METASTATIC AMEBIASIS Figure 26-8 METASTATIC AMEBIASIS Lung abscess formation (arrows) may sometimes result in a bronchopleural fistula. (Courtesy of the Department of Anatomical Pathology, University of Pretoria, Pretoria, South Africa) More about this image found in METASTATIC AMEBIASIS Lung abscess formation (arrows) may sometimes result ...

EPIDERMOTROPIC METASTATIC MELANOMA Figure 22-6 EPIDERMOTROPIC METASTATIC MELANOMA A: Metastatic melanoma is present in the dermis and epidermis. The intraepidermal melanoma is narrower in horizontal dimension that the intradermal tumor cell population. B: Lymphatic tumor emboli are present (arro... More about this image found in EPIDERMOTROPIC METASTATIC MELANOMA A: Metastatic melanoma is present in th...

EPIDERMOTROPIC METASTATIC MELANOMA Figure 22-7 EPIDERMOTROPIC METASTATIC MELANOMA A: Metastatic melanoma is present in the epidermis and dermis. This metastasis simulates the appearance of a primary melanoma. The intraepidermal melanoma extends peripheral to the dermal tumor cells. Clinicopatholo... More about this image found in EPIDERMOTROPIC METASTATIC MELANOMA A: Metastatic melanoma is present in th...

METASTATIC MELANOMA IN THE SUBCUTIS Figure 22-3 METASTATIC MELANOMA IN THE SUBCUTIS A: A partly pigmented tumor nodule is present in the subcutis. B: Melanoma cells with epithelioid cell features surround an area of necrosis. There are also melanophages and associated lymphocytes. More about this image found in METASTATIC MELANOMA IN THE SUBCUTIS A: A partly pigmented tumor nodule is ...

METASTATIC MELANOMA IN DERMIS Figure 22-5 METASTATIC MELANOMA IN DERMIS A: A scanning magnification, the lesion displays intradermal nevus-like features. B: The tumor cells show some evidence of zonation, but they are cytologically atypical. More about this image found in METASTATIC MELANOMA IN DERMIS A: A scanning magnification, the lesion disp...

SPITZOID MELANOMA (OF CHILDHOOD) Figure 19-4 SPITZOID MELANOMA (OF CHILDHOOD) A: Shave biopsy of an ulcerated tumor. B: The tumor cells display severe nuclear atypia. The tumor was associated with homozygous deletions of p16 (not shown). C: Metastatic melanoma in the regional lymph node. More about this image found in SPITZOID MELANOMA (OF CHILDHOOD) A: Shave biopsy of an ulcerated tumor. B...

UNDIFFERENTIATED MELANOMA Figure 21-8 UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle cell neoplasm is seen. It was initially interpreted as sarcoma by a soft tissue pathologist, but the diagnosis was revised to metastatic melanoma after sequence analysis revealed UV signatures and an NRAS Q61R mutation identical to the mutation in the patient’s prior primary melanoma located draining to the site of the undifferentiated tumor. More about this image found in UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle...

SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS Figure 19-2 SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS A: Symmetric silhouette of a compound pigmented spindle and epithelioid cell neoplasm in a young adult. There are clefts between junctional nests and adjacent hyperplastic epidermis. B: A few ... More about this image found in SPITZOID MELANOMA MISDIAGNOSED AS SPITZ NEVUS A: Symmetric silhouette of a...

SUPERFICIAL SPREADING MELANOMA ARISING IN ASSOCIATION WITH A NEVUS Figure 20-1 SUPERFICIAL SPREADING MELANOMA ARISING IN ASSOCIATION WITH A NEVUS A: Asymmetric silhouette of the lesion of a teenager shows an ulcerated nodular growth on the right side and a plaque lesion of a compound nevus on the left. B: Compound melanocytic nevus with bland cytologic features. C: In situ and invasive melanoma are characterized by architectural disorder and nuclear atypia. D: The primary invasive melanoma contains sheets of atypical melanocytes, some of which are in mitosis. E: Metastatic melanoma in the sentinel lymph node. F: The tumor cells homogenously express BRAF V600E. More about this image found in SUPERFICIAL SPREADING MELANOMA ARISING IN ASSOCIATION WITH A NEVUS A: Asym...

METASTATIC MUCINOUS CARCINOMA Figure 8-51 METASTATIC MUCINOUS CARCINOMA Liver biopsy with metastatic mucinous carcinoma. More about this image found in METASTATIC MUCINOUS CARCINOMA Liver biopsy with metastatic mucinous carcin...