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Figure 12-19
Published: 01 December 2024
PRIMARY ADRENAL MELANOMA Figure 12-19 PRIMARY ADRENAL MELANOMA A: A 48-year-old woman complained of abdominal pain; imaging studies revealed a right adrenal mass; the patient had no evidence of melanoma in any other site following rigorous investigation using a multidisciplinary approach. Part More about this image found in PRIMARY ADRENAL MELANOMA A: A 48-year-old woman complained of abdominal pa...
Images
Figure 8-32
Published: 01 December 2024
PIGMENTED PHEOCHROMOCYTOMA Figure 8-32 PIGMENTED PHEOCHROMOCYTOMA The accumulation of melanin in the tumor cells can mimic melanoma and these tumors can appear black on gross examination. More about this image found in PIGMENTED PHEOCHROMOCYTOMA The accumulation of melanin in the tumor cells ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
.... B: Leydig cells contain prominent lipochrome pigment and pathognomonic Reinke crystalloid (arrow). Primary Adrenal Melanoma Only about 20 primary adrenal melanomas have been reported. When considering this diagnosis, and in assessing reported cases, it should be remembered that melanomas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... melanin pigmentation are on record ( 46 ) and represent the most relevant differential diagnosis (see also chapter 9 ). In the group of secondary lesions, melanoma metastases represent the first differential diagnosis that should be taken into account, even in the absence of a previous clinical history...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... to the common neural crest origin of melanocytes and adrenal medulla. Immunohistochemical stains to demonstrate neuroendocrine markers and rule out melanoma should be employed in questionable cases to ensure that the more common diagnosis of metastatic melanoma is not missed (see chapter 12 ). PIGMENTED...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... of lipofuscin, as shown by electron microscopy (see fig. 9-27B ). However, cutaneous type melanin is reported occasionally. The differentiation from melanoma is made by expression of neuroendocrine markers. Although melanomas and the sustentacular cells in paragangliomas both express S-100 protein and SOX10...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...-melanomatous) as well as testicular germ cell tumors, melanomas, lymphomas, and sarcomas. PRECURSOR LESIONS ACC is generally considered to arise de novo. However, data from patients with Carney complex ( 15 , 16 ) and multiple endocrine neoplasia 1 (MEN1)-associated ACC suggest that there may be progression...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 12-1 FEATURES OF SUPERFICIAL SPREADING MELANOMA Clinical Features  Most often young to middle-aged Caucasians  Most often intermittently sun-damaged skin (trunk and proximal extremities)  Irregular surface lesion positive by ABCD criteria (asymmetric, irregular borders...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 13-1 FEATURES OF LENTIGO MALIGNA (MELANOMA IN SITU) Clinical Features  Most often elderly Caucasians  Most often head and neck  Irregular pigmented patch  Slow growth  Dermoscopy: irregular follicular openings, angulated lines, rhomboidal structures Histopathologic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 14-1 FEATURES OF ACRAL MELANOMA Clinical Features  Most common melanoma in non-Caucasians  Wide age range, but most commonly diagnosed between 60 and 70 years of age  Often presenting as atypical pigmented patch, especially on foot  Most melanomas arise de novo; few...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 15-1 VARIANTS OF NODULAR MELANOMA Nodular melanoma, in situ and invasive  De novo  Associated with a melanocytic nevus  Various phenotypes: epithelioid, fusiform, nevoid, spitzoid, desmoplastic plexiform (DPN-like) a , other Nodular melanoma, invasive only...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 16-1 FEATURES OF DESMOPLASTIC MELANOMA Clinical Features  Most often elderly Caucasians  Most often head and neck  Papule, nodule, indurated plaque with or without pigmentation  May have been present for several years  Tendency for local recurrence  Low probability...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 17-1 FEATURES OF NEVOID MELANOMA a Clinical Features  Wide age range  Usually small and circumscribed lesions, often submitted as “irritated nevus”  Flat or raised lesions; some with verrucous/papillomatous surface Histopathologic Findings  Densely...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 18-1 FEATURES OF BLUE NEVUS-RELATED MELANOMA Clinical Features  Most often located on the scalp, but may occur anywhere  There may be a history of a blue nevus that has changed Histopathologic Findings  Fascicles of spindle cells with tumor overgrowth (loss...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 20-1 FEATURES OF PEDIATRIC ADULT SUBTYPE MELANOMA Clinical Features  Adolescents; rare in children  Caucasian  Nevus phenotype (large number of acquired melanocytic nevi) Microscopic Findings  Superficial spreading  Nodular  Acral lentiginous (rare...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...BALLOON CELL MELANOMA Figure 21-1 BALLOON CELL MELANOMA A: Plaque-like lesion with prominent nested and pagetoid growth typical of superficial spreading melanoma. B: Most tumor cells in the epidermis and dermis display abundant pale cytoplasm. MELANOMA WITH PARTIAL BALLOON CELL FEATURES Figure...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 22-1 PRIMARY CUTANEOUS MELANOMA VERSUS CUTANEOUS METASTASIS Primary Melanoma Cutaneous Metastasis Location of tumor Usually both dermis and epidermis Dermis and/or subcutis Epithelial involvement Usually prominent; extending peripherally beyond the intradermal melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-23
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 23-1 AMERICAN JOINT COMMITEE ON CANCER (AJCC) 8TH EDITION PRIMARY CUTANEOUS MELANOMA STAGING (T) a T Category Thickness Ulceration Status Tis (melanoma in situ) Not applicable Not applicable T1 <1.0 mm Unknown/unspecified  T1a <0.8 mm Without...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 19-1 FEATURES OF SPITZOID VERSUS SPITZ MELANOMA Spitzoid Melanoma Spitz Melanoma Spitzoid Histology Spitzoid Histology Immunohistochemical Findings: Immunohistochemical Findings:  May be positive for BRAF V600E  Negative for BRAF V600E  May be positive for ALK, NTRK1...
Images
Figure 12-5
Published: 01 February 2024
MELANOMA IN SITU Figure 12-5 MELANOMA IN SITU The melanoma is predominantly composed of junctional nests (thick arrow) with only a few solitary units of melanocytes in the spinous cell layer (thin arrows). More about this image found in MELANOMA IN SITU The melanoma is predominantly composed of junctional nest...