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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-04
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...Atypical lobular hyperplasia and lobular carcinoma in situ are collectively referred to as lobular neoplasia. However, for reasons discussed in this chapter, when rendering diagnoses and managing patients, it is preferable to separate atypical lobular hyperplasia from lobular carcinoma in situ...
Images
LOBULAR CARCINOMA IN SITU AND ATYPICAL DUCTAL HYPERPLASIA (ADH)  Not infreq...
Published: 01 January 2024
LOBULAR CARCINOMA IN SITU AND ATYPICAL DUCTAL HYPERPLASIA (ADH) Figure 4-8 LOBULAR CARCINOMA IN SITU AND ATYPICAL DUCTAL HYPERPLASIA (ADH) Not infrequently lobular neoplasia (LCIS or ALH) coexists with other lesions in the low-grade breast neoplasia family, as in this example of ADH and LCIS. In ... More about this image found in LOBULAR CARCINOMA IN SITU AND ATYPICAL DUCTAL HYPERPLASIA (ADH) Not infreq...
Images
ACINI OF A TERMINAL DUCT LOBULAR UNIT WITH PROMINENT MYOEPITHELIAL CELLS  T...
Published: 01 January 2024
ACINI OF A TERMINAL DUCT LOBULAR UNIT WITH PROMINENT MYOEPITHELIAL CELLS Figure 4-9 ACINI OF A TERMINAL DUCT LOBULAR UNIT WITH PROMINENT MYOEPITHELIAL CELLS These myoepithelial cells have abundant clear cytoplasm; given their location and prominence, they can be a mimic for the cells of lobular n... More about this image found in ACINI OF A TERMINAL DUCT LOBULAR UNIT WITH PROMINENT MYOEPITHELIAL CELLS T...
Images
ATYPICAL LOBULAR HYPERPLASIA  A: Low-power image of a duct slightly expande...
Published: 01 January 2024
ATYPICAL LOBULAR HYPERPLASIA Figure 4-20 ATYPICAL LOBULAR HYPERPLASIA A: Low-power image of a duct slightly expanded by the same cells as seen in classic LCIS. The limited extension warrants diagnosis as ALH, rather than LCIS. B: Higher power image better illustrates the cytologic dyshesion and ... More about this image found in ATYPICAL LOBULAR HYPERPLASIA A: Low-power image of a duct slightly expande...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-01
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...   Mucocutaneous myxomas   Blue nevi  2. Multiple endocrine neoplasia type   Pigmented nodular adrenocortical disease   Pituitary adenoma   Gonadal tumors   Thyroid tumors   Schwannomas (may include malignant melanotic nerve sheath tumors) Leopard Syndrome: aut dom, PTPN11...
Images
LOBULAR CARCINOMA IN SITU WITH NECROSIS  A: This core needle biopsy was per...
Published: 01 January 2024
LOBULAR CARCINOMA IN SITU WITH NECROSIS Figure 4-19 LOBULAR CARCINOMA IN SITU WITH NECROSIS A: This core needle biopsy was performed because of mammographically detected microcalcifications. The hematoxylin and eosin (H&E) image depicts acini greatly expanded by an atypical epithelial prolife... More about this image found in LOBULAR CARCINOMA IN SITU WITH NECROSIS A: This core needle biopsy was per...
Images
LOBULAR CARCINOMA IN SITU INVOLVING SCLEROSING ADENOSIS  A: This low-power ...
Published: 01 January 2024
LOBULAR CARCINOMA IN SITU INVOLVING SCLEROSING ADENOSIS Figure 6-7 LOBULAR CARCINOMA IN SITU INVOLVING SCLEROSING ADENOSIS A: This low-power image shows a concentric linear array of atypical epithelial cells, along with some nests at the left of the field. B: On high power, the lobular phenotype... More about this image found in LOBULAR CARCINOMA IN SITU INVOLVING SCLEROSING ADENOSIS A: This low-power ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...   Jr , Hood   AF , Tucker   MA , Jampel   RM . Atypical melanocytic nevi of the genital type with a discussion of reciprocal parenchymal-stromal interactions in the biology of neoplasia . Hum Pathol   1998 ; 29 ( Suppl 1 ): S1 - 24 . 14. Gleason   BC , Hirsch   MS , Nucci...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...   BC . The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia . Annu Rev Pathol   2014 ; 9 : 239 - 71 . 39. Lu   C , Zhang   J , Nagahawatte   P , et al . The genomic landscape of childhood and adolescent melanoma . J Invest Dermatol   2015 ; 135...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-03
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... studies to harbor the same genetic alterations as are seen in lesions of the low-grade breast neoplasia pathway (ADH, low nuclear grade DCIS, lobular carcinoma in situ, and low-grade invasive carcinomas), albeit more limited in number ( 12 – 16 ). Specifically, loss of the long arm of chromosome 16...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-09
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... . J Surg Res   2021 ; 264 : 309 - 15 . 3. Ryan   RF , Pernoll   ML . Virginal hypertrophy . Plast Reconstr Surg   1985 ; 75 : 737 - 42 . 4. Li   G , Robinson   GW , Lesche   R , et al . Conditional loss of PTEN leads to precocious development and neoplasia...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-01
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... , Dahlman-Wright   K . Estrogen receptor beta in breast cancer . Mol Cell Endocrinol   2014 ; 382 : 665 - 72 . 35. Shaaban   AM , O’Neill   PA , Davies   MP , et al . Declining estrogen receptor-beta expression defines malignant progression of human breast neoplasia . Am J Surg...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-06
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... with intracytoplasmic vacuoles. C: At high power, the cytologic dyshesion characteristic of lobular neoplasia is readily identified. Myoepithelial cells are difficult to appreciate. If the underlying sclerosing adenosis is not recognized, this type of case can be misdiagnosed as invasive lobular carcinoma. Smooth...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... lobular hyperplasia (ALH) may be seen in and around the invasive component. Low-grade DCIS, ADH, and even FEA may also be present in the adjacent breast parenchyma. These are all considered nonobligate precursor lesions of the low-grade breast neoplasia pathway comprising ER-positive invasive carcinomas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-15
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... lesion on excision. The upgrade rate for ADH remains at approximately 20 percent, even in studies with pure ADH and good radiologic-pathologic concordance ( 20 – 24 ). Incidental classic lobular neoplasias (atypical lobular hyperplasia and classic lobular carcinoma in situ [LCIS]) are among the list...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-11
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... , Evers   BR , et al . Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion . Lab Invest   2011 ; 91 : 1427 - 33 . 30. Matsuda   I , Nakamura   J , Ohkouchi   M , et al . Expression of p16 in nodular fasciitis: an implication for self-limited...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch41
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... a broader category of Carney complex (CNC), which encompasses about 5 to 7 percent of cardiac myxomas. CNC should not be confused with Carney syndrome, a triad that is a distinct neoplasia syndrome ( 58 ). CNC is generally caused by mutations in the 1-alpha regulatory subunit of protein kinase...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch19
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... described in this condition, along with both X-linked and autosomal patterns. Because the primary pathologic presentation of this entity is usually multicentric tumors, the disease is often discussed in the context of cardiac neoplasia (see chapter 45 ). Clinical Features. Mitochondrial disease is one...
Images
ENDOMETRIOSIS AND CLEAR CELL <span class="search-highlight">NEOPLASIA</span>  Polypoid endometriosis (A) with aty...
Published: 01 August 2023
ENDOMETRIOSIS AND CLEAR CELL NEOPLASIA Figure 6-19 ENDOMETRIOSIS AND CLEAR CELL NEOPLASIA Polypoid endometriosis (A) with atypia and complex growth (B) suggests clear cell carcinoma. A focus of tubulocystic clear cell carcinoma (C) is also present. More about this image found in ENDOMETRIOSIS AND CLEAR CELL NEOPLASIA Polypoid endometriosis (A) with aty...
Images
CAUTERIZED FALLOPIAN MUCOSA SIMULATING HYPERPLASIA OR <span class="search-highlight">NEOPLASIA</span>
Published: 01 August 2023
CAUTERIZED FALLOPIAN MUCOSA SIMULATING HYPERPLASIA OR NEOPLASIA Figure 16-20 CAUTERIZED FALLOPIAN MUCOSA SIMULATING HYPERPLASIA OR NEOPLASIA More about this image found in CAUTERIZED FALLOPIAN MUCOSA SIMULATING HYPERPLASIA OR NEOPLASIA