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METASTATIC PHEOCHROMOCYTOMA  The presence of paraganglioma in <span class="search-highlight">lymph</span> node (A...
Published: 01 December 2024
METASTATIC PHEOCHROMOCYTOMA Figure 8-52 METASTATIC PHEOCHROMOCYTOMA The presence of paraganglioma in lymph node (A) or bone (B) is unequivocal evidence of metastatic spread, since these tissues do not harbor paraganglia and therefore the disease cannot represent multifocal primary lesions in a ge... More about this image found in METASTATIC PHEOCHROMOCYTOMA The presence of paraganglioma in lymph node (A...
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<span class="search-highlight">LYMPH</span> NODE METASTASIS OF ABDOMINAL PARAGANGLIOMA  A: This metastatic tumor ...
Published: 01 December 2024
LYMPH NODE METASTASIS OF ABDOMINAL PARAGANGLIOMA Figure 9-40 LYMPH NODE METASTASIS OF ABDOMINAL PARAGANGLIOMA A: This metastatic tumor could be mistaken for a carcinoma with clear cell features, but was known to correspond to one of the lesions in fig. 9-39 . The diagnosis was confirmed by an im... More about this image found in LYMPH NODE METASTASIS OF ABDOMINAL PARAGANGLIOMA A: This metastatic tumor ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... infection, known as infectious mononucleosis, presents with fever, fatigue, malaise, sore throat, lymph node enlargement, hepatosplenomegaly, and a rash. There is usually peripheral lymphocytosis with associated lymphoid cell atypia. Approximately 20 to 40 percent of lymphocytes demonstrate characteristic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-17
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... lymph nodes in cat scratch disease depends on the stage of infection. Follicular hyperplasia, irregular microabscesses, and foci of cortical necrosis are followed by coalescent stellate granulomas with a necrotic center, palisaded histiocytes, and usually, only rare multinucleated giant cells ( 5...
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NORMAL ABDOMINAL PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS  ...
Published: 01 December 2024
NORMAL ABDOMINAL PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS Figure 9-3 NORMAL ABDOMINAL PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS A: Normal paraganglia (arrows) in close proximity to lymph nodes. In a patient with a hereditary paraganglioma syndrome, this anatomic rel... More about this image found in NORMAL ABDOMINAL PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS ...
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METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA  A...
Published: 01 December 2024
METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA Figure 11-5 METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA A 2-year old girl presented with fever and a painless swelling in the abdomen. Blood and urine cultures were negative and initial ultrasound was suspicious of a renal tumor. After referral to an expert center, clinical examination (slight hypertension), laboratory testing (increased urinary catecholamines), and abdominal MRI imaging showed that a diagnosis of metastatic NB was more likely. The MRI depicted a right-sided adrenal mass with retroperitoneal lymph node metastases. Additional MIBG scintigraphy shows increased uptake in the primary adrenal NB and locoregional lymph nodes (black arrow), but also extensive bone marrow metastases throughout. At the top, is a classic orbital metastasis and at the bottom, a tibial metastasis (red arrows). Histopathology showed an undifferentiated NB, with MYCN amplification, indicative of a high-risk NB patient. (Courtesy of Dr. A. J. Braat, University Medical Center Utrecht, The Netherlands) More about this image found in METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA A...
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SF1 IN ADRENAL CORTICAL CARCINOMA  The diagnosis of metastatic adrenal cort...
Published: 01 December 2024
SF1 IN ADRENAL CORTICAL CARCINOMA Figure 6-31 SF1 IN ADRENAL CORTICAL CARCINOMA The diagnosis of metastatic adrenal cortical carcinoma in this transbronchial fine needle aspiration biopsy of a perihilar lymph node (A) is supported by positive nuclear staining for SF1 (B). More about this image found in SF1 IN ADRENAL CORTICAL CARCINOMA The diagnosis of metastatic adrenal cort...
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HEMORRHAGIC NEUROBLASTOMA  NB of the left adrenal gland at autopsy. The tum...
Published: 01 December 2024
HEMORRHAGIC NEUROBLASTOMA Figure 11-7 HEMORRHAGIC NEUROBLASTOMA NB of the left adrenal gland at autopsy. The tumor replaced the entire adrenal gland and invaded the renal parenchyma. Coarse lobulations are seen on cross section, with bulging nodules showing irregular areas of hemorrhage. The tumo... More about this image found in HEMORRHAGIC NEUROBLASTOMA NB of the left adrenal gland at autopsy. The tum...
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GALLIUM 68-DOTATATE POSITRON EMISSION TOMOGRAPHY (PET/CT) SCAN  Coronal (A)...
Published: 01 December 2024
GALLIUM 68-DOTATATE POSITRON EMISSION TOMOGRAPHY (PET/CT) SCAN Figure 8-4 GALLIUM 68-DOTATATE POSITRON EMISSION TOMOGRAPHY (PET/CT) SCAN Coronal (A), horizontal (B), and sagittal (C) views. A markedly 68Ga-DOTATATE avid large right suprarenal mass likely invading the liver has metastasized to the pleura, celiac axis lymph node, and multiple skeletal sites. (Courtesy of Dr. S. Ezzat, Toronto, Canada) More about this image found in GALLIUM 68-DOTATATE POSITRON EMISSION TOMOGRAPHY (PET/CT) SCAN Coronal (A)...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
.... PLoS One 2017;12:e0185190.) Metastatic locations of NBL and GNBL have a wide range, but are frequently seen in bone marrow, bone, lymph nodes, and liver ( figs. 11-4 , 11-5 ). Multiple skin manifestations of NBL may result in the clinical picture of a “blueberry muffin baby.” Less frequent locations...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... to the pleura, celiac axis lymph node, and multiple skeletal sites. (Courtesy of Dr. S. Ezzat, Toronto, Canada) Currently, the major imaging agent is gallium 68-DOTATATE, in which a chelating agent (DOTA, [dodecanetetraacetic acid]) binds the radioisotope 68Ga and is also linked to the somatostatin...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS Figure 9-3 NORMAL ABDOMINAL PARAGANGLIA IN AN EARLY SECOND TRIMESTER STILLBORN FETUS A: Normal paraganglia (arrows) in close proximity to lymph nodes. In a patient with a hereditary paraganglioma syndrome, this anatomic relationship makes...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... at the time of diagnosis. Common sites of metastasis are lung, liver, and lymph nodes, and less frequently, bone ( 39 ). Systemic symptoms also may be present ( 40 ), including prominent weight loss, intermittent low-grade fever (possibly related to extensive tumor necrosis), and anorexia. Hypoglycemia...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... are much more common. The adrenal glands are reported to be the fifth most common anatomic site involved by metastases overall, surpassed only by lymph nodes, lung, liver, and bone ( 92 ). In an autopsy study of 1,000 carcinomas, the adrenal glands were secondarily involved in 27 percent of cases ( 93...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...) or 18F-DOPA PET/CT. Imaging allows the identification of multifocal disease ( fig. 10-1 ) and may be the initial clue to the diagnosis of a hereditary disorder. The distribution of paraganglia is similar to that of para-aortic lymph nodes, and multifocal paragangliomas are sometimes confused...
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EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS  <span class="search-highlight">Lymph</span> node with architectural dist...
Published: 01 September 2024
EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Figure 8-8 EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Lymph node with architectural distortion (A) with focal capsular permeation by lymphoid cells (top), a polymorphic mononuclear infiltrate (B) with associated plasma cells (C) and focal mitotic activity (cen... More about this image found in EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Lymph node with architectural dist...
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MULTICENTRIC CASTLEMAN DISEASE AND KAPOSI SARCOMA  <span class="search-highlight">Lymph</span> node in patient wi...
Published: 01 September 2024
MULTICENTRIC CASTLEMAN DISEASE AND KAPOSI SARCOMA Figure 8-24 MULTICENTRIC CASTLEMAN DISEASE AND KAPOSI SARCOMA Lymph node in patient with HIV where there is HHV8-associated Kaposi sarcoma (A) and Castleman disease (B). More about this image found in MULTICENTRIC CASTLEMAN DISEASE AND KAPOSI SARCOMA Lymph node in patient wi...
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PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL)  A: The <span class="search-highlight">lymph</span> node has irregul...
Published: 01 September 2024
PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL) Figure 9-2 PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL) A: The lymph node has irregularly shaped reactive follicles. B: PGL lymph node follicle in center with macrophage phagocytosis and apoptotic debris. C: HIVp24 stains HIV virus in follicular dend... More about this image found in PERSISTENT GENERALIZED LYMPHADENOPATHY (PGL) A: The lymph node has irregul...
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MESENTERIC <span class="search-highlight">LYMPH</span> NODE INFECTION BY <em>Y. PSEUDOTUBERCULOSIS</em>  ...
Published: 01 September 2024
MESENTERIC LYMPH NODE INFECTION BY Y. PSEUDOTUBERCULOSIS Figure 13-13 MESENTERIC LYMPH NODE INFECTION BY Y. PSEUDOTUBERCULOSIS A–C: There is a mixture of granulomatous and suppurative inflammation, the latter often identified centrally in the granulomatous foci. More about this image found in MESENTERIC LYMPH NODE INFECTION BY Y. PSEUDOTUBERCULOSIS ...
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WHIPPLE DISEASE  A,B: Mesenteric <span class="search-highlight">lymph</span> node with foamy macrophage infiltrat...
Published: 01 September 2024
WHIPPLE DISEASE Figure 13-38 WHIPPLE DISEASE A,B: Mesenteric lymph node with foamy macrophage infiltration and isolated small granulomas. More about this image found in WHIPPLE DISEASE A,B: Mesenteric lymph node with foamy macrophage infiltrat...