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SUBUNGUAL MELANOMA  The nail fold and <span class="search-highlight">matrix</span> are involved by melanoma in si...
Published: 01 February 2024
SUBUNGUAL MELANOMA Figure 14-14 SUBUNGUAL MELANOMA The nail fold and matrix are involved by melanoma in situ (arrow), which extends to the nail bed. There is associated invasive melanoma (*). More about this image found in SUBUNGUAL MELANOMA The nail fold and matrix are involved by melanoma in si...
Images
DESMOPLASTIC MELANOMA  A: A large pink fibrotic area is seen in the dermis ...
Published: 01 February 2024
DESMOPLASTIC MELANOMA Figure 16-1 DESMOPLASTIC MELANOMA A: A large pink fibrotic area is seen in the dermis and subcutis. B: The adjacent and overlying epidermis is involved by melanoma in situ. Amelanotic fusiform melanocytes are dispersed in a fibrous matrix. More about this image found in DESMOPLASTIC MELANOMA A: A large pink fibrotic area is seen in the dermis ...
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SUBUNGUAL NEVUS FROM A CHILD  A: There is a proliferation of solitary units...
Published: 01 February 2024
SUBUNGUAL NEVUS FROM A CHILD Figure 5-4 SUBUNGUAL NEVUS FROM A CHILD A: There is a proliferation of solitary units and nests of melanocytes (arrows) involving the nail matrix associated with hyperpigmentation of epithelial cells. B: The nests (arrows) are well formed and composed of cytologicall... More about this image found in SUBUNGUAL NEVUS FROM A CHILD A: There is a proliferation of solitary units...
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SUBUNGUAL MELANOMA IN SITU  A: There is a proliferation of solitary units o...
Published: 01 February 2024
SUBUNGUAL MELANOMA IN SITU Figure 14-13 SUBUNGUAL MELANOMA IN SITU A: There is a proliferation of solitary units of melanocytes involving the nail bed and nail matrix associated with focal lichenoid inflammation (*). B: The density of melanocytes is above normal, but overall relatively low. C: ... More about this image found in SUBUNGUAL MELANOMA IN SITU A: There is a proliferation of solitary units o...
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MIXED DESMOPLASTIC MELANOMA  A: There is a diffusely infiltrative fibrosing...
Published: 01 February 2024
MIXED DESMOPLASTIC MELANOMA Figure 16-6 MIXED DESMOPLASTIC MELANOMA A: There is a diffusely infiltrative fibrosing tumor involving the dermis and subcutis. B: Close-up view of the area within the inset of A. Focal features of melanoma in situ are characterized by the presence of nests and pageto... More about this image found in MIXED DESMOPLASTIC MELANOMA A: There is a diffusely infiltrative fibrosing...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Desmoplastic melanoma (DM) is characterized microscopically by the association of invasive tumor with dense fibrous stroma ( 1 ). In pure variants, the tumor is a fibrous stroma-rich and cell-poor lesion, with individual tumor cells dispersed throughout in an abundant fibrous matrix ( 2...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... and composed of enlarged epithelioid tumor cells. Some tumor cells have prominent nucleoli or are seen in mitosis (arrow). Subungual melanoma in situ manifests histopathologically as an increased density of melanocytes with abnormal growth and cytologic atypia within the epithelium of the nail matrix...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... on the toe an older individual, for example, favors melanoma, while a small circumscribed macule on the palm of a young person is most likely a nevus. Ancillary studies can be helpful in problematic cases. Nail Matrix Nevi Nail matrix nevi typically manifest as melanonychia. Similar to acral volar lesions...
Images
METAPLASTIC CARCINOMA ARISING IN BENIGN INTRADUCTAL PAPILLOMAS  A: At low p...
Published: 01 January 2024
METAPLASTIC CARCINOMA ARISING IN BENIGN INTRADUCTAL PAPILLOMAS Figure 7-12 METAPLASTIC CARCINOMA ARISING IN BENIGN INTRADUCTAL PAPILLOMAS A: At low power, multiple papillomas are apparent. In the center of the field, there is greater stromal expansion and stromal cellularity associated with the p... More about this image found in METAPLASTIC CARCINOMA ARISING IN BENIGN INTRADUCTAL PAPILLOMAS A: At low p...
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METAPLASTIC CARCINOMA ARISING IN BENIGN INTRADUCTAL PAPILLOMAS  A: At low p...
Published: 01 January 2024
METAPLASTIC CARCINOMA ARISING IN BENIGN INTRADUCTAL PAPILLOMAS Figure 7-12 METAPLASTIC CARCINOMA ARISING IN BENIGN INTRADUCTAL PAPILLOMAS A: At low power, multiple papillomas are apparent. In the center of the field, there is greater stromal expansion and stromal cellularity associated with the p... More about this image found in METAPLASTIC CARCINOMA ARISING IN BENIGN INTRADUCTAL PAPILLOMAS A: At low p...
Images
MARFAN SYNDROME: MUCOID EXTRACELLULAR <span class="search-highlight">MATRIX</span> ACCUMULATION (MEMA)  Top: Abun...
Published: 15 November 2023
MARFAN SYNDROME: MUCOID EXTRACELLULAR MATRIX ACCUMULATION (MEMA) Figure 31-5 MARFAN SYNDROME: MUCOID EXTRACELLULAR MATRIX ACCUMULATION (MEMA) Top: Abundant pools of mucopolysaccharides and glycosaminoglycans deposit within disrupted elastic fibers in a translamellar fashion. Bottom: The pools ma... More about this image found in MARFAN SYNDROME: MUCOID EXTRACELLULAR MATRIX ACCUMULATION (MEMA) Top: Abun...
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MARFAN SYNDROME: MUCOID EXTRACELLULAR <span class="search-highlight">MATRIX</span> ACCUMULATION (MEMA)  A,B: The ...
Published: 15 November 2023
MARFAN SYNDROME: MUCOID EXTRACELLULAR MATRIX ACCUMULATION (MEMA) Figure 31-6 MARFAN SYNDROME: MUCOID EXTRACELLULAR MATRIX ACCUMULATION (MEMA) A,B: The basophilic mucopolysaccharide accumulation is evident on hematoxylin and eosin (H&E) (A) and can be seen within disrupted elastic fibers on el... More about this image found in MARFAN SYNDROME: MUCOID EXTRACELLULAR MATRIX ACCUMULATION (MEMA) A,B: The ...
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LOEYS-DIETZ SYNDROME: MUCOID EXTRACELLULAR <span class="search-highlight">MATRIX</span> ACCUMULATION  A,B: Large ...
Published: 15 November 2023
LOEYS-DIETZ SYNDROME: MUCOID EXTRACELLULAR MATRIX ACCUMULATION Figure 31-10 LOEYS-DIETZ SYNDROME: MUCOID EXTRACELLULAR MATRIX ACCUMULATION A,B: Large pools can be seen depositing in a transmural fashion throughout the aorta (A) with elastic fiber loss (B). C,D: Translamellar MEMA is also noted (... More about this image found in LOEYS-DIETZ SYNDROME: MUCOID EXTRACELLULAR MATRIX ACCUMULATION A,B: Large ...
Images
VASCULAR EHLERS-DANLOS SYNDROME: MUCOID EXTRACELLULAR <span class="search-highlight">MATRIX</span> ACCUMULATION  ...
Published: 15 November 2023
VASCULAR EHLERS-DANLOS SYNDROME: MUCOID EXTRACELLULAR MATRIX ACCUMULATION Figure 31-16 VASCULAR EHLERS-DANLOS SYNDROME: MUCOID EXTRACELLULAR MATRIX ACCUMULATION Translamellar MEMA (left) with elastic loss (right) is noted, similar to other types of connective tissue disorder. More about this image found in VASCULAR EHLERS-DANLOS SYNDROME: MUCOID EXTRACELLULAR MATRIX ACCUMULATION ...
Images
MYXOID EXTRACELLULAR <span class="search-highlight">MATRIX</span>  Left: Small perivascular halos are visible bet...
Published: 15 November 2023
MYXOID EXTRACELLULAR MATRIX Figure 41-9 MYXOID EXTRACELLULAR MATRIX Left: Small perivascular halos are visible between blood vessels and myxoma cells. Right: Abundant myxoma cells within a myxoid background. More about this image found in MYXOID EXTRACELLULAR MATRIX Left: Small perivascular halos are visible bet...
Images
AORTOPATHY OF CONGENITALLY BICUSPID AORTIC VALVE: MUCOID EXTRACELLULAR MATR...
Published: 15 November 2023
AORTOPATHY OF CONGENITALLY BICUSPID AORTIC VALVE: MUCOID EXTRACELLULAR MATRIX ACCUMULATION Figure 31-19 AORTOPATHY OF CONGENITALLY BICUSPID AORTIC VALVE: MUCOID EXTRACELLULAR MATRIX ACCUMULATION H&E staining shows intralamellar MEMA (left) with elastic fiber loss (right). More about this image found in AORTOPATHY OF CONGENITALLY BICUSPID AORTIC VALVE: MUCOID EXTRACELLULAR MATR...
Images
ORGANIZING THROMBUS  A: This low-power photomicrograph shows alternating ar...
Published: 15 November 2023
ORGANIZING THROMBUS Figure 51-19 ORGANIZING THROMBUS A: This low-power photomicrograph shows alternating areas of fibrin and variably cellular zones. B: This high-power view shows fibroblasts moving into dense fibrin at the leading edge of organization. C: The fibroblasts are embedded within a ... More about this image found in ORGANIZING THROMBUS A: This low-power photomicrograph shows alternating ar...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-07
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... of a collagenous matrix admixed with many bland spindle cells suggests a diagnosis of fibromatosis-like metaplastic carcinoma, the degree of cytologic atypia here prompts classification as spindle cell metaplastic carcinoma. E,F: Keratin MNF116 (E) and p63 (F) immunostains highlight the malignant spindle cells...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-05
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... carcinoma, may be a mimic of myxoid fibroadenoma in core needle biopsy specimens where sampling of the stroma may predominate ( fig. 5-20 ). Myxoma is characterized by stellate- and spindle-shaped cells embedded in a delicate myxoid matrix, lacking an epithelial component. The resemblance of myxoid...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-02
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... associated with preexisting autoimmune conditions, particularly type 1 diabetes mellitus. General Features. The etiology and pathophysiology of the condition is not established, however, leading hypotheses invoke the prolonged hyperglycemic state, expansion of the collagenous matrix and decreased...