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myofibroblastic
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in Miscellaneous Primary Testicular, Adnexal, and Spermatic Cord Tumors
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
INFLAMMATORY MYOFIBROBLASTIC TUMOR OF TESTIS Figure 8-131 INFLAMMATORY MYOFIBROBLASTIC TUMOR OF TESTIS A: A circumscribed nodule of eosinophilic-staining, myofibroblastic cells is seen in the testicular parenchyma. B: The cells have plump, elongated nuclei with vesicular chromatin and small nucl... More
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Published: 01 August 2022
TORSION-RELATED PARATESTICULAR REACTION Figure 11-29 TORSION-RELATED PARATESTICULAR REACTION A reparative myofibroblastic reaction is seen in the adnexal region in a case of testicular torsion. More
Images
Published: 01 August 2022
FIBROUS PSEUDOTUMOR Figure 11-75 FIBROUS PSEUDOTUMOR Left: The myofibroblastic cells have fusiform nuclei with open chromatin, small nucleoli, and tapering, lightly eosinophilic cytoplasm. Right: Occasional admixed osteoclast-like giant cells are an infrequent finding. More
Images
Published: 01 August 2022
INFLAMMATORY MYOFIBROBLASTIC TUMOR WITH MALIGNANT FEATURES Figure 11-80 INFLAMMATORY MYOFIBROBLASTIC TUMOR WITH MALIGNANT FEATURES A number of scattered, atypical, hyperchromatic cells are present. More
Images
Published: 01 August 2022
FIBROMATOUS PERIORCHITIS Figure 11-73 FIBROMATOUS PERIORCHITIS Prominent collagen deposits with myofibroblasts, capillaries, and lymphocytes. More
Images
in Miscellaneous Primary Testicular, Adnexal, and Spermatic Cord Tumors
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
ADENOMATOID TUMOR Figure 8-29 ADENOMATOID TUMOR Left: An area of infarcted adenomatoid tumor (top) is surrounded by a zone of light-staining myofibroblastic reaction, with epididymal tubules at bottom. Right: The myofibroblastic reaction masks the adenomatoid tumor and creates confusion with a s... More
Images
Published: 01 August 2022
FIBROMATOUS PERIORCHITIS, EARLY PHASE Figure 11-72 FIBROMATOUS PERIORCHITIS, EARLY PHASE Left: The testis is encased by a prominent myofibroblastic reaction. Right: At higher magnification, tapering myofibroblastic cells are present in a loose stroma with red blood cell extravasation, similar in... More
Images
Published: 01 August 2022
PROLIFERATIVE FUNICULITIS Figure 11-74 PROLIFERATIVE FUNICULITIS A high-power view shows the characteristic myofibroblastic features of the majority of the lesional cells. Note occasional larger “ganglion-like” cells. More
Images
Published: 01 August 2022
FIBROUS PSEUDOTUMOR Figure 11-79 FIBROUS PSEUDOTUMOR Left: An immunostain for smooth muscle actin shows the “tram-track” pattern of reactivity, with subplasmalemmal accentuation, that is characteristic of myofibroblasts. Right: A cytokeratin stain (clone AE1/AE3) is positive in many lesional cel... More
Images
Published: 01 August 2022
SPERM GRANULOMA Figure 11-84 SPERM GRANULOMA A: Within the epididymis, there is a large ruptured duct with inspissated aggregates of basophilic, degenerated spermatozoa surrounded by a myofibroblastic reaction. B: At high magnification, there are congealed sperm with an associated histiocytic an... More
Images
in Tumors of Hematopoietic and Lymphoid Origin
> Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues
Published: 01 August 2022
INTERDIGITATING DENDRITIC CELL TUMOR OF TESTIS Figure 9-37 INTERDIGITATING DENDRITIC CELL TUMOR OF TESTIS Left: Large, epithelioid to spindled tumor cells with ill-defined, lightly eosinophilic cytoplasm and vesicular, sometimes convoluted nuclei are admixed with a predominantly lymphocytic infla... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Publisher: American Registry of Pathology
Published: 01 August 2022
DOI:
10.55418/9781933477220-11
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
..., and vasculopathic changes are related to chronic intermittent torsion ( 46 ). Torsion may also induce prominent reactive changes in the paratesticular soft tissues that may cause confusion with an inflammatory myofibroblastic tumor ( fig. 11-29 ) ( 54 ). Cytoplasmic reactivity for anaplastic lymphoma kinase (ALK...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Publisher: American Registry of Pathology
Published: 01 August 2022
DOI:
10.55418/9781933477220-08
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... mummified tumor are surrounded by a reactive myofibroblastic or granulation tissue response, with sometimes inconspicuous foci of residual typical adenomatoid tumor ( fig. 8-29 ). Irregular peripheral extension of reactive myofibroblasts and the occurrence of this phenomenon in tumors with a solid, cellular...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Publisher: American Registry of Pathology
Published: 01 August 2022
DOI:
10.55418/9781933477220-03
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... Tumors of the Paratesticular Structures and Spermatic Cord Fibroblastic/myofibroblastic Cellular angiofibroma Myofibroblastoma (mammary-type myofibroblastoma) Deep (“aggressive”) angiomyxoma Solitary fibrous tumor Fibromatosis Adipocytic tumors Lipoma/spindle cell...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Publisher: American Registry of Pathology
Published: 01 August 2022
DOI:
10.55418/9781933477220-09
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... and cytoplasmic expression of S-100 protein. Note the highlighted tail-like extensions of cytoplasm. (Figs. 1B and 1D from Nistal M, Gonzalez-Peramato P, Serrano A, Reyes-Mugica M, Cajaiba MM. Primary intratesticular spindle cell tumors: interdigitating dendritic cell tumor and inflammatory myofibroblastic tumor...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Publisher: American Registry of Pathology
Published: 01 August 2022
DOI:
10.55418/9781933477220-02
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... referred to as myoid cells or myofibroblasts ( 21 ), that are embedded in fibrillary lamellar deposits of collagen and laminin ( 21 – 24 ). These cells contain cytoplasmic actin, myosin, and desmin filaments, and on ultrastructural study show numerous peripheral bundles of microfilaments with periodic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Publisher: American Registry of Pathology
Published: 01 August 2022
DOI:
10.55418/9781933477220-06
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
.... Ultrastructural studies show fibroblastic or myofibroblastic differentiation, with the tumor cells containing filaments, subplasmalemmal electron-dense bodies, pinocytotic vesicles, discontinuous basal lamina, and intercellular desmosomes. Although ultrastructural and immunohistochemical studies are of academic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Publisher: American Registry of Pathology
Published: 01 August 2022
DOI:
10.55418/9781933477220-04
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
.... Immediately adjacent to necrotic foci is typically an infiltrate of foamy, lipid-laden macrophages, which corresponds to the yellow zone encircling the necrotic nodule noted on gross examination ( fig. 4-222 ). These macrophages are often admixed with a myofibroblastic proliferation, creating a zone...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Publisher: American Registry of Pathology
Published: 01 June 2022
DOI:
10.55418/9781933477190-5
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
... MEMBRANES Desmoid-Type Fibromatosis. This tumor arises, rarely, as a primary pleural proliferation. This is now viewed as a locally aggressive but nonmetastasizing myofibroblastic neoplasm exhibiting a CTNNB1 gene mutation in about 95 percent of cases ( 97 ). This tumor usually presents in adults...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Publisher: American Registry of Pathology
Published: 01 June 2022
DOI:
10.55418/9781933477190-8
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
.... It remains uncertain whether these reflect a persistent reactive process, a variant of inflammatory myofibroblastic tumor, or a metaplastic process within the submesothelial mesenchyme. One recent case showed an ALK gene rearrangement, providing supportive evidence of an inflammatory myofibroblastic...
