METASTATIC MALIGNANT MELANOMA Figure 14-9 METASTATIC MALIGNANT MELANOMA Left: The black to brown color reflects the presence of melanin pigment. Right: Amelanotic melanoma is tan and soft, and resembles solid primary pancreatic neoplasms grossly. More about this image found in METASTATIC MALIGNANT MELANOMA Left: The black to brown color reflects the ...

METASTATIC MALIGNANT MELANOMA Figure 14-10 METASTATIC MALIGNANT MELANOMA Left: The classic histologic features include a diffuse pattern and epithelioid cells with abundant cytoplasm and prominent nucleoli. Right: Other cases are noncohesive and have little cytoplasm. More about this image found in METASTATIC MALIGNANT MELANOMA Left: The classic histologic features includ...

METASTATIC MALIGNANT MELANOMA Figure 14-11 METASTATIC MALIGNANT MELANOMA Individually arranged large epithelioid cells have abundant cytoplasm and prominent nucleoli (Diff Quik stain). More about this image found in METASTATIC MALIGNANT MELANOMA Individually arranged large epithelioid cell...

VULVAR MELANOMA Figure 5-90 VULVAR MELANOMA Left: The extent of infiltration by vulvar melanoma in skin-covered areas should be noted following the Clark level denomination, in this case level V as the tumor involves subcutaneous fat. Right: In lesions with ulceration or denudation of the overly... More about this image found in VULVAR MELANOMA Left: The extent of infiltration by vulvar melanoma in ski...

CERVICAL MELANOMA Figure 3-71 CERVICAL MELANOMA A polypoid pigmented mass involves the ectocervix (A). Cellular epithelioid and spindled proliferation in the submucosa (B) is composed of atypical cells with evident pleomorphism and hyperchromasia at higher-power magnification (C). Diffuse nuclear... More about this image found in CERVICAL MELANOMA A polypoid pigmented mass involves the ectocervix (A). C...

VAGINAL MELANOMA Figure 4-32 VAGINAL MELANOMA An infiltrative, fleshy, and pigmented mass extensively replaces the vaginal wall. More about this image found in VAGINAL MELANOMA An infiltrative, fleshy, and pigmented mass extensively r...

VAGINAL MELANOMA Figure 4-33 VAGINAL MELANOMA Left: In the vagina, the tumor is more often of the nodular type. Right: This example features prominent intratumoral pigmentation within highly atypical epithelioid cells arranged in nests. More about this image found in VAGINAL MELANOMA Left: In the vagina, the tumor is more often of the nodul...

VULVAR MELANOMA Figure 5-87 VULVAR MELANOMA A,B: The tumor can appear as a polypoid or exophytic pigmented mass (A) or as a maculopapular growth with asymmetry and heterogeneous pigmentation (B). C: Some lesions are ulcerated, which should be noted in the description since ulceration has prognos... More about this image found in VULVAR MELANOMA A,B: The tumor can appear as a polypoid or exophytic pigme...

VULVAR MELANOMA Figure 5-88 VULVAR MELANOMA Left: The tumor is hypercellular and composed of highly pleomorphic cells forming nests. Right: Cells are highly atypical, with prominent nucleoli and brisk mitotic activity. More about this image found in VULVAR MELANOMA Left: The tumor is hypercellular and composed of highly pl...

VULVAR MELANOMA Figure 5-89 VULVAR MELANOMA The tumor cells may have an epithelioid/ round cell morphology (A and right upper corner of B) or a spindle cell appearance (B, center and left side of the image). SOX10 is positive in both components (C). More about this image found in VULVAR MELANOMA The tumor cells may have an epithelioid/ round cell morpho...

CORPORA CAVERNOSA Figure 1-19 CORPORA CAVERNOSA These structures appear as well-defined, elongated vascular and fibromuscular tissue in the midline stroma underneath the clitoris mucosa. In this case, the corpora cavernosa are partially involved by malignant melanoma, which extensively replaces t... More about this image found in CORPORA CAVERNOSA These structures appear as well-defined, elongated vascu...