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DYSPLASTIC NEVUS  A: <span class="search-highlight">Multiple</span> red and brown lesions are present on the uppe...
Published: 01 February 2024
DYSPLASTIC NEVUS Figure 4-1 DYSPLASTIC NEVUS A: Multiple red and brown lesions are present on the upper back shoulder. The arrow points to a lesion, which was excised, and the diagnosis histopathologically confirmed as dysplastic nevus. B: The lesion has a diameter of more than 4 mm and displays... More about this image found in DYSPLASTIC NEVUS A: Multiple red and brown lesions are present on the uppe...
Images
DYSPLASTIC NEVUS  A: <span class="search-highlight">Multiple</span> pigmented lesions are present on the back. Th...
Published: 01 February 2024
DYSPLASTIC NEVUS Figure 4-2 DYSPLASTIC NEVUS A: Multiple pigmented lesions are present on the back. The lesion, which was biopsied and histologically confirmed, is highlighted. B: The lesion displays some asymmetry, has an irregular peripheral border, and has some variation in pigmentation, with... More about this image found in DYSPLASTIC NEVUS A: Multiple pigmented lesions are present on the back. Th...
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Images
MATURING VARIANT OF NEVOID MELANOMA  A: Dermal plaque-like silhouette of th...
Published: 01 February 2024
MATURING VARIANT OF NEVOID MELANOMA Figure 17-3 MATURING VARIANT OF NEVOID MELANOMA A: Dermal plaque-like silhouette of the tumor. B: Analysis of the tumor cells by single nucleotide polymorphism (SNP) array revealed multiple segmental chromosomal aberrations. C: The melanocytes are almost enti... More about this image found in MATURING VARIANT OF NEVOID MELANOMA A: Dermal plaque-like silhouette of th...
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PLAQUE-TYPE BLUE NEVUS WITH CELLULAR NODULES  A: Plaque-like multinodular g...
Published: 01 February 2024
PLAQUE-TYPE BLUE NEVUS WITH CELLULAR NODULES Figure 8-24 PLAQUE-TYPE BLUE NEVUS WITH CELLULAR NODULES A: Plaque-like multinodular growth of melanocytes involving the eyelid. B: The superficial portion of the lesion shows features of pigmented and paucimelanotic common BN. C: The deeper portion ... More about this image found in PLAQUE-TYPE BLUE NEVUS WITH CELLULAR NODULES A: Plaque-like multinodular g...
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<span class="search-highlight">MULTIPLE</span> PAPILLOMAS  A: This intermediate-power image shows several spaces ...
Published: 01 January 2024
MULTIPLE PAPILLOMAS Figure 7-2 MULTIPLE PAPILLOMAS A: This intermediate-power image shows several spaces occupied by papillary proliferations with broad fibrovascular cores and areas of epithelial proliferation. B: At higher power, myoepithelial cells can be identified running along the fibrovas... More about this image found in MULTIPLE PAPILLOMAS A: This intermediate-power image shows several spaces ...
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PAPILLARY DUCTAL CARCINOMA IN SITU  A: Low-power view shows <span class="search-highlight">multiple</span> ducts ...
Published: 01 January 2024
PAPILLARY DUCTAL CARCINOMA IN SITU Figure 7-20 PAPILLARY DUCTAL CARCINOMA IN SITU A: Low-power view shows multiple ducts with papillary proliferations, most of which have delicate fibrovascular cores. At this power, the nuclei of the epithelial proliferation appear hyperchromatic, suggesting atyp... More about this image found in PAPILLARY DUCTAL CARCINOMA IN SITU A: Low-power view shows multiple ducts ...
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PAPILLARY DUCTAL CARCINOMA IN SITU  A: Low-power view shows <span class="search-highlight">multiple</span> ducts ...
Published: 01 January 2024
PAPILLARY DUCTAL CARCINOMA IN SITU Figure 7-20 PAPILLARY DUCTAL CARCINOMA IN SITU A: Low-power view shows multiple ducts with papillary proliferations, most of which have delicate fibrovascular cores. At this power, the nuclei of the epithelial proliferation appear hyperchromatic, suggesting atyp... More about this image found in PAPILLARY DUCTAL CARCINOMA IN SITU A: Low-power view shows multiple ducts ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... nodular aggregates of atypical melanocytes with nuclear atypia, high mitotic rate, and/or necrosis) Molecular Genetic Findings  Somatic NRAS mutation (codon 61) most commonly  Somatic BRAF mutation (codon V600) more commonly in small CMN  Multiple CMN and NCM caused...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-01
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...-defined borders. Multiple lesions may coexist in the same anatomic region. They may collide with each other or with seborrheic or actinic keratoses, become confluent, and appear clinically complex and atypical, prompting concerns for lentigo maligna melanoma. Solar lentigines become more frequent...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with the number, size, and cell volume of such nevi. A child with a giant congenital nevus that has multiple satellite lesions carries a lifetime risk of 10 to 15 percent for developing a melanoma ( 4 , 5 , 21 ). Most of the melanomas that develop in large or giant melanocytic nevi occur during childhood ( Table...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... are solitary, but on occasion, multiple lesions are present at the same time, agminated (grouped) or diffusely and randomly distributed (disseminated). Multiple Spitz nevi also occur in a background of a congenital nevus. Dermoscopy can aide in the clinical diagnosis of Spitz nevi. Pigmented Spitz nevi...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... be a macular component. Also, at least three of the following parameters should be seen: an irregular peripheral border, a diameter of 5 mm or greater, variation in color, or erythema ( figs. 4-1 , 4-2 ). DYSPLASTIC NEVUS Figure 4-1 DYSPLASTIC NEVUS A: Multiple red and brown lesions are present...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... appear late in life. Most are solitary, but on occasion multiple nevi are present, including agminated or linear forms. Preferred anatomic locations include the dorsum of the hands and feet, face, and scalp ( Table 8-1 ). Table 8-1 FEATURES OF COMMON BLUE NEVUS Clinical Features  Uniform blue...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... in association with any given nevus is extremely low. CLINICAL FEATURES Parameters for the clinical diagnosis of SSM are referred to as ABCD criteria ( Table 12-1 ): asymmetry, an irregular border, multiple colors, and a diameter greater than 6 mm are the clinical features that suggest melanoma, especially...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of the papillary dermis by tumor cells, elongated thin rete ridges, and mitoses ( figs. 17-1 – 17-7 ). Another diagnostic clue is the presence of a row of multiple, dense cellular aggregates surrounded by small collarettes of elongated rete ridges. Such an arrangement gives rise to a “puffy shirt”-like appearance...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... is not involved. MICROSCOPIC FINDINGS Melanoma metastatic to the skin usually presents as a nodule or multiple nodules in the dermis and/or subcutis ( 1 ). Occasionally they involve both the epidermis and dermis but rarely does the epidermal component extend peripherally beyond the dermal component. Subclinical...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...) lack nuclear BAP1 expression. BAP1-inactivated melanocytic tumors (BIMT) commonly harbor BRAF V600E mutations, but they may also be associated with NRAS or other mutations. The presence of multiple BIMTs may reflect a BAP1 germline mutation and related tumor predisposition...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... and neck region. In some neurotropic variants of DM, multiple small nerve twigs are involved at the periphery of the tumor. Some tumors display prominent schwannian differentiation (“neural transformation”) and become difficult to distinguish from nerve sheath tumors ( 13 ). Angiotropism and vascular...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with benign junctional nests. PRAME can help in problematic cases: if the melanocytes are strongly and diffusely immunoreactive, they likely represent LM. For the distinction of lichenoid dermatitis with junctional melanocyte nests, clinical correlation (e.g., unusual appearance, presence of multiple lesions...