MOLLUSCUM CONTAGIOSUM Figure 6-12 MOLLUSCUM CONTAGIOSUM Endophytic lobules of hyperplastic epidermis are in the upper dermis (A). There are prominent intracytoplasmic molluscum inclusions (shown at high power in B), with peripheral displacement of the epithelial nucleus. The inclusions typically ... More about this image found in MOLLUSCUM CONTAGIOSUM Endophytic lobules of hyperplastic epidermis are in ...

SEVERE YELLOW FEVER Figure 5-11 SEVERE YELLOW FEVER A,B: The liver shows extensive confluent zonal necrosis, which begins in the lobule midzone. (Courtesy of the CDC Infectious Disease Pathology Branch [IDPB]) More about this image found in SEVERE YELLOW FEVER A,B: The liver shows extensive confluent zonal necrosi...

PLEOMORPHIC LOBULAR CARCINOMA IN SITU AND MICROINVASIVE CARCINOMA Figure 4-18 PLEOMORPHIC LOBULAR CARCINOMA IN SITU AND MICROINVASIVE CARCINOMA A lobule is expanded by atypical, dyshesive epithelial cells with large pleomorphic nuclei. Present in the stroma adjacent to this focus are several scat... More about this image found in PLEOMORPHIC LOBULAR CARCINOMA IN SITU AND MICROINVASIVE CARCINOMA A lobule...

DUCTAL CARCINOMA IN SITU INVOLVING LOBULES Figure 8-29 DUCTAL CARCINOMA IN SITU INVOLVING LOBULES DCIS involving lobules can be a mimic of invasive or microinvasive carcinoma. Observing the lobulocentric arrangement of the tumor cell nests and the presence of a myoepithelial cell layer aid in the... More about this image found in DUCTAL CARCINOMA IN SITU INVOLVING LOBULES DCIS involving lobules can be a...

BREAST LOBULES Figure 1-2 BREAST LOBULES Looser intralobular stroma and denser collagenous inter lobular stroma are seen. More about this image found in BREAST LOBULES Looser intralobular stroma and denser collagenous inter lob...

IMMUNOSTAIN FOR ESTROGEN RECEPTOR (ER) Figure 1-9 IMMUNOSTAIN FOR ESTROGEN RECEPTOR (ER) In normal lobules, the epithelial cells show variable nuclear expression with ER: some cells are negative, others demonstrate weak staining, and still others are strongly positive. More about this image found in IMMUNOSTAIN FOR ESTROGEN RECEPTOR (ER) In normal lobules, the epithelial c...

LACTATING BREAST Figure 1-13 LACTATING BREAST A: In the lactating breast, the lobules expand and have numerous acini. B: The epithelial cells are enlarged, have prominent cytoplasmic vacuolization; there may be hobnailing of the nuclei into lumens of the acini. The myoepithelial cells become att... More about this image found in LACTATING BREAST A: In the lactating breast, the lobules expand and have n...

FIBROADENOMA Figure 5-1 FIBROADENOMA The well-circumscribed, lobulated appearance of the tumor is illustrated grossly. The surface appears to bulge out from the background fibroadipose tissue. There are areas of grooving that correspond to the slit-like ducts characteristic of fibroadenoma. (Cour... More about this image found in FIBROADENOMA The well-circumscribed, lobulated appearance of the tumor is ...

MYXOID FIBROADENOMA Figure 5-16 MYXOID FIBROADENOMA Low- (A) and high- (B) power images of a lobulated fibroadenoma with myxoid stroma and an intracanalicular growth pattern. More about this image found in MYXOID FIBROADENOMA Low- (A) and high- (B) power images of a lobulated fib...

ADENOMYOEPITHELIOMA Figure 7-40 ADENOMYOEPITHELIOMA A: Low-power view shows a lobulated epithelial-myoepithelial proliferation. B,C: At intermediate (B) and high (C) power, the two cell types are readily appreciated, with the epithelial component having more eosinophilic cytoplasm and the myoepi... More about this image found in ADENOMYOEPITHELIOMA A: Low-power view shows a lobulated epithelial-myoepit...

RADIATION EFFECT Figure 2-16 RADIATION EFFECT A: At lower power, an irradiated breast demonstrates atrophic lobules with thickened basement membrane. Hyperchromatic nuclei are apparent in the cells within the lobules even at this power. B: On high power, this lobule has scattered epithelial cell... More about this image found in RADIATION EFFECT A: At lower power, an irradiated breast demonstrates atro...

INVASIVE LOBULAR CARCINOMA Figure 8-32 INVASIVE LOBULAR CARCINOMA Single filing of tumor cells adjacent to a sclerosed lobule. More about this image found in INVASIVE LOBULAR CARCINOMA Single filing of tumor cells adjacent to a scle...

CLEAR CELL CHANGE Figure 1-8 CLEAR CELL CHANGE Low- (A) and high- (B) power images of two examples of clear cell change in lobules. More about this image found in CLEAR CELL CHANGE Low- (A) and high- (B) power images of two examples of c...

PREGNANCY-LIKE HYPERPLASIA Figure 1-7 PREGNANCY-LIKE HYPERPLASIA Cells with clear, vacuolated cytoplasm fill the lobules (A) and in other areas eosinophilic secretions are present in the acini (B). More about this image found in PREGNANCY-LIKE HYPERPLASIA Cells with clear, vacuolated cytoplasm fill the...

INVASIVE LOBULAR CARCINOMA Figure 8-34 INVASIVE LOBULAR CARCINOMA The tumor cells infiltrate around normal ducts and lobules in a “targetoid” pattern; this feature is typical of invasive lobular carcinoma. More about this image found in INVASIVE LOBULAR CARCINOMA The tumor cells infiltrate around normal ducts ...

MICROARCHITECTURE OF NORMAL ADULT FEMALE BREAST TISSUE Figure 1-1 MICROARCHITECTURE OF NORMAL ADULT FEMALE BREAST TISSUE A portion of an extralobular duct (arrow), terminal duct, and lobules, in turn composed of acini, is seen. More about this image found in MICROARCHITECTURE OF NORMAL ADULT FEMALE BREAST TISSUE A portion of an ext...

PHYLLODES TUMOR Figure 5-21 PHYLLODES TUMOR The cut surface of this benign phyllodes tumor demonstrates a well-circumscribed, lobulated tumor. The tumor appears to bulge forth and there are grooves in the cut surface that correspond to the elongated ducts and slit-like spaces seen on microscopic ... More about this image found in PHYLLODES TUMOR The cut surface of this benign phyllodes tumor demonstrate...