TYPHOID FEVER Figure 13-15 TYPHOID FEVER A: Small intestine from a typhoid patient shows mural thickening, numerous foci of ulceration, and an area of bowel perforation. B: Postmortem ileum specimen shows raised, irregularly convoluted and discolored Peyer patches with associated necrosis and ul... More about this image found in TYPHOID FEVER A: Small intestine from a typhoid patient shows mural thicke...

CYSTOISOSPORA BELLI ORGANISMS Figure 26-35 CYSTOISOSPORA BELLI ORGANISMS A: In the small intestine, large sexual forms (arrow) of the organism are readily identified. B,C: Macrogametocytes typically contain a large nucleolus (B), while microgamonts show numerous peripheral small nuclei (arrows) (C). D: Asexual forms (arrow) are small by comparison. Note the associated eosinophils. More about this image found in CYSTOISOSPORA BELLI ORGANISMS A: In the small intestine, ...

INTESTINAL PROTOZOANS Figure 26-38 INTESTINAL PROTOZOANS Comparison of intestinal protozoans that stain with modified acid-fast stains in stool. (Courtesy of the CDC PHIL) More about this image found in INTESTINAL PROTOZOANS Comparison of intestinal protozoans that stain with ...

INTESTINAL SPIROCHETOSIS Figure 13-9 INTESTINAL SPIROCHETOSIS EAEC findings on endoscopic biopsy are closely mimicked by Brachyspira spp organisms (A) and may be confused with an exaggerated colonic epithelial brush border in mild cases. The bacteria in intestinal spirochetosis are also gram negative (B), but unlike EAEC have a more wiry, spiralled morphology and are positive with silver staining (such as Warthin-Starry) (C). A novel finding is the cross reactivity of Brachyspira spp with T. pallidum immunohistochemistry (D). (Courtesy of Dr. E. Montgomery, University of Miami, Miami, FL) More about this image found in INTESTINAL SPIROCHETOSIS EAEC findings on endoscopic biopsy are closely mi...

CHOLERA Figure 13-20 CHOLERA A,B: Documented histologic changes of cholera in small intestinal mucosa are mild and nonspecific, like some other toxin-associated intestinal bacterial infections, and include mild villous shortening and broadening, congestion, and lamina propria mononuclear inflamma... More about this image found in CHOLERA A,B: Documented histologic changes of cholera in small intestinal ...

WHIPPLE DISEASE Figure 13-36 WHIPPLE DISEASE A–C: Endoscopic small intestinal biopsy shows shortened broad villi distended by a striking foamy macrophage infiltrate. D: High-power view demonstrates numerous lamina propria macrophages with scattered intervening plasma cells and eosinophils. These... More about this image found in WHIPPLE DISEASE A–C: Endoscopic small intestinal biopsy shows shortened br...

WHIPPLE DISEASE Figure 13-37 WHIPPLE DISEASE A,B: Endoscopic biopsy shows distorted intestinal villi with a pronounced macrophage infiltrate, scattered fat droplets, and focal lymphangiectasia. (Courtesy of Dr. J. Rigby, University of Stellenbosch, Stellenbosch, South Africa) More about this image found in WHIPPLE DISEASE A,B: Endoscopic biopsy shows distorted intestinal villi wi...

CONGENITAL SYPHILIS Figure 18-9 CONGENITAL SYPHILIS The wall of the intestinal tract (A) and liver (B) are involved. Note the scattered plasma cells. More about this image found in CONGENITAL SYPHILIS The wall of the intestinal tract (A) and liver (B) are...

INTESTINAL SPIROCHETOSIS Figure 18-11 INTESTINAL SPIROCHETOSIS A: Treponema spp immunohistochemical stain on a rectal biopsy confirms the presence of numerous organisms. B: There may be cross reactivity with other spirochetal organisms, such as Brachyspira spp. (Courtesy of Dr. E. Montgomery, University of Miami, Miami, FL) More about this image found in INTESTINAL SPIROCHETOSIS A: Treponema spp immunohistochem...

SMALL INTESTINAL MICROSPORIDIOSIS Figure 22-13 SMALL INTESTINAL MICROSPORIDIOSIS Mild and nonspecific histologic findings, including villous blunting and scattered intraepithelial lymphocytes, are seen. (Courtesy of Dr. R. Yantiss, Weill-Cornell Medicine, New York, NY) More about this image found in SMALL INTESTINAL MICROSPORIDIOSIS Mild and nonspecific histologic findings...

SMALL INTESTINAL INFECTION BY ENCEPHALITOZOON INTESTINALIS Figure 22-16 SMALL INTESTINAL INFECTION BY ENCEPHALITOZOON INTESTINALIS Abundant organisms are in enterocytes (arrows) and lamina propria macrophages (arrowheads), at low (A) and high (B) power. In contrast to Enterocytozoon bieneusi, infection of nonepithelial cells is a distinguishing feature of Encephalitozoon spp. More about this image found in SMALL INTESTINAL INFECTION BY ENCEPHALITOZOON INTESTINALIS...

SMALL INTESTINAL CYCLOSPORIASIS Figure 26-40 SMALL INTESTINAL CYCLOSPORIASIS The nonspecific histologic findings include villous blunting and an increase in lamina propria chronic inflammatory cells. (Courtesy of Dr. J. Greenson, University of Michigan, Ann Arbor, MI) More about this image found in SMALL INTESTINAL CYCLOSPORIASIS The nonspecific histologic findings includ...

SMALL INTESTINAL CYCLOSPORA CAYETANENSIS PARASITES Figure 26-43 SMALL INTESTINAL CYCLOSPORA CAYETANENSIS PARASITES Numerous small intestinal Cyclospora cayetanensis parasites are located in intraepithelial paracytophorous vacuoles (at center, A), focally visible as a “halo” surrounding the organism (arrowhead) (B). More about this image found in SMALL INTESTINAL CYCLOSPORA CAYETANENSIS PARASITES Numero...

CRYPTOSPORIDIUM SPP Figure 26-27 CRYPTOSPORIDIUM SPP These are readily identifiable on routine H&E-stained sections as numerous small basophilic spherical organisms of variable size present in direct relation to the small intestinal epithelium. More about this image found in CRYPTOSPORIDIUM SPP These are readily identifiable on rou...