Search Results for lineage

...-cell lymphoma, nasal type (ENKTL) is a lymphoma of mature NK-cell or T-cell lineage that is extranodal when it develops in the sinonasal tract. It shows angiocentric destruction and prominent tumor cell necrosis, has a cytotoxic phenotype, and has a near constant association with EBV. It is an NK...

... for LCA, CD20, and other B-lineage antigens with light chain restriction, and negative for keratins and p40. Given the poor prognosis of patients with SNUC, it is important to distinguish an aggressive SNUC involving the sinonasal cavity with extension to the nasopharynx from NPC. SNUC is positive...

... reactions should be interpreted with caution because they can be focal and weak, and non-neoplastic cells may also react ( 744 ). SATB2 can be useful to establish an osteoblastic cellular lineage but not to determine benign from malignant. OSTEOSARCOMA Figure 5-192 OSTEOSARCOMA MDM2 reactivity...

... other lineage-specific markers. Molecular Genetic Findings. Mutations in exon 3 of the CTNBB1 gene are found in 85 to 90 percent of fibromatosis patients ( 187 , 188 ), and 5 percent have mutations in APC. Certain mutations are associated with more aggressive tumors. Sequencing for β...

..., a thorough workup for other conditions is warranted as NSM does not recur ( 254 ). HEMATOLYMPHOID TUMORS Definition. Oral hematopoietic neoplasms are tumors of lymphoid, plasma cell, histiocytic/dendritic, or myeloid lineage arising in the oral cavity. General Features. Lymphomas of the oral...

... ( fig. 6-92 ), inhibin, and SOX10 while negative for cytokeratins, desmin, p63, myogenin, and other specific lineage markers. GRANULAR CELL TUMOR Figure 6-92 GRANULAR CELL TUMOR An S-100 protein immunostain shows the characteristic diffuse, strong cytoplasmic and nuclear staining. Ultrastructural...

... Fibroxanthoma Definition. This dermal-based, low-grade mesenchymal neoplasm lacking any specific lineage of differentiation was initially called atypical fibroxanthoma (AFX) to emphasize the highly pleomorphic appearance of this cutaneous neoplasm ( 180 – 182 ), which generally has a benign clinical...

... concurrently with the formation and enlargement of the paravertebral sympathetic ganglia. The longstanding concept of a single sympathoadrenal precursor that gives rise to either chromaffin cells or sympathetic neurons, depending on its environment, has largely been overturned by new lineage-tracing...

..., or metastases to the adrenal gland from distant sites. There are also a few case reports of both endocrine and nonendocrine tumors potentially related to the adrenal gland developmentally, either by steroidogenic lineage or by proximity to the adrenogenital/gonadal ridge (see chapter 1 ). Non-neoplastic causes...

... progenitor cells ( 9 , 10 ). While these new findings are supported by cell lineage analysis and by single cell RNA sequencing experiments, it has been shown recently that the divergence is not absolute and that Schwann cell precursors appear to be responsible for a small, but relevant, fraction...

... PHEOCHROMOCYTOMA Composite pheochromocytomas are rare tumors composed of pheochromocytoma admixed with other elements including ganglioneuroma, ganglioneuroblastoma, neuroblastoma, or peripheral nerve sheath tumor ( 41 , 44 , 90 – 95 ). These neoplasms are all derived from related embryonic lineages...

... neuroendocrine marker and tyrosine hydroxylase as a functional neuroendocrine marker (see figs. 9-3 , 9-5 , 9-7 ) ( 22 ). Transcription factors have also recently been employed as lineage markers, with INSM1 used to identify all neuroendocrine cells ( 23 ) and GATA3 as a selective, although not entirely...

... as derived from steroidogenic lineage. A granular matrix may be prominent within individual mitochondria. ADRENAL CORTICAL CARCINOMA: ULTRASTRUCTURE Figure 6-29 ADRENAL CORTICAL CARCINOMA: ULTRASTRUCTURE A: Tumor cells contain sparse lipid droplets; some have small, irregular microvillous extensions...

... are facultative intracellular, fastidious, pleomorphic gram-negative bacilli that are capable of persisting in erythrocytes and cause a variety of human and animal diseases ( 1 ). Bartonella spp is divided into lineages: B. bacilliformis is the most primitive and only infects humans; B...

... of the CDC IDPB) REFERENCES REFERENCES 1. Kissling   R , Murphy   F , Henderson   B . Marburg virus . Ann NY Acad Sci   1970 ; 174 : 932 - 45 . 2. Bausch   DG , Nichol   ST , Muyembe-Tamfum   JJ , et al . Marburg hemorrhagic fever associated with multiple genetic lineages...

...   JDD . Global Extraintestinal Pathogenic Escherichia coli (ExPEC) lineages . Clin Microbiol Rev   2019 ; 32 : e00135 - 18 . 32. MacFie   J , O’Boyle   C , Mitchell   CJ , Buckley   PM , Johnstone   D , Sudworth   P . Gut origin of sepsis: a prospective study investigating...

... the associated CBN is important for the diagnosis of melanoma ex CBN ( 45 – 47 ). In the setting of a CBN-like melanoma with no definite recognizable associated benign CBN component, molecular studies may attest to the blue tumor lineage. A BN with epithelioid cells may be associated with an ordinary acquired...

... specimens of metastatic and matched primary tumors . Appl Immunohistochem Mol Morphol   2016 ; 24 : 229 - 37 . 15. Boecker   W , Buerger   H . Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem...