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Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
MULTIFOCAL PHEOCHROMOCYTOMA ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) Figure 8-13 MULTIFOCAL PHEOCHROMOCYTOMA ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) The adrenal gland contains a dominant pheochromocytoma as well as two smaller nodules (top) and an expanded pal... More about this image found in MULTIFOCAL PHEOCHROMOCYTOMA ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TY...
Images
in Familial and Syndrome-Related Pheochromocytoma and Paraganglioma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ADRENAL MEDULLARY DISEASE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) Figure 10-2 ADRENAL MEDULLARY DISEASE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) A: The adrenal gland has diffuse medullary hyperplasia as well as multiple nodules that represent pheochromocytomas. B,C: The nodules of adr... More about this image found in ADRENAL MEDULLARY DISEASE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) A:...
Images
in Hereditary Predisposition to Adrenal Cortical Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ADRENAL CORTICAL NODULAR DISEASE IN A PATIENT WITH MULTIPLE ENDOCRINE NEOPLASIA 1 (MEN1) Figure 7-4 ADRENAL CORTICAL NODULAR DISEASE IN A PATIENT WITH MULTIPLE ENDOCRINE NEOPLASIA 1 (MEN1) Transverse sections of adrenal gland with micro- and macronodular nodular disease. The pale yellow cortical ... More about this image found in ADRENAL CORTICAL NODULAR DISEASE IN A PATIENT WITH MULTIPLE ENDOCRINE NEOPL...
Images
in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
MAJOR BIOSYNTHETIC PATHWAYS FOR STEROIDOGENESIS Figure 1-1 MAJOR BIOSYNTHETIC PATHWAYS FOR STEROIDOGENESIS Both adrenal gland and gonadal pathways are shown. Functions distinguishing the adrenal cortical zones from each other and from the gonads are determined by differential expression of steroi... More about this image found in MAJOR BIOSYNTHETIC PATHWAYS FOR STEROIDOGENESIS Both adrenal gland and gon...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... Locations Cluster Other Associated Lesions RET 10q11.2 MEN2 (multiple endocrine neoplasia type 2) Adrenal 2 Medullary thyroid carcinoma; parathyroid hyperplasia or neoplasia Mucocutaneous ganglioneuromas (MEN2B) NF1 17q11.2 NF1 (neurofibromatosis type 1) Adrenal (rarely...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... Familial primary hyperaldosteronism (types I to IV and other variants) CYP11B1-CYP11B2; CLCN2; KCNJ5; CACN1AH; CACN1AD a Bilateral micro- and macronodular disease and adenoma <1% Seizure and neurologic abnormalities a Multiple endocrine neoplasia type 1 (MEN1...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... appearance of this tumor is bright yellow, resembling an adrenal cortical neoplasm. This appearance is due to abundant lipid accumulation, which is seen in pheochromocytomas of patients with VHL disease. MULTIFOCAL PHEOCHROMOCYTOMA ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 (MEN2) Figure 8-13...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... from ectopic disease. This test is based on the fact that even in pathologic conditions, this potent steroid inhibits pituitary ACTH secretion; the response, however, is attenuated in pituitary neoplasia and even more so in most cases of ectopic ACTH/CRH secretion. Increased cortisol levels are seen...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... challenges in cancer diagnosis and staging, and in the assessment of donor organ transplant specimens. It can also give rise to adrenal cortical neoplasia in unexpected locations. Familiarity with its distribution and appearance is therefore essential to avoid diagnostic mishaps. Ectopic adrenal tissue...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Adrenal cortical carcinoma (ACC) is a malignant neoplasm originating from the steroidogenic epithelial cells of the adrenal cortex. EPIDEMIOLOGY ACC accounts for the majority of deaths attributable to primary adrenal neoplasia, but it is a rare disease, meeting the criteria for an “orphan...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
.... The nodules had an heterogeneous density with lesions either <10 or >10 HU. (Courtesy of Prof. A. Veltri and Dr. F. Solitro, San Luigi Hospital, Turin, Italy) PBMAD may arise in a hereditary context, associated with multiple endocrine neoplasia 1 (MEN1), familial adenomatous polyposis, hereditary...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... to the pathologist’s attention even without knowledge of a previous or synchronous malignancy. In this context, metastases should be distinguished morphologically in the majority of cases from adrenal cortical neoplasia, but clear cell neoplasms may pose problems in the differential diagnosis with adenoma. Among those...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... on color Doppler ultrasound, and evolving complex architecture all favor neuroblastoma ( 79 ). Initial clinical management is usually conservative, but many patients eventually undergo interval adrenalectomy either because of persistent symptoms or concern for possible neoplasia ( 77 ). Over time, benign...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... and function in endocrine neoplasia. Endocrine Pathol 2023;34:382-92.) Glucocorticoids regulate the intermediary metabolism of carbohydrates, fat, and proteins, and affect processes including wound healing, growth, inflammation, and functions of the immune system. In addition to these systemic effects...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... Surg 2019 ; 145 : 641 - 6 . 69. Shankavaram U , Fliedner SM , Elkahloun AG , et al . Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas . Neoplasia 2013 ; 15 : 435 - 47 . 70. Aubertine CL , Flieder DB...
Images
Published: 01 September 2024
ADENOCARCINOMA IN SITU (AIS) Figure 9-38 ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervical glands with AIS predominantly on the right. B: Glands with AIS in the lower half show depleted mucin, several mitoses, and apoptosis. C: P16 is positive in glands with AIS and is... More about this image found in ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervica...
Images
Published: 01 September 2024
ADENOCARCINOMA IN SITU (AIS) Figure 9-38 ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervical glands with AIS predominantly on the right. B: Glands with AIS in the lower half show depleted mucin, several mitoses, and apoptosis. C: P16 is positive in glands with AIS and is... More about this image found in ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervica...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... been linked to various forms of lymphoid and epithelial neoplasias ( 12 ). EBV is divided into two genotypes, which are further subclassified into different strains ( 13 ). The genotypes are delineated by their Epstein-Barr nuclear antigens (EBNA), while subtypes are defined by their latent membrane...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-17
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... by a capillary proliferation with a lobular arrangement. The endothelial cells lining these vessels are plump (hence the name bacillary epithelioid angiomatosis) and may even show cytologic atypia, thus mimicking neoplasia. The vascular stroma is either fibrotic or myxoid, and contains a neutrophil-rich...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... not be attributed to opportunistic infection or neoplasia were common ( fig. 9-12A ). Biopsy and autopsy studies indicated a range of diffuse and nodular lymphoid infiltrates, containing both B and T cells, around airways and through the interstitium ( fig. 9-12B,C ). These became grouped together as HIV-associated...
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