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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-24
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... (tuberculosis or leprosy), and parasites, as well as neoplasms such as primary cutaneous malignancies (epithelial, hematolymphoid, and mesenchymal tumors, including lymphoma and Kaposi sarcoma) and skin metastases. Pathologic Findings Excised skin lesions usually grossly reveal nodular gray to tan tissue...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-11
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...Many of the mesenchymal lesions that occur elsewhere in the body are also found in the breast. The critical point when examining spindle cell lesions in the breast is to consider carefully the possibility of metaplastic carcinoma, which is a major entity in the differential diagnosis of most...
Images
Published: 01 February 2024
PN WITH MESENCHYMAL FEATURES Figure 2-19 PN WITH MESENCHYMAL FEATURES A: An amelanotic nodule is present within a CMN. B: The nodule is composed of fibroblast-like cells and myxoid stroma. The tumor cells within the nodule were immunohistochemically negative for melanocyte differentiation antige... More about this image found in PN WITH MESENCHYMAL FEATURES A: An amelanotic nodule is present within a C...
Images
Published: 01 January 2024
METAPLASTIC CARCINOMA WITH HETEROLOGOUS MESENCHYMAL ELEMENTS Figure 8-62 METAPLASTIC CARCINOMA WITH HETEROLOGOUS MESENCHYMAL ELEMENTS In addition to the malignant spindle cells, this tumor has areas of osseous differentiation. More about this image found in METAPLASTIC CARCINOMA WITH HETEROLOGOUS MESENCHYMAL ELEMENTS In addition t...
Images
Published: 01 January 2024
METAPLASTIC CARCINOMA WITH HETEROLOGOUS MESENCHYMAL ELEMENTS Figure 8-63 METAPLASTIC CARCINOMA WITH HETEROLOGOUS MESENCHYMAL ELEMENTS This metaplastic carcinoma has chondroid differentiation. More about this image found in METAPLASTIC CARCINOMA WITH HETEROLOGOUS MESENCHYMAL ELEMENTS This metaplas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... Some fusiform variants of PN show neural (schwannian) or mesenchymal (fibroblastic or chondroid) features (see fig. 2-19 ) ( 14 ). CMN WITH SUPERFICIAL DERMAL PROLIFERATIVE NODULE (PN) Figure 2-15 CMN WITH SUPERFICIAL DERMAL PROLIFERATIVE NODULE (PN) There is a dense nodular aggregate...
Images
Published: 01 January 2024
MULTINUCLEATED STROMAL GIANT CELLS Figure 1-3 MULTINUCLEATED STROMAL GIANT CELLS These cells percolate through the fibrous stroma. It is important to recognize these as mesenchymal cells, and not misinterpret them as infiltrating carcinoma. More about this image found in MULTINUCLEATED STROMAL GIANT CELLS These cells percolate through the fibro...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... nonmelanocytic neoplasms. Depending on the diagnostic problem (e.g., metastatic melanoma versus poorly differentiated carcinoma, lymphoma, or sarcoma) a set of antibodies to melanocytic differentiation antigens, as well as epithelial, lymphoid, and mesenchymal markers, may be necessary for a precise diagnosis...
Images
Published: 15 November 2023
MESENCHYMAL CARDIAC HAMARTOMA Figure 45-7 MESENCHYMAL CARDIAC HAMARTOMA Left: Prominent mature fat and blood vessels are seen among the myocytes. Right: Entrapped nerves and bundles of smooth muscle are also seen within the tumor. More about this image found in MESENCHYMAL CARDIAC HAMARTOMA Left: Prominent mature fat and blood vessels...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-11
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
...These tumors are classified by the World Health Organization (WHO) as mesenchymal and mixed epithelial mesenchymal tumors ( Table 11-1 ) ( 1 ). Table 11-1 THE 2020 WHO CLASSIFICATION OF MESENCHYMAL AND MIXED EPITHELIAL TUMORS OF THE OVARY a Mesenchymal tumors of the ovary...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
..., the focus of concern is small, and would be classified as microinvasion or T1a disease if mucinous carcinoma is favored over DCIS. Invasive lobular carcinoma with extracellular mucin can be a mimic for metaplastic carcinoma with heterologous mesenchymal differentiation. The manner in which the carcinoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-01
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... to recognize these as mesenchymal cells, and not misinterpret them as infiltrating carcinoma. As noted above, the ductal-lobular system of the breast is arranged into segments or lobes, albeit poorly defined with no grossly apparent anatomic boundaries ( 2 ). In fact, the number of segments in the breast...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch45
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... Endocrine Oncocytic collections in glands Renal Cysts, tubular calcifications Ovary Hypoplasia, cysts Cardiac Atrial septal defect Ventricular septal defect Left ventricular noncompaction Endocardial fibroelastosis Hypoplastic left heart syndrome MESENCHYMAL CARDIAC HAMARTOMA Figure 45-7...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-07
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... of cellularity may vary, but most cases are on the hypocellular end of the spectrum. Distinction from metaplastic carcinoma with heterologous mesenchymal differentiation is a major diagnostic challenge. Pleomorphic adenoma lacks the cytologic atypia and mitotic activity present in metaplastic carcinoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch55
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... . Single-center experience with intimal sarcoma, an ultra-orphan, commonly fatal mesenchymal malignancy . Oncol Res Treat 2017 ; 40 : 353 - 9 . 4. Blackmon SH , Reardon MJ . Pulmonary artery sarcoma . Methodist Debakey Cardiovasc J 2010 ; 6 : 38 - 43 . 5. Hu XP , Xu...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch41
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... . 5. Amano J , Kono T , Wada Y , et al . Cardiac myxoma: its origin and tumor characteristics . Ann Thorac Cardiovasc Surg 2003 ; 9 : 215 - 21 . 6. Vaideeswar P , Butany JW . Benign cardiac tumors of the pluripotent mesenchyme . Semin Diagn Pathol 2008 ; 25...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch42
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... . Benign mesenchymal tumor of the heart. Spontaneous regression and disappearance of pulmonary artery stenosis . Chest 1982 ; 82 : 503 - 5 . 39. Filiatrault M , Beland MJ , Neilson KA , Paquet M . Cardiac fibroma presenting with clinically significant arrhythmias in infancy...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch56
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... than pericardiocentesis or sub-xiphoid window. Definition. Cardiac synovial sarcoma is a mesenchymal biphasic malignancy with epithelial and spindle cell components or a monophasic spindle cell malignancy. The tumor is defined by the presence of a characteristic fusion event between...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch53
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... the malignant nature of the process ( fig. 53-1 ). Positron emission tomography (PET) helps to identify metastasis and define the extent of the disease. Like extracardiac mesenchymal neoplasms, continuous evaluation of the terminology has occurred to align these lesions with our evolving understanding of tumor...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch40
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... ). Fibroblasts and more primitive mesenchymal cells are present within the matrix. The surface endothelial cells are hyperplastic and possess numerous organelles and pinocytotic vesicles. Molecular Genetic Findings. As noted above, some PFEs have mutations in exons 2-3 of KRAS. While this finding...
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