Search Results for mutation

ADRENAL CORTICAL CARCINOMA IN A MALE PATIENT WITH BRCA2 GERMLINE MUTATION Figure 7-9 ADRENAL CORTICAL CARCINOMA IN A MALE PATIENT WITH BRCA2 GERMLINE MUTATION The patient had a previous diagnosis of prostate cancer. The adrenal lesion showed predominant features of the myxoid More about this image found in ADRENAL CORTICAL CARCINOMA IN A MALE PATIENT WITH BRCA2 GE...

ADRENAL CORTICAL ADENOMA IN A PATIENT WITH FH GERMLINE MUTATION Figure 7-7 ADRENAL CORTICAL ADENOMA IN A PATIENT WITH FH GERMLINE MUTATION This patient had a previous renal cell carcinoma and a Leydig cell tumor. The adenoma shows a nodular aspect without cytologic atypia More about this image found in ADRENAL CORTICAL ADENOMA IN A PATIENT WITH FH GERMLINE MUT...

PHEOCHROMOCYTOMA AND PARAGANGLIOMA ASSOCIATED WITH GERMLINE FUMARATE HYDRATASE (FH) MUTATION Figure 10-6 PHEOCHROMOCYTOMA AND PARAGANGLIOMA ASSOCIATED WITH GERMLINE FUMARATE HYDRATASE (FH) MUTATION A: The pheochromocytoma is associated with an unusual angiomatous proliferation of the cortical More about this image found in PHEOCHROMOCYTOMA AND PARAGANGLIOMA ASSOCIATED WITH GERMLINE FUMARATE HYDRAT...

PRIMARY BILATERAL MACRONODULAR ADRENAL CORTICAL DISEASE IN A PATIENT WITH A KNOWN ARMC5 MUTATION AND SUBCLINICAL CUSHING SYNDROME Figure 7-1 PRIMARY BILATERAL MACRONODULAR ADRENAL CORTICAL DISEASE IN A PATIENT WITH A KNOWN ARMC5 MUTATION AND SUBCLINICAL CUSHING SYNDROME More about this image found in PRIMARY BILATERAL MACRONODULAR ADRENAL CORTICAL DISEASE IN A PATIENT WITH A...

PULMONARY PARAGANGLIOMA Figure 9-32 PULMONARY PARAGANGLIOMA A: This paraganglioma was a solitary lesion initially interpreted as an epithelial pulmonary NET. The patient was found to have a hereditary SDHC mutation. No other primary tumors were found and this tumor contained abundant More about this image found in PULMONARY PARAGANGLIOMA A: This paraganglioma was a solitary lesion initia...

ABDOMINAL PARAGANGLIOMA Figure 9-13 ABDOMINAL PARAGANGLIOMA A: The tumor, from a patient with a hereditary mutation of the SDHB gene (same specimen as in fig. 9-11 ), has mixed nested and trabecular architecture and is composed of monomorphic cells with slightly eosinophilic cytoplasm More about this image found in ABDOMINAL PARAGANGLIOMA A: The tumor, from a patient with a hereditary mut...

ABDOMINAL PARAGANGLIOMA Figure 9-25 ABDOMINAL PARAGANGLIOMA This tumor is composed of monomorphic cells with slightly eosinophilic cytoplasm and prominent vacuoles creating a pseudoacinar appearance. This appearance is often associated with SDHB mutation. More about this image found in ABDOMINAL PARAGANGLIOMA This tumor is composed of monomorphic cells with s...

SDH-DEFICIENT ABDOMINAL PARAGANGLIOMA Figure 9-26 SDH-DEFICIENT ABDOMINAL PARAGANGLIOMA This paraganglioma with a known SDHB mutation exhibits small intracytoplasmic vacuoles with flocculent content, which are a well-known characteristic of SDH-deficient renal cell carcinoma More about this image found in SDH-DEFICIENT ABDOMINAL PARAGANGLIOMA This paraganglioma with a known

reactivity for SDHB suggests that the tumor is not related to SDHx mutation. More about this image found in PHEOCHROMOCYTOMA: SDHB STAINING A: Loss of SDHB immunoreactivity with reta...

for the development of metastases, but no other tumors were detectable. Staining for neuroendocrine markers showed the usual trend for these markers: synaptophysin > chromogranin > tyrosine hydroxylase. Although decreased expression of functional markers in paragangliomas is often associated with mutations More about this image found in MESENTERIC PARAGANGLIOMA A: This paraganglioma composed of basophilic and ...