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UNDIFFERENTIATED MELANOMA  An amelanotic undifferentiated malignant spindle...
Published: 01 February 2024
UNDIFFERENTIATED MELANOMA Figure 21-8 UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle cell neoplasm is seen. It was initially interpreted as sarcoma by a soft tissue pathologist, but the diagnosis was revised to metastatic melanoma after sequence analysis revealed UV signatures and an NRAS Q61R mutation identical to the mutation in the patient’s prior primary melanoma located draining to the site of the undifferentiated tumor. More about this image found in UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle...
Images
HER2 FLUORESCENCE IN SITU HYBRIDIZATION (FISH) ALGORITHM FOR UNUSUAL FISH R...
Published: 01 January 2024
HER2 FLUORESCENCE IN SITU HYBRIDIZATION (FISH) ALGORITHM FOR UNUSUAL FISH RESULTS Figure 8-8 HER2 FLUORESCENCE IN SITU HYBRIDIZATION (FISH) ALGORITHM FOR UNUSUAL FISH RESULTS Groups 2 to 4 interpreted with concurrent immunohistochemistry (illustrated here with a 2+ immunohistochemistry result). More about this image found in HER2 FLUORESCENCE IN SITU HYBRIDIZATION (FISH) ALGORITHM FOR UNUSUAL FISH R...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... immunophenotype, and the diagnosis becomes apparent with a subsequent metastasis and mutation analysis. UNDIFFERENTIATED MELANOMA Figure 21-8 UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle cell neoplasm is seen. It was initially interpreted as sarcoma by a soft tissue pathologist...
Images
DISPLACED EPITHELIUM  A: Epithelial glands and nests are haphazardly distri...
Published: 01 January 2024
DISPLACED EPITHELIUM Figure 8-30 DISPLACED EPITHELIUM A: Epithelial glands and nests are haphazardly distributed in the cellular biopsy site stroma. B: At higher power, the epithelial elements have some degenerated features characteristic of this phenomenon. Foreign body giant cells and lymphocy... More about this image found in DISPLACED EPITHELIUM A: Epithelial glands and nests are haphazardly distri...
Images
FLORID LOBULAR CARCINOMA IN SITU  A: At low power, the acini are greatly ex...
Published: 01 January 2024
FLORID LOBULAR CARCINOMA IN SITU Figure 4-16 FLORID LOBULAR CARCINOMA IN SITU A: At low power, the acini are greatly expanded by a monotonous proliferation of dyshesive epithelial cells. In several of the spaces, central necrosis is present. B: Higher power view shows the spaces to be filled and... More about this image found in FLORID LOBULAR CARCINOMA IN SITU A: At low power, the acini are greatly ex...
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MYOEPITHELIAL CELL STAINS IN ADENOSIS  A: In this case of lobular carcinoma...
Published: 01 January 2024
MYOEPITHELIAL CELL STAINS IN ADENOSIS Figure 6-11 MYOEPITHELIAL CELL STAINS IN ADENOSIS A: In this case of lobular carcinoma in situ (LCIS) involving adenosis, the arrangement of some of the epithelial cell nests suggests invasive carcinoma rather than LCIS in adenosis. B: A SMMHC stain highligh... More about this image found in MYOEPITHELIAL CELL STAINS IN ADENOSIS A: In this case of lobular carcinoma...
Images
PIGMENTED PAGET DISEASE  A: Clinical photograph illustrating a pigmented le...
Published: 01 January 2024
PIGMENTED PAGET DISEASE Figure 13-14 PIGMENTED PAGET DISEASE A: Clinical photograph illustrating a pigmented lesion involving the nipple and areola, with concomitant scaling of the surface of the nipple. B: Punch biopsy of the pigmented lesion shows a population of atypical epithelioid cells inv... More about this image found in PIGMENTED PAGET DISEASE A: Clinical photograph illustrating a pigmented le...
Images
PIGMENTED PAGET DISEASE  A: Clinical photograph illustrating a pigmented le...
Published: 01 January 2024
PIGMENTED PAGET DISEASE Figure 13-14 PIGMENTED PAGET DISEASE A: Clinical photograph illustrating a pigmented lesion involving the nipple and areola, with concomitant scaling of the surface of the nipple. B: Punch biopsy of the pigmented lesion shows a population of atypical epithelioid cells inv... More about this image found in PIGMENTED PAGET DISEASE A: Clinical photograph illustrating a pigmented le...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... cells. While necrosis in association with nuclear pleomorphism and mitoses supports the interpretation of the tumor as malignant, caution is needed not to misinterpret necrosis associated with bland melanocytes, since ischemic or trauma-related necrosis may be seen in association with a cellular blue...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... inflammatory reaction and secondary to prior tumor necrosis. Such melanotic lesions may be clinically be mistaken for blue nevi. Caution is necessary when interpreting melanosis on a partial biopsy. Localized melanosis may also be associated with a heavily pigmented primary melanoma or nevus. Melanosis can...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... irregular nesting, pagetoid growth, or cytologic atypia  Proliferative nodules (densely cellular foci or nodules of melanocytes) may be present in the dermis or subcutis Differential Diagnosis  Melanoma in situ (clinical context important to interpret pagetoid spread)  Melanoma (expansile...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... Mart1/Melan-A and tyrosinase are sensitive markers to visualize intraepidermal melanocytes, experience is necessary when interpreting these stains to avoid overestimating the number of true melanocytes: dendritic processes from melanocytes wrapped around keratinocytes may seem to decorate the latter...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-14
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... this particular differential diagnostic situation arises, a keratin immunostain supports the distinction. Keratin AE1/AE3 is the preferred antibody, since a keratin cocktail and CAM5.2 may stain dendritic cells and confound interpretation. Keratin immunostains are best reserved for cases in which suspicious...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-04
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... and caution in interpretation is urged ( 10 ). LOBULAR CARCINOMA IN SITU IN ADENOSIS Figure 4-12 LOBULAR CARCINOMA IN SITU IN ADENOSIS A: This low-power image shows an area of adenosis expanded by a proliferation of monomorphic epithelial cells. B: At intermediate power, the cytologic dyshesion...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... as immunohistochemical assays, which are routinely performed in many laboratories. In recent years, the American Society of Clinical Oncology and the College of American Pathologists (ASCO/CAP) have published guidelines for hormone receptor and HER2 receptor testing and interpretation to ensure accuracy...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-07
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
.... A note of caution is required here too, as some myoepithelial cell markers may be reduced or absent in benign sclerosing lesions ( 4 ). Always use more than one marker, and interpret stains carefully and in conjunction with the aforementioned H&E features. Classifying a lesion present in a core...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-06
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... myosin heavy chain (SMMHC), or calponin are used. Depending on the plane of section, individual myoepithelial cell nuclei may or may not be visible, and therefore, the absence of p63 staining around occasional small glands within the proliferation should be interpreted with that in mind and not presumed...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-02
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
.... Initial histologic examination is often underwhelming. In fact, this is one of those diagnostic entities that is easily overlooked and sometimes interpreted as unremarkable or benign breast parenchyma. However, careful microscopic inspection reveals the presence of perivascular, perilobular...
Images
PRIMARY CARDIAC LYMPHOMA  On biopsy, DLBCL manifests as a small round blue ...
Published: 15 November 2023
PRIMARY CARDIAC LYMPHOMA Figure 57-8 PRIMARY CARDIAC LYMPHOMA On biopsy, DLBCL manifests as a small round blue cell neoplasm and can have extensive crush artifact. Immunohistochemistry is necessary for definitive interpretation. More about this image found in PRIMARY CARDIAC LYMPHOMA On biopsy, DLBCL manifests as a small round blue ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-09
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... with more infiltrative growth patterns may be interpreted as invasive ductal carcinoma, NST. As with many unusual lesions in breast pathology, the key to the correct diagnosis is consideration of the possibility. The clinical presentation in a child may be the most helpful clue to the diagnosis; hence...