EBV-ASSOCIATED NASOPHARYNGEAL CARCINOMA Figure 8-11 EBV-ASSOCIATED NASOPHARYNGEAL CARCINOMA Desmoplastic stroma (A) and associated lymphocyte infiltrate (B), with pancytokeratin immunohistochemistry (C) confirm the epithelial nature of the neoplasm. More about this image found in EBV-ASSOCIATED NASOPHARYNGEAL CARCINOMA Desmoplastic stroma (A) and associ...

SUBACUTE SCLEROSING PANENCEPHALITIS Figure 3-29 SUBACUTE SCLEROSING PANENCEPHALITIS The white matter in SSPE shows vacuolization, myelin pallor, mild hypercellularity due to reactive astrocytosis, and perivascular lymphocytic cuffing; this should not be mistaken for a gemistocytic astrocytoma/neo... More about this image found in SUBACUTE SCLEROSING PANENCEPHALITIS The white matter in SSPE shows vacuoli...

VALUE OF IN SITU HYBRIDIZATION IN INFECTIOUS DISEASES PATHOLOGY Figure 1-5 VALUE OF IN SITU HYBRIDIZATION IN INFECTIOUS DISEASES PATHOLOGY H&E (A,B) staining of an adrenal spindle cell neoplasm in an immunocompromised patient. Epstein-Barr virus encoded RNA (EBER) in situ hybridization (ISH) ... More about this image found in VALUE OF IN SITU HYBRIDIZATION IN INFECTIOUS DISEASES PATHOLOGY H&E (A...

CONVENTIONAL MELANOMA WITH SPITZOID FEATURES Figure 19-1 CONVENTIONAL MELANOMA WITH SPITZOID FEATURES A: Silhouette of the neoplasm with a predominant nested growth pattern. B: The tumor cells carry a NRAS Q61R mutation and are uniformly immunoreactive with the antibody SP174. C: The tumor cells display some spitzoid cytologic features; a few clefts are seen between junctional nests and epidermis. D: The tumor cells harbor a number of chromosomal aberrations assessed by single nucleotide polymorphism (SNP) array. More about this image found in CONVENTIONAL MELANOMA WITH SPITZOID FEATURES A: Silhouette of the neoplasm...

COMBINED PIGMENTED EPITHELIOID MELANOCYTOMA Figure 10-15 COMBINED PIGMENTED EPITHELIOID MELANOCYTOMA The predominant cell population of this biphenotypic melanocytic neoplasm shows features of a pigmented epithelioid melanocytoma (*). A minor cell population shows conventional nevus features (arr... More about this image found in COMBINED PIGMENTED EPITHELIOID MELANOCYTOMA The predominant cell populatio...

SUPERFICIAL SPREADING MELANOMA WITH SINGLE CELL INVASION Figure 12-14 SUPERFICIAL SPREADING MELANOMA WITH SINGLE CELL INVASION A: The melanocytic neoplasm is asymmetric. Its intraepidermal tumor cell population is predominantly composed of junctional nests. B: The invasive tumor cell lacks compa... More about this image found in SUPERFICIAL SPREADING MELANOMA WITH SINGLE CELL INVASION A: The melanocyti...

UNDIFFERENTIATED MELANOMA Figure 21-8 UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle cell neoplasm is seen. It was initially interpreted as sarcoma by a soft tissue pathologist, but the diagnosis was revised to metastatic melanoma after sequence analysis revealed UV signatures and an NRAS Q61R mutation identical to the mutation in the patient’s prior primary melanoma located draining to the site of the undifferentiated tumor. More about this image found in UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle...

SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS Figure 19-2 SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS A: Symmetric silhouette of a compound pigmented spindle and epithelioid cell neoplasm in a young adult. There are clefts between junctional nests and adjacent hyperplastic epidermis. B: A few ... More about this image found in SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS A: Symmetric silhouette of a...

NEUROFIBROMA-LIKE DESMOPLASTIC MELANOMA Figure 16-10 NEUROFIBROMA-LIKE DESMOPLASTIC MELANOMA A: Punch biopsy with an intradermal spindle cell proliferation. B: Cytologically bland spindle cells with Schwannian (neurofibroma-like) features. C: The biopsy of the locally persistent tumor shows mel... More about this image found in NEUROFIBROMA-LIKE DESMOPLASTIC MELANOMA A: Punch biopsy with an intraderma...