ECTOPIC ACTH SYNDROME Figure 3-10 ECTOPIC ACTH SYNDROME Large eosinophilic cells replace lipid-rich cells in the zona fasciculata of the adrenal cortex. More about this image found in ECTOPIC ACTH SYNDROME Large eosinophilic cells replace lipid-rich cells in...

PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE Figure 4-24 PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE A large pigmented macronodule and a larger pale yellow nodule with small areas of necrosis are seen. The patient was part of a family pedigree with the complex of myxomas, spotty pigmenta... More about this image found in PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE A large pigmented macrono...

ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE Figure 5-39 ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE Deeply eosinophilic large cells in a diffuse pattern of growth with prominent nucleoli. More about this image found in ADRENAL CORTICAL ADENOMA, ONCOCYTIC TYPE Deeply eosinophilic large cells i...

ADRENAL CORTICAL CARCINOMA Figure 6-7 ADRENAL CORTICAL CARCINOMA A large adrenal cortical carcinoma (ACC) from a 57-year-old woman simulated a renal cell carcinoma. The patient had no recognizable endocrine syndrome. Over half of the neoplasm was necrotic. More about this image found in ADRENAL CORTICAL CARCINOMA A large adrenal cortical carcinoma (ACC) from a...

ADRENAL CORTICAL CARCINOMA Figure 6-9 ADRENAL CORTICAL CARCINOMA This large ACC was resected from a 27-year-old woman with virilization. The tumor measured 17 cm in diameter and invaded both kidney and spleen, which necessitated en bloc removal of these organs along with the tumor. More about this image found in ADRENAL CORTICAL CARCINOMA This large ACC was resected from a 27-year-old ...

ADRENAL CORTICAL CARCINOMA Figure 6-15 ADRENAL CORTICAL CARCINOMA Most tumor cells in this case have large, coarse cytoplasmic vacuoles, which distend many cells and displace the nucleus to the periphery. Some cells have a “signet ring” appearance. More about this image found in ADRENAL CORTICAL CARCINOMA Most tumor cells in this case have large, coars...

LARGE VESSEL INVASION IN ADRENAL CORTICAL CARCINOMA Figure 6-22 LARGE VESSEL INVASION IN ADRENAL CORTICAL CARCINOMA This ACC caused almost complete occlusion of the lumen of the inferior vena cava. The tumor shows extensive necrosis. One portion is attached to the wall of the vein. A few areas of... More about this image found in LARGE VESSEL INVASION IN ADRENAL CORTICAL CARCINOMA This ACC caused almost...

ADRENAL CORTICAL CARCINOMA: ONCOCYTIC VARIANT Figure 6-24 ADRENAL CORTICAL CARCINOMA: ONCOCYTIC VARIANT Large eosinophilic cells with abundant granular cytoplasm (A) and nuclear atypia with prominent nucleoli (B) are characteristic of this variant. More about this image found in ADRENAL CORTICAL CARCINOMA: ONCOCYTIC VARIANT Large eosinophilic cells wit...

PHEOCHROMOCYTOMA Figure 8-8 PHEOCHROMOCYTOMA Large areas of hemorrhage and glistening edema are prominent. More about this image found in PHEOCHROMOCYTOMA Large areas of hemorrhage and glistening edema are promin...

PHEOCHROMOCYTOMA: CYSTIC DEGENERATION Figure 8-9 PHEOCHROMOCYTOMA: CYSTIC DEGENERATION The large cyst at bottom of this 15-cm tumor most likely results from old hemorrhage or infarction and contains only thin blood-tinged fluid. The small cyst to its right contains degenerating blood. More about this image found in PHEOCHROMOCYTOMA: CYSTIC DEGENERATION The large cyst at bottom of this 15-...

PHEOCHROMOCYTOMA Figure 8-20 PHEOCHROMOCYTOMA The tumor cells are large and polygonal, with abundant granular basophilic cytoplasm and indistinct cell borders. More about this image found in PHEOCHROMOCYTOMA The tumor cells are large and polygonal, with abundant gr...

PHEOCHROMOCYTOMA Figure 8-21 PHEOCHROMOCYTOMA Large and polygonal tumor cells have pale eosinophilic cytoplasm and indistinct cell borders. More about this image found in PHEOCHROMOCYTOMA Large and polygonal tumor cells have pale eosinophilic cy...

PHEOCHROMOCYTOMA Figure 8-27 PHEOCHROMOCYTOMA There may be large multi-nucleated giant cells. More about this image found in PHEOCHROMOCYTOMA There may be large multi-nucleated giant cells.

PHEOCHROMOCYTOMA Figure 8-28 PHEOCHROMOCYTOMA Some tumor cells are large, with multinucleated forms and striking nuclear atypia. More about this image found in PHEOCHROMOCYTOMA Some tumor cells are large, with multinucleated forms and...

UNDIFFERENTIATED NEUROBLASTOMA WITH LARGE CELL HISTOLOGY Figure 11-17 UNDIFFERENTIATED NEUROBLASTOMA WITH LARGE CELL HISTOLOGY This tumor was originally diagnosed as malignant rhabdoid tumor on the basis of morphology and loss of BRG1 immunostaining, until resection showed foci of ganglion cell d... More about this image found in UNDIFFERENTIATED NEUROBLASTOMA WITH LARGE CELL HISTOLOGY This tumor was or...

ADRENAL INVOLVEMENT BY LYMPHOMA Figure 12-28 ADRENAL INVOLVEMENT BY LYMPHOMA A: The tumor, a large B-cell lymphoma, replaces much of the adrenal gland, with only a few small nests of pale-staining cortical cells present in this field. B: Immunostain for CD20 is diffusely positive. More about this image found in ADRENAL INVOLVEMENT BY LYMPHOMA A: The tumor, a large B-cell lymphoma, rep...

POST-TREATMENT CHANGE IN NEUROBLASTOMA Figure 11-26 POST-TREATMENT CHANGE IN NEUROBLASTOMA Largely necrotic NB, with focal calcification. The biologic potential of the remaining nucleated tumor cells is frequently difficult to estimate. More about this image found in POST-TREATMENT CHANGE IN NEUROBLASTOMA Largely necrotic NB, with focal cal...

LIVER METASTASIS FROM ADRENAL CORTICAL CARCINOMA Figure 6-38 LIVER METASTASIS FROM ADRENAL CORTICAL CARCINOMA A: Hepatic lobectomy specimen is largely replaced by metastatic ACC. The tumor is mottled tan-yellow. B: Metastatic ACC disrupts the liver parenchyma and has a large nesting pattern. More about this image found in LIVER METASTASIS FROM ADRENAL CORTICAL CARCINOMA A: Hepatic lobectomy spec...

NODULAR ADRENAL MEDULLARY HYPERPLASIA IN A PATIENT WITH MEN2A Figure 8-61 NODULAR ADRENAL MEDULLARY HYPERPLASIA IN A PATIENT WITH MEN2A A: The adrenal medulla is diffusely thickened and contains multiple nodules. B: At higher magnification there are three nodules that can be distinguished based ... More about this image found in NODULAR ADRENAL MEDULLARY HYPERPLASIA IN A PATIENT WITH MEN2A A: The adren...

PHEOCHROMOCYTOMA: EXTENSIVE CYSTIC DEGENERATION Figure 8-11 PHEOCHROMOCYTOMA: EXTENSIVE CYSTIC DEGENERATION This lesion was identified as a large cyst on imaging; focal calcification is present in the wall. More about this image found in PHEOCHROMOCYTOMA: EXTENSIVE CYSTIC DEGENERATION This lesion was identified...