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Images
Published: 01 December 2024
PARAGANGLIOMA INVOLVING LIVER BY DIRECT EXTENSION Figure 9-42 PARAGANGLIOMA INVOLVING LIVER BY DIRECT EXTENSION The liver was infiltrated by tumor cells from a 10-cm partly intrahepatic and partly extrahepatic mass. The mass was a known recurrence of an extrahepatic tumor, and the intrahepatic More about this image found in PARAGANGLIOMA INVOLVING LIVER BY DIRECT EXTENSION The liver was infiltrate...
Images
in Other Adrenal Neoplasms and Tumor-Like Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
KAPOSI SARCOMA EXTENSIVELY INVOLVING ADRENAL GLAND Figure 12-29 KAPOSI SARCOMA EXTENSIVELY INVOLVING ADRENAL GLAND A: Kaposi sarcoma involving the adrenal gland in an adult male with acquired immunodeficiency syndrome (AIDS). The tumor obscures much of normal histology and architecture More about this image found in KAPOSI SARCOMA EXTENSIVELY INVOLVING ADRENAL GLAND A: Kaposi sarcoma invol...
Images
in Other Adrenal Neoplasms and Tumor-Like Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ADRENAL INVOLVEMENT BY LYMPHOMA Figure 12-28 ADRENAL INVOLVEMENT BY LYMPHOMA A: The tumor, a large B-cell lymphoma, replaces much of the adrenal gland, with only a few small nests of pale-staining cortical cells present in this field. B: Immunostain for CD20 is diffusely positive. More about this image found in ADRENAL INVOLVEMENT BY LYMPHOMA A: The tumor, a large B-cell lymphoma, rep...
Images
Published: 01 December 2024
NECROSIS IN ADRENAL CORTICAL CARCINOMA Figure 6-12 NECROSIS IN ADRENAL CORTICAL CARCINOMA Necrotic areas may be focal punctate (A) or extensive (B), in some cases involving most of the tumor (C). More about this image found in NECROSIS IN ADRENAL CORTICAL CARCINOMA Necrotic areas may be focal punctat...
Images
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
NEUROBLASTOMA METASTATIC TO BONE AND BONE MARROW Figure 11-37 NEUROBLASTOMA METASTATIC TO BONE AND BONE MARROW This trephine biopsy shows extensive involvement by NB, which is even appreciated without immunohistochemistry. More about this image found in NEUROBLASTOMA METASTATIC TO BONE AND BONE MARROW This trephine biopsy show...
Images
in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
. The tumor had a soft, almost encephaloid, texture. Several regional lymph nodes are involved by metastases. More about this image found in HEMORRHAGIC NEUROBLASTOMA NB of the left adrenal gland at autopsy. The tum...
Images
in Congenital Disorders of the Adrenal Gland
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
and hemorrhagic regressing fetal or provisional cortex. B: Developing adult cortex at left of field, with fetal cortex at right. At this early stage in postnatal life, fetal cortex is undergoing normal regression. C: Marked adrenal cytomegaly involves cells of the fetal, or provisional, cor tex. Nucleomegaly More about this image found in BECKWITH-WIEDEMANN SYNDROME A: Transverse sections of adrenal gland from a...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... Perivascular Epithelioid Cell Tumors (PEComas). Angiomyolipomas and other PEComas involving the adrenal gland most often arise in the kidney and involve the adrenal gland secondarily, but occasional primary adrenal examples have been reported ( 23 , 33 , 43 ). The tumors occur predominantly in women...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... union are distinguished by the presence or absence, respectively, of a continuous connective tissue capsule ( 1 ). In adrenal adhesion, which may involve either kidney or liver, there is an intervening thick or thin capsule ( fig. 2-1A ), while in adrenal union, there is intermingling of parenchymal...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... ). The genetic alterations are most often hereditary, giving rise to familial disease that can involve only PPGL formation, but usually is associated with other disorders. Some are nonhereditary disorders that cause syndromic manifestations. At least 20 genes have been implicated in familial disorders...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... macroscopic (i.e., exceeding 1 cm) nodules enriched in clear cells. Despite the homogeneous pathologic features, primary bilateral macronodular adrenal cortical disease has a complex pathogenesis, with several molecular mechanisms involved, including some that are responsible for genetic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... appearance between the two glands ( fig. 4-12 ), a feature that may complicate the distinction of this from a unilateral disease ( 21 ). Bilateral involvement may be asynchronous, with disease developing in one gland even years after the first clinical presentation. The internodular adrenal cortex may...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... (Ondine curse) Blueberry muffin baby a VIP = vasoactive intestinal protein. Patients with a primary tumor or tumor localization in the head and neck area may present with Horner syndrome due to involvement of the superior cervical ganglion. This syndrome consists of a combination of one or more...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... involving downregulated genes ( 21 ). In another study using high-resolution single nucleotide polymorphism arrays, more than 70 percent of copy number gains detected in adenomas were also present in carcinomas. Among the signaling pathways involved in both benign and malignant tumors, the Notch signaling...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... tinnitus, hearing abnormalities, or aural fullness; and vagal paragangliomas present as neck masses and are more often associated with cranial nerve involvement ( 43 ). These tumors are now increasingly discovered as incidentalomas or in the course of screening patients with hereditary tumor syndromes ( 61...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... in both males and females, with only a minor predilection for either sex in most series. In some studies, the right adrenal gland is involved more frequently than the left, possibly due to the slightly larger size of the medulla in that gland ( 29 , 30 ). In adults, there is an average delay...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... and CACNA1H have been reported in different subtypes of familial hyperaldosteronism. The cascade of steroidogenic enzymes that is involved in aldosterone synthesis include CYP11A1, 3βHSD, CYP21A, and CYP11B2; the latter is specific for aldosterone biosynthesis, and antibodies that can be applied...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... also contain a high proportion of norepinephrine, suggestive of functional immaturity. Fetal chromaffin tissue may be involved in the homeostatic maintenance of vascular tone and blood pressure in utero. An important stimulus of catecholamine secretion, both from extra-ad-renal sites and from adrenal...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
.... They show a female predominance and are nonfunctioning in more than 50 percent of cases ( 32 ). In one study of nonfunctioning cases, there was no expression of the enzymes involved in steroidogenesis that were examined ( 33 ). Hormonally active tumors more frequently secrete cortisol or sex steroid...
Images
Published: 01 September 2024
SECONDARY SYPHILIS INVOLVING A LYMPH NODE Figure 18-7 SECONDARY SYPHILIS INVOLVING A LYMPH NODE Endothelial cell swelling, plasma cell infiltration (A), and early granuloma formation (B). More about this image found in SECONDARY SYPHILIS INVOLVING A LYMPH NODE Endothelial cell swelling, plasm...
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