SOLID PSEUDOPAPILLARY NEOPLASM Figure 11-22 SOLID PSEUDOPAPILLARY NEOPLASM Ultrastructurally, heterogeneous, membrane-bound, electron-dense granules fill the cytoplasm (left), which is rich in mitochondria (right). Annulate lamellae are present (left, inset). More about this image found in SOLID PSEUDOPAPILLARY NEOPLASM Ultrastructurally, heterogeneous, membrane-...

PANCREATOBLASTOMA Figure 10-9 PANCREATOBLASTOMA The immunolabeling of squamoid nests is somewhat variable. Occasionally, they are positive for chromogranin A (A) or CEA (B). More consistently, epithelial membrane antigen is expressed (C). More about this image found in PANCREATOBLASTOMA The immunolabeling of squamoid nests is somewhat variabl...

SOLID PSEUDOPAPILLARY NEOPLASM Figure 11-20 SOLID PSEUDOPAPILLARY NEOPLASM Immunolabeling for β-catenin shows diffuse aberrant nuclear positivity (left). There is loss of membranous E-cadherin expression (right). More about this image found in SOLID PSEUDOPAPILLARY NEOPLASM Immunolabeling for β-catenin shows diffuse ...

DUCTAL ADENOCARCINOMA Figure 7-18 DUCTAL ADENOCARCINOMA A,B: Invasion into the muscularis propria of the duodenum by remarkably well-differentiated malignant glands. C: Invasion into the mucosa of the duodenum with colonization of the basement membrane of the villi can mimic an in situ neoplasm.... More about this image found in DUCTAL ADENOCARCINOMA A,B: Invasion into the muscularis propria of the duo...

ISLET CELLS Figure 1-19 ISLET CELLS By electron microscopy, secretory granules are distinctive for each cell type. The granules of insulin-producing β cells are polymorphous, with crystalline cores and a wide halo beneath the limiting membrane (lower right). Glucagon-secreting α cell granules are... More about this image found in ISLET CELLS By electron microscopy, secretory granules are distinctive for...

INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM, LOW GRADE Figure 6-39 INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM, LOW GRADE Left: A papillary cluster with columnar epithelium from an IPMN. The elongated nuclei are crowded and some nuclei have lost basal orientation. Right: Sheets of epithelium from a low-... More about this image found in INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM, LOW GRADE Left: A papillary clust...

EXOPHYTIC CONDYLOMA Figure 4-1 EXOPHYTIC CONDYLOMA Left: There is prominent exophytic growth with papillomatosis. Right: Koilocytic atypia in the upper epithelial layers is seen, characterized by nuclear enlargement, nuclear membrane irregularity, hyperchromasia, and irregularly-distributed peri... More about this image found in EXOPHYTIC CONDYLOMA Left: There is prominent exophytic growth with papillo...

ADENOID CYSTIC CARCINOMA Figure 3-55 ADENOID CYSTIC CARCINOMA Left: The neoplasm is composed of infiltrative cellular nests. Right: The nests consist of basaloid cells forming luminal spaces as well as pseudoluminal spaces containing basophilic basement membrane-like material. More about this image found in ADENOID CYSTIC CARCINOMA Left: The neoplasm is composed of infiltrative ce...

VULVAR BASAL CELL CARCINOMA Figure 5-37 VULVAR BASAL CELL CARCINOMA A: The tumor typically appears as a white raised lesion with irregular borders. B: Microscopically, this example shows the typical appearance characterized by irregular interanastomosing nests of basaloid epithelium; note the re... More about this image found in VULVAR BASAL CELL CARCINOMA A: The tumor typically appears as a white rais...

SEBACEOUS CELL CARCINOMA Figure 5-38 SEBACEOUS CELL CARCINOMA Similar to basaloid squamous cell carcinoma, this tumor has a predominant nested and basaloid epithelial cell population (A); vacuolated cells (aka sebocytes), which are appreciable at higher magnification, help establish the diagnosis... More about this image found in SEBACEOUS CELL CARCINOMA Similar to basaloid squamous cell carcinoma, this...

ADENOID CYSTIC CARCINOMA OF BARTHOLIN GLAND Figure 5-49 ADENOID CYSTIC CARCINOMA OF BARTHOLIN GLAND A: A heterogeneous ill-defined mass is located beneath the mucosal surface (located at top of image). B–D: The tumor has an infiltrative growth pattern (B) and displays a basaloid population arran... More about this image found in ADENOID CYSTIC CARCINOMA OF BARTHOLIN GLAND A: A heterogeneous ill-defined...

FLAT LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION Figure 4-2 FLAT LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION A: Thickened but flat epithelium with surface koilocytotic change. B: Koilocytosis is seen in the form of enlarged, hyperchromatic nuclei with irregular nuclear membranes and perinuclear halo... More about this image found in FLAT LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION A: Thickened but flat epith...

EXOPHYTIC IMMATURE LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (IMMATURE CONDYLOMA, PAPILLARY IMMATURE METAPLASIA, OR PAPILLOMA) Figure 3-5 EXOPHYTIC IMMATURE LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (IMMATURE CONDYLOMA, PAPILLARY IMMATURE METAPLASIA, OR PAPILLOMA) Features include variable papill... More about this image found in EXOPHYTIC IMMATURE LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (IMMATURE COND...

EXOPHYTIC IMMATURE LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (IMMATURE CONDYLOMA, PAPILLARY IMMATURE METAPLASIA, OR PAPILLOMA) Figure 3-5 EXOPHYTIC IMMATURE LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (IMMATURE CONDYLOMA, PAPILLARY IMMATURE METAPLASIA, OR PAPILLOMA) Features include variable papill... More about this image found in EXOPHYTIC IMMATURE LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (IMMATURE COND...