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Images
Published: 01 September 2024
INFECTIVE ENDOCARDITIS Figure 16-4 INFECTIVE ENDOCARDITIS The layered fibrin and associated inflammatory cells make up the valvular vegetation (A,B). A fungal Grocott methenamine silver (GMS) stain highlights scattered bacterial organisms (C), which may show altered morphologic and tinctorial cha... More about this image found in INFECTIVE ENDOCARDITIS The layered fibrin and associated inflammatory cell...
Images
Published: 01 September 2024
MOLLUSCUM CONTAGIOSUM Figure 6-12 MOLLUSCUM CONTAGIOSUM Endophytic lobules of hyperplastic epidermis are in the upper dermis (A). There are prominent intracytoplasmic molluscum inclusions (shown at high power in B), with peripheral displacement of the epithelial nucleus. The inclusions typically ... More about this image found in MOLLUSCUM CONTAGIOSUM Endophytic lobules of hyperplastic epidermis are in ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-06
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... sarcoma virus (KSHV or HHV8, discussed in chapter 7 ). The name herpes is derived from the Greek word for crawl or creep and early descriptions of the disease have been ascribed to Hippocrates ( 1 ). All human herpesviruses have a similar structure and consist of four layers: the core (containing...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-15
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... threatening (such as necrotizing fasciitis). Table 15-1 presents the different types of skin and soft tissue infections, their characteristics, and the causative organisms. Infections that produce necrosis can occur in any skin or soft tissue layer, and their rapid progression and deadly consequence were...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-23
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... is necrotizing granulomatous inflammation, which is most striking in the lung. The prototypical granuloma has a trizonal appearance, with peripheral fibrosis, an adjacent layer of epithelioid and multinucleated giant cells, and central fibrillogranular (caseous) necrosis ( fig. 23-4 ). In contrast...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-02
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... reveals widespread brain involvement, most striking in the cerebellum, where amyloid plaques are multicentric and predominantly located in the molecular layer. In FFI, amyloid deposition is less striking and mainly involves the thalamus and inferior olivary nuclei. In kuru, plaques are typically dense...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-16
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... bacteria ( fig. 16-4 ). INFECTIVE ENDOCARDITIS Figure 16-4 INFECTIVE ENDOCARDITIS The layered fibrin and associated inflammatory cells make up the valvular vegetation (A,B). A fungal Grocott methenamine silver (GMS) stain highlights scattered bacterial organisms (C), which may show altered morphologic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-19
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... Keratin layer of the skin Tinea nigra Skin abrasion Hyperchromic plaques on palms and soles Subcutaneous tissues Chromomycosis Trauma Chronic evolution from small papules to verrucous plaques Subcutaneous tissues Eumycetoma Trauma Chronic evolution of deep soft tissue infection, forming...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-12
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., and recent surgery. The different layers that envelop Legionella organisms are responsible for the virulence properties ( fig. 12-6 ) ( 15 ). The bacterial inner membrane contains proteins that allow the acquisition of iron (which is crucial for growth), and proteins that facilitate adhesion...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-11
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... and foamy macrophages (more prominent perivascularly) are seen. In biliary tract involvement, cholecystectomy specimens show transmural neutrophil infiltration, edema, focal necrosis, and mucosal ulceration ( 10 ). Necrosis sometimes extends to the muscular layer, and underlying changes of chronic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... commonly hyperkeratosis Hyperkeratosis, parakeratosis Papillary architecture may be present Cells affected by cytologic changes More prominent in superficial layers Immature cells in the lower third of the epithelium, with minimal atypia All layers of squamous epithelium Immature cells occupy up...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-21
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... exposed to aerosolized conidia and propagules when they disturb the top soil layer for agricultural purposes, especially when working in coffee or tobacco crops ( 31 ). Other high-risk occupational activities include gardening, construction, and truck driving ( 34 ). Human-to-human transmission has...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-24
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... Infection Site Disease Pathogenetic Mechanism Clinical Manifestations Nail Onychomycosis Trauma Rare; abnormal nail plate color and morphology Skin keratin layer Tinea nigra Skin abrasion Hyperpigmented plaques on palms and soles Skin, subcutaneous and soft tissue Chromomycosis Trauma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-25
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... stage, the bradyzoite, which has a slower metabolism and multiplication rate, and forms tissue cysts that contain a few to hundreds of parasites. The third stage is the sporozoite, which is found inside an oocyst that is protected from the environment by multiple hardy layers. The protozoan can invade...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... involuted germinal centers, with surrounding lymphocytes and polyclonal plasma cells, typically in a layered or concentric arrangement, imparting an “onion-skin” appearance to the mantle zone ( fig. 8-23 ). Sometimes, there is synchronous neoplasia in the lymph node, such as in KS ( fig. 8-24 ) or B-cell...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-18
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... metabolic pathways. The bacterium thus primarily derives sources of energy and amino acids from the host ( 2 ). Like other spirochetes, its cytoplasmic membrane is surrounded by a thin peptidoglycan layer and an outer membrane; the space between these two membranes contains the spiral endoflagella, which...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-03
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... to the M protein and traverses the phospholipid layer, thus being the only protein exposed externally. The G protein acts as a ligand for host cells using one of three receptors, nicotine acetylcholine, neural cell adhesion molecule, or the low-affinity neurotrophin ( 15 ). Once viral copies have been...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-26
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... ). Some organisms appear intraluminal, especially with tangential sectioning. Ultrastructural examination reveals that the cryptosporidial forms are actually located in paracytophorous vacuoles in the microvillus layer directly beneath the epithelial cell membrane, although often appearing protuberant...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-14
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... in cutaneous anthrax demonstrate extensive coagulative necrosis and edema throughout the different skin layers ( fig. 14-9 ) ( 17 ). The epidermis shows acantholysis, bulla formation, and ulceration. Variable numbers of inflammatory cells, mostly neutrophils but sometimes also mononuclear cells, are found...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-13
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...-like organism) testing, a convenient technique using fresh endoscopic biopsy material to show an increase in pH due to the production of ammonia, should H. pylori be present. Selective urease tests are more sensitive and specific than the single layer rapid urease methodology. The second...
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