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mesothelioma

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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Published: 01 June 2022
DOI: 10.55418/9781933477190-3
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
...Diffuse mesothelioma is a malignant tumor originating from mesothelial cells that diffusely infiltrates and covers the serosal surfaces. Diffuse mesothelioma should be differentiated from localized mesothelioma (see chapter 4 ), which has a different clinical behavior ( 1 ). Tumors...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-5
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
..., nephroblastoma, melanoma, small cell mesothelioma ( 90 , 94 ), and medullary thyroid carcinoma, but it is also immunoreactive with folliculogenic (papillary and follicular) thyroid tumors ( 95 ). Protein Gene Product 9.5 (PGP9.5) Protein gene product 9.5/ubiquitin c-terminal hydrolase-L1 (PGP9.5/UCHL1...
Images
MALIGNANT <span class="search-highlight">MESOTHELIOMA</span>  Left: Tubules of <span class="search-highlight">mesothelioma</span> invade between the se...
Published: 01 August 2022
MALIGNANT MESOTHELIOMA Figure 8-40 MALIGNANT MESOTHELIOMA Left: Tubules of mesothelioma invade between the seminiferous tubules of the testis. Right: A rare case shows prominent growth of malignant mesothelial cells within the seminiferous tubules of the testis. More
Images
MALIGNANT <span class="search-highlight">MESOTHELIOMA</span>  Slit-like tubules are associated with prominent foc...
Published: 01 August 2022
MALIGNANT MESOTHELIOMA Figure 8-37 MALIGNANT MESOTHELIOMA Slit-like tubules are associated with prominent foci of tumor necrosis. More
Images
WELL-DIFFERENTIATED PAPILLARY <span class="search-highlight">MESOTHELIOMA</span>/MESOTHELIAL TUMOR  Complex invag...
Published: 01 August 2022
WELL-DIFFERENTIATED PAPILLARY MESOTHELIOMA/MESOTHELIAL TUMOR Figure 8-34 WELL-DIFFERENTIATED PAPILLARY MESOTHELIOMA/MESOTHELIAL TUMOR Complex invaginations extend into a hyalinized stroma, mimicking invasion. More
Images
MALIGNANT <span class="search-highlight">MESOTHELIOMA</span>  Left: The tumor grows in nodules and sheets of eosi...
Published: 01 August 2022
MALIGNANT MESOTHELIOMA Figure 8-36 MALIGNANT MESOTHELIOMA Left: The tumor grows in nodules and sheets of eosinophilic epithelioid cells. Right: Diffuse growth of epithelioid cells with pale cytoplasm. More
Images
MALIGNANT <span class="search-highlight">MESOTHELIOMA</span>  Left: An immunostain for calretinin highlights the ...
Published: 01 August 2022
MALIGNANT MESOTHELIOMA Figure 8-41 MALIGNANT MESOTHELIOMA Left: An immunostain for calretinin highlights the nuclei and cytoplasm of the tumor cells. Right: The tumor cell nuclei are positive with an immunostain directed against WT1. More
Images
MALIGNANT <span class="search-highlight">MESOTHELIOMA</span>  Left: Eosinophilic epithelioid tumor cells with mod...
Published: 01 August 2022
MALIGNANT MESOTHELIOMA Figure 8-39 MALIGNANT MESOTHELIOMA Left: Eosinophilic epithelioid tumor cells with moderate nuclear pleomorphism. Mitotic figures are not apparent, and are not always identifiable. Right: An unusual case with marked pleomorphism and tumor necrosis. More
Images
MALIGNANT <span class="search-highlight">MESOTHELIOMA</span>: BIPHASIC TYPE  Left: In this biphasic pattern, the ...
Published: 01 August 2022
MALIGNANT MESOTHELIOMA: BIPHASIC TYPE Figure 8-38 MALIGNANT MESOTHELIOMA: BIPHASIC TYPE Left: In this biphasic pattern, the epithelioid and undifferentiated spindle cell components are integrated with each other. Right: An area of sarcomatoid growth of atypical spindle cells. Areas of epithelioi... More
Images
MALIGNANT <span class="search-highlight">MESOTHELIOMA</span>  A: The tunica vaginalis is studded by focally confl...
Published: 01 August 2022
MALIGNANT MESOTHELIOMA Figure 8-32 MALIGNANT MESOTHELIOMA A: The tunica vaginalis is studded by focally confluent papillary tumor tissue. (Fig. 8.7 from Young RH, Scully RE. Testicular tumors. Chicago: ASCP Press; 1990:172.) B: Tan, confluent nodules of tumor grow between the tunica vaginalis an... More
Images
WELL-DIFFERENTIATED PAPILLARY <span class="search-highlight">MESOTHELIOMA</span>/MESOTHELIAL TUMOR  A: A papillar...
Published: 01 August 2022
WELL-DIFFERENTIATED PAPILLARY MESOTHELIOMA/MESOTHELIAL TUMOR Figure 8-33 WELL-DIFFERENTIATED PAPILLARY MESOTHELIOMA/MESOTHELIAL TUMOR A: A papillary neoplasm arises from the parietal tunica vaginalis and projects from it. Inflammatory infiltrates and hemosiderin are visible within the nodule. B:... More
Images
MALIGNANT <span class="search-highlight">MESOTHELIOMA</span>  A: This invasive tumor forms papillary structures w...
Published: 01 August 2022
MALIGNANT MESOTHELIOMA Figure 8-35 MALIGNANT MESOTHELIOMA A: This invasive tumor forms papillary structures within multiple cystic spaces. A desmoplastic reaction occurs at the periphery of many of the spaces. B: Small papillae surrounded by retraction artifact irregularly invade the stroma. The... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-08
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... of the rete testis ( 20 ), and they may also be misinterpreted as mesotheliomas. The typical location of rete carcinomas in the hilus and the presence on microscopic examination of tumor nests in dilated rete channels are helpful in the differential diagnosis, as is the characteristic papillary budding...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-03
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
...   Mucinous cystadenoma   Mucinous tumor of borderline malignancy   Mucinous cystadenocarcinoma   Endometrioid carcinoma   Clear cell adenocarcinoma   Brenner tumor  Mesothelial tumors   Adenomatoid tumor   Mesothelioma    Malignant mesothelioma    Well-differentiated papillary...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-11
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... atypical mesothelial cells with pseudoinvasive growth may cause concern for malignant mesothelioma. In some cases, there is also papillary mesothelial hyperplasia involving the surface. In contrast to most mesotheliomas, these reactive mesothelial proliferations do not form a grossly evident lesion...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-10
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
...) ( 17 ). Malignant mesothelioma of pleural origin has also been reported ( 18 ). ADENOCARCINOMA OF PROSTATE METASTATIC TO TESTIS Figure 10-1 ADENOCARCINOMA OF PROSTATE METASTATIC TO TESTIS A multinodular, yellow-brown tumor has replaced most of the testis. ADENOCARCINOMA OF PROSTATE METASTATIC...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Published: 01 June 2022
DOI: 10.55418/9781933477190-4
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
...Tumors of mesothelial origin that are distinguished from diffuse mesothelioma either by morphologic differences, anatomic localization, or both, lead to differences in management and prognosis, thus warranting separate classification. The entity “mesothelioma of the atrioventricular node” is now...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Published: 01 June 2022
DOI: 10.55418/9781933477190-2
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
..., WITH SUBTYPES a Tumors Morphology Code b Benign and preinvasive mesothelial tumors  Well-differentiated papillary mesothelial tumor 9052/1  Adenomatoid tumor 9054/0  Mesothelioma in situ 9050/2 Mesothelioma  Diffuse mesothelioma 9050/3    Epithelioid...
Images
SARCOMATOID <span class="search-highlight">MESOTHELIOMA</span>  Antibody to podoplanin (D2-40) strongly stains th...
Published: 01 June 2022
SARCOMATOID MESOTHELIOMA Figure 3-76 SARCOMATOID MESOTHELIOMA Antibody to podoplanin (D2-40) strongly stains this sarcomatoid mesothelioma. The staining is more granular and cytoplasmic than seen in epithelioid mesothelioma. More
Images
EPITHELIOID <span class="search-highlight">MESOTHELIOMA</span>: MTAP STAIN  A,B: In a cell block stained with H&a...
Published: 01 June 2022
EPITHELIOID MESOTHELIOMA: MTAP STAIN Figure 3-105 EPITHELIOID MESOTHELIOMA: MTAP STAIN A,B: In a cell block stained with H&E (A), MTAP expression is lost in the mesothelioma cells, while it is retained in histiocytes and inflammatory cells (B). C,D: MTAP expression is lost in mesothelioma ce... More