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mitochondrial

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<span class="search-highlight">MITOCHONDRIAL</span> CARDIOMYOPATHIES: HYPERTROPHIC PHENOTYPE  <span class="search-highlight">Mitochondrial</span> cardi...
Published: 15 November 2023
MITOCHONDRIAL CARDIOMYOPATHIES: HYPERTROPHIC PHENOTYPE Figure 19-5 MITOCHONDRIAL CARDIOMYOPATHIES: HYPERTROPHIC PHENOTYPE Mitochondrial cardiomyopathy in an infant produces symmetric left ventricular hypertrophy. More about this image found in MITOCHONDRIAL CARDIOMYOPATHIES: HYPERTROPHIC PHENOTYPE Mitochondrial cardi...
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<span class="search-highlight">MITOCHONDRIAL</span> CARDIOMYOPATHIES: DILATED PHENOTYPE  Biventricular dilatation...
Published: 15 November 2023
MITOCHONDRIAL CARDIOMYOPATHIES: DILATED PHENOTYPE Figure 19-4 MITOCHONDRIAL CARDIOMYOPATHIES: DILATED PHENOTYPE Biventricular dilatation in Friedreich ataxia produces cardiomegaly (normal age- and sex-matched heart on the right, for comparison). More about this image found in MITOCHONDRIAL CARDIOMYOPATHIES: DILATED PHENOTYPE Biventricular dilatation...
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<span class="search-highlight">MITOCHONDRIAL</span> CARDIOMYOPATHY  Prominent sarcoplasmic vacuolization is seen ...
Published: 15 November 2023
MITOCHONDRIAL CARDIOMYOPATHY Figure 19-8 MITOCHONDRIAL CARDIOMYOPATHY Prominent sarcoplasmic vacuolization is seen on light microscopy. Sarcoplasmic granularity is also present, indicated by the increased mitochondria. More about this image found in MITOCHONDRIAL CARDIOMYOPATHY Prominent sarcoplasmic vacuolization is seen ...
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<span class="search-highlight">MITOCHONDRIAL</span> CARDIOMYOPATHY  Toluidine blue staining of semi-thin sections...
Published: 15 November 2023
MITOCHONDRIAL CARDIOMYOPATHY Figure 19-9 MITOCHONDRIAL CARDIOMYOPATHY Toluidine blue staining of semi-thin sections offers better resolution of intracellular detail, allowing for visualization of the mitochondria more directly. More about this image found in MITOCHONDRIAL CARDIOMYOPATHY Toluidine blue staining of semi-thin sections...
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<span class="search-highlight">MITOCHONDRIAL</span> CARDIOMYOPATHY: ULTRASTRUCTURE  A: Increased numbers of mitoc...
Published: 15 November 2023
MITOCHONDRIAL CARDIOMYOPATHY: ULTRASTRUCTURE Figure 19-10 MITOCHONDRIAL CARDIOMYOPATHY: ULTRASTRUCTURE A: Increased numbers of mitochondria (mitochondriosis) are seen, essentially filling each myocyte. B,C: The mitochondria exhibit abnormal forms, such as targetoid arrangement of the cristae (B)... More about this image found in MITOCHONDRIAL CARDIOMYOPATHY: ULTRASTRUCTURE A: Increased numbers of mitoc...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch19
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... DMPK AD Conduction system disturbances; dilated  Type 2 CNBP AD Conduction system disturbances; dilated Nemaline myopathy NEB, ACTA1 AR; AD Dilated; hypertrophic (rarely) a AD = autosomal dominant; AR = autosomal recessive. Table 19-2 MITOCHONDRIAL DISEASE...
Images
LEFT VENTRICULAR NONCOMPACTION  The trabeculated layer (double-headed yello...
Published: 15 November 2023
LEFT VENTRICULAR NONCOMPACTION Figure 19-6 LEFT VENTRICULAR NONCOMPACTION The trabeculated layer (double-headed yellow arrow) is more than twice as thick as the compact layer (double-headed white arrow). Although a nonspecific finding, noncompaction can be seen in the setting of mitochondrial car... More about this image found in LEFT VENTRICULAR NONCOMPACTION The trabeculated layer (double-headed yello...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch13
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... , Wahlander   H , Eriksson   BO , Oldfors   A , Holme   E , Tulinius   M . Cardiomyopathy in children with mitochondrial disease; clinical course and cardiological findings . Eur Heart J   2003 ; 24 : 280 - 8 . 10. Sohn   DW , Kim   HK , Kim   YJ , Oh   S , Seong   MW...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch45
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
.... Edston   E , Perskvist   N . Histiocytoid cardiomyopathy and ventricular non-compaction in a case of sudden death in a female infant . Int J Legal Med   2009 ; 123 : 47 - 53 . 42. Finsterer   J , Stollberger   C . Is mitochondrial disease the common cause of histiocytoid...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch23
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
.... Sudarikova Yu   V , Bakeeva   LE , Tsiplenkova   VG.   Ultrastructure of mitochondrial reticulum of human cardiomyocytes in alcohol cardiomyopathy . Biochemistry (Mosc)   1997 ; 62 : 989 - 1002 . 41. Mashimo   K , Sato   S , Ohno   Y . Chronic effects of ethanol on cultured...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch15
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
.... Mitochondrial damage is consistently present, characterized by increased mitochondrial number, mitochondrial swelling, and cristae disruption. Increased ribosomes are also seen in most cases. Molecular Genetic Findings. HCM is the most common monogenic (disease produced by a mutation in a single gene/allele...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch04
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... , Ishihara   T . Basophilic degeneration of the myocardium: histological, immunohistochemical and immuno-electronmicroscopic studies . Histopathology   1995 ; 26 : 501 - 8 . 3. Terman   A , Brunk   UT . The aging myocardium: roles of mitochondrial damage and lysosomal degradation . Heart...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch14
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... such as “acquired,” “syndromic,” and “nonsyndromic” have been employed as well; only nonsyndromic is discussed here. Syndromic includes the muscular dystrophies and mitochondrial conditions that we consider systemic disease, and acquired are all the ischemic, hypertensive, and valvular diseases. Approximately 70...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch39
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...   SD , Ferkol   T , et al . Laterality defects other than situs inversus totalis in primary ciliary dyskinesia: insights into situs ambiguus and heterotaxy . Chest   2014 ; 146 : 1176 - 86 . 31. Burkhalter   MD , Sridhar   A , Sampaio   P , et al . Imbalanced mitochondrial...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... HD <5% TGFβR2 3p HD, Bi-IM Tumors with MSI ZIM2 19q LOH+IM <5% DNA repair BRCA2 13q Germline 7% FANC-C 9q HD, LOH+IM <5% FANC-G 9p LOH+IM <5% MLH1 3p Germline, Meth 3-15% Mitochondrial genome Multiple...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-13
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
.... Severina   IS . [ Possible mechanism of selective inhibition of rat liver mitochondrial mono-amine oxidase by chlorgiline and deprenyl ]. Biokhimiia   1979 ; 44 : 195 - 207 . [ Russian ] 105. Mora   J , Modak   S , Cheung   NK , et al   Desmoplastic small round cell tumor 20 years after...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-06
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... , 206 ). IOPNs label strongly with antibodies against mitochondrial antigens such as 111.3 ( 5 ). IOPNs usually label for B72.3; however, most label inconsistently for CEA and CA19-9 ( 5 ). Interestingly, about 60 percent immunolabel with hepatocyte-1 (Hep-Par-1) antibodies ( 206 ). Most IOPNs...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-3
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... benign, but also non-neoplastic ( 265 ). The same group showed that there is no clonal relationship between the epithelial and mesenchymal components using mitochondrial DNA mutational analysis. Differential Diagnosis. At the very low-grade end of the spectrum, adenosarcoma must be distinguished from...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
10.55418/9781933477251-2
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... to 3.0 hemizygous deletion of 22q11.2 (defects due to haploinsufficiency of TBX1 gene) Velocardiofacial syndrome Autosomal dominant 1.5 to 3.0 hemizygous deletion of 22q11.2 (defects due to haploinsufficiency of TBX1 gene) Kearns-Sayre syndrome Mitochondrial DNA abnormalities...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
10.55418/9781933477220-02
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... membrane. The mitochondrial cristae are mostly tubular, but a few appear plate-like. Single-stranded, smooth, and rough endoplasmic reticulum are present in small quantities, as are variable quantities of cytoplasmic glycogen. Crystalloids of Lubarsch, bundles of parallel arrays of microtubules...