Search Results for lci

LOBULAR CARCINOMA IN SITU (LCIS) WITH MICROINVASION Figure 8-26 LOBULAR CARCINOMA IN SITU (LCIS) WITH MICROINVASION A: Extensive LCIS is present in this case, characterized by large nests of cells with round, monomorphic nuclei. The presence of an inflammatory cell infiltrate should prompt More about this image found in LOBULAR CARCINOMA IN SITU (LCIS) WITH MICROINVASION A: Extensive LCIS is p...

LOBULAR CARCINOMA IN SITU AND ATYPICAL DUCTAL HYPERPLASIA (ADH) Figure 4-8 LOBULAR CARCINOMA IN SITU AND ATYPICAL DUCTAL HYPERPLASIA (ADH) Not infrequently lobular neoplasia (LCIS or ALH) coexists with other lesions in the low-grade breast neoplasia family, as in this example of ADH and LCIS More about this image found in LOBULAR CARCINOMA IN SITU AND ATYPICAL DUCTAL HYPERPLASIA (ADH) Not infreq...

COLLAGENOUS SPHERULOSIS WITH LOBULAR CARCINOMA IN SITU (LCIS), CLASSIC TYPE MIMICKING ADH AND LOW NUCLEAR GRADE DCIS Figure 3-21 COLLAGENOUS SPHERULOSIS WITH LOBULAR CARCINOMA IN SITU (LCIS), CLASSIC TYPE MIMICKING ADH AND LOW NUCLEAR GRADE DCIS A: At scanning magnification, the TDLU appears More about this image found in COLLAGENOUS SPHERULOSIS WITH LOBULAR CARCINOMA IN SITU (LCIS), CLASSIC TYPE...

LOBULAR CARCINOMA IN SITU (LCIS) Figure 4-1 LOBULAR CARCINOMA IN SITU (LCIS) A: A lower-power view demonstrates terminal duct lobular units (TDLUs) expanded by a monomorphic proliferation of cells; some dyshesion is apparent and intracytoplasmic vacuoles are present. B: High power better More about this image found in LOBULAR CARCINOMA IN SITU (LCIS) A: A lower-power view demonstrates termin...

LOBULAR CARCINOMA IN SITU: TYPE A Figure 4-3 LOBULAR CARCINOMA IN SITU: TYPE A The LCIS cells in these acini are loosely cohesive and have small, round, even nuclei. More about this image found in LOBULAR CARCINOMA IN SITU: TYPE A The LCIS cells in these acini are loosel...

LOBULAR CARCINOMA IN SITU INVOLVING A DUCT Figure 4-6 LOBULAR CARCINOMA IN SITU INVOLVING A DUCT Occasionally, LCIS confers an irregular or “cloverleaf” contour to the involved duct. Note also the pagetoid growth pattern under the attenuated normal ductal epithelial cell layer. More about this image found in LOBULAR CARCINOMA IN SITU INVOLVING A DUCT Occasionally, LCIS confers an i...

TUBULOLOBULAR CARCINOMA Figure 8-45 TUBULOLOBULAR CARCINOMA A: LCIS is present in the center of the field; angulated glands of tubular carcinoma present at the top of the field begin to merge with invasive lobular carcinoma cells at the left side of the field. B,C: High power of the tubular (B More about this image found in TUBULOLOBULAR CARCINOMA A: LCIS is present in the center of the field; ang...

ATYPICAL LOBULAR HYPERPLASIA Figure 4-20 ATYPICAL LOBULAR HYPERPLASIA A: Low-power image of a duct slightly expanded by the same cells as seen in classic LCIS. The limited extension warrants diagnosis as ALH, rather than LCIS. B: Higher power image better illustrates the cytologic dyshesion More about this image found in ATYPICAL LOBULAR HYPERPLASIA A: Low-power image of a duct slightly expande...

LOBULAR CARCINOMA IN SITU IN ADENOSIS Figure 4-12 LOBULAR CARCINOMA IN SITU IN ADENOSIS A: This low-power image shows an area of adenosis expanded by a proliferation of monomorphic epithelial cells. B: At intermediate power, the cytologic dyshesion characteristic of LCIS is appreciated. C More about this image found in LOBULAR CARCINOMA IN SITU IN ADENOSIS A: This low-power image shows an are...

LOBULAR CARCINOMA IN SITU INVOLVING TUBULAR ADENOSIS Figure 6-24 LOBULAR CARCINOMA IN SITU INVOLVING TUBULAR ADENOSIS A: All the tubules in this case were involved by LCIS. Note the elongated, occasionally branching, tubules, which have a somewhat disorganized arrangement at low power. B More about this image found in LOBULAR CARCINOMA IN SITU INVOLVING TUBULAR ADENOSIS A: All the tubules in...

MYOEPITHELIAL CELL STAINS IN ADENOSIS Figure 6-11 MYOEPITHELIAL CELL STAINS IN ADENOSIS A: In this case of lobular carcinoma in situ (LCIS) involving adenosis, the arrangement of some of the epithelial cell nests suggests invasive carcinoma rather than LCIS in adenosis. B: A SMMHC stain More about this image found in MYOEPITHELIAL CELL STAINS IN ADENOSIS A: In this case of lobular carcinoma...

PLEOMORPHIC APOCRINE LOBULAR CARCINOMA IN SITU Figure 4-15 PLEOMORPHIC APOCRINE LOBULAR CARCINOMA IN SITU This example of pleomorphic LCIS has abundant eosinophilic cytoplasm in addition to the pronounced nuclear pleomorphism and prominent nucleoli. More about this image found in PLEOMORPHIC APOCRINE LOBULAR CARCINOMA IN SITU This example of pleomorphic...

LOBULAR CARCINOMA IN SITU Figure 4-2 LOBULAR CARCINOMA IN SITU A: At low power, several acini and a duct are expanded by a monomorphic proliferation of dyshesive cells. B: High power reveals the cytologic monotony and intracytoplasmic vacuoles characteristic of LCIS. More about this image found in LOBULAR CARCINOMA IN SITU A: At low power, several acini and a duct are ex...

LOBULAR CARCINOMA IN SITU: PAGETOID GROWTH PATTERN Figure 4-5 LOBULAR CARCINOMA IN SITU: PAGETOID GROWTH PATTERN One characteristic feature of LCIS is the presence of cells under the ductal epithelium, which in turn becomes attenuated, as in this example. More about this image found in LOBULAR CARCINOMA IN SITU: PAGETOID GROWTH PATTERN One characteristic feat...

LOBULAR CARCINOMA IN SITU WITH ADMIXED MYOEPITHELIAL CELLS Figure 4-7 LOBULAR CARCINOMA IN SITU WITH ADMIXED MYOEPITHELIAL CELLS In this intermediate-power image of a duct involved by LCIS, admixed myoepithelial cells, recognized by their dark, spindle-shaped nuclei, percolate between More about this image found in LOBULAR CARCINOMA IN SITU WITH ADMIXED MYOEPITHELIAL CELLS In this interme...

PLEOMORPHIC WITH ADJACENT CLASSIC LOBULAR CARCINOMA IN SITU Figure 4-17 PLEOMORPHIC WITH ADJACENT CLASSIC LOBULAR CARCINOMA IN SITU A: Intermediate-power image shows adjacent areas of classic (right side of image) and pleomorphic LCIS (central and left side of image). B: High power shows More about this image found in PLEOMORPHIC WITH ADJACENT CLASSIC LOBULAR CARCINOMA IN SITU A: Intermediat...

to distinguish on occasion. A lack of polarization in LCIS (A) versus areas of microacinar or rosette formation in DCIS (B) are useful morphologic features that can aid in differentiation. Note particularly the more subtle areas to the right of the involved space. More about this image found in LOBULAR CARCINOMA IN SITU AND LOW NUCLEAR GRADE DUCTAL CARCINOMA IN SITU AN...

and expanded by classic LCIS cells with an area of central necrosis. C: E-cadherin immunostain shows an absence of expression, with normal internal control. D: p120 immunostain demonstrating cytoplasmic expression. These immunophenotypic patterns support interpretation as a lobular phenotype. More about this image found in FLORID LOBULAR CARCINOMA IN SITU A: At low power, the acini are greatly ex...