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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... syndrome, with risk for ocular melanoma, mesothelioma, renal cell carcinoma, and other neoplasms ( Table 10-2 ) ( 11 ). Microscopic features suggestive of a germline mutation include the presence of junctional nests with BAP1 loss and fatty metaplasia of dermal melanocytes. Some BAP1-inactivated nevi show...
Images
Published: 15 November 2023
PERICARDIAL MESOTHELIOMA Figure 27-4 PERICARDIAL MESOTHELIOMA A primary pericardial mesothelioma extends circumferentially around the heart, involving both the visceral and parietal layers of the pericardium. Definitionally, there should only be limited, if any, pleural involvement. More about this image found in PERICARDIAL MESOTHELIOMA A primary pericardial mesothelioma extends circum...
Images
Published: 15 November 2023
PERICARDIAL MESOTHELIOMA Figure 56-17 PERICARDIAL MESOTHELIOMA This surgically resected mesothelioma was localized to the parietal pericardium, but produced an impressive mass effect on the adjacent cardiac chambers. More about this image found in PERICARDIAL MESOTHELIOMA This surgically resected mesothelioma was localiz...
Images
Published: 15 November 2023
PERICARDIAL MESOTHELIOMA: GROWTH PATTERNS Figure 56-19 PERICARDIAL MESOTHELIOMA: GROWTH PATTERNS Epithelioid mesotheliomas can grow in either a sheet-like fashion (left) or form gland-like structures that infiltrate adjacent tissues inciting a desmoplastic response (right). More about this image found in PERICARDIAL MESOTHELIOMA: GROWTH PATTERNS Epithelioid mesotheliomas can gr...
Images
Published: 15 November 2023
PERICARDIAL MESOTHELIOMA: TYPES Figure 27-5 PERICARDIAL MESOTHELIOMA: TYPES Epithelioid-type (A), sarcomatoid-type (B), and biphasic-type (C) pericardial mesotheliomas. More about this image found in PERICARDIAL MESOTHELIOMA: TYPES Epithelioid-type (A), sarcomatoid-type (B)...
Images
Published: 15 November 2023
PERICARDIAL MESOTHELIOMA: IMMUNOHISTOCHEMISTRY Figure 56-20 PERICARDIAL MESOTHELIOMA: IMMUNOHISTOCHEMISTRY The malignant cells are diffusely reactive with antibodies directed against calretinin (left) and WT-1 (nuclear) (right), helping to confirm mesothelial differentiation. More about this image found in PERICARDIAL MESOTHELIOMA: IMMUNOHISTOCHEMISTRY The malignant cells are dif...
Images
Published: 15 November 2023
PERICARDIAL MESOTHELIOMA: TYPES Figure 56-18 PERICARDIAL MESOTHELIOMA: TYPES Left: The epithelioid type consists of round cells with moderate cytoplasm that cluster and form vague gland-like structures that infiltrate adjacent tissue. Right: The sarcomatoid type consists of malignant spindle cel... More about this image found in PERICARDIAL MESOTHELIOMA: TYPES Left: The epithelioid type consists of rou...
Images
Published: 15 November 2023
PERICARDIAL MESOTHELIOMA Figure 56-16 PERICARDIAL MESOTHELIOMA The tumor surrounds and envelopes the heart, involving both the visceral and parietal layers of the pericardium. The tumor infiltrates to focally involve the superficial left ventricular (LV) myocardium (white arrowhead), allowing dis... More about this image found in PERICARDIAL MESOTHELIOMA The tumor surrounds and envelopes the heart, invo...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch56
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 56-1 IMMUNOHISTOCHEMICAL DIFFERENTIATION OF MESOTHELIOMA FROM CARCINOMA Mesothelial Markers Carcinoma Markers Calretinin B72.3 WT-1 BerEP4 (EpCAM) D2-40 (podoplanin) BG8 GATA3 CEA CK5/6 CD15 (LeuM1) Claudin-4 MOC31 CARDIAC PARAGANGLIOMA Figure 56-21 CARDIAC...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch48
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... with diastase. REFERENCES REFERENCES 1. Fenoglio JJ Jr , Jacobs DW , McAllister HA Jr . Ultrastructure of the mesothelioma of the atrioventricular node . Cancer 1977 ; 40 : 721 - 7 . 2. Cameselle-Teijeiro J , Abdulkader I , Soares P , Alfonsín-Barreiro N...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch27
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... and adjacent fibroadipose tissue. Right: Metastatic breast carcinoma invading the pericardial lymphatics. PERICARDIAL MESOTHELIOMA Figure 27-4 PERICARDIAL MESOTHELIOMA A primary pericardial mesothelioma extends circumferentially around the heart, involving both the visceral and parietal layers...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch54
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... BT , Colby T , Gown AM , et al . Malignant vascular tumors of the serous membranes mimicking mesothelioma. A report of 14 cases . Am J Surg Pathol 1996 ; 20 : 1431 - 9 . 66. Tazelaar HD , Locke TJ , McGregor CG . Pathology of surgically excised primary cardiac...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch52
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
.... Senkottaiyan N , Seacord LM , Fulling KH , Birchem JA , Fraley MA , Alpert MA . Sarcomatous pleural mesothelioma metastatic to left ventricular endocardium . Angiology 2006 ; 57 : 517 - 21 . 41. Glancy DL , Roberts WC . The heart in malignant melanoma...
Images
Published: 01 August 2023
MALIGNANT MESOTHELIOMA Figure 5-18 MALIGNANT MESOTHELIOMA Peritoneal mesotheliomas often show uniform nuclei (A) with less stratification than is seen in high-grade serous carcinoma. A panel of immunostains (including calretinin, B), establishes the diagnosis. Mesotheliomas can show higher grade ... More about this image found in MALIGNANT MESOTHELIOMA Peritoneal mesotheliomas often show uniform nuclei ...
Images
Published: 01 August 2023
MALIGNANT MESOTHELIOMA INVOLVING FALLOPIAN TUBE Figure 16-46 MALIGNANT MESOTHELIOMA INVOLVING FALLOPIAN TUBE Lesional cells are cuboidal, lack significant nuclear atypia (A), and are focally arranged in papillae (B). Papillary architecture should not necessarily be equated with a diagnosis of wel... More about this image found in MALIGNANT MESOTHELIOMA INVOLVING FALLOPIAN TUBE Lesional cells are cuboida...
Images
Published: 01 August 2023
MALIGNANT EPITHELIOID MESOTHELIOMA OF PERITONEUM Figure 6-23 MALIGNANT EPITHELIOID MESOTHELIOMA OF PERITONEUM Bland cuboidal cells form a monolayer around papillary cores. The immunophenotype differs from clear cell carcinoma. More about this image found in MALIGNANT EPITHELIOID MESOTHELIOMA OF PERITONEUM Bland cuboidal cells form...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-04
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... with malignant peritoneal mesothelioma. Recent work indicates that immunohistochemistry with BAP1 and Claudin-4, but not MTAP, can be used to distinguish low-grade serous ovarian tumors from peritoneal mesothelioma ( 24a ). The tubal cysts of endosalpingiosis are often associated with both serous...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-05
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... The epithelial component of carcinosarcoma can predominate but the presence of a malignant stromal component (at left) establishes the diagnosis of carcinosarcoma. High-grade serous carcinoma is distinguished from malignant mesothelioma based on routine hematoxylin and eosin (H&E) stains in most...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-06
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
..., and the nuclear features, immunophenotype, and clinical presentation differ. SEX CORD TUMOR WITH ANNULAR TUBULES Figure 6-22 SEX CORD TUMOR WITH ANNULAR TUBULES This tumor resembles clear cell carcinoma due to cytoplasmic clearing and stromal hyalinization. Malignant epithelioid mesotheliomas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-16
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... +; calretinin +; EMA negative or focal Broad ligament Mesothelioma Papillary, glandular, sarcomatoid, mixed epithelioid and sarcomatoid; low or intermediate nulear grade; low mitotic index Calretinin +; WT1 +; podoplanin +; CK5/6 +; BerEp4 -, B72.3 -; BAP1 -/+; MTAP -/+ Peritoneum, sometimes secondarily...
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