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malignant

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UNDIFFERENTIATED MELANOMA  An amelanotic undifferentiated <span class="search-highlight">malignant</span> spindle...
Published: 01 February 2024
UNDIFFERENTIATED MELANOMA Figure 21-8 UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle cell neoplasm is seen. It was initially interpreted as sarcoma by a soft tissue pathologist, but the diagnosis was revised to metastatic melanoma after sequence analysis revealed UV signatures and an NRAS Q61R mutation identical to the mutation in the patient’s prior primary melanoma located draining to the site of the undifferentiated tumor. More about this image found in UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... occasion, is seen in primary melanomas ( 8 ). In the absence of associated melanoma in situ, immunostains may be necessary to distinguish a primary nodular melanoma with rhabdoid features from a primary soft tissue or cutaneous metastasis or another malignant neoplasm with rhabdoid features. RHABDOID...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...Melanoma may develop in association with a blue nevus or simulate histopathologically the appearance of a blue nevus (blue nevus-like melanoma) ( 1 – 7 ). Such tumors have historically been referred to as “malignant blue nevus” ( 2 ). “Malignant blue tumor” is a better term to avoid...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... to a distinct subtype of spitzoid melanoma: the malignant Spitz tumor (also termed Spitz melanoma) ( 3 , 4 ). The term Spitz melanoma has been suggested for a spitzoid melanocytic neoplasm judged to be malignant by microscopic and/or genomic aberrations and found to be associated...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...), but can be supported by molecular methods (e.g., same mutation profile as the primary tumor). Metastatic Melanoma versus Clear Cell Sarcoma (Melanoma of Soft Parts). Most textbooks classify clear cell sarcoma as a soft tissue neoplasm of uncertain histogenesis. It is a malignant tumor usually presenting...
Images
<span class="search-highlight">MALIGNANT</span> PHYLLODES TUMOR  A: At low power, the leaf-like projections and h...
Published: 01 January 2024
MALIGNANT PHYLLODES TUMOR Figure 5-30 MALIGNANT PHYLLODES TUMOR A: At low power, the leaf-like projections and highly cellular stroma are immediately apparent. B: At higher power, benign epithelium is seen overlying the leaf-like projections. A myoepithelial cell layer is also visible, particula... More about this image found in MALIGNANT PHYLLODES TUMOR A: At low power, the leaf-like projections and h...
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<span class="search-highlight">MALIGNANT</span> PHYLLODES TUMOR  A: This section illustrates the heterogeneity th...
Published: 01 January 2024
MALIGNANT PHYLLODES TUMOR Figure 5-31 MALIGNANT PHYLLODES TUMOR A: This section illustrates the heterogeneity that can be encountered in phyllodes tumor, with a more hypocellular, myxoid-appearing area in the upper piece of tissue and a considerably more cellular section of tissue in the lower po... More about this image found in MALIGNANT PHYLLODES TUMOR A: This section illustrates the heterogeneity th...
Images
<span class="search-highlight">MALIGNANT</span> PHYLLODES TUMOR  A: Intermediate-power view demonstrates infiltra...
Published: 01 January 2024
MALIGNANT PHYLLODES TUMOR Figure 5-32 MALIGNANT PHYLLODES TUMOR A: Intermediate-power view demonstrates infiltration of the adjacent adipose tissue. The stroma in this case shows smooth muscle differentiation with scattered, markedly atypical spindle cells and mitoses. B: High-power view highlig... More about this image found in MALIGNANT PHYLLODES TUMOR A: Intermediate-power view demonstrates infiltra...
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<span class="search-highlight">MALIGNANT</span> PHYLLODES TUMOR WITH STROMAL OVERGROWTH  A: Several low-power fie...
Published: 01 January 2024
MALIGNANT PHYLLODES TUMOR WITH STROMAL OVERGROWTH Figure 5-33 MALIGNANT PHYLLODES TUMOR WITH STROMAL OVERGROWTH A: Several low-power fields in this tumor lacked epithelial elements. B: Another low power field without epithelial elements. Note also the heterogeneity in stromal cellularity. More about this image found in MALIGNANT PHYLLODES TUMOR WITH STROMAL OVERGROWTH A: Several low-power fie...
Images
<span class="search-highlight">MALIGNANT</span> PHYLLODES TUMOR  A: Low power demonstrates an admixture of benign...
Published: 01 January 2024
MALIGNANT PHYLLODES TUMOR Figure 5-34 MALIGNANT PHYLLODES TUMOR A: Low power demonstrates an admixture of benign epithelial elements, malignant spindle cells, and adipocytes. B,C: At intermediate (B) and high (C) power, the marked cytologic atypia of the stromal cells is apparent; lipoblasts are... More about this image found in MALIGNANT PHYLLODES TUMOR A: Low power demonstrates an admixture of benign...
Images
<span class="search-highlight">MALIGNANT</span> PHYLLODES TUMOR  A: At low power, this core needle biopsy appears...
Published: 01 January 2024
MALIGNANT PHYLLODES TUMOR Figure 5-36 MALIGNANT PHYLLODES TUMOR A: At low power, this core needle biopsy appears to be composed entirely of spindle cells. The lesion is hypercellular. The tissue fragment at upper right has a focus of benign-appearing epithelium (arrow). B: Higher power shows the... More about this image found in MALIGNANT PHYLLODES TUMOR A: At low power, this core needle biopsy appears...
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<span class="search-highlight">MALIGNANT</span> PHYLLODES TUMOR WITH PERIDUCTAL STROMAL TUMOR-LIKE AREAS
Published: 01 January 2024
MALIGNANT PHYLLODES TUMOR WITH PERIDUCTAL STROMAL TUMOR-LIKE AREAS Figure 5-39 MALIGNANT PHYLLODES TUMOR WITH PERIDUCTAL STROMAL TUMOR-LIKE AREAS More about this image found in MALIGNANT PHYLLODES TUMOR WITH PERIDUCTAL STROMAL TUMOR-LIKE AREAS
Images
INVASIVE PAGET DISEASE  A: A low-power image of the nipple shows <span class="search-highlight">malignant</span> ...
Published: 01 January 2024
INVASIVE PAGET DISEASE Figure 13-17 INVASIVE PAGET DISEASE A: A low-power image of the nipple shows malignant epithelial cells predominantly at the basal aspect of the epidermis, with overlying erosion and associated exudate. There is a brisk inflammatory cell infiltrate at the dermoepidermal jun... More about this image found in INVASIVE PAGET DISEASE A: A low-power image of the nipple shows malignant ...
Images
INVASIVE PAGET DISEASE  A: A low-power image of the nipple shows <span class="search-highlight">malignant</span> ...
Published: 01 January 2024
INVASIVE PAGET DISEASE Figure 13-17 INVASIVE PAGET DISEASE A: A low-power image of the nipple shows malignant epithelial cells predominantly at the basal aspect of the epidermis, with overlying erosion and associated exudate. There is a brisk inflammatory cell infiltrate at the dermoepidermal jun... More about this image found in INVASIVE PAGET DISEASE A: A low-power image of the nipple shows malignant ...
Images
SQUAMOUS CELL CARCINOMA IN SITU  A: At low power, sheets of <span class="search-highlight">malignant</span>-appea...
Published: 01 January 2024
SQUAMOUS CELL CARCINOMA IN SITU Figure 13-18 SQUAMOUS CELL CARCINOMA IN SITU A: At low power, sheets of malignant-appearing epithelioid cells involving the epidermis are apparent. B: At higher power, the cytologic atypia is better appreciated; the nuclei are large and pleomorphic; the cytoplasm ... More about this image found in SQUAMOUS CELL CARCINOMA IN SITU A: At low power, sheets of malignant-appea...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., it is currently not yet known whether the reported low recurrence rates reflect the fact that these tumors tend to be small and thin or whether other factors play a role. REFERENCES REFERENCES 1. Theodosiou   G , Johansson   I , Hamnerius   N , Svensson   Å . Naevoid malignant melanoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... are found. Copy number gains or amplifications at 8q24 are especially characteristic of amelanotic nodular melanomas ( 12 ). DIFFERENTIAL DIAGNOSIS The differential diagnosis is broad and includes primary benign and malignant melanocytic and nonmelanocytic neoplasms as well as metastatic tumors ( Table 15...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... “true” Spitz, and whether it is clearly benign, malignant, intermediate, or indeterminate in its appearance and biologic potential ( 10 , 11 ). Integrating molecular findings into the definition of Spitz neoplasms has permitted a more reproducible classification of these lesions ( 11 – 17 ), at least...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... prompt a careful evaluation for other evidence of malignancy. Approximately two thirds of CBNs display a biphasic pattern, which implies a mix of features of common BN and cellular areas. On occasion, features of common BN are very focal or absent, giving rise to a monophasic spindle cell CBN ( 28...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... for uniformly stroma-rich cell pure melanomas that convey a microscopic picture of low-grade malignancy. IMMUNOHISTOCHEMICAL FINDINGS Most invasive DMs lack any or significant staining for melanocyte markers other than S-100 protein, SOX10, or NGFR (p75) ( fig. 16-9 ) ( 14 , 15 ). If there is an associated...