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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-11
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... organisms disrupt the normal cellular processes by altering mitochondrial shape and function, degrading endoplasmic reticulum, and secreting nucleomodulins. The nucleomodulins increase cyclic-di-AMP levels, which leads to the release of pathogen-associated molecular patterns and decreased production...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-28
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... for adequate visualization. They have a thin membrane, large nucleus, and a characteristic rod-shaped, darkly staining kinetoplast (a paranuclear body comprised of mitochondrial DNA). The latter is sometimes not identifiable due to the orientation of the parasite. Leishmania spp have a dull blue-gray...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... show intracytoplasmic eosinophilic inclusions, which on electron microscopy are giant mitochondria, indicating inhibition of mitochondrial replication ( fig. 9-20 ). Trichrome stains highlight the inclusions as fuchsinophilic red bodies ( 26 ). TENOFOVIR TOXICITY Figure 9-20 TENOFOVIR TOXICITY...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-03
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... ceroid lipofuscinosis and mitochondrial disease ( 43 ). In adult-onset SSPE, some studies have shown that fewer patients present with personality change and more have purely ophthalmologic manifestations, such as blurred or decreased vision, papillitis, chorioretinitis, and macular changes ( 45...
Images
Published: 15 November 2023
MITOCHONDRIAL CARDIOMYOPATHIES: HYPERTROPHIC PHENOTYPE Figure 19-5 MITOCHONDRIAL CARDIOMYOPATHIES: HYPERTROPHIC PHENOTYPE Mitochondrial cardiomyopathy in an infant produces symmetric left ventricular hypertrophy. More about this image found in MITOCHONDRIAL CARDIOMYOPATHIES: HYPERTROPHIC PHENOTYPE Mitochondrial cardi...
Images
Published: 15 November 2023
MITOCHONDRIAL CARDIOMYOPATHIES: DILATED PHENOTYPE Figure 19-4 MITOCHONDRIAL CARDIOMYOPATHIES: DILATED PHENOTYPE Biventricular dilatation in Friedreich ataxia produces cardiomegaly (normal age- and sex-matched heart on the right, for comparison). More about this image found in MITOCHONDRIAL CARDIOMYOPATHIES: DILATED PHENOTYPE Biventricular dilatation...
Images
Published: 15 November 2023
MITOCHONDRIAL CARDIOMYOPATHY Figure 19-8 MITOCHONDRIAL CARDIOMYOPATHY Prominent sarcoplasmic vacuolization is seen on light microscopy. Sarcoplasmic granularity is also present, indicated by the increased mitochondria. More about this image found in MITOCHONDRIAL CARDIOMYOPATHY Prominent sarcoplasmic vacuolization is seen ...
Images
Published: 15 November 2023
MITOCHONDRIAL CARDIOMYOPATHY Figure 19-9 MITOCHONDRIAL CARDIOMYOPATHY Toluidine blue staining of semi-thin sections offers better resolution of intracellular detail, allowing for visualization of the mitochondria more directly. More about this image found in MITOCHONDRIAL CARDIOMYOPATHY Toluidine blue staining of semi-thin sections...
Images
Published: 15 November 2023
MITOCHONDRIAL CARDIOMYOPATHY: ULTRASTRUCTURE Figure 19-10 MITOCHONDRIAL CARDIOMYOPATHY: ULTRASTRUCTURE A: Increased numbers of mitochondria (mitochondriosis) are seen, essentially filling each myocyte. B,C: The mitochondria exhibit abnormal forms, such as targetoid arrangement of the cristae (B)... More about this image found in MITOCHONDRIAL CARDIOMYOPATHY: ULTRASTRUCTURE A: Increased numbers of mitoc...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch19
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... DMPK AD Conduction system disturbances; dilated Type 2 CNBP AD Conduction system disturbances; dilated Nemaline myopathy NEB, ACTA1 AR; AD Dilated; hypertrophic (rarely) a AD = autosomal dominant; AR = autosomal recessive. Table 19-2 MITOCHONDRIAL DISEASE...
Images
Published: 15 November 2023
LEFT VENTRICULAR NONCOMPACTION Figure 19-6 LEFT VENTRICULAR NONCOMPACTION The trabeculated layer (double-headed yellow arrow) is more than twice as thick as the compact layer (double-headed white arrow). Although a nonspecific finding, noncompaction can be seen in the setting of mitochondrial car... More about this image found in LEFT VENTRICULAR NONCOMPACTION The trabeculated layer (double-headed yello...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch13
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... , Wahlander H , Eriksson BO , Oldfors A , Holme E , Tulinius M . Cardiomyopathy in children with mitochondrial disease; clinical course and cardiological findings . Eur Heart J 2003 ; 24 : 280 - 8 . 10. Sohn DW , Kim HK , Kim YJ , Oh S , Seong MW...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch45
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
.... Edston E , Perskvist N . Histiocytoid cardiomyopathy and ventricular non-compaction in a case of sudden death in a female infant . Int J Legal Med 2009 ; 123 : 47 - 53 . 42. Finsterer J , Stollberger C . Is mitochondrial disease the common cause of histiocytoid...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch23
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
.... Sudarikova Yu V , Bakeeva LE , Tsiplenkova VG. Ultrastructure of mitochondrial reticulum of human cardiomyocytes in alcohol cardiomyopathy . Biochemistry (Mosc) 1997 ; 62 : 989 - 1002 . 41. Mashimo K , Sato S , Ohno Y . Chronic effects of ethanol on cultured...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch15
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
.... Mitochondrial damage is consistently present, characterized by increased mitochondrial number, mitochondrial swelling, and cristae disruption. Increased ribosomes are also seen in most cases. Molecular Genetic Findings. HCM is the most common monogenic (disease produced by a mutation in a single gene/allele...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch04
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... , Ishihara T . Basophilic degeneration of the myocardium: histological, immunohistochemical and immuno-electronmicroscopic studies . Histopathology 1995 ; 26 : 501 - 8 . 3. Terman A , Brunk UT . The aging myocardium: roles of mitochondrial damage and lysosomal degradation . Heart...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch14
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... such as “acquired,” “syndromic,” and “nonsyndromic” have been employed as well; only nonsyndromic is discussed here. Syndromic includes the muscular dystrophies and mitochondrial conditions that we consider systemic disease, and acquired are all the ischemic, hypertensive, and valvular diseases. Approximately 70...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch39
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... SD , Ferkol T , et al . Laterality defects other than situs inversus totalis in primary ciliary dyskinesia: insights into situs ambiguus and heterotaxy . Chest 2014 ; 146 : 1176 - 86 . 31. Burkhalter MD , Sridhar A , Sampaio P , et al . Imbalanced mitochondrial...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... HD <5% TGFβR2 3p HD, Bi-IM Tumors with MSI ZIM2 19q LOH+IM <5% DNA repair BRCA2 13q Germline 7% FANC-C 9q HD, LOH+IM <5% FANC-G 9p LOH+IM <5% MLH1 3p Germline, Meth 3-15% Mitochondrial genome Multiple...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-13
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
.... Severina IS . [ Possible mechanism of selective inhibition of rat liver mitochondrial mono-amine oxidase by chlorgiline and deprenyl ]. Biokhimiia 1979 ; 44 : 195 - 207 . [ Russian ] 105. Mora J , Modak S , Cheung NK , et al Desmoplastic small round cell tumor 20 years after...
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