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metastasi
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Images
Published: 01 December 2024
LIVER METASTASIS FROM ADRENAL CORTICAL CARCINOMA Figure 6-38 LIVER METASTASIS FROM ADRENAL CORTICAL CARCINOMA A: Hepatic lobectomy specimen is largely replaced by metastatic ACC. The tumor is mottled tan-yellow. B: Metastatic ACC disrupts the liver parenchyma and has a large nesting pattern. More about this image found in LIVER METASTASIS FROM ADRENAL CORTICAL CARCINOMA A: Hepatic lobectomy spec...
Images
Published: 01 December 2024
SITES OF METASTASIS FROM ADRENAL CORTICAL CARCINOMA Figure 6-39 SITES OF METASTASIS FROM ADRENAL CORTICAL CARCINOMA Lung (A), bone (B), brain (C), and skin (a surgically excised nodule on the scalp, D) metastases from ACC. More about this image found in SITES OF METASTASIS FROM ADRENAL CORTICAL CARCINOMA Lung (A), bone (B), br...
Images
Published: 01 December 2024
PEDIATRIC ADRENAL CORTICAL CARCINOMA Figure 6-44 PEDIATRIC ADRENAL CORTICAL CARCINOMA Synchronous brain metastasis from a malignant pediatric adrenal cortical tumor. (Same case as fig. 6-42 .) More about this image found in PEDIATRIC ADRENAL CORTICAL CARCINOMA Synchronous brain metastasis from a m...
Images
Published: 01 December 2024
LYMPH NODE METASTASIS OF ABDOMINAL PARAGANGLIOMA Figure 9-40 LYMPH NODE METASTASIS OF ABDOMINAL PARAGANGLIOMA A: This metastatic tumor could be mistaken for a carcinoma with clear cell features, but was known to correspond to one of the lesions in fig. 9-39 . The diagnosis was confirmed by an im... More about this image found in LYMPH NODE METASTASIS OF ABDOMINAL PARAGANGLIOMA A: This metastatic tumor ...
Images
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
BONE MARROW METASTASIS OF NEUROBLASTOMA Figure 11-38 BONE MARROW METASTASIS OF NEUROBLASTOMA A: Chromogranin A highlights the presence of isolated fields of tumor cells in paucicellular bone marrow following chemotherapy. B: Synaptophysin highlights the presence of isolated fields of tumor cells... More about this image found in BONE MARROW METASTASIS OF NEUROBLASTOMA A: Chromogranin A highlights the p...
Images
in Other Adrenal Neoplasms and Tumor-Like Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
RENAL CELL CARCINOMA METASTATIC TO ADRENAL GLAND Figure 12-27 RENAL CELL CARCINOMA METASTATIC TO ADRENAL GLAND A: Adrenal metastasis from an ipsilateral renal cell carcinoma. The patient had undergone radical nephrectomy for a large renal cell carcinoma. Metastatic clear cell renal carcinoma is p... More about this image found in RENAL CELL CARCINOMA METASTATIC TO ADRENAL GLAND A: Adrenal metastasis fro...
Images
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA Figure 11-5 METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA A 2-year old girl presented with fever and a painless swelling in the abdomen. Blood and urine cultures were negative and initial ultrasound was suspicious of a renal tumor. After referral to an expert center, clinical examination (slight hypertension), laboratory testing (increased urinary catecholamines), and abdominal MRI imaging showed that a diagnosis of metastatic NB was more likely. The MRI depicted a right-sided adrenal mass with retroperitoneal lymph node metastases. Additional MIBG scintigraphy shows increased uptake in the primary adrenal NB and locoregional lymph nodes (black arrow), but also extensive bone marrow metastases throughout. At the top, is a classic orbital metastasis and at the bottom, a tibial metastasis (red arrows). Histopathology showed an undifferentiated NB, with MYCN amplification, indicative of a high-risk NB patient. (Courtesy of Dr. A. J. Braat, University Medical Center Utrecht, The Netherlands) More about this image found in METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA A...
Images
in Clinicopathologic Features of the Adrenal Cortex
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ECTOPIC ACTH SYNDROME Figure 3-11 ECTOPIC ACTH SYNDROME Diffuse ACTH-dependent adrenocortical hyperplasia from an adrenal metastasis of an ACTH-secreting lung neuroendocrine tumor. More about this image found in ECTOPIC ACTH SYNDROME Diffuse ACTH-dependent adrenocortical hyperplasia fr...
Images
Published: 01 December 2024
PARAGANGLIOMA METASTATIC TO VERTEBRAL BONE Figure 9-41 PARAGANGLIOMA METASTATIC TO VERTEBRAL BONE Residual bone is present at bottom center. Since normal paraganglia do not occur in bone, the diagnosis of metastasis is unequivocal. More about this image found in PARAGANGLIOMA METASTATIC TO VERTEBRAL BONE Residual bone is present at bot...
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Published: 01 December 2024
PULMONARY PARAGANGLIOMA Figure 9-32 PULMONARY PARAGANGLIOMA A: This paraganglioma was a solitary lesion initially interpreted as an epithelial pulmonary NET. The patient was found to have a hereditary SDHC mutation. No other primary tumors were found and this tumor contained abundant sustentacular cells. In view of the clinical and histologic findings and the low metastasis frequency associated with SDHC mutation, the tumor was consistent with a primary pulmonary paraganglioma. B: High magnification shows nested architecture and cells of varied sizes. C: S-100 protein highlights sustentacular cells. More about this image found in PULMONARY PARAGANGLIOMA A: This paraganglioma was a solitary lesion initia...
Images
in Other Adrenal Neoplasms and Tumor-Like Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND Figure 12-26 HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND A: Hepatocellular carcinoma metastatic to the adrenal gland can simulate a primary adrenal cortical carcinoma. This metastasis has a prominent trabecular pattern with delicate si... More about this image found in HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND A: Hepatocellular car...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... lymphomas represent less than 1 percent of non-Hodgkin lymphomas and less than 3 percent of all extranodal lymphomas ( 70 ). In some cases, adrenal involvement is accompanied or followed by more widespread disease, and the categorization as primary versus metastasis is uncertain even with strict exclusion...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., since it is evident that this distinction is not currently possible or reliable. Instead, as with other neuroendocrine tumors, these neoplasms are all considered to have malignant potential, and those that do give rise to metastasis are classified as “metastatic.” Moreover, with increasing awareness...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... with an increased risk of metastasis and mutations of succinate dehydrogenase genes ( 56 ). Patients with tumors that produce exclusively dopamine usually do not exhibit signs of catecholamine excess, and may present with large tumors and mass effects ( 56 ). The mass effects can be particularly devastating...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... adrenal, and therefore ACC has a higher chance to occur ( 23 ). Synchronous or metachronous bilateral involvement may occur, comprising roughly 2 to 10 percent of cases ( 24 ), including functioning cases ( 25 ), but the possibility of a contralateral adrenal metastasis should be considered. Exceptional...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... effect (abdominal distension) or pain. Hypertension may develop due to hormonal overproduction or local compression of the renal artery through tumor growth, but appears limited to a minority (4 percent) of patients ( 32 ). In case of (extensive) metastasis, infants and children may show constitutional...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... SYNDROME Figure 3-11 ECTOPIC ACTH SYNDROME Diffuse ACTH-dependent adrenocortical hyperplasia from an adrenal metastasis of an ACTH-secreting lung neuroendocrine tumor. Transition from diffuse to nodular architecture in ACTH-dependent hyperplasia may occur in advanced stages of Cushing disease...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... recurrence or metastasis ( fig. 7-3 ) ( 15 , 16 ). This suggests that adrenal cortical carcinomas in Carney complex develop from adrenal adenomas in a multistep model of tumor progression through benign nodule to cancer, but the exact mechanisms remain to be elucidated ( 17 ). One patient had both...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... of melanoma, since an adrenal metastasis may be the first clinical evidence of disease ( 47 ). “BLACK” ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Figure 5-44 “BLACK” ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Tumor cells express steroidogenic factor 1 (SF1, A), Melan-A (red, B), and a low Ki-67...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... be a source of confusion in assessing invasiveness or metastasis of pheochromocytomas. JUXTACAPSULAR RESTS OF CHROMAFFIN CELLS Figure 1-41 JUXTACAPSULAR RESTS OF CHROMAFFIN CELLS A: Nest of chromaffin cells in the outer adrenal cortex just outside the capsule of the adrenal gland. A capsular arteriole...
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