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Book Chapter

Ear and Temporal Bone

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
... and Foerster, chondrodermatitis chronica auriculae, perforating necrobiotic granuloma, perforating dermatosis, nodular chondrodermatitis, and chondrodermatitis nodularis helicis, all of which are eschewed in favor of CNCH. General Features. The dermal injury, which initiates CNCH, is thought to be caused...
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Book Chapter

Hypopharynx, Larynx, and Trachea

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... the epithelium of the pharynx, and the mesodermal tissue gives rise to the underlying skeletal muscle and fibroconnective tissues ( 2 , 3 ). Histologically, the hypopharynx is lined by stratified squamous epithelium, which is normally nonkeratinizing unless there is injury or inflammation ( fig. 6-1...
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Book Chapter

Sinonasal Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... it probably deserves: LCH is the preferred terminology. The pathogenesis of LCH is unknown, although a neovascular response to a stimulus or injury, and hormonal factors, seem to play various roles. The neovascular response to a stimulus results in an imbalance between promoters and inhibitors, with primitive...
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Book Chapter

Clinicopathologic Features of the Adrenal Cortex

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... dysfunction, as well as nephropathy and osteoporosis. Injuries in other target organs include inflammatory bowel disease and pulmonary lesions. Due to the variety of tissues damaged, it is important to detect and treat primary aldosteronism as early as possible to avoid or reduce its intractable organ...
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Images
Figure 7-2

ENTEROVIRUS MYOCARDITIS A scant lymphocyte infiltrate and myocyte injury (...

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in Heart > Pathology of Non-Helminth Infectious Diseases
Published: 01 September 2024
ENTEROVIRUS MYOCARDITIS Figure 7-2 ENTEROVIRUS MYOCARDITIS A scant lymphocyte infiltrate and myocyte injury (A) are seen. Lymphocytic infiltration can be patchy (C), making detection on endomyocardial biopsy difficult. Confirmatory enterovirus immunohistochemistry (B) demonstrates red More about this image found in ENTEROVIRUS MYOCARDITIS A scant lymphocyte infiltrate and myocyte injury (...
Images
Figure 7-3

INFLUENZA B VIRUS MYOCARDITIS At low (A) and high power (B), a discrete pe...

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in Heart > Pathology of Non-Helminth Infectious Diseases
Published: 01 September 2024
INFLUENZA B VIRUS MYOCARDITIS Figure 7-3 INFLUENZA B VIRUS MYOCARDITIS At low (A) and high power (B), a discrete perivascular lymphocyte infiltrate and associated myocyte injury are seen. Immunohistochemical staining did not demonstrate influenza B virus in the myocardium, although More about this image found in INFLUENZA B VIRUS MYOCARDITIS At low (A) and high power (B), a discrete pe...
Images
Figure 14-35

ROCKY MOUNTAIN SPOTTED FEVER Histopathology of renal (A), lung (B), and br...

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in Systemic Infections > Pathology of Non-Helminth Infectious Diseases
Published: 01 September 2024
ROCKY MOUNTAIN SPOTTED FEVER Figure 14-35 ROCKY MOUNTAIN SPOTTED FEVER Histopathology of renal (A), lung (B), and brain white matter (C). There are predominantly mononuclear cell inflammatory cell infiltrates and foci of endothelial injury with erythrocyte extravasation. Note the early More about this image found in ROCKY MOUNTAIN SPOTTED FEVER Histopathology of renal (A), lung (B), and br...
Book Chapter

Heart

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-07
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... Figure 7-2 ENTEROVIRUS MYOCARDITIS A scant lymphocyte infiltrate and myocyte injury (A) are seen. Lymphocytic infiltration can be patchy (C), making detection on endomyocardial biopsy difficult. Confirmatory enterovirus immunohistochemistry (B) demonstrates red cytoplasmic positivity in myocytes...
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Book Chapter

Liver and Gastrointestinal Tract

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-05
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... for screening purposes; for acute infection due to HAV or HEV, serology is usually diagnostic. The distinction between acute and chronic viral hepatitis is chiefly a clinical one based on disease duration, with persistently raised transaminase enzymes indicating ongoing hepatocellular injury and chronic...
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Book Chapter

Heart

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-16
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... in the endocardial lining ( fig. 16-1 ) ( 4 ). This trauma can be due to inflammation as a result of degenerative changes or rheumatic heart disease, mechanical injury secondary to catheter or electrode insertion, particulate matter injected with IV drugs, or turbulent blood flow. The traumatic injury leads...
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Book Chapter

Respiratory Tract

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-04
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... neutralization assays are available to define whether the antibodies are neutralizing, although such testing is only available at referral laboratories ( 28 ). The extrapulmonary pathology in COVID-19 can involve numerous organ systems. Coagulopathy/microthrombi and/or endothelial injury and endothelialitis...
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Book Chapter

Hemorrhagic Fevers

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-10
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...; endothelial dysfunction; alterations in the immune system; endothelial injury with coagulopathy; and direct organ damage ( 7 ). Marburg virus infection has an incubation period ranging from a few days to a week, and typically begins with a non-itchy skin rash. This is associated with a sudden onset of high...
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Book Chapter

Central Nervous System

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-03
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... affects smaller vessels (arterioles, capillaries, and venules), with endothelial cell damage, fibrinoid necrosis, formation of multinucleated (syncytial) cells, and an associated inflammatory (neutrophil and mononuclear) cell infiltrate ( fig. 3-46 ) ( 98 ). Secondary thrombosis and ischemic tissue injury...
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Book Chapter

Systemic Infections

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-27
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... with P. vivax; includes cerebral malaria, acute respiratory distress, acute kidney injury, cardiovascular collapse, severe hemolysis (parasitemia >5%), hemoglobinuria, metabolic acidosis, hypoglycemia, and coagulation abnormalities Splenic rupture Can be caused by P. vivax...
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Book Chapter

Gastrointestinal Tract

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-13
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... mucosal injury EAEC Acute nonmucoid, nonbloody/watery diarrhea, vomiting, abdominal pain, and low-grade fever Can be associated with chronic diarrhea, wasting, and postinfectious irritable bowel syndrome Usually prominent surface epithelial coating by straight gram-negative bacilli Otherwise normal...
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Book Chapter

Respiratory Tract

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-21
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... with significant soft tissue injury and/or necrosis, especially secondary to major physical trauma, burns, or recent surgery. Primary gastrointestinal mucormycosis can occur in premature neonates and the malnourished. Iron overload and deferoxamine therapy are further risk factors, due to the pivotal role...
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Book Chapter

Sexually Transmitted Infections

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-18
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., but primarily includes other venereal diseases such as syphilis and gonorrhea. In rectal involvement, the intense inflammation and chronic mucosal injury raises the possibility of chronic inflammatory bowel disease (especially ulcerative proctitis). Lymph node involvement in LGV suggests cat scratch disease...
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Book Chapter

Sexually Transmitted and Urogenital Infections

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-09
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... ethnicity, absence of HLA C7 allele, and positivity for BKV. Transplanted organ risk factors include a long cold ischemia time, reperfusion injury, delayed graft function, biopsy proven acute rejection, implantation of a ureteric stent at the time of transplant, and (most importantly) the type of immune...
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Book Chapter

Respiratory Tract

Available to Purchase

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-12
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... of epithelial cells, as well as a bronchiolitis obliterans injury pattern. Larger surgical lung biopsies may illustrate diffuse alveolar damage (DAD) with intra-alveolar fibrin exudation. Granulomas may be identified in chronic extrapulmonary disease, and encephalitis may be associated with fibrinoid necrosis...
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Book Chapter

Systemic Infections

Available to Purchase

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-14
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... of endothelial injury with erythrocyte extravasation. Note the early microglial nodule formation in the white matter. (Courtesy of the CDC IDPB) BURKHOLDERIA PSEUDOMALLEI PATHOGENETIC MECHANISMS Figure 14-28 BURKHOLDERIA PSEUDOMALLEI PATHOGENETIC MECHANISMS LEPTOSPIROSIS Figure 14-27...
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