URINARY BLADDER PARAGANGLIOMA Figure 9-18 URINARY BLADDER PARAGANGLIOMA This paraganglioma shows extensive superficial growth beneath the mucosa. The tumor is a potential mimic of urothelial carcinoma because of its growth pattern and pale eosinophilic to clear cytoplasm. More about this image found in URINARY BLADDER PARAGANGLIOMA This paraganglioma shows extensive superfici...

NORORVIRUS INFECTION Figure 5-15 NORORVIRUS INFECTION A,B: The duodenal mucosa shows mild villous broadening, an increase in lamina propria chronic inflammatory cells, a mild increase in intraepithelial lymphocytes, and focal surface epithelial degeneration. C,D: Colonic biopsies demonstrate nea... More about this image found in NORORVIRUS INFECTION A,B: The duodenal mucosa shows mild villous broadenin...

HIV VIRUS IN THE COLORECTAL MUCOSA Figure 9-17 HIV VIRUS IN THE COLORECTAL MUCOSA Abundant virus is seen with HIVp24 immunohistochemistry. More about this image found in HIV VIRUS IN THE COLORECTAL MUCOSA Abundant virus is seen with HIVp24 immu...

WHIPPLE DISEASE Figure 13-35 WHIPPLE DISEASE At endoscopy, enteric mucosa has multiple small yellow patches and plaques. (Courtesy of Dr. E. Montgomery, University of Miami, Miami, FL) More about this image found in WHIPPLE DISEASE At endoscopy, enteric mucosa has multiple small yellow pat...

CONJUNCTIVAL RHINOSPORIDIOSIS Figure 21-45 CONJUNCTIVAL RHINOSPORIDIOSIS Inflamed red granular mucosa of an early lesion. More about this image found in CONJUNCTIVAL RHINOSPORIDIOSIS Inflamed red granular mucosa of an early les...

CRYPTOSPORIDIUM PARASITES Figure 26-31 CRYPTOSPORIDIUM PARASITES Giemsa stain highlights luminal parasites in infected gallbladder mucosa. More about this image found in CRYPTOSPORIDIUM PARASITES Giemsa stain highlights luminal...

E. HISTOLYTICA TROPHOZOITES Figure 26-6 E. HISTOLYTICA TROPHOZOITES A cluster of E. histolytica trophozoites in the lumen adjacent to intact mucosa in the vicinity of a colonic ulcer. Such organisms may easily be overlooked or mistaken for histiocytes/cell debris. More about this image found in E. HISTOLYTICA TROPHOZOITES A cluster of E. histolytica t...

MEASLES RASH Figure 4-27 MEASLES RASH Typical measles maculopapular rash starts on the head (A) and is usually preceded by Koplik spots, located on the buccal mucosa opposite the molars (B). These spots may sometimes be inconspicuous. (Courtesy of the CDC PHIL) More about this image found in MEASLES RASH Typical measles maculopapular rash starts on the head (A) and...

TYPHOID FEVER Figure 13-16 TYPHOID FEVER A,B: Extensive necrosis and deep ulceration extending to the muscularis propria are features. Note the prominent lymphohistiocytic infiltrate and the near absence of neutrophils. C: Scant plasma cells are present in the adjacent intact mucosa. More about this image found in TYPHOID FEVER A,B: Extensive necrosis and deep ulceration extending to the...

PARACOCCIDIOIDOMYCOSIS Figure 21-15 PARACOCCIDIOIDOMYCOSIS Juvenile form involving the skin (A), and chronic adult form showing lesions of the eye and tongue, as well as a destructive lesion that spans the mouth and nose (B). Note the granular “mulberry”-like appearance of the mucosa. (Courtesy o... More about this image found in PARACOCCIDIOIDOMYCOSIS Juvenile form involving the skin (A), and chronic a...

E. HISTOLYTICA TROPHOZOITES Figure 26-10 E. HISTOLYTICA TROPHOZOITES The associated cell debris adjacent to colonic mucosa shows organisms with light eosinophilic granular cytoplasm, imparting a histiocyte-like morphology. (Courtesy of A. Cardona, Hospital Pablo Tobón Uribe, Medellín, Columbia) More about this image found in E. HISTOLYTICA TROPHOZOITES The associated cell debris ad...

CYTOMEGALOVIRUS (CMV) COLITIS Figure 5-17 CYTOMEGALOVIRUS (CMV) COLITIS CMV colitis affecting the sigmoid colon shows a patchy hemorrhagic mucosa and scattered well-circumscribed deep ulcers. (Courtesy of Dr. A. E. van der Hoven, University of Pretoria, Pretoria, South Africa) More about this image found in CYTOMEGALOVIRUS (CMV) COLITIS CMV colitis affecting the sigmoid colon show...

RECTAL SYPHILIS Figure 18-5 RECTAL SYPHILIS A: Early crypt drop-out and architectural distortion, with striking lamina propria plasma cell infiltrate. Note the focal endothelial cell swelling. B: Plasma cell infiltration is disproportionately prominent in the deep aspect of the mucosa and submuc... More about this image found in RECTAL SYPHILIS A: Early crypt drop-out and architectural distortion, with...

CHOLERA Figure 13-20 CHOLERA A,B: Documented histologic changes of cholera in small intestinal mucosa are mild and nonspecific, like some other toxin-associated intestinal bacterial infections, and include mild villous shortening and broadening, congestion, and lamina propria mononuclear inflamma... More about this image found in CHOLERA A,B: Documented histologic changes of cholera in small intestinal ...

KAPOSI SARCOMA Figure 8-16 KAPOSI SARCOMA A: Kaposi sarcoma (KS) of the thoracic skin shows numerous characteristic violaceous plaques. (Courtesy of L. M. Gomez, Department of Dermatology, Pontifica Bolivariana University, Medellín, Colombia) B: Palatal mucosa with KS lesions. (Courtesy of the C... More about this image found in KAPOSI SARCOMA A: Kaposi sarcoma (KS) of the thoracic skin shows numerous ...

PEDIATRIC ENTEROTOXIGENIC E. COLI (ETEC) INFECTION Figure 13-6 PEDIATRIC ENTEROTOXIGENIC E. COLI (ETEC) INFECTION A,B: Endoscopic biopsy histology shows normal/near normal colon mucosa with nonspecific histologic alterations, including mild goblet cell depletion, focal lamina propria edema, and a mild increase in superficial mucosal mononuclear cells. More about this image found in PEDIATRIC ENTEROTOXIGENIC E. COLI (ETEC) INFECTION A,B: E...

H. HEILMANNII INFECTION Figure 13-34 H. HEILMANNII INFECTION A: A methylene blue stain demonstrates two long spiraled H. heilmannii organisms (arrow) adjacent the gastric mucosa. B: H. heilmannii bacilli stain with an H. pylori immunoperoxidase stain. The organisms’ characteristic spirochetal morphology is demonstrated on this high-power view. (Courtesy of Dr. B. Kovái, University of Szeged, Szeged, Hungary) More about this image found in H. HEILMANNII INFECTION A: A methylene blue stain demonst...

DISSEMINATED EMERGOMYCES AFRICANUS INFECTION Figure 19-8 DISSEMINATED EMERGOMYCES AFRICANUS INFECTION A: The antral mucosa in the stomach of an AIDS patient shows a pronounced histiocytic infiltrate with focal poor granuloma formation. B: Large numbers of intracellular fungal yeasts reveal focal narrow-neck to tubular budding (arrow), visible on an H&E stain. C: PAS-D highlights the focally budding, small ovoid to round yeasts (arrow). More about this image found in DISSEMINATED EMERGOMYCES AFRICANUS INFECTION A: The antra...