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PERSISTENT MELANOCYTIC NEVUS  There is a trizonal pattern showing a pigment...
Published: 01 February 2024
PERSISTENT MELANOCYTIC NEVUS Figure 6-3 PERSISTENT MELANOCYTIC NEVUS There is a trizonal pattern showing a pigmented junctional melanocytic proliferation overlying a scar, with residual intradermal nevus (arrows) and inflammation at the bottom of the scar. More about this image found in PERSISTENT MELANOCYTIC NEVUS There is a trizonal pattern showing a pigment...
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COMPOUND DYSPLASTIC NEVUS WITH PARTIAL REGRESSION  There is a gap (arrows) ...
Published: 01 February 2024
COMPOUND DYSPLASTIC NEVUS WITH PARTIAL REGRESSION Figure 4-7 COMPOUND DYSPLASTIC NEVUS WITH PARTIAL REGRESSION There is a gap (arrows) in the dermal melanocyte population, with inflammation and slightly hypervascular stroma separating dermal nevus cell aggregates. More about this image found in COMPOUND DYSPLASTIC NEVUS WITH PARTIAL REGRESSION There is a gap (arrows) ...
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LENTIGINOUS COMPOUND DYSPLASTIC NEVUS WITH LAMELLAR FIBROSIS  Thin layers o...
Published: 01 February 2024
LENTIGINOUS COMPOUND DYSPLASTIC NEVUS WITH LAMELLAR FIBROSIS Figure 4-5 LENTIGINOUS COMPOUND DYSPLASTIC NEVUS WITH LAMELLAR FIBROSIS Thin layers of fibrosis surround rete ridges, creating a zone separating junctional from dermal melanocytes. There is associated bland-like inflammation. More about this image found in LENTIGINOUS COMPOUND DYSPLASTIC NEVUS WITH LAMELLAR FIBROSIS Thin layers o...
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MELANOMA IN SITU ASSOCIATED WITH A MELANOCYTIC NEVUS  A: Melanoma in situ w...
Published: 01 February 2024
MELANOMA IN SITU ASSOCIATED WITH A MELANOCYTIC NEVUS Figure 12-8 MELANOMA IN SITU ASSOCIATED WITH A MELANOCYTIC NEVUS A: Melanoma in situ with asymmetric and broad growth of melanocytes as nests and solitary units at the dermoepidermal junction associated with inflammation. B: Melanoma in situ i... More about this image found in MELANOMA IN SITU ASSOCIATED WITH A MELANOCYTIC NEVUS A: Melanoma in situ w...
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SUBUNGUAL MELANOMA IN SITU  A: There is a proliferation of solitary units o...
Published: 01 February 2024
SUBUNGUAL MELANOMA IN SITU Figure 14-13 SUBUNGUAL MELANOMA IN SITU A: There is a proliferation of solitary units of melanocytes involving the nail bed and nail matrix associated with focal lichenoid inflammation (*). B: The density of melanocytes is above normal, but overall relatively low. C: ... More about this image found in SUBUNGUAL MELANOMA IN SITU A: There is a proliferation of solitary units o...
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EPIDERMOTROPIC METASTATIC MELANOMA  A: Metastatic melanoma is present in th...
Published: 01 February 2024
EPIDERMOTROPIC METASTATIC MELANOMA Figure 22-7 EPIDERMOTROPIC METASTATIC MELANOMA A: Metastatic melanoma is present in the epidermis and dermis. This metastasis simulates the appearance of a primary melanoma. The intraepidermal melanoma extends peripheral to the dermal tumor cells. Clinicopatholo... More about this image found in EPIDERMOTROPIC METASTATIC MELANOMA A: Metastatic melanoma is present in th...
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NONSURGICALLY TRAUMATIZED MELANOCYTIC NEVUS (NO RECOLLECTION OR DOCUMENTATI...
Published: 01 February 2024
NONSURGICALLY TRAUMATIZED MELANOCYTIC NEVUS (NO RECOLLECTION OR DOCUMENTATION OF PRIOR BIOPSY) Figure 6-8 NONSURGICALLY TRAUMATIZED MELANOCYTIC NEVUS (NO RECOLLECTION OR DOCUMENTATION OF PRIOR BIOPSY) A: A compound melanocytic nevus with a trizonal pattern is characterized by architectural disord... More about this image found in NONSURGICALLY TRAUMATIZED MELANOCYTIC NEVUS (NO RECOLLECTION OR DOCUMENTATI...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... size and shape, predominantly at the dermoepidermal junction. PERSISTENT MELANOCYTIC NEVUS Figure 6-3 PERSISTENT MELANOCYTIC NEVUS There is a trizonal pattern showing a pigmented junctional melanocytic proliferation overlying a scar, with residual intradermal nevus (arrows) and inflammation...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., with or without mitoses  Maturation often absent or incomplete, but beware of “pseudomaturation” Often de novo, but approx. one third may be associated with a nevus  Associated stromal changes include variable inflammation and fibrosis (sometimes reflecting partial regression) Immunohistochemical...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-23
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... is defined as a cutaneous or subcutaneous tumor deposit adjacent or deep to a primary melanoma recognized on microscopic examination of the primary tumor excision. It must clearly be discontinuous from the primary tumor and not be embedded in a scar or inflammation that is incontinuity with the primary tumor...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...-14 ) and invades deeply. Sometimes a lichenoid inflammatory cell infiltrate and superficial dermal fibrosis are clues to early invasive LMM. On the other hand, inflammation and fibrosis may also obscure invasive melanoma, making it difficult to recognize without immunohistochemical studies ( 16...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...: The tumor shows some evidence of zonation and is associated with some inflammation. Cytologically, metastases are composed of epithelioid and/or spindle cells in variable proportions. Large epithelioid cells may display prominent eosinophilic nucleoli and nuclear cytoplasmic pseudoinclusions. Mitotic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... atypical nevi, there is focal pagetosis and/or adnexal extension of junctional melanocytes. Intradermal melanocytes may be associated with stromal fibrosis and inflammation ( fig. 5-5 ). Cytologic atypia is common. These lesions may show overlap with what has been reported as “dysplastic nevi” at other...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., neurotization, lipidization, inflammation, desmoplasia, edema, hypervascularity, other) Ancillary Test Findings  Immunohistochemistry   Most ordinary nevi homogenously express SOX10 and S-100 protein   Epithelioid cells are usually immunoreactive for Melan-A and tyrosinase   Neurotized spindle...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... (see figs. 15-5 , 15-7 ). In untreated patients, florid inflammation and features of regression ( fig. 15-8 ) also favor a primary melanoma. On occasion, however, inflammation and regression are found with metastatic melanoma deposits, especially after treatment with immunotherapy. NODULAR MELANOMA...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... COMPOUND DYSPLASTIC NEVUS WITH LAMELLAR FIBROSIS Figure 4-5 LENTIGINOUS COMPOUND DYSPLASTIC NEVUS WITH LAMELLAR FIBROSIS Thin layers of fibrosis surround rete ridges, creating a zone separating junctional from dermal melanocytes. There is associated bland-like inflammation. INFLAMED DYSPLASTIC NEVUS...
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INVASIVE LOBULAR CARCINOMA  A: At low power, invasive lobular carcinoma wit...
Published: 01 January 2024
INVASIVE LOBULAR CARCINOMA Figure 8-35 INVASIVE LOBULAR CARCINOMA A: At low power, invasive lobular carcinoma with low nuclear grade can resemble chronic inflammation. B: Higher-power examination reveals the epithelial nature of the cells as well as the characteristic cytologic features. More about this image found in INVASIVE LOBULAR CARCINOMA A: At low power, invasive lobular carcinoma wit...
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FAT NECROSIS  Intermediate-power view of an area of fat necrosis showing ch...
Published: 01 January 2024
FAT NECROSIS Figure 2-19 FAT NECROSIS Intermediate-power view of an area of fat necrosis showing chronic inflammation, multinucleated giant cells, and histiocytes infiltrating through the fibrous parenchyma and adipose tissue. Note the presence of a cyst-like area at the lower portion of the fiel... More about this image found in FAT NECROSIS Intermediate-power view of an area of fat necrosis showing ch...
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PROBABLE SQUAMOUS METAPLASIA OF LACTIFEROUS DUCTS (SMOLD)  A: Low-power vie...
Published: 01 January 2024
PROBABLE SQUAMOUS METAPLASIA OF LACTIFEROUS DUCTS (SMOLD) Figure 13-2 PROBABLE SQUAMOUS METAPLASIA OF LACTIFEROUS DUCTS (SMOLD) A: Low-power view shows blood and inflammatory cells. B: At higher power, the inflammation is noted to be mixed, composed of lymphocytes, neutrophils, and multi-nucleat... More about this image found in PROBABLE SQUAMOUS METAPLASIA OF LACTIFEROUS DUCTS (SMOLD) A: Low-power vie...
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CYSTIC NEUTROPHILIC GRANULOMATOUS MASTITIS  A: Scanning magnification of a ...
Published: 01 January 2024
CYSTIC NEUTROPHILIC GRANULOMATOUS MASTITIS Figure 2-5 CYSTIC NEUTROPHILIC GRANULOMATOUS MASTITIS A: Scanning magnification of a breast core needle biopsy showing granulomatous inflammation. B: High power of a granuloma shows the admixed neutrophils. C: Cystic areas surrounded by a cuff of neutrophils. D: Brown and Brenn stain illustrates the presence of Gram-positive rods within a cystic space. The organisms are consistent with Corynebacteria species. More about this image found in CYSTIC NEUTROPHILIC GRANULOMATOUS MASTITIS A: Scanning magnification of a ...