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malignant
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Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) Figure 8-58 COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) This tumor is composed of an admixture of pheochromocytoma with a highly cellular nerve sheath tumor (A–D). The pheochromocyt... More about this image found in COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MP...
Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) Figure 8-58 COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) This tumor is composed of an admixture of pheochromocytoma with a highly cellular nerve sheath tumor (A–D). The pheochromocyt... More about this image found in COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MP...
Images
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
MALIGNANT TRANSFORMATION OF A GANGLIONEUROMA Figure 11-44 MALIGNANT TRANSFORMATION OF A GANGLIONEUROMA This tumor first presented at 13 months as an unresectable abdominal NB and was treated with abdominal mega-voltage irradiation. At age 17 years, the patient presented again with an abdominal tu... More about this image found in MALIGNANT TRANSFORMATION OF A GANGLIONEUROMA This tumor first presented at...
Images
in Other Adrenal Neoplasms and Tumor-Like Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
MALIGNANT ADRENAL PECOMA Figure 12-16 MALIGNANT ADRENAL PECOMA A: Spindle cell area with cytologic atypia and a mitosis. B: Area of extensive necrosis (top of field). More about this image found in MALIGNANT ADRENAL PECOMA A: Spindle cell area with cytologic atypia and a ...
Images
in Other Adrenal Neoplasms and Tumor-Like Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
MALIGNANT PERIPHERAL NERVE SHEATH TUMOR Figure 12-17 MALIGNANT PERIPHERAL NERVE SHEATH TUMOR Interlacing fascicles of spindle cells and epithelioid cells are present beneath a small area of residual adrenal cortex. More about this image found in MALIGNANT PERIPHERAL NERVE SHEATH TUMOR Interlacing fascicles of spindle c...
Images
Published: 01 December 2024
PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE Figure 4-24 PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE A large pigmented macronodule and a larger pale yellow nodule with small areas of necrosis are seen. The patient was part of a family pedigree with the complex of myxomas, spotty pigmenta... More about this image found in PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE A large pigmented macrono...
Images
Published: 01 December 2024
PEDIATRIC ADRENAL CORTICAL CARCINOMA Figure 6-44 PEDIATRIC ADRENAL CORTICAL CARCINOMA Synchronous brain metastasis from a malignant pediatric adrenal cortical tumor. (Same case as fig. 6-42 .) More about this image found in PEDIATRIC ADRENAL CORTICAL CARCINOMA Synchronous brain metastasis from a m...
Images
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
UNDIFFERENTIATED NEUROBLASTOMA Figure 11-12 UNDIFFERENTIATED NEUROBLASTOMA Closely packed, poorly differentiated neuroblasts form solid sheets. Patterns such as this may cause confusion with other childhood neoplasms such as malignant lymphoma. Most nuclei have a single, small nucleolus. The tumo... More about this image found in UNDIFFERENTIATED NEUROBLASTOMA Closely packed, poorly differentiated neuro...
Images
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
UNDIFFERENTIATED NEUROBLASTOMA WITH LARGE CELL HISTOLOGY Figure 11-17 UNDIFFERENTIATED NEUROBLASTOMA WITH LARGE CELL HISTOLOGY This tumor was originally diagnosed as malignant rhabdoid tumor on the basis of morphology and loss of BRG1 immunostaining, until resection showed foci of ganglion cell d... More about this image found in UNDIFFERENTIATED NEUROBLASTOMA WITH LARGE CELL HISTOLOGY This tumor was or...
Images
Published: 01 December 2024
ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOMA AND CARCINOMA Figure 5-31 ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOMA AND CARCINOMA A diagnosis of adrenal cortical carcinoma was suspected because of the presence of predominant oncocyti... More about this image found in ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOM...
Images
in Hereditary Predisposition to Adrenal Cortical Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ADRENAL CORTICAL TUMOR IN A PATIENT HARBORING ARMC5 GERMLINE VARIANT Figure 7-2 ADRENAL CORTICAL TUMOR IN A PATIENT HARBORING ARMC5 GERMLINE VARIANT The adrenal mass (A) is composed of a peripheral benign macronodular component (A, upper left), and is associated with a central component made of eosinophilic cells (B, lower right) showing malignancy-related features, including increased mitotic activity (B, red circle) for a total Weiss score of 4. More about this image found in ADRENAL CORTICAL TUMOR IN A PATIENT HARBORING ARMC5 GERMLI...
Images
in Congenital Disorders of the Adrenal Gland
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
HETEROTOPIC/ACCESSORY ADRENAL CORTICAL TISSUE WITHIN THE TESTIS Figure 2-8 HETEROTOPIC/ACCESSORY ADRENAL CORTICAL TISSUE WITHIN THE TESTIS Heterotopic or accessory adrenal cortical tissue is encapsulated and presents as a small nodule within the testicular parenchyma near the hilum of the testis.... More about this image found in HETEROTOPIC/ACCESSORY ADRENAL CORTICAL TISSUE WITHIN THE TESTIS Heterotopi...
Images
in Congenital Disorders of the Adrenal Gland
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ADRENAL CORTICAL NEOPLASM ASSOCIATED WITH CONGENITAL ADRENAL HYPERPLASIA Figure 2-13 ADRENAL CORTICAL NEOPLASM ASSOCIATED WITH CONGENITAL ADRENAL HYPERPLASIA A: A large adrenal cortical tumor present on the right is seen next to hyperplastic lipid-depleted adrenal cortex and a normal adrenal medu... More about this image found in ADRENAL CORTICAL NEOPLASM ASSOCIATED WITH CONGENITAL ADRENAL HYPERPLASIA A...
Images
Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA ARISING IN ADRENAL CORTICAL ADENOMA Figure 6-6 ADRENAL CORTICAL CARCINOMA ARISING IN ADRENAL CORTICAL ADENOMA This adrenal lesion, 11 cm in size (same case as shown in fig. 6-1 ), has two distinct areas: a benign one with <10 HU and the malignant one at 30 HU. (A: C... More about this image found in ADRENAL CORTICAL CARCINOMA ARISING IN ADRENAL CORTICAL ADENOMA This adrena...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Adrenal cortical carcinoma (ACC) is a malignant neoplasm originating from the steroidogenic epithelial cells of the adrenal cortex. EPIDEMIOLOGY ACC accounts for the majority of deaths attributable to primary adrenal neoplasia, but it is a rare disease, meeting the criteria for an “orphan...
Images
in Other Adrenal Neoplasms and Tumor-Like Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PRIMARY ADRENAL HEMANGIOMA Figure 12-7 PRIMARY ADRENAL HEMANGIOMA A: The subcortical area has a delicate capillary pattern, while more central areas are cavernous and have nonendothelial supporting cells. Fibrin thrombi are also present. B: The more cavernous pattern, with dilated vascular space... More about this image found in PRIMARY ADRENAL HEMANGIOMA A: The subcortical area has a delicate capillar...
Images
in Other Adrenal Neoplasms and Tumor-Like Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PRIMARY ADRENAL MELANOMA Figure 12-19 PRIMARY ADRENAL MELANOMA A: A 48-year-old woman complained of abdominal pain; imaging studies revealed a right adrenal mass; the patient had no evidence of melanoma in any other site following rigorous investigation using a multidisciplinary approach. Part of... More about this image found in PRIMARY ADRENAL MELANOMA A: A 48-year-old woman complained of abdominal pa...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Various neoplastic and non-neoplastic lesions cause enlargement of the adrenal glands. Aside from cortical and chromaffin cell tumors, the neoplasms most often encountered are primary benign or malignant tumors arising from non-endocrine cell types that reside in the normal adrenal gland...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... paragangliomas in different locations. A more fundamental conceptual change, first introduced in the 2017 WHO classification and maintained in the more recent 5th edition, is elimination of the previous separate classifications of benign and malignant pheochromocytoma ( 9 ). This concept has now been abandoned...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... age group in White populations and a slightly lower incidence in Black individuals (6.8 cases per million). There is a slight male predominance ( 13 ). In the first year of life, they together comprise the most common malignancy, with an incidence of 25 to 50 per million individuals ( 14 ). Most...
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