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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-04
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...Atypical lobular hyperplasia and lobular carcinoma in situ are collectively referred to as lobular neoplasia. However, for reasons discussed in this chapter, when rendering diagnoses and managing patients, it is preferable to separate atypical lobular hyperplasia from lobular carcinoma in situ...
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INVASIVE <span class="search-highlight">LOBULAR</span> CARCINOMA  A: At low power, invasive <span class="search-highlight">lobular</span> carcinoma wit...
Published: 01 January 2024
INVASIVE LOBULAR CARCINOMA Figure 8-35 INVASIVE LOBULAR CARCINOMA A: At low power, invasive lobular carcinoma with low nuclear grade can resemble chronic inflammation. B: Higher-power examination reveals the epithelial nature of the cells as well as the characteristic cytologic features. More about this image found in INVASIVE LOBULAR CARCINOMA A: At low power, invasive lobular carcinoma wit...
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<span class="search-highlight">LOBULAR</span> CARCINOMA IN SITU INVOLVING SCLEROSING ADENOSIS  A: This low-power ...
Published: 01 January 2024
LOBULAR CARCINOMA IN SITU INVOLVING SCLEROSING ADENOSIS Figure 6-7 LOBULAR CARCINOMA IN SITU INVOLVING SCLEROSING ADENOSIS A: This low-power image shows a concentric linear array of atypical epithelial cells, along with some nests at the left of the field. B: On high power, the lobular phenotype... More about this image found in LOBULAR CARCINOMA IN SITU INVOLVING SCLEROSING ADENOSIS A: This low-power ...
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INVASIVE CARCINOMA WITH DUCTAL AND <span class="search-highlight">LOBULAR</span> FEATURES  Some invasive carcinom...
Published: 01 January 2024
INVASIVE CARCINOMA WITH DUCTAL AND LOBULAR FEATURES Figure 8-19 INVASIVE CARCINOMA WITH DUCTAL AND LOBULAR FEATURES Some invasive carcinomas demonstrate a combination of well-formed glands and tumor cells that infiltrate in single files with some cytologic features of lobular differentiation (e.g... More about this image found in INVASIVE CARCINOMA WITH DUCTAL AND LOBULAR FEATURES Some invasive carcinom...
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<span class="search-highlight">LOBULAR</span> CARCINOMA IN SITU WITH NECROSIS  A: This core needle biopsy was per...
Published: 01 January 2024
LOBULAR CARCINOMA IN SITU WITH NECROSIS Figure 4-19 LOBULAR CARCINOMA IN SITU WITH NECROSIS A: This core needle biopsy was performed because of mammographically detected microcalcifications. The hematoxylin and eosin (H&E) image depicts acini greatly expanded by an atypical epithelial prolife... More about this image found in LOBULAR CARCINOMA IN SITU WITH NECROSIS A: This core needle biopsy was per...
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INVASIVE <span class="search-highlight">LOBULAR</span> CARCINOMA  The tumor cells infiltrate around normal ducts ...
Published: 01 January 2024
INVASIVE LOBULAR CARCINOMA Figure 8-34 INVASIVE LOBULAR CARCINOMA The tumor cells infiltrate around normal ducts and lobules in a “targetoid” pattern; this feature is typical of invasive lobular carcinoma. More about this image found in INVASIVE LOBULAR CARCINOMA The tumor cells infiltrate around normal ducts ...
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INVASIVE <span class="search-highlight">LOBULAR</span> CARCINOMA, PLEOMORPHIC TYPE  The nuclei are large, and var...
Published: 01 January 2024
INVASIVE LOBULAR CARCINOMA, PLEOMORPHIC TYPE Figure 8-38 INVASIVE LOBULAR CARCINOMA, PLEOMORPHIC TYPE The nuclei are large, and vary considerably in size and shape, sufficient for a diagnosis of pleomorphic lobular carcinoma. More about this image found in INVASIVE LOBULAR CARCINOMA, PLEOMORPHIC TYPE The nuclei are large, and var...
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<span class="search-highlight">LOBULAR</span> INVOLUTION IN POSTMENOPAUSAL BREAST  A few scattered atrophic acini...
Published: 01 January 2024
LOBULAR INVOLUTION IN POSTMENOPAUSAL BREAST Figure 1-14 LOBULAR INVOLUTION IN POSTMENOPAUSAL BREAST A few scattered atrophic acini are dispersed in either fibrotic (A) or fatty stroma (B). More about this image found in LOBULAR INVOLUTION IN POSTMENOPAUSAL BREAST A few scattered atrophic acini...
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SECRETORY CHANGE  A: Low power shows a terminal duct <span class="search-highlight">lobular</span> unit with secr...
Published: 01 January 2024
SECRETORY CHANGE Figure 2-24 SECRETORY CHANGE A: Low power shows a terminal duct lobular unit with secretory change, flocculent luminal secretions, and calcifications. B: High power demonstrates the abundant vacuolated cytoplasm and protuberant nuclei characteristic of this entity. More about this image found in SECRETORY CHANGE A: Low power shows a terminal duct lobular unit with secr...
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FLAT EPITHELIAL ATYPIA AND ATYPICAL <span class="search-highlight">LOBULAR</span> HYPERPLASIA  In the center of t...
Published: 01 January 2024
FLAT EPITHELIAL ATYPIA AND ATYPICAL LOBULAR HYPERPLASIA Figure 3-5 FLAT EPITHELIAL ATYPIA AND ATYPICAL LOBULAR HYPERPLASIA In the center of the image is a single acinus lined by cells with low-grade cytologic atypia, i.e., FEA. Surrounding this space are lobules filled with, but not distended by,... More about this image found in FLAT EPITHELIAL ATYPIA AND ATYPICAL LOBULAR HYPERPLASIA In the center of t...
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COLLAGENOUS SPHERULOSIS WITH <span class="search-highlight">LOBULAR</span> CARCINOMA IN SITU (LCIS), CLASSIC TYPE...
Published: 01 January 2024
COLLAGENOUS SPHERULOSIS WITH LOBULAR CARCINOMA IN SITU (LCIS), CLASSIC TYPE MIMICKING ADH AND LOW NUCLEAR GRADE DCIS Figure 3-21 COLLAGENOUS SPHERULOSIS WITH LOBULAR CARCINOMA IN SITU (LCIS), CLASSIC TYPE MIMICKING ADH AND LOW NUCLEAR GRADE DCIS A: At scanning magnification, the TDLU appears expa... More about this image found in COLLAGENOUS SPHERULOSIS WITH LOBULAR CARCINOMA IN SITU (LCIS), CLASSIC TYPE...
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DUCTAL CARCINOMA IN SITU: INTERMEDIATE NUCLEAR GRADE  <span class="search-highlight">Lobular</span> involvement b...
Published: 01 January 2024
DUCTAL CARCINOMA IN SITU: INTERMEDIATE NUCLEAR GRADE Figure 3-26 DUCTAL CARCINOMA IN SITU: INTERMEDIATE NUCLEAR GRADE Lobular involvement by DCIS. More about this image found in DUCTAL CARCINOMA IN SITU: INTERMEDIATE NUCLEAR GRADE Lobular involvement b...
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<span class="search-highlight">LOBULAR</span> CARCINOMA IN SITU (LCIS)  A: A lower-power view demonstrates termin...
Published: 01 January 2024
LOBULAR CARCINOMA IN SITU (LCIS) Figure 4-1 LOBULAR CARCINOMA IN SITU (LCIS) A: A lower-power view demonstrates terminal duct lobular units (TDLUs) expanded by a monomorphic proliferation of cells; some dyshesion is apparent and intracytoplasmic vacuoles are present. B: High power better demonst... More about this image found in LOBULAR CARCINOMA IN SITU (LCIS) A: A lower-power view demonstrates termin...
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<span class="search-highlight">LOBULAR</span> CARCINOMA IN SITU  A: At low power, several acini and a duct are ex...
Published: 01 January 2024
LOBULAR CARCINOMA IN SITU Figure 4-2 LOBULAR CARCINOMA IN SITU A: At low power, several acini and a duct are expanded by a monomorphic proliferation of dyshesive cells. B: High power reveals the cytologic monotony and intracytoplasmic vacuoles characteristic of LCIS. More about this image found in LOBULAR CARCINOMA IN SITU A: At low power, several acini and a duct are ex...
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<span class="search-highlight">LOBULAR</span> CARCINOMA IN SITU: TYPE A  The LCIS cells in these acini are loosel...
Published: 01 January 2024
LOBULAR CARCINOMA IN SITU: TYPE A Figure 4-3 LOBULAR CARCINOMA IN SITU: TYPE A The LCIS cells in these acini are loosely cohesive and have small, round, even nuclei. More about this image found in LOBULAR CARCINOMA IN SITU: TYPE A The LCIS cells in these acini are loosel...
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<span class="search-highlight">LOBULAR</span> CARCINOMA IN SITU: TYPE B  In contrast to the prior case, this exam...
Published: 01 January 2024
LOBULAR CARCINOMA IN SITU: TYPE B Figure 4-4 LOBULAR CARCINOMA IN SITU: TYPE B In contrast to the prior case, this example demonstrates greater variability in nuclear size and shape. More about this image found in LOBULAR CARCINOMA IN SITU: TYPE B In contrast to the prior case, this exam...
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<span class="search-highlight">LOBULAR</span> CARCINOMA IN SITU: PAGETOID GROWTH PATTERN  One characteristic feat...
Published: 01 January 2024
LOBULAR CARCINOMA IN SITU: PAGETOID GROWTH PATTERN Figure 4-5 LOBULAR CARCINOMA IN SITU: PAGETOID GROWTH PATTERN One characteristic feature of LCIS is the presence of cells under the ductal epithelium, which in turn becomes attenuated, as in this example. More about this image found in LOBULAR CARCINOMA IN SITU: PAGETOID GROWTH PATTERN One characteristic feat...
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<span class="search-highlight">LOBULAR</span> CARCINOMA IN SITU INVOLVING A DUCT  Occasionally, LCIS confers an i...
Published: 01 January 2024
LOBULAR CARCINOMA IN SITU INVOLVING A DUCT Figure 4-6 LOBULAR CARCINOMA IN SITU INVOLVING A DUCT Occasionally, LCIS confers an irregular or “cloverleaf” contour to the involved duct. Note also the pagetoid growth pattern under the attenuated normal ductal epithelial cell layer. More about this image found in LOBULAR CARCINOMA IN SITU INVOLVING A DUCT Occasionally, LCIS confers an i...
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<span class="search-highlight">LOBULAR</span> CARCINOMA IN SITU WITH ADMIXED MYOEPITHELIAL CELLS  In this interme...
Published: 01 January 2024
LOBULAR CARCINOMA IN SITU WITH ADMIXED MYOEPITHELIAL CELLS Figure 4-7 LOBULAR CARCINOMA IN SITU WITH ADMIXED MYOEPITHELIAL CELLS In this intermediate-power image of a duct involved by LCIS, admixed myoepithelial cells, recognized by their dark, spindle-shaped nuclei, percolate between the atypica... More about this image found in LOBULAR CARCINOMA IN SITU WITH ADMIXED MYOEPITHELIAL CELLS In this interme...
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<span class="search-highlight">LOBULAR</span> CARCINOMA IN SITU AND ATYPICAL DUCTAL HYPERPLASIA (ADH)  Not infreq...
Published: 01 January 2024
LOBULAR CARCINOMA IN SITU AND ATYPICAL DUCTAL HYPERPLASIA (ADH) Figure 4-8 LOBULAR CARCINOMA IN SITU AND ATYPICAL DUCTAL HYPERPLASIA (ADH) Not infrequently lobular neoplasia (LCIS or ALH) coexists with other lesions in the low-grade breast neoplasia family, as in this example of ADH and LCIS. In ... More about this image found in LOBULAR CARCINOMA IN SITU AND ATYPICAL DUCTAL HYPERPLASIA (ADH) Not infreq...