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FETAL ADRENAL GLAND AND KIDNEY Figure 1-4 FETAL ADRENAL GLAND AND KIDNEY Coronal sections (left and right) of adrenal gland and kidney from a fetus of about 18 weeks’ gestational age. External aspect of one specimen is at bottom. Medullary tissue is not evident macroscopically at this early More about this image found in FETAL ADRENAL GLAND AND KIDNEY Coronal sections (left and right) of adrena...

CUSHING SYNDROME Figure 3-1 CUSHING SYNDROME The clinical features of this disorder (left) can be caused by pituitary adrenocorticotropic hormone (ACTH) excess (top right), ectopic ACTH causing massive adrenal hyperplasia (right middle), or primary adrenal disease (bottom right). (From Netter FH More about this image found in CUSHING SYNDROME The clinical features of this disorder (left) can be caus...

CUSHING DISEASE Figure 3-8 CUSHING DISEASE Histology of left (upper panels) and right (lower panels) adrenal glands from a patient with a recurrent ACTH-secreting pituitary tumor (same case as fig. 3-3 ). Both glands show a similar morphologic appearance, with a homogeneous increase of cortical More about this image found in CUSHING DISEASE Histology of left (upper panels) and right (lower panels) ...

ADRENAL CORTICAL CARCINOMA Figure 6-4 ADRENAL CORTICAL CARCINOMA This 19-cm adrenal lesion in the left adrenal gland has marked intratumoral heterogeneity. Upper panels: CT scan. Basal (A, >20 HU); heterogeneous uptake in the venous (B) and arterial (C) phases. Lower panels: MRI scan. T2 More about this image found in ADRENAL CORTICAL CARCINOMA This 19-cm adrenal lesion in the left adrenal g...

COMPUTERIZED TOMOGRAPHY (CT) SCAN Figure 8-1 COMPUTERIZED TOMOGRAPHY (CT) SCAN A pheochromocytoma in the left adrenal gland of an adult measures 5.3 cm and has focal hemorrhage (A: coronal view; B: transverse view). More about this image found in COMPUTERIZED TOMOGRAPHY (CT) SCAN A pheochromocytoma in the left adrenal g...

THYROID GLAND PARAGANGLIOMA Figure 9-34 THYROID GLAND PARAGANGLIOMA Thyroid tissue is present on the left. More about this image found in THYROID GLAND PARAGANGLIOMA Thyroid tissue is present on the left.

HEMORRHAGIC NEUROBLASTOMA Figure 11-7 HEMORRHAGIC NEUROBLASTOMA NB of the left adrenal gland at autopsy. The tumor replaced the entire adrenal gland and invaded the renal parenchyma. Coarse lobulations are seen on cross section, with bulging nodules showing irregular areas of hemorrhage More about this image found in HEMORRHAGIC NEUROBLASTOMA NB of the left adrenal gland at autopsy. The tum...

POST-TREATMENT CHANGE IN NEUROBLASTOMA Figure 11-25 POST-TREATMENT CHANGE IN NEUROBLASTOMA Resection of left adrenal gland in 7-year-old boy with pretreated NB shows limited chemotherapy effect, but frequent lymphocytic infiltrates, in addition to vital tumor tissue with immature stroma More about this image found in POST-TREATMENT CHANGE IN NEUROBLASTOMA Resection of left adrenal gland in ...

DIFFERENTIATING NEUROBLASTOMA Figure 11-29 DIFFERENTIATING NEUROBLASTOMA Left adrenal biopsy of 13-month-old boy shows morphologically heterogeneous tumor with varying ganglion cell differentiation, next to areas with neuroblasts, separated by neuropil. More about this image found in DIFFERENTIATING NEUROBLASTOMA Left adrenal biopsy of 13-month-old boy show...

CAROTID BODY PARAGANGLIOMA Figure 9-12 CAROTID BODY PARAGANGLIOMA The tumor is completely encapsulated and has protruding segments of nerve and artery (top left). The cut surface shows focal cystic degeneration and prominent cavernous blood vessels. A distinct large fleshy nodule is present More about this image found in CAROTID BODY PARAGANGLIOMA The tumor is completely encapsulated and has pr...

GANGLIONEUROBLASTOMA INTERMIXED Figure 11-19 GANGLIONEUROBLASTOMA INTERMIXED This tumor had more than 50 percent of schwannian stroma and may be called stroma rich. A: There is a mixture of mature and immature elements with schwannian stroma to the lower left and upper right. B: Focus More about this image found in GANGLIONEUROBLASTOMA INTERMIXED This tumor had more than 50 percent of sch...

fleshy nodule at lower left in the gross photograph ( fig. 9-12 ) and the adjacent tissue, shows a sharp transition between large irregular cell nests in the nodule and adjacent small nests. C: Reticulin stain highlights different architectural patterns. D: Immunostain for chromogranin More about this image found in CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (sam...

fleshy nodule at lower left in the gross photograph ( fig. 9-12 ) and the adjacent tissue, shows a sharp transition between large irregular cell nests in the nodule and adjacent small nests. C: Reticulin stain highlights different architectural patterns. D: Immunostain for chromogranin More about this image found in CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (sam...

ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Figure 5-18 ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME The tumor is composed of clear (upper right) and compact cells (left). More about this image found in ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME The tumor is composed of clea...

ADRENAL MYELOLIPOMA Figure 12-4 ADRENAL MYELOLIPOMA The tumor consists of tri-lineage hematopoietic cells with a moderate amount of admixed fat. A peripheral rim of normal adrenal cortex is present at left. More about this image found in ADRENAL MYELOLIPOMA The tumor consists of tri-lineage hematopoietic cells ...

RESECTED NEUROBLASTOMA Figure 11-6 RESECTED NEUROBLASTOMA Gross image of sliced resection specimen of NB without previous chemo therapy treatment. Preexistent adrenal gland in left slice and possible calcifications in second slice from the right. More about this image found in RESECTED NEUROBLASTOMA Gross image of sliced resection specimen of NB with...

ETIOLOGY OF NONIATROGENIC ACTH-DEPENDENT CUSHING SYNDROME Figure 3-2 ETIOLOGY OF NONIATROGENIC ACTH-DEPENDENT CUSHING SYNDROME Normal hypothalamic-pituitary-adrenal axis (upper left), pituitary-dependent Cushing disease (upper right), and ectopic ACTH syndrome. More about this image found in ETIOLOGY OF NONIATROGENIC ACTH-DEPENDENT CUSHING SYNDROME Normal hypothala...

CUSHING DISEASE Figure 3-12 CUSHING DISEASE Bilateral adrenal hyperplasia in a patient with ACTH-secreting pituitary tumor. There is mild and micronodular increase in size in the left (A) and right (B) adrenal glands. The right gland also has a macronodule (over 1 cm). More about this image found in CUSHING DISEASE Bilateral adrenal hyperplasia in a patient with ACTH-secre...

NORMAL ADRENAL MEDULLA IN AN ADULT Figure 1-39 NORMAL ADRENAL MEDULLA IN AN ADULT Well-preserved chromaffin cells are arranged in nests and anastomosing short cords. The cells vary in size, with some larger or smaller than the zona reticularis cells at top left. A few cells have moderately More about this image found in NORMAL ADRENAL MEDULLA IN AN ADULT Well-preserved chromaffin cells are arr...

-neoplastic adrenal cortical tissue (top left). More about this image found in BETA-CATENIN IN ADRENAL CORTICAL CARCINOMA Altered nuclear and cytoplasmic...