSFORMATION OF A GANGLIONEUROMA This tumor first presented at...
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GANGLIONEUROMA  A: This tumor contained a few small ganglia. A small myelin...
Published: 01 December 2024
GANGLIONEUROMA Figure 11-42 GANGLIONEUROMA A: This tumor contained a few small ganglia. A small myelinated nerve is present at one pole of a ganglion. The ganglion is probably incorporated secondarily in the tumor. B: A large bundle of myelinated nerve is present in this GN and is most likely se... More about this image found in GANGLIONEUROMA A: This tumor contained a few small ganglia. A small myelin...
Images
PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE  A large pigmented macrono...
Published: 01 December 2024
PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE Figure 4-24 PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE A large pigmented macronodule and a larger pale yellow nodule with small areas of necrosis are seen. The patient was part of a family pedigree with the complex of myxomas, spotty pigmenta... More about this image found in PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE A large pigmented macrono...
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CAROTID BODY PARAGANGLIOMA  The tumor is completely encapsulated and has pr...
Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA Figure 9-12 CAROTID BODY PARAGANGLIOMA The tumor is completely encapsulated and has protruding segments of nerve and artery (top left). The cut surface shows focal cystic degeneration and prominent cavernous blood vessels. A distinct large fleshy nodule is present at lo... More about this image found in CAROTID BODY PARAGANGLIOMA The tumor is completely encapsulated and has pr...
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VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA  The figure s...
Published: 01 December 2024
VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA Figure 1-44 VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA The figure shows a single VIP-expressing neuron, a myelinated nerve containing VIP-positive axons (arrow), and branching VIP-positive terminal fibers between chr... More about this image found in VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA The figure s...
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SYNAPTOPHYSIN IN NORMAL ADRENAL GLAND  A: Synaptophysin expression is shown...
Published: 01 December 2024
SYNAPTOPHYSIN IN NORMAL ADRENAL GLAND Figure 1-55 SYNAPTOPHYSIN IN NORMAL ADRENAL GLAND A: Synaptophysin expression is shown in a patchy distribution in the zona fasciculata. This contrasts with diffuse strong staining in the adrenal medulla at bottom of the field. B: Strong but variable express... More about this image found in SYNAPTOPHYSIN IN NORMAL ADRENAL GLAND A: Synaptophysin expression is shown...
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PRIMARY ADRENAL HEMANGIOMA GROSSLY MIMICKING A RESOLVING HEMATOMA  A: The g...
Published: 01 December 2024
PRIMARY ADRENAL HEMANGIOMA GROSSLY MIMICKING A RESOLVING HEMATOMA Figure 12-6 PRIMARY ADRENAL HEMANGIOMA GROSSLY MIMICKING A RESOLVING HEMATOMA A: The gross appearance of this retracted fibrinous and hemorrhagic lesion is suggestive of a resolving hematoma. B: Histologic sections show resolving ... More about this image found in PRIMARY ADRENAL HEMANGIOMA GROSSLY MIMICKING A RESOLVING HEMATOMA A: The g...
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ABDOMINAL PORTION OF THE PREAORTIC SYMPATHETIC TRUNK, WITH THE CELIAC AND H...
Published: 01 December 2024
ABDOMINAL PORTION OF THE PREAORTIC SYMPATHETIC TRUNK, WITH THE CELIAC AND HYPOGASTRIC PLEXUSES Figure 9-2 ABDOMINAL PORTION OF THE PREAORTIC SYMPATHETIC TRUNK, WITH THE CELIAC AND HYPOGASTRIC PLEXUSES The major distribution of abdominal paraganglia coincides with the distribution of nerve fibers ... More about this image found in ABDOMINAL PORTION OF THE PREAORTIC SYMPATHETIC TRUNK, WITH THE CELIAC AND H...
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NORMAL CAROTID BODY  A: This developing carotid body in an early second tri...
Published: 01 December 2024
NORMAL CAROTID BODY Figure 9-7 NORMAL CAROTID BODY A: This developing carotid body in an early second trimester stillborn fetus (same case as in figs. 9-3 and 9-4 ), shows more complex architecture and greater admixture of cell types than the abdominal paraganglia. B: Tyrosine hydroxylase exp... More about this image found in NORMAL CAROTID BODY A: This developing carotid body in an early second tri...
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NORMAL PERITHYROIDAL PARAGANGLION  A: This paraganglion, discovered inciden...
Published: 01 December 2024
NORMAL PERITHYROIDAL PARAGANGLION Figure 9-10 NORMAL PERITHYROIDAL PARAGANGLION A: This paraganglion, discovered incidentally in peri-thyroidal soft tissue in an adult patient with a multinodular goiter, is architecturally similar to the carotid body in figure 9-7 . The intimate association of n... More about this image found in NORMAL PERITHYROIDAL PARAGANGLION A: This paraganglion, discovered inciden...
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NORMAL ABDOMINAL PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS  ...
Published: 01 December 2024
NORMAL ABDOMINAL PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS Figure 9-3 NORMAL ABDOMINAL PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS A: Normal paraganglia (arrows) in close proximity to lymph nodes. In a patient with a hereditary paraganglioma syndrome, this anatomic rel... More about this image found in NORMAL ABDOMINAL PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...DEVELOPMENT, ANATOMY, AND FUNCTION OF NORMAL PARAGANGLIA Paraganglia are neuroendocrine organs associated with paraxial sympathetic nerves and branches of the glossopharyngeal and vagus nerves in the head and neck. In the late 19th century, the anatomist Alfred Kohn proposed...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... that chromaffin cells derive from peripheral glial stem cells, known as Schwann cell progenitor cells, which have limited capability for expansion and migrate along preganglionic nerves to reach their adrenal medulla destination. In contrast, sympathetic neurons are still thought to originate from neural crest...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... of the neuroendocrine cells comprising the medulla to respond to trans-synaptic signals from preganglionic sympathetic nerves by exocytosis of presynthesized pools of catecholamines stored in secretory granules ( 15 ). The clearance of catecholamines within the blood is also rapid, and epinephrine and norepinephrine...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... PHEOCHROMOCYTOMA Composite pheochromocytomas are rare tumors composed of pheochromocytoma admixed with other elements including ganglioneuroma, ganglioneuroblastoma, neuroblastoma, or peripheral nerve sheath tumor ( 41 , 44 , 90 – 95 ). These neoplasms are all derived from related embryonic lineages...