ACUTE VIRAL HEPATITIS Figure 5-2 ACUTE VIRAL HEPATITIS A: Single cell dropout (spotty necrosis) at left, and more extensive confluent necrosis at top right. Note the dark eosinophilic cytoplasm and pyknotic nuclei of the degenerated liver cells. B,C: Degeneration of large numbers of adjacent hep... More about this image found in ACUTE VIRAL HEPATITIS A: Single cell dropout (spotty necrosis) at left, an...

PNEUMONIC PLAGUE Figure 14-20 PNEUMONIC PLAGUE From left to right, the photomicrographs illustrate the transition of a bubo to septicemic and secondary pneumonic plague, leading to primary pneumonic plague after spread to a second host. (Courtesy of the CDC IDPB) More about this image found in PNEUMONIC PLAGUE From left to right, the photomicrographs illustrate the t...

PITYRIASIS VERSICOLOR Figure 24-46 PITYRIASIS VERSICOLOR Coalescent hyperpigmented chest wall macules (left), are contrasted with multiple hypopigmented macular lesions on the trunk of another patient (right). (Courtesy of Dr. S. Glassman, University of the Witwatersrand, Johannesburg, South Afri... More about this image found in PITYRIASIS VERSICOLOR Coalescent hyperpigmented chest wall macules (left),...

HSIL/LSIL Figure 9-40 HSIL/LSIL A: HSIL with diffuse, strong cytoplasmic and nuclear (“block”) staining for p16, interpreted as a positive result. B: LSIL on the right (short arrow), while the differential diagnosis for the area on the left (long arrow) includes immature squamous metaplasia and ... More about this image found in HSIL/LSIL A: HSIL with diffuse, strong cytoplasmic and nuclear (“block”) s...

ANTHRAX Figure 14-7 ANTHRAX Schematic of Bacillus anthracis virulence factors, with electron micrograph of the bacterium (bottom left). (Courtesy of the CDC PHIL) More about this image found in ANTHRAX Schematic of Bacillus anthracis virulence factors...

KERION Figure 24-36 KERION Medium-power view shows severe endothrix involvement of the hair shaft in the follicle on the left, with an intense and diffuse surrounding dermal inflammatory infiltrate. More about this image found in KERION Medium-power view shows severe endothrix involvement of the hair sh...

SKIN BIOPSY IN PATIENT WITH MENINGOCOCCEMIA Figure 11-10 SKIN BIOPSY IN PATIENT WITH MENINGOCOCCEMIA A: Hematoxylin and eosin (H&E) stain (left) shows leukocytoclastic vasculitis. B: Scant intracellular cocci are seen with immunohistochemistry. (A,B: courtesy of the CDC IDPB) More about this image found in SKIN BIOPSY IN PATIENT WITH MENINGOCOCCEMIA A: Hematoxylin and eosin (H&am...

HUMAN PAPILLOMAVIRUS (HPV) Figure 9-33 HUMAN PAPILLOMAVIRUS (HPV) A: Electron microphotograph of a negative stain (courtesy of the CDC PHIL) and schematic (right) of HPV structure (left). B: Schematic of HPV genome (not to scale). C: Schematic of mechanism of E6- and E7-mediated HPV carcinogene... More about this image found in HUMAN PAPILLOMAVIRUS (HPV) A: Electron microphotograph of a negative stain...

TINEA CAPITIS DUE TO TRICHOPHYTON VIOLACEUM IN AN HIV-INFECTED INDIVIDUAL Figure 24-35 TINEA CAPITIS DUE TO TRICHOPHYTON VIOLACEUM IN AN HIV-INFECTED INDIVIDUAL H&E stain (left) shows an endothrix pattern of hair shaft involvement, with large numbers of arthrospores visible with a PAS stain (right). More about this image found in TINEA CAPITIS DUE TO TRICHOPHYTON VIOLACEUM IN AN HIV-INFE...

HISTOPLASMA ENDOCARDITIS Figure 23-7 HISTOPLASMA ENDOCARDITIS A: This most often affects the left heart valves, particularly the aortic valve. B,C: There is often underlying valvular disease and organisms usually appear enmeshed in fibrin (B). Short hyphal forms may be seen in these lesions (C) (GMS stain). More about this image found in HISTOPLASMA ENDOCARDITIS A: This most often affects the l...

NONCIRRHOTIC PORTAL HYPERTENSION Figure 9-24 NONCIRRHOTIC PORTAL HYPERTENSION A: Trichrome stain of a liver biopsy with obliterated portal vein (bottom left, above bile duct). B: Portal vein sclerosis is highlighted on an elastic van Gieson stain. C: Low-power view of liver shows nodular regene... More about this image found in NONCIRRHOTIC PORTAL HYPERTENSION A: Trichrome stain of a liver biopsy with...

HEPATOCELLULAR CARCINOMA (HCC) ARISING AGAINST A BACKGROUND OF CHRONIC HCV INFECTION Figure 5-9 HEPATOCELLULAR CARCINOMA (HCC) ARISING AGAINST A BACKGROUND OF CHRONIC HCV INFECTION A: Gross view of cirrhotic liver with portal hypertension and circumscribed tumor at left. B,C: Neoplastic hepatocy... More about this image found in HEPATOCELLULAR CARCINOMA (HCC) ARISING AGAINST A BACKGROUND OF CHRONIC HCV ...

SPECTRUM OF CRYPTOCOCCAL MORPHOLOGY Figure 20-5 SPECTRUM OF CRYPTOCOCCAL MORPHOLOGY The characteristic thin-walled, round to ovoid yeasts are of variable size. In gelatinous disease, the encapsulated yeasts are surrounded by abundant clear mucoid material (left and top center). The organisms typi... More about this image found in SPECTRUM OF CRYPTOCOCCAL MORPHOLOGY The characteristic thin-walled, round ...

HSIL AND CARCINOMA Figure 9-37 HSIL AND CARCINOMA A: Cohesive and singly scattered hyperchromatic cells, with high nuclear to cytoplasmic ratio, coarse chromatin, and nuclear irregularity (SurePath cytology, Papanicolaou stain). B: HSIL with acanthosis, hyperkeratosis (at left), parakeratosis (a... More about this image found in HSIL AND CARCINOMA A: Cohesive and singly scattered hyperchromatic cells, ...

HSIL AND CARCINOMA Figure 9-37 HSIL AND CARCINOMA A: Cohesive and singly scattered hyperchromatic cells, with high nuclear to cytoplasmic ratio, coarse chromatin, and nuclear irregularity (SurePath cytology, Papanicolaou stain). B: HSIL with acanthosis, hyperkeratosis (at left), parakeratosis (a... More about this image found in HSIL AND CARCINOMA A: Cohesive and singly scattered hyperchromatic cells, ...

MPOX Figure 6-11 MPOX Microscopic features of skin lesions. (Courtesy of the CDC IDPB) A: Early changes showing a lichenoid papillary dermal and perivascular mixed inflammatory cell infiltrate, which includes lymphocytes, macrophages, and rare eosinophils. Single dyskeratotic cells are visible i... More about this image found in MPOX Microscopic features of skin lesions. (Courtesy of the CDC IDPB) A: ...

MPOX Figure 6-11 MPOX Microscopic features of skin lesions. (Courtesy of the CDC IDPB) A: Early changes showing a lichenoid papillary dermal and perivascular mixed inflammatory cell infiltrate, which includes lymphocytes, macrophages, and rare eosinophils. Single dyskeratotic cells are visible i... More about this image found in MPOX Microscopic features of skin lesions. (Courtesy of the CDC IDPB) A: ...