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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-4
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... regions of the ovaries and testes, along the course of the spermatic cord, and within inguinal hernia sacs ( 140 , 141 , 144 ). Rare sites of accessory adrenal tissue include pancreas, spleen, liver, mesentery, lung, and brain ( 140 , 145 ). Adrenal rests within the spermatic cord...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-1
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... hormone secretion. Insulin-like growth factor 1 (IGF-1), or somatonectin C, which is produced by the liver, mediates many of the effects of GH. IGF-1 exerts a negative feedback effect on GH secretion at the hypothalamic and pituitary levels. Lactotroph (PRL) Cells Lactotroph cells (mammotrophs...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-3
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... involved in glycogen synthesis, degradation, and regulation. Those disorders that result in abnormal storage of glycogen are known as glycogen storage diseases. The liver and skeletal muscle are most affected by glycogen storage diseases. Involvement of the thyroid gland has been reported in a few...
Images
TERATOMA, POSTPUBERTAL TYPE  <span class="search-highlight">Liver</span>-like differentiation with macrovesicular...
Published: 01 August 2022
TERATOMA, POSTPUBERTAL TYPE Figure 4-171 TERATOMA, POSTPUBERTAL TYPE Liver-like differentiation with macrovesicular fatty change is seen in this tumor. A small bile duct is present (upper right). More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-10
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
...-differentiated neuroendocrine tumor/carcinoid tumor) ( 14 ), salivary gland (adenoid cystic carcinoma) ( 1 ), ureter ( 1 ), penis ( 11 ), skin (Merkel cell carcinoma) ( fig. 10-14 ) ( 15 ), liver (hepatocellular carcinoma) ( 16 ), pulmonary carcinoid tumor ( fig. 10-15 ), and thyroid gland (medullary carcinoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-01
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... cell carcinomas of the lung, renal cell carcinomas, and carcinomas of the gallbladder ( 44 – 59 ). Non-neoplastic liver disease may also cause AFP elevation. Among the germ cell tumors, however, elevation strongly correlates with the presence of yolk sac tumor elements ( 60 ). Elevated serum hCG levels...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-03
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... or extra-abdominal involvement; 2. Lymph nodes ≥2 cm or lymph nodes >1 cm but <2 cm on short axis by multiplanar imaging CT b that fail to resolve on re-imaging at 4–6 weeks. IV 1. Distant metastases, including liver, lung, bone, and brain. a Table 3 from Childhood...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-04
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... of the testis, it is highly likely that the patient has a histologically undetected nonseminomatous element, perhaps in metastases. Modest AFP elevations may reflect liver disease, including metastatic involvement ( 184 ), and have also been found, rarely, in patients with pure seminomas of the testis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-06
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... commonly to regional lymph nodes (35 percent), liver (24 percent), lung (23 percent), bone (10 percent), and inguinal lymph nodes (8 percent) ( 75 ). Up to 32 percent of the patients with clinically malignant tumors have metastases at the time of diagnosis ( 75 , 81 ). The treatment of a Leydig cell tumor...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-05
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... carcinoid” or low-grade neuroendocrine carcinoma, see Prognosis) ( 63 ). When metastases do occur they are mostly in a hematogenous distribution, involving liver, lung, bone, soft tissue, skin, heart, and contralateral testis, although lymph node involvement is also seen ( 69 ). Clinical Features. In up...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-08
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... commonly involved are lung/pleura and liver ( 115a ). Peritoneal implants are also relatively frequent. Treatment and Prognosis. Mesothelioma arising in the tunica vaginalis typically pursues an aggressive clinical course, similar to mesotheliomas arising in the pleura, peritoneal cavity, and pericardium...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-11
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... of patients with the continuous form have severe defects of the extremities (peromelia), sometimes associated with micrognathia. Other associated developmental anomalies include anal atresia, abnormal fissures of the lung and liver, and asymmetry of the skull ( 258 ). One patient with 46,XY disorder of sex...
Images
DIFFUSE MESOTHELIOMA: PLEURA  Metastatic tumor nodules are seen on the surf...
Published: 01 June 2022
DIFFUSE MESOTHELIOMA: PLEURA Figure 3-10 DIFFUSE MESOTHELIOMA: PLEURA Metastatic tumor nodules are seen on the surface of the liver at postmortem examination. More
Images
DIFFUSE MESOTHELIOMA:PERITONEUM  A: Mesenteric fat is covered by multiple f...
Published: 01 June 2022
DIFFUSE MESOTHELIOMA:PERITONEUM Figure 3-11 DIFFUSE MESOTHELIOMA:PERITONEUM A: Mesenteric fat is covered by multiple foci of mesothelioma. B: This diffuse tumor encases loops of bowel. C: This tumor appears as multiple small nodules. Note the liver metastases. More
Images
HEMOTHORAX DUE TO IATROGENIC INJURY  Left: Atypical epithelioid cells were ...
Published: 01 June 2022
HEMOTHORAX DUE TO IATROGENIC INJURY Figure 8-14 HEMOTHORAX DUE TO IATROGENIC INJURY Left: Atypical epithelioid cells were seen in a blood-stained pleural effusion, and a cell block was subsequently created. Right: The cell block shows clusters of histologically normal liver parenchyma, presumabl... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Published: 01 June 2022
DOI: 10.55418/9781933477190-4
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
..., and systemic symptoms. Age range is variable: in one series it ranged from 6 to 82 years, with 75 percent in males ( 35 , 36 ). Pleural and peritoneal examples are described, as well as rare examples in the liver ( 35 ), pancreas ( 37 ), and spleen ( 38 ). It may be impossible to distinguish cases from...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Published: 01 June 2022
DOI: 10.55418/9781933477190-6
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
... in children with congenital immunodeficiency ( 16 ) and after therapy with tyrosine kinase inhibitors ( 17 ). Immunosenescence and possibly chronic liver disease are contributing factors ( 18 – 20 ). Gross Findings. PELs are most common in the pleural cavity, followed by peritoneal and pericardial cavities...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Published: 01 June 2022
DOI: 10.55418/9781933477190-1
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
...) in the peritoneum overlying the liver, which is clinically relevant in relation to the spread of endometriosis to the right pleural space ( 1 ). The visceral peritoneum covers the intra-abdominal organs and their mesenteries. The parietal peritoneum lines the abdominal wall, the pelvis, the inferior surface...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Published: 01 June 2022
DOI: 10.55418/9781933477190-7
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
... the diaphragm from abdominal or liver metastasis or from direct extension from the chest wall, as in breast cancer. Pleural effusion occurs when lymphatic or nodal involvement impedes fluid clearance from the space. When malignant cells are found in the fluid, this is termed malignant pleural effusion...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
DOI: 10.55418/9781933477183-1
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
...Table 1-1 CAUSES OF ACUTE LIVER FAILURE Acetaminophen: 40 percent (in USA, Canada, and Europe; less frequent elsewhere) Idiopathic: 30 percent; no definite cause identified after full clinical and histologic evaluation Drug-induced liver injury: 20 percent; includes herbal medications...