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CONVENTIONAL MELANOMA WITH SPITZOID FEATURES  A: Silhouette of the <span class="search-highlight">neoplasm</span>...
Published: 01 February 2024
CONVENTIONAL MELANOMA WITH SPITZOID FEATURES Figure 19-1 CONVENTIONAL MELANOMA WITH SPITZOID FEATURES A: Silhouette of the neoplasm with a predominant nested growth pattern. B: The tumor cells carry a NRAS Q61R mutation and are uniformly immunoreactive with the antibody SP174. C: The tumor cells display some spitzoid cytologic features; a few clefts are seen between junctional nests and epidermis. D: The tumor cells harbor a number of chromosomal aberrations assessed by single nucleotide polymorphism (SNP) array. More about this image found in CONVENTIONAL MELANOMA WITH SPITZOID FEATURES A: Silhouette of the neoplasm...
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COMBINED PIGMENTED EPITHELIOID MELANOCYTOMA  The predominant cell populatio...
Published: 01 February 2024
COMBINED PIGMENTED EPITHELIOID MELANOCYTOMA Figure 10-15 COMBINED PIGMENTED EPITHELIOID MELANOCYTOMA The predominant cell population of this biphenotypic melanocytic neoplasm shows features of a pigmented epithelioid melanocytoma (*). A minor cell population shows conventional nevus features (arr... More about this image found in COMBINED PIGMENTED EPITHELIOID MELANOCYTOMA The predominant cell populatio...
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SUPERFICIAL SPREADING MELANOMA WITH SINGLE CELL INVASION  A: The melanocyti...
Published: 01 February 2024
SUPERFICIAL SPREADING MELANOMA WITH SINGLE CELL INVASION Figure 12-14 SUPERFICIAL SPREADING MELANOMA WITH SINGLE CELL INVASION A: The melanocytic neoplasm is asymmetric. Its intraepidermal tumor cell population is predominantly composed of junctional nests. B: The invasive tumor cell lacks compa... More about this image found in SUPERFICIAL SPREADING MELANOMA WITH SINGLE CELL INVASION A: The melanocyti...
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UNDIFFERENTIATED MELANOMA  An amelanotic undifferentiated malignant spindle...
Published: 01 February 2024
UNDIFFERENTIATED MELANOMA Figure 21-8 UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle cell neoplasm is seen. It was initially interpreted as sarcoma by a soft tissue pathologist, but the diagnosis was revised to metastatic melanoma after sequence analysis revealed UV signatures and an NRAS Q61R mutation identical to the mutation in the patient’s prior primary melanoma located draining to the site of the undifferentiated tumor. More about this image found in UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle...
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SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS  A: Symmetric silhouette of a...
Published: 01 February 2024
SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS Figure 19-2 SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS A: Symmetric silhouette of a compound pigmented spindle and epithelioid cell neoplasm in a young adult. There are clefts between junctional nests and adjacent hyperplastic epidermis. B: A few ... More about this image found in SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS A: Symmetric silhouette of a...
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NEUROFIBROMA-LIKE DESMOPLASTIC MELANOMA  A: Punch biopsy with an intraderma...
Published: 01 February 2024
NEUROFIBROMA-LIKE DESMOPLASTIC MELANOMA Figure 16-10 NEUROFIBROMA-LIKE DESMOPLASTIC MELANOMA A: Punch biopsy with an intradermal spindle cell proliferation. B: Cytologically bland spindle cells with Schwannian (neurofibroma-like) features. C: The biopsy of the locally persistent tumor shows mel... More about this image found in NEUROFIBROMA-LIKE DESMOPLASTIC MELANOMA A: Punch biopsy with an intraderma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...The term spitzoid melanoma is used for a melanoma bearing some resemblance to a Spitz nevus ( 1 ). It is a diagnostic pitfall ( 2 ): a melanocytic neoplasm may at first glance look like an atypical Spitz nevus or Spitz tumor, but is eventually diagnosed as melanoma based on clinical follow...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... (in case of an associated blue nevus) Differential Diagnosis  Cellular blue nevus  Blue nevus with epithelioid cell features  Pigmented epithelioid melanocytoma  Pigmented nodular conventional melanoma  Pigment-synthesizing melanoma  Malignant melanotic schwannian neoplasm...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... in the potential for diagnostic confusion with skin adnexal (sebaceous or sweat gland) neoplasms, metastatic renal cell carcinoma, or xanthomatous histiocytic proliferations. DEEP PENETRATING NEVUS-LIKE (PLEXIFORM) MELANOMA Some melanomas may be confused with, or arise in association with, a deep penetrating...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of associated genetic and genomic findings are available, some of these tumors can be further classified as Spitz melanocytoma ( 12 ). Spitz nevi, melanocytomas, atypical Spitz tumors (AST), and Spitz melanomas represent a spectrum of melanocytic neoplasms that share microscopic features and molecular...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-11
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... (ATP2B4-PRKCA or RNF13-PRKCA). Some cases have also been reported with mutations of MAP2K1 or no detectable distinct mutation. PEM-like melanocytic neoplasms with mutations of GNAQ or CYSLTR2 are best regarded as blue nevi with epithelioid cell features ( 10...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... impression is often that of a diffusely pink fibrosing process, suggesting a possible scar or fibroma. At higher magnification, DM manifests in its pure form as a paucicellular infiltrative amelanotic neoplasm, usually composed of fusiform melanocytes predominantly dispersed as solitary units in an abundant...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... syndrome, with risk for ocular melanoma, mesothelioma, renal cell carcinoma, and other neoplasms ( Table 10-2 ) ( 11 ). Microscopic features suggestive of a germline mutation include the presence of junctional nests with BAP1 loss and fatty metaplasia of dermal melanocytes. Some BAP1-inactivated nevi show...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of the epidermis. Pagetoid spread is seen focally or throughout the entire width of the melanoma in situ. It is often found at the peripheral advancing edge of the neoplasm. SUPERFICIAL SPREADING MELANOMA Figure 12-2 SUPERFICIAL SPREADING MELANOMA A: The silhouette of the lesion is asymmetric with regard...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... nonmelanocytic neoplasms. Depending on the diagnostic problem (e.g., metastatic melanoma versus poorly differentiated carcinoma, lymphoma, or sarcoma) a set of antibodies to melanocytic differentiation antigens, as well as epithelial, lymphoid, and mesenchymal markers, may be necessary for a precise diagnosis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... melanoma are de novo melanocytic neoplasms. However, a nodular melanoma may be associated with a melanocytic nevus ( fig. 15-5 ) ( 9 ). NODULAR MELANOMA ASSOCIATED WITH ACQUIRED INTRADERMAL MELANOCYTIC NEVUS Figure 15-5 NODULAR MELANOMA ASSOCIATED WITH ACQUIRED INTRADERMAL MELANOCYTIC NEVUS...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... in the spectrum of spitzoid neoplasms ( 26 , 28 ). Nodular Melanoma of Large/Giant Congenital Nevus Subtype. Melanomas associated with a large or giant congenital nevus typically present as a nodular proliferation in the deep dermis or subcutis ( 4 , 21 , 30 – 34 ). The tumor usually stands out from...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... or “borderline” DPN-like melanocytic neoplasm of uncertain malignant potential ( 12 ). TREATMENT AND PROGNOSIS DPN is a benign melanocytic neoplasm. Local recurrences of histopathologically incompletely removed lesions are rare ( 7 ). The risk for progression to melanoma is unknown, but likely a rare event...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... acquired nevus. The term dysplastic nevus was originally used to describe large irregular nevi in hereditary melanoma kindreds with the hypothesis that these lesions had considerable risk for transformation to melanoma ( 1 , 5 ). In analogy to concepts of tumor progression of epithelial neoplasms (e.g...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... microscopic features, a correctly diagnosed melanocytic nevus of any site, including the special sites mentioned in this chapter, is a benign neoplasm. No further surgery is needed. There is no evidence that suggests that a particular anatomic site or associated microscopic findings implies a higher risk...