HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND Figure 12-26 HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND A: Hepatocellular carcinoma metastatic to the adrenal gland can simulate a primary adrenal cortical carcinoma. This metastasis has a prominent trabecular pattern with delicate si... More about this image found in HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND A: Hepatocellular car...

SF1 IN ADRENAL CORTICAL CARCINOMA Figure 6-31 SF1 IN ADRENAL CORTICAL CARCINOMA The diagnosis of metastatic adrenal cortical carcinoma in this transbronchial fine needle aspiration biopsy of a perihilar lymph node (A) is supported by positive nuclear staining for SF1 (B). More about this image found in SF1 IN ADRENAL CORTICAL CARCINOMA The diagnosis of metastatic adrenal cort...

METASTATIC PHEOCHROMOCYTOMA Figure 8-52 METASTATIC PHEOCHROMOCYTOMA The presence of paraganglioma in lymph node (A) or bone (B) is unequivocal evidence of metastatic spread, since these tissues do not harbor paraganglia and therefore the disease cannot represent multifocal primary lesions in a ge... More about this image found in METASTATIC PHEOCHROMOCYTOMA The presence of paraganglioma in lymph node (A...

LYMPH NODE METASTASIS OF ABDOMINAL PARAGANGLIOMA Figure 9-40 LYMPH NODE METASTASIS OF ABDOMINAL PARAGANGLIOMA A: This metastatic tumor could be mistaken for a carcinoma with clear cell features, but was known to correspond to one of the lesions in fig. 9-39 . The diagnosis was confirmed by an im... More about this image found in LYMPH NODE METASTASIS OF ABDOMINAL PARAGANGLIOMA A: This metastatic tumor ...

PARAGANGLIOMA METASTATIC TO VERTEBRAL BONE Figure 9-41 PARAGANGLIOMA METASTATIC TO VERTEBRAL BONE Residual bone is present at bottom center. Since normal paraganglia do not occur in bone, the diagnosis of metastasis is unequivocal. More about this image found in PARAGANGLIOMA METASTATIC TO VERTEBRAL BONE Residual bone is present at bot...

NEUROBLASTOMA METASTATIC TO BONE AND BONE MARROW Figure 11-37 NEUROBLASTOMA METASTATIC TO BONE AND BONE MARROW This trephine biopsy shows extensive involvement by NB, which is even appreciated without immunohistochemistry. More about this image found in NEUROBLASTOMA METASTATIC TO BONE AND BONE MARROW This trephine biopsy show...

ADENOCARCINOMA OF BREAST METASTATIC TO ADRENAL GLAND Figure 12-24 ADENOCARCINOMA OF BREAST METASTATIC TO ADRENAL GLAND A: The pattern of growth shows a well-developed glandular arrangement of tumor cells. B: Metastatic poorly differentiated adenocarcinoma has a sinusoidal pattern, with growth as... More about this image found in ADENOCARCINOMA OF BREAST METASTATIC TO ADRENAL GLAND A: The pattern of gro...

ADENOCARCINOMA METASTATIC TO ADRENAL GLAND Figure 12-25 ADENOCARCINOMA METASTATIC TO ADRENAL GLAND A: Core needle biopsy of an adrenal mass in a patient with non-small cell lung carcinoma. The tumor replaces much of adrenal tissue, with only small nests of residual pale-staining cortical cells vi... More about this image found in ADENOCARCINOMA METASTATIC TO ADRENAL GLAND A: Core needle biopsy of an adr...

RENAL CELL CARCINOMA METASTATIC TO ADRENAL GLAND Figure 12-27 RENAL CELL CARCINOMA METASTATIC TO ADRENAL GLAND A: Adrenal metastasis from an ipsilateral renal cell carcinoma. The patient had undergone radical nephrectomy for a large renal cell carcinoma. Metastatic clear cell renal carcinoma is p... More about this image found in RENAL CELL CARCINOMA METASTATIC TO ADRENAL GLAND A: Adrenal metastasis fro...

LIVER METASTASIS FROM ADRENAL CORTICAL CARCINOMA Figure 6-38 LIVER METASTASIS FROM ADRENAL CORTICAL CARCINOMA A: Hepatic lobectomy specimen is largely replaced by metastatic ACC. The tumor is mottled tan-yellow. B: Metastatic ACC disrupts the liver parenchyma and has a large nesting pattern. More about this image found in LIVER METASTASIS FROM ADRENAL CORTICAL CARCINOMA A: Hepatic lobectomy spec...

PHEOCHROMOCYTOMA: ANGIOINVASION Figure 8-47 PHEOCHROMOCYTOMA: ANGIOINVASION A,B: The presence of vascular invasion is a worrisome finding, but unlike in other neoplasms, it is not reliably associated with the development of metastatic disease. More about this image found in PHEOCHROMOCYTOMA: ANGIOINVASION A,B: The presence of vascular invasion is ...

PHEOCHROMOCYTOMA: VARIATION IN SUSTENTACULAR CELLS Figure 8-53 PHEOCHROMOCYTOMA: VARIATION IN SUSTENTACULAR CELLS Immunohistochemical stain for S-100 protein shows intratumoral variation in density of sustentacular cells in a pheochromocytoma from a patient with MEN2A (same patient as figure 8-3... More about this image found in PHEOCHROMOCYTOMA: VARIATION IN SUSTENTACULAR CELLS Immunohistochemical sta...

PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE Figure 4-24 PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE A large pigmented macronodule and a larger pale yellow nodule with small areas of necrosis are seen. The patient was part of a family pedigree with the complex of myxomas, spotty pigmenta... More about this image found in PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE A large pigmented macrono...

METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA Figure 11-5 METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA A 2-year old girl presented with fever and a painless swelling in the abdomen. Blood and urine cultures were negative and initial ultrasound was suspicious of a renal tumor. After referral to an expert center, clinical examination (slight hypertension), laboratory testing (increased urinary catecholamines), and abdominal MRI imaging showed that a diagnosis of metastatic NB was more likely. The MRI depicted a right-sided adrenal mass with retroperitoneal lymph node metastases. Additional MIBG scintigraphy shows increased uptake in the primary adrenal NB and locoregional lymph nodes (black arrow), but also extensive bone marrow metastases throughout. At the top, is a classic orbital metastasis and at the bottom, a tibial metastasis (red arrows). Histopathology showed an undifferentiated NB, with MYCN amplification, indicative of a high-risk NB patient. (Courtesy of Dr. A. J. Braat, University Medical Center Utrecht, The Netherlands) More about this image found in METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA A...