VAGAL PARAGANGLIOMA Figure 9-16 VAGAL PARAGANGLIOMA A: The prominent blood vessels and a pericyte-like arrangement of tumor cells may suggest a vascular tumor in the differential diagnosis. B: A different area of the same tumor shows a solid growth pattern with prominent perivascular pseudoroset... More about this image found in VAGAL PARAGANGLIOMA A: The prominent blood vessels and a pericyte-like arr...

PRIMARY ADRENAL ADENOMATOID TUMOR Figure 12-14 PRIMARY ADRENAL ADENOMATOID TUMOR A: Numerous small gland-like spaces transition into cysts with a flattened lining. At top left, the tumor insinuates between and envelops small nests of adrenal cortical cells. B: Higher magnification of a more soli... More about this image found in PRIMARY ADRENAL ADENOMATOID TUMOR A: Numerous small gland-like spaces tran...

PRIMARY ADRENAL ADENOMATOID TUMOR Figure 12-14 PRIMARY ADRENAL ADENOMATOID TUMOR A: Numerous small gland-like spaces transition into cysts with a flattened lining. At top left, the tumor insinuates between and envelops small nests of adrenal cortical cells. B: Higher magnification of a more soli... More about this image found in PRIMARY ADRENAL ADENOMATOID TUMOR A: Numerous small gland-like spaces tran...

RETICULIN STAIN Figure 1-31 RETICULIN STAIN Reticulin stain highlights the columns of the zona fasciculata (right), net-like arrangement of the zona reticularis, and nests (“Zellballen”) of chromaffin cells in the adrenal medulla. More about this image found in RETICULIN STAIN Reticulin stain highlights the columns of the zona fascicu...

GANGLIONEUROMA Figure 11-42 GANGLIONEUROMA A: This tumor contained a few small ganglia. A small myelinated nerve is present at one pole of a ganglion. The ganglion is probably incorporated secondarily in the tumor. B: A large bundle of myelinated nerve is present in this GN and is most likely se... More about this image found in GANGLIONEUROMA A: This tumor contained a few small ganglia. A small myelin...

PHEOCHROMOCYTOMA: CYSTIC DEGENERATION Figure 8-9 PHEOCHROMOCYTOMA: CYSTIC DEGENERATION The large cyst at bottom of this 15-cm tumor most likely results from old hemorrhage or infarction and contains only thin blood-tinged fluid. The small cyst to its right contains degenerating blood. More about this image found in PHEOCHROMOCYTOMA: CYSTIC DEGENERATION The large cyst at bottom of this 15-...

ADRENAL HEMANGIOMA Figure 12-8 ADRENAL HEMANGIOMA The well-developed features of anastomosing adrenal hemangioma include a prominent frame work of non endothelial supporting cells creating a “spleen-like” pattern of vascular channels lined by hobnail endothelial cells and containing occasional fi... More about this image found in ADRENAL HEMANGIOMA The well-developed features of anastomosing adrenal hem...

ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Figure 5-47 ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA A: The tumor cells have much smooth endoplasmic reticulum and a few lipid droplets, which vary in size. Microvillous cytoplasmic extensions are evident along the cell borders. Mitochondria ha... More about this image found in ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA A: The tumor cells have muc...

GALLIUM 68-DOTATATE POSITRON EMISSION TOMOGRAPHY (PET/CT) SCAN Figure 8-4 GALLIUM 68-DOTATATE POSITRON EMISSION TOMOGRAPHY (PET/CT) SCAN Coronal (A), horizontal (B), and sagittal (C) views. A markedly ⁶⁸Ga-DOTATATE avid large right suprarenal mass likely invading the liver has metastasized to the pleura, celiac axis lymph node, and multiple skeletal sites. (Courtesy of Dr. S. Ezzat, Toronto, Canada) More about this image found in GALLIUM 68-DOTATATE POSITRON EMISSION TOMOGRAPHY (PET/CT) SCAN Coronal (A)...

KAPOSI SARCOMA EXTENSIVELY INVOLVING ADRENAL GLAND Figure 12-29 KAPOSI SARCOMA EXTENSIVELY INVOLVING ADRENAL GLAND A: Kaposi sarcoma involving the adrenal gland in an adult male with acquired immunodeficiency syndrome (AIDS). The tumor obscures much of normal histology and architecture of the gla... More about this image found in KAPOSI SARCOMA EXTENSIVELY INVOLVING ADRENAL GLAND A: Kaposi sarcoma invol...

ZONATION OF ADULT ADRENAL GLAND Figure 1-29 ZONATION OF ADULT ADRENAL GLAND An indistinct, discontinuous zona glomerulosa beneath the adrenal capsule has a ball-like arrangement of cells, with less abundant lipid-rich cytoplasm than cells of the zona fasciculata. Radial cords of zona fasciculata ... More about this image found in ZONATION OF ADULT ADRENAL GLAND An indistinct, discontinuous zona glomerul...

NORMAL PERITHYROIDAL PARAGANGLION Figure 9-10 NORMAL PERITHYROIDAL PARAGANGLION A: This paraganglion, discovered incidentally in peri-thyroidal soft tissue in an adult patient with a multinodular goiter, is architecturally similar to the carotid body in figure 9-7 . The intimate association of n... More about this image found in NORMAL PERITHYROIDAL PARAGANGLION A: This paraganglion, discovered inciden...

MEDIAL ASPECT OF DEVELOPING ADRENAL GLAND IN HUMAN FETUS Figure 1-9 MEDIAL ASPECT OF DEVELOPING ADRENAL GLAND IN HUMAN FETUS Coronal section of fetal adrenal gland shows close association with developing sympathetic plexus (on far left). Small nests of primitive sympathetic cells (white arrows) a... More about this image found in MEDIAL ASPECT OF DEVELOPING ADRENAL GLAND IN HUMAN FETUS Coronal section o...

ABDOMINAL PARAGANGLIA AND ADJACENT DEVELOPING ADRENAL GLAND Figure 9-4 ABDOMINAL PARAGANGLIA AND ADJACENT DEVELOPING ADRENAL GLAND A: Normal paraganglia are fully formed before the adrenal medulla exists. This adrenal gland shows only provisional cortex and a small cluster of primitive adrenal me... More about this image found in ABDOMINAL PARAGANGLIA AND ADJACENT DEVELOPING ADRENAL GLAND A: Normal para...

MESENTERIC PARAGANGLIOMA Figure 9-14 MESENTERIC PARAGANGLIOMA A: This paraganglioma composed of basophilic and clear cells was incidentally discovered in an asymptomatic patient with no other tumors. Fat invasion, poorly defined irregular cell nests, and diffuse growth are putative risk factors f... More about this image found in MESENTERIC PARAGANGLIOMA A: This paraganglioma composed of basophilic and ...

METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA Figure 11-5 METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA A 2-year old girl presented with fever and a painless swelling in the abdomen. Blood and urine cultures were negative and initial ultrasound was suspicious of a renal tumor. After referral to an expert center, clinical examination (slight hypertension), laboratory testing (increased urinary catecholamines), and abdominal MRI imaging showed that a diagnosis of metastatic NB was more likely. The MRI depicted a right-sided adrenal mass with retroperitoneal lymph node metastases. Additional MIBG scintigraphy shows increased uptake in the primary adrenal NB and locoregional lymph nodes (black arrow), but also extensive bone marrow metastases throughout. At the top, is a classic orbital metastasis and at the bottom, a tibial metastasis (red arrows). Histopathology showed an undifferentiated NB, with MYCN amplification, indicative of a high-risk NB patient. (Courtesy of Dr. A. J. Braat, University Medical Center Utrecht, The Netherlands) More about this image found in METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA A...