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Images
Figure 2-34
Published: 01 June 2025
PLEOMORPHIC ADENOMA Figure 2-34 PLEOMORPHIC ADENOMA A: Low-magnification view of a palate pleomorphic adenoma with areas of cellular myoepithelial cells, ducts, and myxoid stroma. B: High-magnification view shows sheets of myoepithelial cells with bland cytology, nodular areas of myxoid stroma More about this image found in PLEOMORPHIC ADENOMA A: Low-magnification view of a palate pleomorphic aden...
Images
Figure 1-50
Published: 01 June 2025
LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA Figure 1-50 LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA A: Cases harboring BRAF p.V600E mutation have an unusual appearance, frequently with micropapillary growth and two cell types: an inner ductal cell and an outer myoepithelial More about this image found in LOW-GRADE NONINTESTINAL SINONASAL ADENOCARCINOMA A: Cases harboring
Images
Figure 8-71
Published: 01 June 2025
CERUMINOUS ADENOMA Figure 8-71 CERUMINOUS ADENOMA A: All the neoplastic cells are strongly positive with pancytokeratin. B: The luminal cells tend to be highlighted with CK7 specifically. C: The basal-myoepithelial cells are highlighted by p63. D: GATA3 highlights the luminal-glandular cells More about this image found in CERUMINOUS ADENOMA A: All the neoplastic cells are strongly positive with ...
Images
Figure 6-82
Published: 01 June 2025
PLEOMORPHIC ADENOMA Figure 6-82 PLEOMORPHIC ADENOMA A: The tumor shows a uniform population of ovoid myoepithelial cells dispersed in a chondromyxoid matrix. B: Areas of tumor resemble cartilage with loose, basophilic matrix and lacunae. More about this image found in PLEOMORPHIC ADENOMA A: The tumor shows a uniform population of ovoid myoep...
Images
Figure 1-55
Published: 01 June 2025
HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA Figure 1-55 HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: This is a biphasic tumor type, with a predominance of myoepithelial cells that exhibit varying degrees of cytoplasmic clearing (A) and spindling (B). C,D: Ducts are usually present More about this image found in HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: This is a biphasic tu...
Images
Figure 8-69
Published: 01 June 2025
CERUMINOUS PLEOMORPHIC ADENOMA Figure 8-69 CERUMINOUS PLEOMORPHIC ADENOMA A: Low power shows a pleomorphic adenoma below the surface. B: The biphasic appearance of the pleomorphic adenoma is easy to detect below an intact squamous epithelium. C: The epithelial-myoepithelial nature More about this image found in CERUMINOUS PLEOMORPHIC ADENOMA A: Low power shows a pleomorphic adenoma be...
Images
Figure 1-57
Published: 01 June 2025
HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA Figure 1-57 HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: The biphasic nature of the tumor is demonstrated. Myoepithelial cells stain for markers like smooth muscle actin (A), and the ductal elements are positive for CD117 (B). C,D More about this image found in HPV-RELATED MULTIPHENOTYPIC SINONASAL CARCINOMA A,B: The biphasic nature o...
Images
Figure 8-75
Published: 01 June 2025
: There is a desmoplastic stromal reaction to the islands of neoplastic cells. D: A biphasic appearance is seen, with luminal atypical columnar cells and basal-myoepithelial cells. More about this image found in CERUMINOUS ADENOCARCINOMA, NOS A: Large cystically dilated spaces are line...
Images
Figure 4-65
Published: 01 June 2025
and eosinophilic cytoplasm are commonly seen in minor salivary gland pleomorphic adenomas. D: Myoepithelial-rich pleomorphic adenoma with a chondroid matrix. More about this image found in PLEOMORPHIC ADENOMA A: Characteristic low-power image shows varying patter...
Images
Figure 8-68
Published: 01 June 2025
CERUMINOUS ADENOMA Figure 8-68 CERUMINOUS ADENOMA A: A dual cell population consists of inner luminal apocrine-type cells subtended by a myoepithelial layer. B: Florid apocrine change is seen, with ample eosinophilic cytoplasm forming blebs. The basal layer is intact. C: The biphasic More about this image found in CERUMINOUS ADENOMA A: A dual cell population consists of inner luminal apo...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-2
ISBN: 978-1-933477-61-9
... of staining when only partially positive, solid adenoid cystic carcinoma is either p40 (and p63) negative or has a peripheral nest positivity pattern which is probably evidence of partial myoepithelial differentiation ( 37 , 42 ). Some basaloid SCCs histologically mimic solid adenoid cystic carcinoma...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-3
ISBN: 978-1-933477-61-9
... 46.0 61.7 Adenocarcinoma, NOS 33.7 48.8 Mucoepidermoid carcinoma 14.2 65.3 Epithelial-myoepithelial carcinoma 2.2 100.0 Polymorphous adenocarcinoma 1.9 100.0 Myoepithelial carcinoma 1.1 N/A b Acinic cell carcinoma 0.6 N/A a Based on 358 cases (excluding...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
... by RREB1::MKL2 fusions ( 158 , 159 ). A minority has other molecular drivers, including EWSR1 ( 158 , 163 ). Differential Diagnosis. Myoepithelioma and pleomorphic adenoma share some histologic overlap with ECT; however, ECT is usually negative for p63, calponin, and other myoepithelial...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
... and an outer myoepithelial cell layer. The secretory cells contain abundant, brightly eosinophilic cytoplasm, prominent cell borders, and occasional golden ceroid pigment granules ( fig. 8-2 ). The supranuclear lipoid and pigment granules are refractile, siderophilic, and fluorescent, staining light yellow...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... practical role for ancillary studies in making a diagnosis of REAH. Although myoepithelial/basal cell markers are positive in most REAHs, an absence does not support a diagnosis of adenocarcinoma ( 81 ). Differential Diagnosis. The most important lesion to exclude is a low-grade sinonasal adenocarcinoma...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
... protein, EMA, and brachyury ( 211 ), the latter a transcriptional factor that is specific for notochordal differentiation. Chordomas are negative for a host of myoepithelial, endothelial, and cartilaginous markers such as PAX8, calponin, smooth muscle actin, and D2-40. Molecular Genetic Findings. Minimal...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... of pleomorphic adenoma are similar in different anatomic sites throughout the body. They are biphasic tumors consisting of a combination of myoepithelial and ductal epithelial components within a myxochondroid matrix ( fig. 6-82 ). Myoepithelial cells often predominate and are seen as dispersed cells within...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... . A study of gata3 and phox2b expression in tumors of the autonomic nervous system . Am J Surg Pathol   2013 ; 37 : 1236 - 41 . 27. Miettinen   M , McCue   PA , Sarlomo-Rikala   M , et al . Sox10—a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors...
Images
Figure 1-5
Published: 01 January 2024
MYOEPITHELIAL CELLS: MYRIAD HISTOLOGIC APPEARANCES Figure 1-5 MYOEPITHELIAL CELLS: MYRIAD HISTOLOGIC APPEARANCES A: Myoepithelial cells with more attenuated spindled cells. B: Myoid myoepithelial cells (see also fig. 1-4 : clear myoepithelial cells). More about this image found in MYOEPITHELIAL CELLS: MYRIAD HISTOLOGIC APPEARANCES A: Myoepithelial cells ...
Images
Figure 1-6
Published: 01 January 2024
IMMUNOSTAINS FOR THE PRESENCE OF MYOEPITHELIAL CELLS Figure 1-6 IMMUNOSTAINS FOR THE PRESENCE OF MYOEPITHELIAL CELLS A: The myoepithelial cell nuclei surrounding the ducts and lobules stain positively with p63; the epithelial cell nuclei are negative. B: Smooth muscle myosin heavy chain stains More about this image found in IMMUNOSTAINS FOR THE PRESENCE OF MYOEPITHELIAL CELLS A: The myoepithelial ...