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melanoma

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METASTATIC MALIGNANT <span class="search-highlight">MELANOMA</span>  Left: The black to brown color reflects the ...
Published: 01 March 2023
METASTATIC MALIGNANT MELANOMA Figure 14-9 METASTATIC MALIGNANT MELANOMA Left: The black to brown color reflects the presence of melanin pigment. Right: Amelanotic melanoma is tan and soft, and resembles solid primary pancreatic neoplasms grossly. More about this image found in METASTATIC MALIGNANT MELANOMA Left: The black to brown color reflects the ...
Images
METASTATIC MALIGNANT <span class="search-highlight">MELANOMA</span>  Left: The classic histologic features includ...
Published: 01 March 2023
METASTATIC MALIGNANT MELANOMA Figure 14-10 METASTATIC MALIGNANT MELANOMA Left: The classic histologic features include a diffuse pattern and epithelioid cells with abundant cytoplasm and prominent nucleoli. Right: Other cases are noncohesive and have little cytoplasm. More about this image found in METASTATIC MALIGNANT MELANOMA Left: The classic histologic features includ...
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METASTATIC MALIGNANT <span class="search-highlight">MELANOMA</span>  Individually arranged large epithelioid cell...
Published: 01 March 2023
METASTATIC MALIGNANT MELANOMA Figure 14-11 METASTATIC MALIGNANT MELANOMA Individually arranged large epithelioid cells have abundant cytoplasm and prominent nucleoli (Diff Quik stain). More about this image found in METASTATIC MALIGNANT MELANOMA Individually arranged large epithelioid cell...
Images
VULVAR <span class="search-highlight">MELANOMA</span>  Left: The extent of infiltration by vulvar <span class="search-highlight">melanoma</span> in ski...
Published: 01 February 2023
VULVAR MELANOMA Figure 5-90 VULVAR MELANOMA Left: The extent of infiltration by vulvar melanoma in skin-covered areas should be noted following the Clark level denomination, in this case level V as the tumor involves subcutaneous fat. Right: In lesions with ulceration or denudation of the overly... More about this image found in VULVAR MELANOMA Left: The extent of infiltration by vulvar melanoma in ski...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-14
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
...Table 14-1 ORIGIN OF PANCREATIC METASTASES IN AUTOPSY SERIES a Reference (Num.) Primary Site N b Lung Breast Melanoma Stomach Colorectum Kidney Ovary Other Abrams ( 71 ) 116 16 23 0 28 6 2 10 31 Berge ( 72 ) 189 64 11 34 12 11 7 5...
Images
CERVICAL <span class="search-highlight">MELANOMA</span>  A polypoid pigmented mass involves the ectocervix (A). C...
Published: 01 February 2023
CERVICAL MELANOMA Figure 3-71 CERVICAL MELANOMA A polypoid pigmented mass involves the ectocervix (A). Cellular epithelioid and spindled proliferation in the submucosa (B) is composed of atypical cells with evident pleomorphism and hyperchromasia at higher-power magnification (C). Diffuse nuclear... More about this image found in CERVICAL MELANOMA A polypoid pigmented mass involves the ectocervix (A). C...
Images
Images
VAGINAL <span class="search-highlight">MELANOMA</span>  Left: In the vagina, the tumor is more often of the nodul...
Published: 01 February 2023
VAGINAL MELANOMA Figure 4-33 VAGINAL MELANOMA Left: In the vagina, the tumor is more often of the nodular type. Right: This example features prominent intratumoral pigmentation within highly atypical epithelioid cells arranged in nests. More about this image found in VAGINAL MELANOMA Left: In the vagina, the tumor is more often of the nodul...
Images
VULVAR <span class="search-highlight">MELANOMA</span>  A,B: The tumor can appear as a polypoid or exophytic pigme...
Published: 01 February 2023
VULVAR MELANOMA Figure 5-87 VULVAR MELANOMA A,B: The tumor can appear as a polypoid or exophytic pigmented mass (A) or as a maculopapular growth with asymmetry and heterogeneous pigmentation (B). C: Some lesions are ulcerated, which should be noted in the description since ulceration has prognos... More about this image found in VULVAR MELANOMA A,B: The tumor can appear as a polypoid or exophytic pigme...
Images
VULVAR <span class="search-highlight">MELANOMA</span>  Left: The tumor is hypercellular and composed of highly pl...
Published: 01 February 2023
VULVAR MELANOMA Figure 5-88 VULVAR MELANOMA Left: The tumor is hypercellular and composed of highly pleomorphic cells forming nests. Right: Cells are highly atypical, with prominent nucleoli and brisk mitotic activity. More about this image found in VULVAR MELANOMA Left: The tumor is hypercellular and composed of highly pl...
Images
VULVAR <span class="search-highlight">MELANOMA</span>  The tumor cells may have an epithelioid/ round cell morpho...
Published: 01 February 2023
VULVAR MELANOMA Figure 5-89 VULVAR MELANOMA The tumor cells may have an epithelioid/ round cell morphology (A and right upper corner of B) or a spindle cell appearance (B, center and left side of the image). SOX10 is positive in both components (C). More about this image found in VULVAR MELANOMA The tumor cells may have an epithelioid/ round cell morpho...
Images
CORPORA CAVERNOSA  These structures appear as well-defined, elongated vascu...
Published: 01 February 2023
CORPORA CAVERNOSA Figure 1-19 CORPORA CAVERNOSA These structures appear as well-defined, elongated vascular and fibromuscular tissue in the midline stroma underneath the clitoris mucosa. In this case, the corpora cavernosa are partially involved by malignant melanoma, which extensively replaces t... More about this image found in CORPORA CAVERNOSA These structures appear as well-defined, elongated vascu...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
...-4% Lynch syndrome MLH1, MSH2, others 8-10X 5% Peutz-Jeghers syndrome STK11 75-125X 30-60% a 3 FDR with pc = 3 or more first-degree relatives with pancreatic cancer; FAMMM = familial atypical multiple mole melanoma syndrome; pc = pancreatic cancer. Table 7-2...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-08
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
...   2015 ; 6 : 115 - 25 . 11. Whelan   AJ , Bartsch   D , Goodfellow   PJ . Brief report: a familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene . N Engl J Med   1995 ; 333 : 975 - 7 . 12. Kaiser   J , Hinz   U , Mayer   P...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI: 10.55418/9781933477268-5
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... - + b - - + b - - - - Secondary EMPD, urothelial type + b + + b - - - - + + d Pagetoid HSIL a + d - + - - - - + b + b Melanoma in situ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-13
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... ). The mesenchymal appearance suggests solitary fibrous tumor, a myoepithelial neoplasm, sclerosing epithelioid fibrosarcoma ( 89 ), gastrointestinal stromal tumor, and melanoma, among other possibilities in the differential diagnosis. The co-expression of cytokeratin, vimentin, and CD99 is unique for a tumor...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI: 10.55418/9781933477275-12
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... melanoma (FAMMM) CDKN2A PanNETs, PDACs Other carcinomas Other germline mutations associated with clinically sporadic PanNETs b BRCA2, MUTHY, CHEK2, CDKN1B, and APC PanNETs a NET = neuroendocrine tumor; SCN = serous cystic neoplasm; CNS = central...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI: 10.55418/9781933477268-4
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... with discernible cross striations, confirming a skeletal muscle phenotype. VAGINAL MELANOMA Figure 4-32 VAGINAL MELANOMA An infiltrative, fleshy, and pigmented mass extensively replaces the vaginal wall. VAGINAL MELANOMA Figure 4-33 VAGINAL MELANOMA Left: In the vagina, the tumor is more often of the nodular...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI: 10.55418/9781933477268-3
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
.... BLUE NEVUS Figure 3-69 BLUE NEVUS Densely pigmented dendritic cells with inconspicuous nuclei are haphazardly distributed throughout the superficial stroma. CERVICAL MELANOSIS Figure 3-70 CERVICAL MELANOSIS There is uniform pigmentation of the basal epithelial layer. CERVICAL MELANOMA Figure 3-71...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI: 10.55418/9781933477268-1
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... in the midline stroma underneath the clitoris mucosa. In this case, the corpora cavernosa are partially involved by malignant melanoma, which extensively replaces the epithelium. BARTHOLIN GLAND Figure 1-20 BARTHOLIN GLAND Left: The Bartholin gland is composed of ducts and acinar tissue, the latter lined...