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Book Chapter

Hypopharynx, Larynx, and Trachea

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... are other, more significant forms of squamous neoplasia, such as papillary dysplasia, and most importantly, papillary SCC. Papillary dysplasia is uncommon in the head and neck, fortunately. These lesions have similar features to flat dysplasia with hyperkeratosis, altered maturation, increased mitotic...
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Book Chapter

Neck

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
..., 20.6 years) ( 135 ). The pathogenesis is still largely undefined, but there are several consistent associations, particularly with different forms of true neoplasia, most commonly Hodgkin and non-Hodgkin lymphomas, cutaneous clear cell sarcomas, and myelodysplastic syndromes ( 137 ). There are also...
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Book Chapter

Oral Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
..., neurofibromatosis type 1, and multiple endocrine neoplasia type 2B ( 103 , 110 ). The clinical presentation of multiple, often coalescing papules, along with the histology, rule out most of these entities. The characteristic nuclear features of mitosoid figures composed of cells with karyorrhectic nuclei...
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Book Chapter

Oropharynx

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-2
ISBN: 978-1-933477-61-9
... and separating otherwise intact, normal tissues is a strong sign for hematolymphoid neoplasia (and against carcinoma, which usually is associated with some type of stromal reaction). As opposed to the normal tonsillar lymphoid tissue, which has relatively circumscribed contours and a defined microscopic...
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Book Chapter

Nasopharynx

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-3
ISBN: 978-1-933477-61-9
.... It is unclear whether teratocarcinosarcomas should be considered true germ cell tumors, but they are often included within the context of germ cell neoplasia. Teratocarcinosarcomas have been discussed in chapter 1 . Clinical Features. Teratomas in the head and neck occur with equal gender frequency, and most...
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Book Chapter

Ear and Temporal Bone

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
..., with a higher incidence in reproductive-aged females ( 1090 – 1093 ). Several genetic predispositions are known, but most commonly identified in neurofibromatosis type 2 (NF2, a tumor suppressor gene), schwannomatosis (germline mutations in SMARCB1), and multiple endocrine neoplasia type I...
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Book Chapter

Sinonasal Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... are known, but are most commonly associated with neurofibromatosis type 2 (NF2, a tumor suppressor gene), schwannomatosis (germline mutations in SMARCB1), and multiple endocrine neoplasia type 1 (MEN1). These are related to deletions of chromosome 22 and mutations in the chromosome 22q12.2...
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Book Chapter

Jaw

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
...   2001 ; 37 : 17 - 27 . 127. Vickers   RA , Gorlin   RJ . Ameloblastoma: delineation of early histopathologic features of neoplasia . Cancer   1970 ; 26 : 699 - 710 . 128. Tsaknis   PJ , Nelson   JF . The maxillary ameloblastoma: an analysis of 24 cases . J Oral Surg   1980...
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Figure 8-13

MULTIFOCAL PHEOCHROMOCYTOMA ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TY...

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in Pheochromocytoma and Adrenal Medullary Hyperplasia > Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
MULTIFOCAL PHEOCHROMOCYTOMA ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) Figure 8-13 MULTIFOCAL PHEOCHROMOCYTOMA ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) The adrenal gland contains a dominant pheochromocytoma as well as two smaller nodules (top) and an expanded More about this image found in MULTIFOCAL PHEOCHROMOCYTOMA ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TY...
Images
Figure 10-2

ADRENAL MEDULLARY DISEASE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) A:...

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in Familial and Syndrome-Related Pheochromocytoma and Paraganglioma > Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ADRENAL MEDULLARY DISEASE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) Figure 10-2 ADRENAL MEDULLARY DISEASE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) A: The adrenal gland has diffuse medullary hyperplasia as well as multiple nodules that represent pheochromocytomas. B,C: The nodules More about this image found in ADRENAL MEDULLARY DISEASE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) A:...
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Figure 7-4

ADRENAL CORTICAL NODULAR DISEASE IN A PATIENT WITH MULTIPLE ENDOCRINE NEOPL...

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in Hereditary Predisposition to Adrenal Cortical Lesions > Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ADRENAL CORTICAL NODULAR DISEASE IN A PATIENT WITH MULTIPLE ENDOCRINE NEOPLASIA 1 (MEN1) Figure 7-4 ADRENAL CORTICAL NODULAR DISEASE IN A PATIENT WITH MULTIPLE ENDOCRINE NEOPLASIA 1 (MEN1) Transverse sections of adrenal gland with micro- and macronodular nodular disease. The pale yellow cortical More about this image found in ADRENAL CORTICAL NODULAR DISEASE IN A PATIENT WITH MULTIPLE ENDOCRINE NEOPL...
Images
Figure 1-1

MAJOR BIOSYNTHETIC PATHWAYS FOR STEROIDOGENESIS Both adrenal gland and gon...

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in Physiology, Development, and Anatomy of the Adrenal Glands > Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
variety of tissues. A small amount of testosterone may be produced in the adrenal zona reticularis by 17β-HSD type 5 (also known as aldo-keto reductase family 1 member C3 [AKR1C3]). (Fig. 5 from Asa SL, Uccella S, Tischler A. The unique importance of differentiation and function in endocrine neoplasia More about this image found in MAJOR BIOSYNTHETIC PATHWAYS FOR STEROIDOGENESIS Both adrenal gland and gon...
Book Chapter

Familial and Syndrome-Related Pheochromocytoma and Paraganglioma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... Locations Cluster Other Associated Lesions RET 10q11.2 MEN2 (multiple endocrine neoplasia type 2) Adrenal 2 Medullary thyroid carcinoma; parathyroid hyperplasia or neoplasia Mucocutaneous ganglioneuromas (MEN2B) NF1 17q11.2 NF1 (neurofibromatosis type 1) Adrenal (rarely...
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Book Chapter

Hereditary Predisposition to Adrenal Cortical Lesions

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... Familial primary hyperaldosteronism (types I to IV and other variants) CYP11B1-CYP11B2; CLCN2; KCNJ5; CACN1AH; CACN1AD a Bilateral micro- and macronodular disease and adenoma <1% Seizure and neurologic abnormalities a Multiple endocrine neoplasia type 1 (MEN1...
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Book Chapter

Pheochromocytoma and Adrenal Medullary Hyperplasia

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... appearance of this tumor is bright yellow, resembling an adrenal cortical neoplasm. This appearance is due to abundant lipid accumulation, which is seen in pheochromocytomas of patients with VHL disease. MULTIFOCAL PHEOCHROMOCYTOMA ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) Figure 8-13...
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Book Chapter

Clinicopathologic Features of the Adrenal Cortex

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... from ectopic disease. This test is based on the fact that even in pathologic conditions, this potent steroid inhibits pituitary ACTH secretion; the response, however, is attenuated in pituitary neoplasia and even more so in most cases of ectopic ACTH/CRH secretion. Increased cortisol levels are seen...
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Book Chapter

Congenital Disorders of the Adrenal Gland

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... challenges in cancer diagnosis and staging, and in the assessment of donor organ transplant specimens. It can also give rise to adrenal cortical neoplasia in unexpected locations. Familiarity with its distribution and appearance is therefore essential to avoid diagnostic mishaps. Ectopic adrenal tissue...
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Book Chapter

Adrenal Cortical Carcinoma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Adrenal cortical carcinoma (ACC) is a malignant neoplasm originating from the steroidogenic epithelial cells of the adrenal cortex. EPIDEMIOLOGY ACC accounts for the majority of deaths attributable to primary adrenal neoplasia, but it is a rare disease, meeting the criteria for an “orphan...
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Book Chapter

Adrenal Cortical Nodular Diseases

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
.... The nodules had an heterogeneous density with lesions either <10 or >10 HU. (Courtesy of Prof. A. Veltri and Dr. F. Solitro, San Luigi Hospital, Turin, Italy) PBMAD may arise in a hereditary context, associated with multiple endocrine neoplasia 1 (MEN1), familial adenomatous polyposis, hereditary...
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Book Chapter

Adrenal Cortical Adenoma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... to the pathologist’s attention even without knowledge of a previous or synchronous malignancy. In this context, metastases should be distinguished morphologically in the majority of cases from adrenal cortical neoplasia, but clear cell neoplasms may pose problems in the differential diagnosis with adenoma. Among those...
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