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Images
Published: 01 September 2024
HSIL/LSIL Figure 9-40 HSIL/LSIL A: HSIL with diffuse, strong cytoplasmic and nuclear (“block”) staining for p16, interpreted as a positive result. B: LSIL on the right (short arrow), while the differential diagnosis for the area on the left (long arrow) includes immature squamous metaplasia and ... More about this image found in HSIL/LSIL A: HSIL with diffuse, strong cytoplasmic and nuclear (“block”) s...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-07
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... for at least 2 days before obtaining EMB (to make sure there is no spontaneous recovery), performing a biopsy earlier to establish a more rapid diagnosis may be necessary and may also impact treatment. In order to be considered adequate, EMB requires at least four fragments of interpretable myocardium...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-25
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., although its interpretation can be complex. The Sabin-Feldman dye test was the first used for the diagnosis of toxoplasmosis and continues to be considered the gold standard. The test uses live tachyzoites that are incubated with complement and the patient’s serum, followed by methylene blue staining...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-01
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... such as diaminobenzidine (DAB) for the detection of spirochetal organisms (such as Treponema pallidum) in skin biopsies can lead to confusion with cutaneous melanin pigment, thus complicating interpretation of the assay. As with special stains, it is always important to correlate any positivity noted...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-19
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... often to highlight the fungal cell wall. Silver stains need to be interpreted with caution, however, since they are frequently associated with nonspecific background (“dirty”) staining and also mark numerous other tissue structures, including neurosecretory granules, the basement membrane, collagen...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-30
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... the identification of motile T. vaginalis trophozoites and has traditionally been the usual method for confirming the diagnosis. This technique, which should be interpreted within 10 minutes of procuring the specimen, is inexpensive and has a sensitivity of 50 to 70 percent (depending on the expertise...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... diagnosis including HSIL; and 4) histology is LSIL or less, but prebiopsy cytology demonstrates atypical squamous or glandular cells (ASC or AGC) or HSIL. P16 should not be used as a routine adjunct to assess biopsies with unequivocal morphologic interpretations of negative LSIL (–IN1) and HSIL (–IN3). Only...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-18
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... on the expertise of the individual interpreting the test. Rapid POC immunoassays using genital specimens are also available for clinical settings, where the patient may be lost to follow-up, but their sensitivity is only moderate. Nucleic acid detection has become the mainstay of testing in clinical laboratories...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-17
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...). Etiologic organisms in the bartonelloses are usually highlighted with bacterial silver (Warthin-Starry or Steiner), Giemsa, or Gimenez stains, although interpretation of silver stains can be difficult due to the frequent presence of nonspecific background staining and deposits. These special stains are also...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-22
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... ). Conversely, the demonstration of Candida and Candida-like yeasts in transcutaneous biopsy material from any sterile tissues (such as visceral sites) should always be interpreted with great skepticism, especially if not accompanied by an inflammatory response, due to the possibility...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-21
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., on the other hand, have higher ct values that may be difficult to differentiate from colonization by the organism. Molecular techniques are thus extremely difficult to standardize and interpret, limiting their use in routine clinical practice. Prevention and Treatment Both the prevention/prophylaxis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-15
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... purposes, thin and thick blood smears stained with any of the Romanowsky stains (as performed in malaria diagnosis) are useful during the febrile episodes of borrelial relapsing fevers. This is due to the large number of circulating spirochetes. Interpretation of thick smears can be difficult, however, due...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-12
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... NOCARDIA ASTEROIDES Culture shows the typical colony morphology. (Courtesy of the CDC PHIL) Since Nocardia spp are ubiquitous and can contaminate cultures, the isolation of these organisms from a specimen, without clinical evidence of infection, should be interpreted with great caution...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-03
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... mimic an astrocytic neoplasm if interpreted out of context. Macrophages can also be found in the brain parenchyma and perivascular spaces ( fig. 3-30 ). SUBACUTE SCLEROSING PANENCEPHALITIS Figure 3-24 SUBACUTE SCLEROSING PANENCEPHALITIS In late stages of disease, there is meningeal fibrosis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-13
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... Microbiol Rev 2018 ; 31 : e00087 - 17 . 35. Binnicker MJ . Multiplex molecular panels for diagnosis of gastrointestinal infection: performance, result interpretation, and cost-effectiveness . J Clin Microbiol 2015 ; 53 : 3723 - 8 . 36. Freedman SB , Xie J , Neufeld MS...
Images
Published: 01 February 2024
UNDIFFERENTIATED MELANOMA Figure 21-8 UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle cell neoplasm is seen. It was initially interpreted as sarcoma by a soft tissue pathologist, but the diagnosis was revised to metastatic melanoma after sequence analysis revealed UV signatures and an NRAS Q61R mutation identical to the mutation in the patient’s prior primary melanoma located draining to the site of the undifferentiated tumor. More about this image found in UNDIFFERENTIATED MELANOMA An amelanotic undifferentiated malignant spindle...
Images
Published: 01 January 2024
HER2 FLUORESCENCE IN SITU HYBRIDIZATION (FISH) ALGORITHM FOR UNUSUAL FISH RESULTS Figure 8-8 HER2 FLUORESCENCE IN SITU HYBRIDIZATION (FISH) ALGORITHM FOR UNUSUAL FISH RESULTS Groups 2 to 4 interpreted with concurrent immunohistochemistry (illustrated here with a 2+ immunohistochemistry result). More about this image found in HER2 FLUORESCENCE IN SITU HYBRIDIZATION (FISH) ALGORITHM FOR UNUSUAL FISH R...
Images
Published: 01 January 2024
DISPLACED EPITHELIUM Figure 8-30 DISPLACED EPITHELIUM A: Epithelial glands and nests are haphazardly distributed in the cellular biopsy site stroma. B: At higher power, the epithelial elements have some degenerated features characteristic of this phenomenon. Foreign body giant cells and lymphocy... More about this image found in DISPLACED EPITHELIUM A: Epithelial glands and nests are haphazardly distri...
Images
Published: 01 January 2024
FLORID LOBULAR CARCINOMA IN SITU Figure 4-16 FLORID LOBULAR CARCINOMA IN SITU A: At low power, the acini are greatly expanded by a monotonous proliferation of dyshesive epithelial cells. In several of the spaces, central necrosis is present. B: Higher power view shows the spaces to be filled and... More about this image found in FLORID LOBULAR CARCINOMA IN SITU A: At low power, the acini are greatly ex...
Images
Published: 01 January 2024
MYOEPITHELIAL CELL STAINS IN ADENOSIS Figure 6-11 MYOEPITHELIAL CELL STAINS IN ADENOSIS A: In this case of lobular carcinoma in situ (LCIS) involving adenosis, the arrangement of some of the epithelial cell nests suggests invasive carcinoma rather than LCIS in adenosis. B: A SMMHC stain highligh... More about this image found in MYOEPITHELIAL CELL STAINS IN ADENOSIS A: In this case of lobular carcinoma...
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