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Images
Published: 01 March 2023
SURVIVAL WITH PANCREATOBLASTOMA Figure 10-17 SURVIVAL WITH PANCREATOBLASTOMA More than half of patients experience long-term survival in the pediatric age group. (Courtesy of Dr. N. N. Shukla, New York, NY) More
Images
Published: 01 March 2023
LEIOMYOSARCOMA Figure 13-29 LEIOMYOSARCOMA Left: Long fascicles of spindle cells with blunt-ended nuclei and eosinophilic cytoplasm without perinuclear vacuoles help to distinguish this neoplasm from a GIST. Right: The neoplastic cells have dense eosinophilic cytoplasm and myxoid changes are pre... More
Images
Published: 01 March 2023
INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM WITH ASSOCIATED TUBULAR-TYPE INVASIVE CARCINOMA Figure 6-12 INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM WITH ASSOCIATED TUBULAR-TYPE INVASIVE CARCINOMA A dilated branch duct (long black arrow) contains intraductal papillary tumor tissue and shows accompanying i... More
Images
Published: 01 March 2023
ANATOMIC VARIATIONS IN THE UNION OF THE COMMON BILE DUCT AND THE MAIN PANCREATIC DUCT AT THE MAJOR PAPILLA Figure 1-4 ANATOMIC VARIATIONS IN THE UNION OF THE COMMON BILE DUCT AND THE MAIN PANCREATIC DUCT AT THE MAJOR PAPILLA A: Early fusion with a long common channel of 3 mm or more. B: Late fus... More
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-14
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... metastasize to the pancreas after exceptionally long latency (up to 20, 19, 18, and 23 years, respectively) ( 13 – 16 ). A good clinical history is important when considering the diagnosis of a metastasis to the pancreas. Neoplasms originating outside the pancreas may secondarily involve the pancreas through...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-16
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
.... At this point, the bile duct is opened along the posterior surface of the gland using scissors. Calculi and bile duct strictures should be documented, and, when present, may help identify subtle neoplasms. The pancreatic parenchyma is then sectioned in a bread loaf fashion using a sharp knife or long blade at 2...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-06
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... MUCINOUS NEOPLASM WITH ASSOCIATED TUBULAR-TYPE INVASIVE CARCINOMA Figure 6-12 INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM WITH ASSOCIATED TUBULAR-TYPE INVASIVE CARCINOMA A dilated branch duct (long black arrow) contains intraductal papillary tumor tissue and shows accompanying invasive carcinoma...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-12
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... in 1958. PanNETs have long been recognized to differ histologically and clinically from other types of pancreatic neoplasms. As the genomic features of neoplasms of the pancreas were described, it became clear that PanNETs were genetically distinct, since they usually lacked mutations in the most common...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-01
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... of signaling pathways involved in development and cancer ( 78 ). ANATOMY The long, tapered, mature pancreas is 14 to 20 cm long and has uniform lobularity. The adult organ weighs on average 100 g; the male pancreas is slightly heavier than the female. The pancreas increases in size until a plateau is reached...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... Americans; established risk factors include cigarette smoking, obesity, and long-term diabetes mellitus ( 22 ). Age is a significant risk factor for pancreatic cancer ( 6 , 23 ). The median age at diagnosis is 70 years, and the majority (80 percent) of patients are diagnosed between the ages of 60 and 80...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-11
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... extension into adjacent structures ( 23 , 53 , 207 ). Resection of liver metastases and even liver transplantation have been performed and may be associated with long-term survival ( 20 , 208 – 212 ), although survival for years in the presence of unresected hepatic metastases is also observed. There have...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-10
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... For pancreatoblastomas presenting with limited (organ-confined) disease, surgical resection represents the best chance for cure, especially in pediatric cases where complete resection is associated with significant long-term survival ( 19 , 79 ). Favorable responses to chemotherapy, with or without radiation, have been...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-05
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
.... The epithelioid luteinized stroma cells label for inhibin (C). ULTRASTRUCTURAL FINDINGS The columnar epithelial cells are attached to each other by junctional complexes; they contain abundant apical mucin vacuoles and have short and long microvilli on their apical surfaces ( fig. 5-22 , left) ( 22...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-13
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
.... A longitudinal study has shown pancreatic lipomas are stable in size and morphology. Short-term observation may be prudent to detect early liposarcoma; however, long-term follow-up is likely not necessary ( 57 ). Perineurioma. Perineurioma, originally described by Lazarus in 1978 as a neoplasm arising...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-08
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... with infiltrating ductal adenocarcinomas ( 32 ). Some, but not all, of the improved survival associated with colloid carcinomas is lost, however, when one controls for stage, but long-term survival has been noted even in cases with lymph node metastases ( 32 , 33 ). One patient developed pseudomyxoma peritonei...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-15
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... characterized by long-lasting inflammatory injury to the pancreas with irreversible replacement of the acinar tissue by fibrosis that ultimately also affects the ducts and the islets of Langerhans ( 3 , 4 ). Epidemiology and Etiology. Clinically evident chronic pancreatitis affects approximately 3 to 4 per...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-09
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... and for patients with advanced (blue line) disease is 19.6 months ( 39 ). It has been suggested that pediatric patients with acinar cell carcinomas may have a better prognosis than adults ( 2 ). Experience with this neoplasm in childhood is limited, but long-term survival and cure of pediatric patients has been...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI:
10.55418/9781933477268-4
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... . Gynecol Oncol 2015 ; 139 : 377 - 84 . 27. Rome RM , England PG . Management of vaginal intraepithelial neoplasia: a series of 132 cases with long-term follow-up . Int J Gynecol Cancer 2000 ; 10 : 382 - 90 . 28. Aho M , Vesterinen E , Meyer B , Purola E...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI:
10.55418/9781933477268-5
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... , Berkhof J , Bleeker MC . Vulvar intraepithelial neoplasia: incidence and long-term risk of vulvar squamous cell carcinoma . Int J Cancer 2021 ; 148 : 90 – 8 . 58a. Parra-Herran C , Nucci MR , Singh N , et al HPV-independent, p53-wild-type vulvar intraepithelial...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
DOI:
10.55418/9781933477268-3
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... perpendicular to the long axis It is acceptable to put more than one slice of node into a single block Cut pairs of sections at 200-µm intervals through the block and stain one section at each interval with H&E. The 200-µm (0.2 mm) interval should ensure that most micrometastases are identified...
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