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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Melanoma can affect the skin not only as a primary tumor, but also as a metastatic tumor deposit. Metastatic melanoma has not originated at the site where it is found, but represents secondary growth after intravascular, intralymphatic or potentially perivascular spread. CLINICAL FEATURES Melanoma...
Images
EPIDERMOTROPIC <span class="search-highlight">METASTATIC</span> MELANOMA  A: <span class="search-highlight">Metastatic</span> melanoma is present in th...
Published: 01 February 2024
EPIDERMOTROPIC METASTATIC MELANOMA Figure 22-6 EPIDERMOTROPIC METASTATIC MELANOMA A: Metastatic melanoma is present in the dermis and epidermis. The intraepidermal melanoma is narrower in horizontal dimension that the intradermal tumor cell population. B: Lymphatic tumor emboli are present (arro... More about this image found in EPIDERMOTROPIC METASTATIC MELANOMA A: Metastatic melanoma is present in th...
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EPIDERMOTROPIC <span class="search-highlight">METASTATIC</span> MELANOMA  A: <span class="search-highlight">Metastatic</span> melanoma is present in th...
Published: 01 February 2024
EPIDERMOTROPIC METASTATIC MELANOMA Figure 22-7 EPIDERMOTROPIC METASTATIC MELANOMA A: Metastatic melanoma is present in the epidermis and dermis. This metastasis simulates the appearance of a primary melanoma. The intraepidermal melanoma extends peripheral to the dermal tumor cells. Clinicopatholo... More about this image found in EPIDERMOTROPIC METASTATIC MELANOMA A: Metastatic melanoma is present in th...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch52
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... of the lung (primary tumor, white arrow) has invaded the structures of the superior mediastinum (black asterisk) and is directly invading the wall of the trachea. METASTASIS BY RETROGRADE LYMPHATIC SPREAD Figure 52-2 METASTASIS BY RETROGRADE LYMPHATIC SPREAD Left: Metastatic high-grade urothelial carcinoma...
Images
<span class="search-highlight">METASTATIC</span> MELANOMA IN THE SUBCUTIS  A: A partly pigmented tumor nodule is ...
Published: 01 February 2024
METASTATIC MELANOMA IN THE SUBCUTIS Figure 22-3 METASTATIC MELANOMA IN THE SUBCUTIS A: A partly pigmented tumor nodule is present in the subcutis. B: Melanoma cells with epithelioid cell features surround an area of necrosis. There are also melanophages and associated lymphocytes. More about this image found in METASTATIC MELANOMA IN THE SUBCUTIS A: A partly pigmented tumor nodule is ...
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<span class="search-highlight">METASTATIC</span> MELANOMA IN DERMIS  A: A scanning magnification, the lesion disp...
Published: 01 February 2024
METASTATIC MELANOMA IN DERMIS Figure 22-5 METASTATIC MELANOMA IN DERMIS A: A scanning magnification, the lesion displays intradermal nevus-like features. B: The tumor cells show some evidence of zonation, but they are cytologically atypical. More about this image found in METASTATIC MELANOMA IN DERMIS A: A scanning magnification, the lesion disp...
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SPITZOID MELANOMA (OF CHILDHOOD)  A: Shave biopsy of an ulcerated tumor.  B...
Published: 01 February 2024
SPITZOID MELANOMA (OF CHILDHOOD) Figure 19-4 SPITZOID MELANOMA (OF CHILDHOOD) A: Shave biopsy of an ulcerated tumor. B: The tumor cells display severe nuclear atypia. The tumor was associated with homozygous deletions of p16 (not shown). C: Metastatic melanoma in the regional lymph node. More about this image found in SPITZOID MELANOMA (OF CHILDHOOD) A: Shave biopsy of an ulcerated tumor. B...
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UNDIFFERENTIATED MELANOMA  An amelanotic undifferentiated malignant spindle...
Published: 01 February 2024
UNDIFFERENTIATED MELANOMA Figure 21-8 UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle cell neoplasm is seen. It was initially interpreted as sarcoma by a soft tissue pathologist, but the diagnosis was revised to metastatic melanoma after sequence analysis revealed UV signatures and an NRAS Q61R mutation identical to the mutation in the patient’s prior primary melanoma located draining to the site of the undifferentiated tumor. More about this image found in UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... in the potential for diagnostic confusion with skin adnexal (sebaceous or sweat gland) neoplasms, metastatic renal cell carcinoma, or xanthomatous histiocytic proliferations. DEEP PENETRATING NEVUS-LIKE (PLEXIFORM) MELANOMA Some melanomas may be confused with, or arise in association with, a deep penetrating...
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SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS  A: Symmetric silhouette of a...
Published: 01 February 2024
SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS Figure 19-2 SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS A: Symmetric silhouette of a compound pigmented spindle and epithelioid cell neoplasm in a young adult. There are clefts between junctional nests and adjacent hyperplastic epidermis. B: A few ... More about this image found in SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS A: Symmetric silhouette of a...
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SUPERFICIAL SPREADING MELANOMA ARISING IN ASSOCIATION WITH A NEVUS  A: Asym...
Published: 01 February 2024
SUPERFICIAL SPREADING MELANOMA ARISING IN ASSOCIATION WITH A NEVUS Figure 20-1 SUPERFICIAL SPREADING MELANOMA ARISING IN ASSOCIATION WITH A NEVUS A: Asymmetric silhouette of the lesion of a teenager shows an ulcerated nodular growth on the right side and a plaque lesion of a compound nevus on the left. B: Compound melanocytic nevus with bland cytologic features. C: In situ and invasive melanoma are characterized by architectural disorder and nuclear atypia. D: The primary invasive melanoma contains sheets of atypical melanocytes, some of which are in mitosis. E: Metastatic melanoma in the sentinel lymph node. F: The tumor cells homogenously express BRAF V600E. More about this image found in SUPERFICIAL SPREADING MELANOMA ARISING IN ASSOCIATION WITH A NEVUS A: Asym...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of melanin pigment. They tend to grow faster and are thicker at the time of diagnosis. Furthermore, they can be more easily confused with metastatic melanoma. CLINICAL FEATURES Clinically, nodular melanoma presents as a papule, nodule, or plaque ( fig. 15-1 ). If there is an associated nevus precursor...
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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... common  Periadnexal aggregation of dendritic cells often  Infiltration of smooth muscle, nerves Differential Diagnosis  Dermal melanocytoses  Pigmented neurofibroma  Melanosis, postinflammatory hyperpigmentation  Melanoma, especially BN-like metastatic melanoma Microscopic Findings...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-11
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... sheet-like aggregates of melanophages. The lesion may be associated with spontaneous or treatment-related tumor regression or primary or metastatic melanoma. In contrast to PEM, the pigment-laden macrophages of tumoral melanosis tend to be smaller, with smaller nuclei with inconspicuous nucleoli. Large...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...  Metastatic melanoma  Tumoral melanosis Molecular Genetic Findings  Genomic aberrations common (e.g., loss in 1p, monosomy 3, gain in 6p and/or 8q)  Mutations: GNAQ, GNA11, PLCB4, CYSLTR2, rarely SF3B1, or unknown driver mutation In the absence of tumor necrosis and marked...
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<span class="search-highlight">METASTATIC</span> SEROUS CARCINOMA  A: Low-power view of a core needle biopsy with...
Published: 01 January 2024
METASTATIC SEROUS CARCINOMA Figure 7-36 METASTATIC SEROUS CARCINOMA A: Low-power view of a core needle biopsy with a papillary lesion, dense lymphocytic infiltrate, and microcalcifications. B,C: At intermediate (B) and high (C) power view, the cytologic atypia is striking. This constellation of ... More about this image found in METASTATIC SEROUS CARCINOMA A: Low-power view of a core needle biopsy with...
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IMMUNOSTAINS IN <span class="search-highlight">METASTATIC</span> BREAST CARCINOMA  Mammaglobin (A) and GCDFP-15 (...
Published: 01 January 2024
IMMUNOSTAINS IN METASTATIC BREAST CARCINOMA Figure 8-24 IMMUNOSTAINS IN METASTATIC BREAST CARCINOMA Mammaglobin (A) and GCDFP-15 (B) are two immunostains that are useful in supporting the diagnosis metastatic breast carcinoma. It is important to know that the staining is often patchy. More about this image found in IMMUNOSTAINS IN METASTATIC BREAST CARCINOMA Mammaglobin (A) and GCDFP-15 (...
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<span class="search-highlight">METASTATIC</span> BREAST CARCINOMA TO COLON  A: Low-power examination reveals grea...
Published: 01 January 2024
METASTATIC BREAST CARCINOMA TO COLON Figure 8-71 METASTATIC BREAST CARCINOMA TO COLON A: Low-power examination reveals greater cellularity in the lamina propria than is typical. B: On higher-power examination, single atypical epithelial cells and glands are identified. C: An ER stain supports t... More about this image found in METASTATIC BREAST CARCINOMA TO COLON A: Low-power examination reveals grea...
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<span class="search-highlight">METASTATIC</span> MUCINOUS CARCINOMA TO ILIAC BONE  A: Mucinous carcinoma present ...
Published: 01 January 2024
METASTATIC MUCINOUS CARCINOMA TO ILIAC BONE Figure 8-72 METASTATIC MUCINOUS CARCINOMA TO ILIAC BONE A: Mucinous carcinoma present in an iliac bone biopsy. B: A GATA3 immunostain is positive, supporting the diagnosis of metastatic breast carcinoma. More about this image found in METASTATIC MUCINOUS CARCINOMA TO ILIAC BONE A: Mucinous carcinoma present ...