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Figure 8-58
Published: 01 December 2024
COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) Figure 8-58 COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) This tumor is composed of an admixture of pheochromocytoma with a highly cellular nerve sheath tumor (A–D More about this image found in COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MP...
Images
Figure 8-58
Published: 01 December 2024
COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) Figure 8-58 COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) This tumor is composed of an admixture of pheochromocytoma with a highly cellular nerve sheath tumor (A–D More about this image found in COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MP...
Images
Figure 9-8
Published: 01 December 2024
NORMAL PARAGANGLION WITHIN A GANGLION OF THE VAGUS NERVE Figure 9-8 NORMAL PARAGANGLION WITHIN A GANGLION OF THE VAGUS NERVE The paraganglion contrasts with the neurons adjacent to it. More about this image found in NORMAL PARAGANGLION WITHIN A GANGLION OF THE VAGUS NERVE The paraganglion ...
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Figure 9-9
Published: 01 December 2024
ECTOPIC PARATHYROID TISSUE WITHIN VAGUS NERVE Figure 9-9 ECTOPIC PARATHYROID TISSUE WITHIN VAGUS NERVE Non-neoplastic ectopic parathyroid tissue and parathyroid adenomas within the vagus, as in this example, are potentially mistaken for vagal paraganglia and paragangliomas. More about this image found in ECTOPIC PARATHYROID TISSUE WITHIN VAGUS NERVE Non-neoplastic ectopic parat...
Images
Figure 12-17
Published: 01 December 2024
MALIGNANT PERIPHERAL NERVE SHEATH TUMOR Figure 12-17 MALIGNANT PERIPHERAL NERVE SHEATH TUMOR Interlacing fascicles of spindle cells and epithelioid cells are present beneath a small area of residual adrenal cortex. More about this image found in MALIGNANT PERIPHERAL NERVE SHEATH TUMOR Interlacing fascicles of spindle c...
Images
Figure 11-44
Published: 01 December 2024
tumor. A: Mature GN was seen in much of the resected tumor when the patient was a little over 18 years of age during a debulking procedure. B: Other areas of the same tumor show transition to a malignant peripheral nerve sheath tumor. C: Transition zone of a malignant peripheral nerve sheath tumor More about this image found in MALIGNANT TRANSFORMATION OF A GANGLIONEUROMA This tumor first presented at...
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Figure 11-42
Published: 01 December 2024
GANGLIONEUROMA Figure 11-42 GANGLIONEUROMA A: This tumor contained a few small ganglia. A small myelinated nerve is present at one pole of a ganglion. The ganglion is probably incorporated secondarily in the tumor. B: A large bundle of myelinated nerve is present in this GN and is most likely More about this image found in GANGLIONEUROMA A: This tumor contained a few small ganglia. A small myelin...
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Figure 4-24
Published: 01 December 2024
pigmentation, and endocrine overactivity (Carney complex). There was a complex history of a retrogastric malignant melanotic nerve sheath tumor (formerly “melanotic schwannoma”), fibrolamellar hepatoma, hyperpigmentation of the inner canthus of both eyes, and most recently, an ovarian serous cystadenoma More about this image found in PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE A large pigmented macrono...
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Figure 9-12
Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA Figure 9-12 CAROTID BODY PARAGANGLIOMA The tumor is completely encapsulated and has protruding segments of nerve and artery (top left). The cut surface shows focal cystic degeneration and prominent cavernous blood vessels. A distinct large fleshy nodule is present More about this image found in CAROTID BODY PARAGANGLIOMA The tumor is completely encapsulated and has pr...
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Figure 1-44
Published: 01 December 2024
VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA Figure 1-44 VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA The figure shows a single VIP-expressing neuron, a myelinated nerve containing VIP-positive axons (arrow), and branching VIP-positive terminal fibers between More about this image found in VASOACTIVE INTESTINAL PEPTIDE (VIP) IN NORMAL ADRENAL MEDULLA The figure s...
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Figure 1-55
Published: 01 December 2024
expression of synaptophysin in the zona fasciculata and reticularis. A few immunoreactive nerve fibers traverse the cortex in the unstained area (arrow). More about this image found in SYNAPTOPHYSIN IN NORMAL ADRENAL GLAND A: Synaptophysin expression is shown...
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Images
Figure 9-2
Published: 01 December 2024
ABDOMINAL PORTION OF THE PREAORTIC SYMPATHETIC TRUNK, WITH THE CELIAC AND HYPOGASTRIC PLEXUSES Figure 9-2 ABDOMINAL PORTION OF THE PREAORTIC SYMPATHETIC TRUNK, WITH THE CELIAC AND HYPOGASTRIC PLEXUSES The major distribution of abdominal paraganglia coincides with the distribution of nerve fibers More about this image found in ABDOMINAL PORTION OF THE PREAORTIC SYMPATHETIC TRUNK, WITH THE CELIAC AND H...
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Figure 9-7
Published: 01 December 2024
expression in chief cells of developing carotid body. C: Chromogranin A in chief cells of developing carotid body. D: Prominent nerve fibers in developing carotid body highlighted by S-100 protein. More about this image found in NORMAL CAROTID BODY A: This developing carotid body in an early second tri...
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Figure 9-10
Published: 01 December 2024
of neuroendocrine cells and nerve fibers is potentially mistaken for perineural infiltration by paraganglioma, medullary thyroid carcinoma, or other tumors. Paragangliomas arising from normal paraganglia in or near the thyroid gland are especially likely to be mistaken for medullary thyroid carcinoma. B: Normal More about this image found in NORMAL PERITHYROIDAL PARAGANGLION A: This paraganglion, discovered inciden...
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Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...DEVELOPMENT, ANATOMY, AND FUNCTION OF NORMAL PARAGANGLIA Paraganglia are neuroendocrine organs associated with paraxial sympathetic nerves and branches of the glossopharyngeal and vagus nerves in the head and neck. In the late 19th century, the anatomist Alfred Kohn proposed...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... that chromaffin cells derive from peripheral glial stem cells, known as Schwann cell progenitor cells, which have limited capability for expansion and migrate along preganglionic nerves to reach their adrenal medulla destination. In contrast, sympathetic neurons are still thought to originate from neural crest...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... of the neuroendocrine cells comprising the medulla to respond to trans-synaptic signals from preganglionic sympathetic nerves by exocytosis of presynthesized pools of catecholamines stored in secretory granules ( 15 ). The clearance of catecholamines within the blood is also rapid, and epinephrine and norepinephrine...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... PHEOCHROMOCYTOMA Composite pheochromocytomas are rare tumors composed of pheochromocytoma admixed with other elements including ganglioneuroma, ganglioneuroblastoma, neuroblastoma, or peripheral nerve sheath tumor ( 41 , 44 , 90 – 95 ). These neoplasms are all derived from related embryonic lineages...