NEUROBLASTOMA METASTATIC TO BONE AND BONE MARROW Figure 11-37 NEUROBLASTOMA METASTATIC TO BONE AND BONE MARROW This trephine biopsy shows extensive involvement by NB, which is even appreciated without immunohistochemistry. More about this image found in NEUROBLASTOMA METASTATIC TO BONE AND BONE MARROW This trephine biopsy show...

BONE MARROW METASTASIS OF NEUROBLASTOMA Figure 11-38 BONE MARROW METASTASIS OF NEUROBLASTOMA A: Chromogranin A highlights the presence of isolated fields of tumor cells in paucicellular bone marrow following chemotherapy. B: Synaptophysin highlights the presence of isolated fields of tumor cells... More about this image found in BONE MARROW METASTASIS OF NEUROBLASTOMA A: Chromogranin A highlights the p...

DISTRIBUTION OF NEUROBLASTOMA BY SEX AND STAGE OVER AGE Figure 11-1 DISTRIBUTION OF NEUROBLASTOMA BY SEX AND STAGE OVER AGE Nearly 90 percent of patients are below 5 years of age at diagnosis. The left side of each pair of columns represents male patients and the right side of each pair of column... More about this image found in DISTRIBUTION OF NEUROBLASTOMA BY SEX AND STAGE OVER AGE Nearly 90 percent ...

METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA Figure 11-5 METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA A 2-year old girl presented with fever and a painless swelling in the abdomen. Blood and urine cultures were negative and initial ultrasound was suspicious of a renal tumor. After referral to an expert center, clinical examination (slight hypertension), laboratory testing (increased urinary catecholamines), and abdominal MRI imaging showed that a diagnosis of metastatic NB was more likely. The MRI depicted a right-sided adrenal mass with retroperitoneal lymph node metastases. Additional MIBG scintigraphy shows increased uptake in the primary adrenal NB and locoregional lymph nodes (black arrow), but also extensive bone marrow metastases throughout. At the top, is a classic orbital metastasis and at the bottom, a tibial metastasis (red arrows). Histopathology showed an undifferentiated NB, with MYCN amplification, indicative of a high-risk NB patient. (Courtesy of Dr. A. J. Braat, University Medical Center Utrecht, The Netherlands) More about this image found in METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA A...

PARVOVIRUS B19 Figure 8-3 PARVOVIRUS B19 Bone marrow histology shows a hypercellular appearance, with intranuclear parvovirus B19 inclusions affecting erythroid precursors (A, center and B, bottom). More about this image found in PARVOVIRUS B19 Bone marrow histology shows a hypercellular appearance, wit...

EBV-ASSOCIATED HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS Figure 8-9 EBV-ASSOCIATED HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS Bone marrow trephine biopsy (A,B) and aspirate (C,D). More about this image found in EBV-ASSOCIATED HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS Bone marrow trephine bio...

GELATINOUS TRANSFORMATION OF BONE MARROW INTERSTITIUM IN HIV Figure 9-4 GELATINOUS TRANSFORMATION OF BONE MARROW INTERSTITIUM IN HIV Serous or mucoid-like replacement of bone marrow tissue and hemopoietic atrophy are seen. More about this image found in GELATINOUS TRANSFORMATION OF BONE MARROW INTERSTITIUM IN HIV Serous or muc...

HEMOPHAGOCYTOSIS OF BONE MARROW Figure 9-5 HEMOPHAGOCYTOSIS OF BONE MARROW Macrophages are abundant and enlarged, and engulf erythrocytes and nucleated cells. More about this image found in HEMOPHAGOCYTOSIS OF BONE MARROW Macrophages are abundant and enlarged, and...

BRUCELLOSIS Figure 14-5 BRUCELLOSIS Bone marrow involvement in brucellosis demonstrates histiocyte aggregates and poor granuloma formation. More about this image found in BRUCELLOSIS Bone marrow involvement in brucellosis demonstrates histiocyte...

PARVOVIRUS B19-ASSOCIATED TRANSIENT APLASTIC CRISIS Figure 8-4 PARVOVIRUS B19-ASSOCIATED TRANSIENT APLASTIC CRISIS The HIV patient has a hypercellular bone marrow (A) with numerous large atypical pronormoblasts (B). More about this image found in PARVOVIRUS B19-ASSOCIATED TRANSIENT APLASTIC CRISIS The HIV patient has a ...

BARTONELLA-ASSOCIATED PELIOSIS Figure 17-5 BARTONELLA-ASSOCIATED PELIOSIS In the liver (A) and bone marrow (B) characteristic randomly distributed and cystic, blood-filled cavities are seen, which typify this disorder. Warthin-Starry silver stain (C) demonstrates numerous etiologic bacteria. More about this image found in BARTONELLA-ASSOCIATED PELIOSIS In the liver (A) and bone ...

USE OF SPECIAL STAINS IN THE DIAGNOSIS OF INFECTIOUS DISEASES Figure 1-2 USE OF SPECIAL STAINS IN THE DIAGNOSIS OF INFECTIOUS DISEASES A,B: Bone marrow H&E (A) and Grocott methenamine silver (B) stains. The latter shows numerous budding Histoplasma capsulatum yeasts. C–E: H&E stain (C,D) on a pituitary gland specimen showing histologic findings suspicious for tissue pathogens. A strongly positive von Kossa calcium stain (E), however, confirms the suspicious deposits as calcifications and excludes infectious microorganisms. More about this image found in USE OF SPECIAL STAINS IN THE DIAGNOSIS OF INFECTIOUS DISEASES A,B: Bone ma...