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PUSHING MARGIN  Some carcinomas, particularly grade 3, triple-<span class="search-highlight">negative</span> tumo...
Published: 01 January 2024
PUSHING MARGIN Figure 8-15 PUSHING MARGIN Some carcinomas, particularly grade 3, triple-negative tumors are characterized by a more circumscribed or “pushing” margin. More about this image found in PUSHING MARGIN Some carcinomas, particularly grade 3, triple-negative tumo...
Images
PN WITH MESENCHYMAL FEATURES  A: An amelanotic nodule is present within a C...
Published: 01 February 2024
PN WITH MESENCHYMAL FEATURES Figure 2-19 PN WITH MESENCHYMAL FEATURES A: An amelanotic nodule is present within a CMN. B: The nodule is composed of fibroblast-like cells and myxoid stroma. The tumor cells within the nodule were immunohistochemically negative for melanocyte differentiation antige... More about this image found in PN WITH MESENCHYMAL FEATURES A: An amelanotic nodule is present within a C...
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COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-POSITIVE MELANOCYTES  A: Compound...
Published: 01 February 2024
COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-POSITIVE MELANOCYTES Figure 4-11 COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-POSITIVE MELANOCYTES A: Compound dysplastic nevus (hematoxylin and eosin [H&E]-stain). B: Immunostain for PRAME. Most nuclei of junctional melanocytes (long arrow) and intrade... More about this image found in COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-POSITIVE MELANOCYTES A: Compound...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... are immunoreactive for S-100 protein. In mixed DM, the nondesmoplastic tumor component, especially if it displays an epithelioid cell morphology, may be positive for Mart1/Melan-A, tyrosinase, MITF, or HMB-45. A rare undifferentiated DM may be negative for, or only minimally positive, for all melanocyte markers...
Images
METASTATIC MELANOMA  A: This low-power image of a core needle biopsy sample...
Published: 01 January 2024
METASTATIC MELANOMA Figure 12-6 METASTATIC MELANOMA A: This low-power image of a core needle biopsy sample from a breast mass shows atypical epithelioid-appearing cells. B: At high power, the degree of nuclear atypia is striking. Mitoses are present. The morphology is in keeping with a triple-ne... More about this image found in METASTATIC MELANOMA A: This low-power image of a core needle biopsy sample...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... Molecular Genetic Findings  Common mutations include: NF1, TP53Negative for BRAF V600E LENTIGO MALIGNA MELANOMA IN SITU WITH ADNEXAL INVOLVEMENT Figure 13-7 LENTIGO MALIGNA MELANOMA IN SITU WITH ADNEXAL INVOLVEMENT The tumor cells proliferate at the dermoepidermal junction...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... in context with a history of change ( fig. 12-1 ) ( 6 ). Dermoscopic findings, such as an atypical pigment network, streaks, irregular blotches, or peripheral brown structureless areas, assist in the diagnosis ( 7 ). A negative pigment network, atypical dots and globules, blue white structures, and atypical...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
..., as well as in mismatch repair genes ( Table 8-1 ) ( 10 – 15 ). Guidelines for genetic testing vary depending on the age of the patient at breast cancer diagnosis, type of breast cancer (for example, triple negative or lobular), and number and degree of family members with breast, ovarian, and other types...
Images
ENCAPSULATED PAPILLARY CARCINOMA  A: Low-power scanning magnification shows...
Published: 01 January 2024
ENCAPSULATED PAPILLARY CARCINOMA Figure 7-23 ENCAPSULATED PAPILLARY CARCINOMA A: Low-power scanning magnification shows a well-circumscribed, encapsulated papillary carcinoma. B: At high power, the epithelial atypia is better appreciated, with cribriform architecture in addition to the underlyin... More about this image found in ENCAPSULATED PAPILLARY CARCINOMA A: Low-power scanning magnification shows...
Images
ENCAPSULATED PAPILLARY CARCINOMA  A: Low-power scanning magnification shows...
Published: 01 January 2024
ENCAPSULATED PAPILLARY CARCINOMA Figure 7-23 ENCAPSULATED PAPILLARY CARCINOMA A: Low-power scanning magnification shows a well-circumscribed, encapsulated papillary carcinoma. B: At high power, the epithelial atypia is better appreciated, with cribriform architecture in addition to the underlyin... More about this image found in ENCAPSULATED PAPILLARY CARCINOMA A: Low-power scanning magnification shows...
Images
DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL)  A: Scanning magnification of a core ...
Published: 01 January 2024
DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) Figure 12-3 DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) A: Scanning magnification of a core needle biopsy specimen from a young woman (32 years of age) who presented with a breast mass demonstrates diffuse infiltration of the breast parenchyma by malignant epitheli... More about this image found in DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) A: Scanning magnification of a core ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... VERSUS SPITZ MELANOMA Spitzoid Melanoma Spitz Melanoma Spitzoid Histology Spitzoid Histology Immunohistochemical Findings: Immunohistochemical Findings:  May be positive for BRAF V600E  Negative for BRAF V600E  May be positive for ALK, NTRK1, ROS1 Molecular Genetic Aberrations...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...-POSITIVE MELANOCYTES Figure 4-11 COMPOUND DYSPLASTIC NEVUS WITH RARE PRAME-POSITIVE MELANOCYTES A: Compound dysplastic nevus (hematoxylin and eosin [H&E]-stain). B: Immunostain for PRAME. Most nuclei of junctional melanocytes (long arrow) and intradermal melanocytes (short arrow) are negative...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... melanocytes may only express SOX10 or S-100 protein   Most ordinary nevi express p16, some only partially; a few are negative by IHC   Most nevi are negative for PRAME, but some are partially positive  Cytogenetics   Usually no aberrations; occasionally a few isolated aberrations may be found...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... surrounded by collarettes of thin rete ridges (“puffy shirt sign”)  Nuclear atypia  Mitoses Differential Diagnosis  Mitotically active nevus  Nevus with unusual/atypical features Ancillary Tests  Immunohistochemistry:   Most nevoid melanomas express PRAME; most nevi are negative...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... are negative for HMB-45, lesions in which melanocytes display features of a blue or deep penetrating nevus usually express gp100, the antigen recognized by HMB-45. An immunostain for BAP1 helps document BAP1 deficiency when the morphologic findings suggest that possibility. In BAP1-inactivated combined nevi...
Images
GEOGRAPHIC NECROSIS  Although unusual, large zones of “geographic” necrosis...
Published: 01 January 2024
GEOGRAPHIC NECROSIS Figure 8-16 GEOGRAPHIC NECROSIS Although unusual, large zones of “geographic” necrosis can be seen in invasive breast carcinomas, particularly grade 3, triple-negative carcinomas. More about this image found in GEOGRAPHIC NECROSIS Although unusual, large zones of “geographic” necrosis...
Images
IMMUNOSTAIN FOR ESTROGEN RECEPTOR (ER)  In normal lobules, the epithelial c...
Published: 01 January 2024
IMMUNOSTAIN FOR ESTROGEN RECEPTOR (ER) Figure 1-9 IMMUNOSTAIN FOR ESTROGEN RECEPTOR (ER) In normal lobules, the epithelial cells show variable nuclear expression with ER: some cells are negative, others demonstrate weak staining, and still others are strongly positive. More about this image found in IMMUNOSTAIN FOR ESTROGEN RECEPTOR (ER) In normal lobules, the epithelial c...
Images
INVASIVE BREAST CARCINOMA, NST, GRADE 3  There are sheets of tumor cells wi...
Published: 01 January 2024
INVASIVE BREAST CARCINOMA, NST, GRADE 3 Figure 8-3 INVASIVE BREAST CARCINOMA, NST, GRADE 3 There are sheets of tumor cells with large pleomorphic nuclei. Zones of necrosis are present; while not a criterion of grading, necrosis is more likely to be seen in grade 3 and triple-negative breast cance... More about this image found in INVASIVE BREAST CARCINOMA, NST, GRADE 3 There are sheets of tumor cells wi...
Images
IMMUNOSTAINS FOR THE PRESENCE OF MYOEPITHELIAL CELLS  A: The myoepithelial ...
Published: 01 January 2024
IMMUNOSTAINS FOR THE PRESENCE OF MYOEPITHELIAL CELLS Figure 1-6 IMMUNOSTAINS FOR THE PRESENCE OF MYOEPITHELIAL CELLS A: The myoepithelial cell nuclei surrounding the ducts and lobules stain positively with p63; the epithelial cell nuclei are negative. B: Smooth muscle myosin heavy chain stains t... More about this image found in IMMUNOSTAINS FOR THE PRESENCE OF MYOEPITHELIAL CELLS A: The myoepithelial ...