ROUTINE STAINING IN THE DIAGNOSIS OF INFECTIOUS DISEASES Figure 1-1 ROUTINE STAINING IN THE DIAGNOSIS OF INFECTIOUS DISEASES Hematoxylin and eosin (H&E) stain of a skin biopsy (A–C); Gram stain of the culture (D). More about this image found in ROUTINE STAINING IN THE DIAGNOSIS OF INFECTIOUS DISEASES Hematoxylin and e...

USE OF SPECIAL STAINS IN THE DIAGNOSIS OF INFECTIOUS DISEASES Figure 1-2 USE OF SPECIAL STAINS IN THE DIAGNOSIS OF INFECTIOUS DISEASES A,B: Bone marrow H&E (A) and Grocott methenamine silver (B) stains. The latter shows numerous budding Histoplasma capsulatum yeasts. C–E: H&E stain (C,D) on a pituitary gland specimen showing histologic findings suspicious for tissue pathogens. A strongly positive von Kossa calcium stain (E), however, confirms the suspicious deposits as calcifications and excludes infectious microorganisms. More about this image found in USE OF SPECIAL STAINS IN THE DIAGNOSIS OF INFECTIOUS DISEASES A,B: Bone ma...

IMMUNOHISTOCHEMICAL STAINING IN THE DIAGNOSIS OF INFECTIOUS DISEASE Figure 1-4 IMMUNOHISTOCHEMICAL STAINING IN THE DIAGNOSIS OF INFECTIOUS DISEASE H&E (A–C) stains of colonic ulceration reveal scattered large atypical cells in the ulcer base. Cytomegalovirus (CMV) immunoperoxidase stain (D) s... More about this image found in IMMUNOHISTOCHEMICAL STAINING IN THE DIAGNOSIS OF INFECTIOUS DISEASE H&...

VALUE OF IN SITU HYBRIDIZATION IN INFECTIOUS DISEASES PATHOLOGY Figure 1-5 VALUE OF IN SITU HYBRIDIZATION IN INFECTIOUS DISEASES PATHOLOGY H&E (A,B) staining of an adrenal spindle cell neoplasm in an immunocompromised patient. Epstein-Barr virus encoded RNA (EBER) in situ hybridization (ISH) ... More about this image found in VALUE OF IN SITU HYBRIDIZATION IN INFECTIOUS DISEASES PATHOLOGY H&E (A...

USE OF MOLECULAR TECHNIQUE (rRNA) IN DIAGNOSING INFECTIOUS DISEASES Figure 1-6 USE OF MOLECULAR TECHNIQUE (rRNA) IN DIAGNOSING INFECTIOUS DISEASES Polymerase chain reaction (PCR) using one of the 16S mRNA conserved regions (V1-3) on a suspected bacterial tissue pathogen yields a product. The latt... More about this image found in USE OF MOLECULAR TECHNIQUE (rRNA) IN DIAGNOSING INFECTIOUS DISEASES Polyme...

UTILITY OF MOLECULAR TESTING IN INFECTIOUS DISEASES DIAGNOSIS Figure 1-7 UTILITY OF MOLECULAR TESTING IN INFECTIOUS DISEASES DIAGNOSIS Abdominal computerized tomography (CT) scan (A) shows a liver mass; H&E (B,C), Grocott methenamine silver (D), and Lilly Twort gram (E) stains of histologic m... More about this image found in UTILITY OF MOLECULAR TESTING IN INFECTIOUS DISEASES DIAGNOSIS Abdominal co...

EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Figure 8-6 EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Usually, there is a peripheral lymphocytosis and atypical lymphocytes (A,B) are seen on the peripheral blood smear. More about this image found in EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Usually, there is a peripheral lym...

EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Figure 8-8 EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Lymph node with architectural distortion (A) with focal capsular permeation by lymphoid cells (top), a polymorphic mononuclear infiltrate (B) with associated plasma cells (C) and focal mitotic activity (cen... More about this image found in EBV-ASSOCIATED INFECTIOUS MONONUCLEOSIS Lymph node with architectural dist...

WEST NILE VIRUS ENCEPHALITIS Figure 3-5 WEST NILE VIRUS ENCEPHALITIS Perivascular lymphocyte cuffing (A) and encephalitis with neuronal loss (B). (Courtesy of the CDC Infectious Disease Pathology Branch [IDPB]) More about this image found in WEST NILE VIRUS ENCEPHALITIS Perivascular lymphocyte cuffing (A) and encep...

MARBURG VIRUS HISTOPATHOLOGY Figure 10-2 MARBURG VIRUS HISTOPATHOLOGY Patchy liver necrosis (A,B) and a hepatocyte with eosinophilic intracytoplasmic inclusions (C). (Courtesy of the CDC Infectious Disease Pathology Branch [IDPB]) More about this image found in MARBURG VIRUS HISTOPATHOLOGY Patchy liver necrosis (A,B) and a hepatocyte ...

CUTANEOUS ANTHRAX Figure 14-9 CUTANEOUS ANTHRAX The typical necrosis and ulceration (A) are seen, with predominantly perivascular inflammation, dermal edema, and hemorrhage (B). (Courtesy of the CDC Infectious Disease Pathology Branch [IDPB]) More about this image found in CUTANEOUS ANTHRAX The typical necrosis and ulceration (A) are seen, with p...

SEVERE YELLOW FEVER Figure 5-11 SEVERE YELLOW FEVER A,B: The liver shows extensive confluent zonal necrosis, which begins in the lobule midzone. (Courtesy of the CDC Infectious Disease Pathology Branch [IDPB]) More about this image found in SEVERE YELLOW FEVER A,B: The liver shows extensive confluent zonal necrosi...

GRANULOMATOUS AMEBIC ENCEPHALITIS Figure 25-15 GRANULOMATOUS AMEBIC ENCEPHALITIS Histologically, there is necrosis with associated mononuclear inflammation (A), as well as typical protozoan trophozoites and cysts (B,D, Acanthamoeba; C,E, Balamuthia). (Courtesy of the CDC Infectious Disease Pathology Branch [IDPB]) More about this image found in GRANULOMATOUS AMEBIC ENCEPHALITIS Histologically, there is necrosis with a...

PLACENTA AND AMNION IN NEONATAL LISTERIOSIS Figure 11-4 PLACENTA AND AMNION IN NEONATAL LISTERIOSIS A placental abscess (A, top) and scant necrotic debris in the amnion (B) are seen, with detectable bacterial organisms on a Gram stain (C). (Courtesy of the CDC Infectious Disease Pathology Branch ... More about this image found in PLACENTA AND AMNION IN NEONATAL LISTERIOSIS A placental abscess (A, top) a...

MULTIPLE ORGAN INVOLVEMENT IN MALARIA Figure 27-3 MULTIPLE ORGAN INVOLVEMENT IN MALARIA Lung (A), liver (B), skeletal muscle (C), and brain (D) show dark brown hemozoin pigment. (Courtesy of the Centers for Disease Control and Prevention [CDC] Infectious Disease Pathology Branch [IDPB]) More about this image found in MULTIPLE ORGAN INVOLVEMENT IN MALARIA Lung (A), liver (B), skeletal muscle...

IMMUNOHISTOCHEMICAL POSITIVE CONTROL FOR STAPHYLOCOCCUS AUREUS Figure 1-3 IMMUNOHISTOCHEMICAL POSITIVE CONTROL FOR STAPHYLOCOCCUS AUREUS The positive (dark red) bacteria are formalin-fixed and paraffin-embedded between sectioned fragments of normal tissue. (Courtesy of the Centers for Disease Control and Prevention [CDC] Infectious Disease Pathology Branch (IDPB) More about this image found in IMMUNOHISTOCHEMICAL POSITIVE CONTROL FOR STAPHYLOCOCCUS AUREUS...

NECROTIZING FASCIITIS CAUSED BY CLOSTRIDIUM SPP Figure 15-1 NECROTIZING FASCIITIS CAUSED BY CLOSTRIDIUM SPP A: There is pronounced necrotizing and purulent inflammation. B: Scattered causative gram-positive bacteria are demonstrated with special staining. (Courtesy of the Centers for Disease Control and Prevention [CDC] Infectious Disease Pathology Branch [IDPB]) More about this image found in NECROTIZING FASCIITIS CAUSED BY CLOSTRIDIUM SPP A: There ...