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Figure 1-46

PROTRUSION OF NORMAL CORTICAL CELLS INTO THE LUMEN OF THE CENTRAL VEIN Whe...

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in Physiology, Development, and Anatomy of the Adrenal Glands > Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
intravascular protrusions covered by an intact endothelial layer. More about this image found in PROTRUSION OF NORMAL CORTICAL CELLS INTO THE LUMEN OF THE CENTRAL VEIN Whe...
Book Chapter

Clinicopathologic Features of the Adrenal Cortex

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... is variable ( figs. 3-7 , 3-8 ). The adrenal medulla appears normal. Ectopic ACTH- or CRH-secreting tumors result in more pronounced diffuse cortical hyperplasia, with loss of normal zonation of the lipid-rich fasciculata layer. The cortex is instead composed of a thick layer of acidophilic compact cells...
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Book Chapter

Physiology, Development, and Anatomy of the Adrenal Glands

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... concentrated in the head and body of the gland (see fig. 1-22 ) and should not be confused with the brown-yellow inner cortex. Where chromaffin cells are absent (e.g., tail of the gland), the opposing layers of adrenal cortex are demarcated by the interalar raphe, which may appear as a wider pigmented zone...
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Book Chapter

Adrenal Cortical Carcinoma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... pattern with anastomosing columns and cords of cells, often 10 to 20 or more cells wide, separated by delicate, gaping sinusoids lined by an attenuated endothelial layer. Occasionally, the trabeculae are oriented in a more parallel, elongated array, or have an irregular contour with a daisy-like or clover...
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Book Chapter

Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... with serous or hemorrhagic content and have only a thin patchy layer of neoplastic cells on the cyst wall. Microscopic Findings NBLs and GNBLs consist of two components: immature or maturing neurons and stroma. The former compartment consists of neuroblasts or neuroblastic cells that may exhibit varying...
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Images
Figure 16-4

INFECTIVE ENDOCARDITIS The layered fibrin and associated inflammatory cell...

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in Heart > Pathology of Non-Helminth Infectious Diseases
Published: 01 September 2024
INFECTIVE ENDOCARDITIS Figure 16-4 INFECTIVE ENDOCARDITIS The layered fibrin and associated inflammatory cells make up the valvular vegetation (A,B). A fungal Grocott methenamine silver (GMS) stain highlights scattered bacterial organisms (C), which may show altered morphologic and tinctorial More about this image found in INFECTIVE ENDOCARDITIS The layered fibrin and associated inflammatory cell...
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Figure 6-12

MOLLUSCUM CONTAGIOSUM Endophytic lobules of hyperplastic epidermis are in ...

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in Skin and Soft Tissue > Pathology of Non-Helminth Infectious Diseases
Published: 01 September 2024
change from eosinophilic to basophilic at the level of the granular layer. (Courtesy of Prof. W. Grayson, Ampath Pathology Laboratories, Johannesburg, South Africa) More about this image found in MOLLUSCUM CONTAGIOSUM Endophytic lobules of hyperplastic epidermis are in ...
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Skin and Soft Tissue

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-06
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... inclusions Mixed dermal inflammatory infiltrate with increased vascularity Molluscum contagiosum Lobular epidermal hyperplasia with basal layer mitotic figures, cytoplasmic vacuolation, and eosinophilic globules in lower epidermis Compression of squamous epithelial nuclei by large intracytoplasmic...
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Skin and Soft Tissue

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-15
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... Associated Bacteria Superficial Non-necrotizing Impetigo Purulent crusts in upper layers of the skin; may have bullous appearance Staphylococcus aureus, β-hemolytic streptococci Folliculitis Infection of hair follicles (appears as small, yellow pustules); also known as furuncles...
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Book Chapter

Systemic Infections

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-23
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... of active histoplasmosis in the immune competent is necrotizing granulomatous inflammation, which is most striking in the lung. The prototypical granuloma has a trizonal appearance, with peripheral fibrosis, an adjacent layer of epithelioid and multinucleated giant cells, and central fibrillogranular...
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Book Chapter

Prion Diseases

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-02
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... reveals widespread brain involvement, most striking in the cerebellum, where amyloid plaques are multicentric and predominantly located in the molecular layer. In FFI, amyloid deposition is less striking and mainly involves the thalamus and inferior olivary nuclei. In kuru, plaques are typically dense...
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Book Chapter

Heart

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-16
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... INFECTIVE ENDOCARDITIS The layered fibrin and associated inflammatory cells make up the valvular vegetation (A,B). A fungal Grocott methenamine silver (GMS) stain highlights scattered bacterial organisms (C), which may show altered morphologic and tinctorial characteristics after prior antibiotic therapy...
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Book Chapter

Overview

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-19
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...Table 19-1 CHARACTERISTICS OF COMMON HUMAN FUNGAL INFECTIONS Site Name Predisposing Cause Clinical Manifestations Nails Onychomycosis Trauma Infrequent; discoloration and abnormal nail plate morphology Keratin layer of the skin Tinea nigra Skin abrasion Hyperchromic plaques...
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Book Chapter

Respiratory Tract

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-12
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., are usually present as well ( fig. 12-27 ). Gram-negative bacteria are characterized by a thin peptidoglycan cell wall layer in the periplasmic space between two lipopolysaccharide (LPS) layers. The crystal violet Gram stain reagent is thus easily decolorized and the bacteria stain a characteristic...
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Book Chapter

Central Nervous System

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-11
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...) are seen. In biliary tract involvement, cholecystectomy specimens show transmural neutrophil infiltration, edema, focal necrosis, and mucosal ulceration ( 10 ). Necrosis sometimes extends to the muscular layer, and underlying changes of chronic cholecystitis (unrelated to the infection) can be present...
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Book Chapter

Sexually Transmitted and Urogenital Infections

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... Squamous hyperplasia/acanthosis, papillomatosis Parakeratosis, less commonly hyperkeratosis Hyperkeratosis, parakeratosis Papillary architecture may be present Cells affected by cytologic changes More prominent in superficial layers Immature cells in the lower third of the epithelium, with minimal...
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Book Chapter

Respiratory Tract

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-21
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... not cleared by the ciliary mechanism are phagocytosed by alveolar macrophages and recruited neutrophils. The conidia have multiple cell wall layers and shed the hydrophobin and melanin layers as a step to germination. This exposes the β-(1-3)-glucan layer, which activates several inflammatory pathways...
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Book Chapter

Skin and Soft Tissue

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-24
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... FUNGI Infection Site Disease Pathogenetic Mechanism Clinical Manifestations Nail Onychomycosis Trauma Rare; abnormal nail plate color and morphology Skin keratin layer Tinea nigra Skin abrasion Hyperpigmented plaques on palms and soles Skin, subcutaneous and soft tissue...
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Book Chapter

Central Nervous System

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-25
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... an oocyst that is protected from the environment by multiple hardy layers. The protozoan can invade many types of nucleated host cells by means of cellular attachment of its apical end and moving this junction to its posterior end, thereby forming a parasitophorous vacuole. A complex series of processes...
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Book Chapter

Lymph Nodes and Bone Marrow

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... ). The nodal architecture is usually preserved although germinal centers show prominent and sometimes hyalinized arterioli. There is associated fibrin and immunoglobulin deposition in the somewhat involuted germinal centers, with surrounding lymphocytes and polyclonal plasma cells, typically in a layered...
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