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Figure 1-8
Published: 01 December 2024
CURRENT CONCEPT OF NEURAL CREST CELL MIGRATION Figure 1-8 CURRENT CONCEPT OF NEURAL CREST CELL MIGRATION A: Neural crest cells directly migrate laterally and ventrally to give rise to cutaneous melanocytes and sympathetic ganglia (SG). B: Slightly later in embryogenesis a different group More about this image found in CURRENT CONCEPT OF NEURAL CREST CELL MIGRATION A: Neural crest cells direc...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... A: Spindle cell area with cytologic atypia and a mitosis. B: Area of extensive necrosis (top of field). PEComas are characterized immunohisto-chemically by the expression of both smooth muscle markers and melanocytic markers such as HMB-45, Melan-A/MART-1, MITF, and cathepsin K. Marker expression...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... to the common neural crest origin of melanocytes and adrenal medulla. Immunohistochemical stains to demonstrate neuroendocrine markers and rule out melanoma should be employed in questionable cases to ensure that the more common diagnosis of metastatic melanoma is not missed (see chapter 12 ). PIGMENTED...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... cells directly migrate laterally and ventrally to give rise to cutaneous melanocytes and sympathetic ganglia (SG). B: Slightly later in embryogenesis a different group of neural crest-derived cells migrates from the dorsal route ganglia (DRG) along sensory axons to reach preganglionic sympathetic axons...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... . A study of gata3 and phox2b expression in tumors of the autonomic nervous system . Am J Surg Pathol   2013 ; 37 : 1236 - 41 . 27. Miettinen   M , McCue   PA , Sarlomo-Rikala   M , et al . Sox10—a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-15
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... infiltrate, which may occasionally contain a few neutrophils and eosinophils. Epidermal changes include acanthosis, spongiosis, hyperkeratosis, and parakeratosis ( fig. 15-37D ). In pinta, there is a decrease in the number of basal layer melanocytes. In comparison to syphilis, these treponematoses show...
Book Chapter
Book cover for <span class="search-highlight">Melanocytic</span> Tumors of the Skin
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Table 2-1 FEATURES OF CONGENITAL MELANOCYTIC NEVUS Clinical Features  Present at birth  Anywhere on the body  Tan, brown, dark brown, or near black papule or plaque  Well-demarcated with regular or irregular borders  Variable size  Classification based on expected size...
Book Chapter
Book cover for <span class="search-highlight">Melanocytic</span> Tumors of the Skin
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., inflammation, desmoplasia, edema, hypervascularity, other) Ancillary Test Findings  Immunohistochemistry   Most ordinary nevi homogenously express SOX10 and S-100 protein   Epithelioid cells are usually immunoreactive for Melan-A and tyrosinase   Neurotized spindle melanocytes may only express...
Book Chapter
Book cover for <span class="search-highlight">Melanocytic</span> Tumors of the Skin
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
.... There is a band-like lymphocytic infiltrate. B: The melanocytic proliferation is predominantly junctional, but a few nests of melanocytes are seen in a fibrotic dermis. PIGMENTED LENTIGINOUS COMPOUND DYSPLASTIC NEVUS Figure 4-4 PIGMENTED LENTIGINOUS COMPOUND DYSPLASTIC NEVUS A: The silhouette of a broad...
Book Chapter
Book cover for <span class="search-highlight">Melanocytic</span> Tumors of the Skin
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... architectural disorder Pagetosis may be present Intradermal melanocytes are usually bland Breast Premenopausal May have benign or irregular features Large, confluent junctional nests Cell dyscohesion Focal pagetosis Nuclear atypia Stromal fibrosis Ear Often poorly circumscribed Poor lateral...
Book Chapter
Book cover for <span class="search-highlight">Melanocytic</span> Tumors of the Skin
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... Not characteristic Lateral circumscription Sharp Irregular Confluent growth Above scar Beyond scar Irregular nesting Above/within scar Beyond scar Pagetoid growth Above scar, with nests Beyond scar, single cells Cytologic atypia Lower degree Higher degree ULCERATED MELANOCYTIC NEVUS Figure 6...
Book Chapter
Book cover for <span class="search-highlight">Melanocytic</span> Tumors of the Skin
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... neoplasms (in descending order of association with the syndrome):  BAP1-inactivated melanocytic tumors (BIMT)  Uveal melanoma  Mesothelioma  Cutaneous melanoma  Renal cell carcinoma  Misc other tumors (e.g., basal cell carcinoma, hepatocellular carcinoma, meningioma) a Basal cell...
Book
Book cover for <span class="search-highlight">Melanocytic</span> Tumors of the Skin
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
Images
Figure 3-13
Published: 01 February 2024
MELANOCYTIC NEVUS WITH EDEMA Figure 3-13 MELANOCYTIC NEVUS WITH EDEMA A: Compound melanocytic nevus with prominent edema of its dermal stroma. B: Cytologically bland dermal melanocytes are separated by an edematous stroma. More about this image found in MELANOCYTIC NEVUS WITH EDEMA A: Compound melanocytic nevus with prominent ...
Images
Figure 3-17
Published: 01 February 2024
MELANOCYTIC NEVUS WITH MITOSES Figure 3-17 MELANOCYTIC NEVUS WITH MITOSES A: Silhouette of a melanocytic nevus that had grown during pregnancy. B: Most of the melanocytes are seen in the dermis, but there is also a junctional proliferation of melanocytes. C: A few mitotic figures are seen More about this image found in MELANOCYTIC NEVUS WITH MITOSES A: Silhouette of a melanocytic nevus that h...
Images
Figure 6-1
Published: 01 February 2024
PERSISTENT MELANOCYTIC NEVUS Figure 6-1 PERSISTENT MELANOCYTIC NEVUS A: There is a focal junctional melanocytic proliferation (inset) confined to the epidermis overlying an inflamed scar. B: Close up of inset shows melanocytes at the dermoepidermal junction above the scar displaying More about this image found in PERSISTENT MELANOCYTIC NEVUS A: There is a focal junctional melanocytic pr...
Images
Figure 2-10
Published: 01 February 2024
BALLOON CELL COMPOUND MELANOCYTIC NEVUS Figure 2-10 BALLOON CELL COMPOUND MELANOCYTIC NEVUS A dominant population of melanocytes displays abundant cytoplasm with clear cell (balloon cell) features. More about this image found in BALLOON CELL COMPOUND MELANOCYTIC NEVUS A dominant population of melanocyt...
Images
Figure 3-5
Published: 01 February 2024
COMPOUND MELANOCYTIC NEVUS Figure 3-5 COMPOUND MELANOCYTIC NEVUS Melanocytes are present both at the dermoepidermal junction as well as in the superficial dermis. More about this image found in COMPOUND MELANOCYTIC NEVUS Melanocytes are present both at the dermoepider...
Images
Figure 3-12
Published: 01 February 2024
MELANOCYTIC NEVUS WITH PSEUDOVASCULAR CHANGES Figure 3-12 MELANOCYTIC NEVUS WITH PSEUDOVASCULAR CHANGES Some of the melanocytes are discohesive and create spaces (*) resembling vascular lumens lined by endothelial cells. More about this image found in MELANOCYTIC NEVUS WITH PSEUDOVASCULAR CHANGES Some of the melanocytes are ...
Images
Figure 3-14
Published: 01 February 2024
MELANOCYTIC NEVUS WITH LIPIDIZATION Figure 3-14 MELANOCYTIC NEVUS WITH LIPIDIZATION Some of the melanocytes show microvesicular lipidized cytoplasm similar to sebocytes (arrows). More about this image found in MELANOCYTIC NEVUS WITH LIPIDIZATION Some of the melanocytes show microvesi...