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in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
OVARIAN THECAL METAPLASIA Figure 1-36 OVARIAN THECAL METAPLASIA Ovarian thecal metaplasia appears as a broad zone of bland spindle cells. Nests of pale-staining cortical cells are present within the spindle cell component. More about this image found in OVARIAN THECAL METAPLASIA Ovarian thecal metaplasia appears as a broad zon...
Images
in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
FAT CELL METAPLASIA Figure 1-35 FAT CELL METAPLASIA Normal adrenal cortex in an adult shows patchy areas with confluent lipid vacuoles and some individual cells resembling mature adipocytes. This has been referred to as lipomatous metaplasia. More about this image found in FAT CELL METAPLASIA Normal adrenal cortex in an adult shows patchy areas w...
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in Congenital Disorders of the Adrenal Gland
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ACCESSORY ADRENAL CORTICAL TISSUE WITH OVARIAN THECAL METAPLASIA Figure 2-9 ACCESSORY ADRENAL CORTICAL TISSUE WITH OVARIAN THECAL METAPLASIA A: The heterotopic adrenal cortical rest was located near the broad ligament in an adult woman. Cortical cells are present in the center of the nodule and a... More about this image found in ACCESSORY ADRENAL CORTICAL TISSUE WITH OVARIAN THECAL METAPLASIA A: The he...
Images
Published: 01 December 2024
PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE Figure 4-18 PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE Myelolipomatous metaplasia with bone formation. More about this image found in PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE Myelolipomatous meta...
Images
Published: 01 December 2024
“BLACK” ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Figure 5-43 “BLACK” ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME This black adenoma is characterized by a variably pigmented cell population (A), focally dense lymphocytic infiltration and adipose metaplasia (B). More about this image found in “BLACK” ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME This black adenoma is...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... the term “suprarenal capsules”) ( 50 ). ARTIFACTUAL FISSURE FORMATION IN A NORMAL ADRENAL GLAND Figure 1-34 ARTIFACTUAL FISSURE FORMATION IN A NORMAL ADRENAL GLAND Autolysis at a plane roughly between cortex and medulla can create the appearance of an empty sac. Fat Cell Metaplasia. In some...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... tissue ( 22 ). These neoplasms can pose severe diagnostic challenges. Although the developmentally predictable distribution of ectopic adrenal tissue helps explain where some of these arise, some cases defy ready embryologic explanation. ACCESSORY ADRENAL CORTICAL TISSUE WITH OVARIAN THECAL METAPLASIA...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... to the adrenogenital/gonadal ridge (see chapter 1 ). The former include granulosa cell tumor ( 63 ) and a fibrous tumor of the adrenal gland resembling ovarian fibroma ( fig. 12-20 ). This lesion is possibly related to “ovarian thecal metaplasia” (covered in chapter 1 ), and may have a sex-cord stromal derivation...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., hyalinization, macro- or microcystic changes, hemorrhage with hemosiderin deposition, bone metaplasia, and rarely, necrosis of the infarction type ( figs. 5-27 – 5-30 ). The presence of all of the above may create problems in the differential diagnosis with other entities (such as vascular tumors or other soft...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... or basophilic material or a few degenerated cortical cells. Nodules can be seen in every region of the cortex, and the degree of nodularity can vary widely from gland to gland. The nodules may be larger than 2 cm in diameter, and have areas of lipomatous, myelolipomatous, or even osseous metaplasia ( fig. 4-18...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... associated with individual necrotic cells. Metaplastic bone formation is rarely seen. Lipomatous or myelolipomatous metaplasia can occur, but is usually more rare and focal than in adrenal cortical adenoma. Extensive myxoid changes are characteristic of the myxoid variant, but they may be focal...
Images
Published: 01 September 2024
PULMONARY TUBERCULOSIS Figure 12-55 PULMONARY TUBERCULOSIS Striking fibrillogranular (caseous) necrosis has been extruded into a bronchiole demonstrating extensive squamous metaplasia (top right). More about this image found in PULMONARY TUBERCULOSIS Striking fibrillogranular (caseous) necrosis has be...
Images
Published: 01 September 2024
PERTUSSIS IN THE TRACHEA AND BRONCHI Figure 12-18 PERTUSSIS IN THE TRACHEA AND BRONCHI There is degeneration of the epithelium (A, low power; B, high power), with early squamous metaplasia (A). (Courtesy of the CDC IDPB) More about this image found in PERTUSSIS IN THE TRACHEA AND BRONCHI There is degeneration of the epitheli...
Images
Published: 01 September 2024
DIFFERENTIAL DIAGNOSIS OF HSIL Figure 9-42 DIFFERENTIAL DIAGNOSIS OF HSIL A: Atrophy with reactive atypia and negative p16 immunohistochemistry (inset) excludes HSIL. B: Immature squamous metaplasia and negative p16 (inset) excludes HSIL. More about this image found in DIFFERENTIAL DIAGNOSIS OF HSIL A: Atrophy with reactive atypia and negativ...
Images
Published: 01 September 2024
HSIL/LSIL Figure 9-40 HSIL/LSIL A: HSIL with diffuse, strong cytoplasmic and nuclear (“block”) staining for p16, interpreted as a positive result. B: LSIL on the right (short arrow), while the differential diagnosis for the area on the left (long arrow) includes immature squamous metaplasia and ... More about this image found in HSIL/LSIL A: HSIL with diffuse, strong cytoplasmic and nuclear (“block”) s...
Images
Published: 01 September 2024
ADENOCARCINOMA IN SITU (AIS) Figure 9-38 ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervical glands with AIS predominantly on the right. B: Glands with AIS in the lower half show depleted mucin, several mitoses, and apoptosis. C: P16 is positive in glands with AIS and is... More about this image found in ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervica...
Images
Published: 01 September 2024
ADENOCARCINOMA IN SITU (AIS) Figure 9-38 ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervical glands with AIS predominantly on the right. B: Glands with AIS in the lower half show depleted mucin, several mitoses, and apoptosis. C: P16 is positive in glands with AIS and is... More about this image found in ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervica...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-30
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... inflammatory changes, which are usually seen on cervical and/or vaginal biopsy. Microscopy may show pronounced acute or chronic inflammatory cell infiltration accompanied by edema, reserve cell hyperplasia, squamous metaplasia, and even mild papillomatosis ( fig. 30-3 ). Similar inflammatory changes can...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
.... 9-38D ), tubal metaplasia ( fig. 9-38E ), microglandular hyperplasia ( fig. 9-38F ), endometriosis, and mesonephric remnants ( fig. 9-38G ). In these cases, however, the glands do not show increased mitoses or apoptosis, and p16 does not show diffuse strong positivity. Invasive endocervical...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-18
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., lymphocytes, plasma cells, and eosinophils, which eventually leads to the formation of lymphoid follicles, some with germinal centers. These features are accompanied by prominent vascularity, epithelial changes such as papillarity and metaplasia, and focal necrosis. During active infection, intracellular...
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