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melanoma
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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Superficial spreading melanoma (SSM) refers to a group of melanomas that usually occur at intermittently sun-exposed skin ( 1 – 3 ). Clinically, they tend to present as peripherally spreading, pigmented surface lesions. Under the microscope, they display an intraepidermal growth pattern...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Lentigo maligna melanoma (LMM) is a variant of melanoma that occurs on chronically sun-damaged skin. It is histopathologically characterized by a junctional proliferation of predominantly solitary units of melanocytes ( 1 – 4 ). The noninvasive melanoma confined to the epidermis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Acral melanoma is a melanoma arising in the skin of the palms, soles, or nail apparatus ( 1 , 2 ). The intraepidermal tumor cells of many acral melanomas display a predominant lentiginous, junctional single cell growth pattern. These tumors are referred to as acral lentiginous...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...There are two microscopically descriptive scenarios for nodular melanoma. One is a primary dermal invasive melanoma without associated in situ melanoma; the other is a primary invasive melanoma accompanied by in situ melanoma that does not extend peripherally beyond the invasive tumor...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Desmoplastic melanoma (DM) is characterized microscopically by the association of invasive tumor with dense fibrous stroma ( 1 ). In pure variants, the tumor is a fibrous stroma-rich and cell-poor lesion, with individual tumor cells dispersed throughout in an abundant fibrous matrix ( 2...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Nevoid melanoma is a melanoma that closely resembles a melanocytic nevus microscopically. It is not a distinct clinical, microscopic, or molecular entity. The term nevoid melanoma refers to a diagnostic pitfall: “a diagnosis of a nevus that you later regret” ( 1 ). Most often the term...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Melanoma may develop in association with a blue nevus or simulate histopathologically the appearance of a blue nevus (blue nevus-like melanoma) ( 1 – 7 ). Such tumors have historically been referred to as “malignant blue nevus” ( 2 ). “Malignant blue tumor” is a better term to avoid...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Pediatric melanomas encompass melanomas that affect individuals before they reach adulthood (usually prior to age 18 years). They are further subdivided into early childhood (prepubescent) and adolescent (postpubescent) melanomas. Three groups of pediatric melanomas are currently...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...This chapter discusses unusual morphologic variants of primary cutaneous melanomas that have not been discussed elsewhere in the Fascicle. The purpose of commenting on these variants is for the practicing pathologist to be aware of the morphologic spectrum of melanomas, and to consider...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Melanoma can affect the skin not only as a primary tumor, but also as a metastatic tumor deposit. Metastatic melanoma has not originated at the site where it is found, but represents secondary growth after intravascular, intralymphatic or potentially perivascular spread. CLINICAL FEATURES Melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-23
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...PROGNOSTIC FACTORS Once a diagnosis of melanoma has been established, it is important for the pathologist to provide prognostic information for patients and their clinical care team. At the time of diagnosis approximately 90 percent of individuals with primary cutaneous melanoma have no evidence...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...The term spitzoid melanoma is used for a melanoma bearing some resemblance to a Spitz nevus ( 1 ). It is a diagnostic pitfall ( 2 ): a melanocytic neoplasm may at first glance look like an atypical Spitz nevus or Spitz tumor, but is eventually diagnosed as melanoma based on clinical follow...
Images
Published: 01 February 2024
MELANOMA IN SITU Figure 12-5 MELANOMA IN SITU The melanoma is predominantly composed of junctional nests (thick arrow) with only a few solitary units of melanocytes in the spinous cell layer (thin arrows). More about this image found in MELANOMA IN SITU The melanoma is predominantly composed of junctional nest...
Images
Published: 01 February 2024
MELANOMA IN SITU ASSOCIATED WITH A MELANOCYTIC NEVUS Figure 12-8 MELANOMA IN SITU ASSOCIATED WITH A MELANOCYTIC NEVUS A: Melanoma in situ with asymmetric and broad growth of melanocytes as nests and solitary units at the dermoepidermal junction associated with inflammation. B: Melanoma in situ i... More about this image found in MELANOMA IN SITU ASSOCIATED WITH A MELANOCYTIC NEVUS A: Melanoma in situ w...
Images
Published: 01 February 2024
MELANOMA WITH PSEUDOMATURATION Figure 12-16 MELANOMA WITH PSEUDOMATURATION The invasive melanoma displays a reduction in cell size and extent of pigmentation from the superficial to the mid dermis. More about this image found in MELANOMA WITH PSEUDOMATURATION The invasive melanoma displays a reduction ...
Images
Published: 01 February 2024
LENTIGO MALIGNA MELANOMA WITH SINGLE CELL MICROINVASION Figure 13-11 LENTIGO MALIGNA MELANOMA WITH SINGLE CELL MICROINVASION Melanoma in situ is associated with isolated atypical melanocytes (arrows) in a fibrosed papillary dermis. More about this image found in LENTIGO MALIGNA MELANOMA WITH SINGLE CELL MICROINVASION Melanoma in situ i...
Images
Published: 01 February 2024
LENTIGO MALIGNA MELANOMA Figure 13-14 LENTIGO MALIGNA MELANOMA Dense sheet-like aggregates of invasive melanoma cells are flanked by LMM. More about this image found in LENTIGO MALIGNA MELANOMA Dense sheet-like aggregates of invasive melanoma ...
Images
Published: 01 February 2024
LENTIGO MALIGNA MELANOMA Figure 13-16 LENTIGO MALIGNA MELANOMA A: Inflamed lentigo maligna melanoma. B: It is difficult to determine on the H&E stain whether melanoma cells are admixed with the inflammatory cell infiltrate in the superficial dermis. C: An immunostain for Melan-A highlights ... More about this image found in LENTIGO MALIGNA MELANOMA A: Inflamed lentigo maligna melanoma. B: It is d...
Images
Published: 01 February 2024
ACRAL LENTIGINOUS MELANOMA IN SITU Figure 14-6 ACRAL LENTIGINOUS MELANOMA IN SITU This melanoma displays high cell density, with confluency of melanocytes, nests, and some pagetoid scatter in the spinous cell layer. More about this image found in ACRAL LENTIGINOUS MELANOMA IN SITU This melanoma displays high cell densit...
Images
Published: 01 February 2024
ACRAL MELANOMA WITH SYRINGOTROPISM: IN SITU AND INVASIVE Figure 14-8 ACRAL MELANOMA WITH SYRINGOTROPISM: IN SITU AND INVASIVE A: The melanoma in situ displays a mixed lentiginous, nested, and pagetoid pattern. It extends along the epithelial stromal junction of eccrine ducts (white arrows). B,C:... More about this image found in ACRAL MELANOMA WITH SYRINGOTROPISM: IN SITU AND INVASIVE A: The melanoma i...
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