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Images
Published: 01 December 2024
BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Figure 6-34 BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Altered nuclear and cytoplasmic beta-catenin expression in ACC may be focal with a “clonal” pattern or more frequently, diffuse as in the figure. Membrane pattern is visible in peritumoral non More about this image found in BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Altered nuclear and cytoplasmic...
Images
Published: 01 December 2024
of the nuclear membrane. B: Cristae of mitochondria have a tubular or vesicular profile typical of steroid-producing cells. There is prominent smooth endoplasmic reticulum as well as a few free polyribosomes. More about this image found in ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME A: A nuclear pseudoinclusion ...
Images
in Physiology, Development, and Anatomy of the Adrenal Glands
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
cores, sometimes with a wide asymmetric halo (arrows), while those containing epinephrine have lighter, more granular cores and a tight limiting membrane. A small amount of rough endoplasmic reticulum is at lower left. More about this image found in CHROMAFFIN CELLS IN ADRENAL MEDULLA Portions of adjacent chromaffin cells ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... smooth endoplasmic reticulum. In the presence of nuclear pseudoinclusions, these are due to an irregularity in the nuclear membrane, with indentation and infolding of cell cytoplasm, often with the same complement and density of cellular organelles. Mitochondria may be prominent, and are usually round...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... into dopamine, which is transported into the storage vesicle where the membrane-bound enzyme dopamine beta-hydroxylase (DBH) mediates the formation of norepinephrine. The terminal enzyme in catecholamine synthesis is phenylethanolamine N-methyltransferase (PNMT) ( 12 ), which is present in the cytosol...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... irregularities or infoldings of the nuclear membrane and intranuclear extension of the cell cytoplasm. ADRENAL CORTICAL CARCINOMA: NUCLEAR ATYPIA Figure 6-17 ADRENAL CORTICAL CARCINOMA: NUCLEAR ATYPIA A–C: Pleomorphic cells are variably present, including multinucleated large cells. ADRENAL CORTICAL CARCINOMA...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... microscopy, the tumors have all the features of neuroendocrine tumors with secretory granules. The extensive lipid degeneration can be associated with hemosiderin deposition and focal fibrosis. VHL-associated tumors have strong membranous positivity for CAIX, an important stain for diagnosis ( 49 , 50...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... the rate-limiting step in steroid hormone biosynthesis, cholesterol side-chain cleavage, by facilitating the movement of cholesterol to the inner mitochondrial membrane where the reaction takes place. STAR mutations cause congenital lipoid adrenal hyperplasia, the most severe form of CAH...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... markers for lymphoblastic lymphoma, WT1 for Wilms tumor, and possibly epithelial membrane antigen (EMA), keratins, and WT1 (C-terminus) for desmoplastic small round cell tumor. The second application for immunohistochemistry in the workup of NBL and GNBL is in the detection of minimal residual disease...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... pheochromocytoma, has recently been reported to be expressed in a high percentage of paragangliomas, especially those with a SDHx/VHL-driven pseudohypoxic signature ( 121 ). Membrane staining for carbonic anhydrase IX (CAIX) has been reported as a highly selective, although relatively insensitive, marker for VHL...
Images
Published: 01 September 2024
and marginalize native chromatin to the nuclear membrane. More about this image found in EARLY STAGES OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML) In stereo...
Images
Published: 01 September 2024
HANTAVIRUS CARDIOPULMONARY SYNDROME (HCPS) Figure 4-21 HANTAVIRUS CARDIOPULMONARY SYNDROME (HCPS) Lung tissue with intraalveolar and interstitial edema, early hyaline membrane formation, congestion, and minimal septal lymphocyte infiltration (A,B). The spleen reveals scattered prominent More about this image found in HANTAVIRUS CARDIOPULMONARY SYNDROME (HCPS) Lung tissue with intraalveolar ...
Images
Published: 01 September 2024
in an individual with acquired immunodeficiency syndrome (AIDS), showing a fragment of tympanic membrane and associated eosinophilic exudate. More about this image found in DISSEMINATED PNEUMOCYSTOSIS A,B: The characteristic foamy exudate is seen....
Images
Published: 01 September 2024
ADENOVIRUS GASTROENTERITIS IN AN IMMUNOCOMPROMISED PATIENT Figure 5-16 ADENOVIRUS GASTROENTERITIS IN AN IMMUNOCOMPROMISED PATIENT A: There is nuclear enlargement, with multiple eosinophilic to basophilic enteric surface epithelial inclusions. There are indistinct nuclear membranes (“smudged More about this image found in ADENOVIRUS GASTROENTERITIS IN AN IMMUNOCOMPROMISED PATIENT A: There is nuc...
Images
Published: 01 September 2024
PULMONARY COVID-19 Figure 4-10 PULMONARY COVID-19 A: Initial changes show some intra-alveolar fibrin with focal early hyaline membrane formation, scattered intra-alveolar red blood cells, and focal mild interstitial lymphocyte infiltration. B: Low-power view of patchy intra-alveolar fibrin More about this image found in PULMONARY COVID-19 A: Initial changes show some intra-alveolar fibrin with...
Images
Published: 01 September 2024
LSIL Figure 9-36 LSIL A: A normal intermediate cell is indicated (arrow). Other cells show features of LSIL with nuclear enlargement, coarse chromatin, nuclear membrane irregularities, perinuclear halo (“koilocyte”), and multinucleation (SurePath cytology, Papanicolaou stain). B: Condyloma More about this image found in LSIL A: A normal intermediate cell is indicated (arrow). Other cells show ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-04
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...), conjunctivitis, and otitis media Pneumonia Extrapulmonary disease is rare Pneumonia or diffuse alveolar damage (DAD) with hyaline membrane formation and giant cells showing cytoplasmic inclusions 83 , 86 Human metapneumovirus Pneumoviridae Fever, cough, dyspnea, sore throat, and bronchiolitis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-30
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... is appreciated. T. vaginalis trophozoites appear ovoid and pear- or kite-shaped, and have an average size of 10 x 7 μm. The protozoan demonstrates four flagella and a cytosome at one pole (anterior), one flagellum (attached to the axostyle) at the other (posterior) pole, and an undulating membrane...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-10
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... surfaces, skin defects, or parenterally, and begins with viral surface glycoprotein binding to the host cell membrane ( 6 , 7 ). After attachment, the virus enters the cell by formation of a pinocytic vesicle. Upon acidification, the viral and vesicle membranes fuse, releasing the viral nucleocapsid...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-06
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... of infected cells, and not being toxic to neurons. HSV1, 2, and VZV use surface glycoproteins (gC, gB, gL, gH) to attach to several classes of host cell surface receptors (including heparan sulfate and nectines) in mucous membranes or damaged skin ( 4 ). The viral envelope then merges with the host cell...
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