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KI-67 IN ADRENAL CORTICAL CARCINOMA  The Ki-67 proliferative <span class="search-highlight">index</span> is highl...
Published: 01 December 2024
KI-67 IN ADRENAL CORTICAL CARCINOMA Figure 6-35 KI-67 IN ADRENAL CORTICAL CARCINOMA The Ki-67 proliferative index is highly variable in ACC, as illustrated in the two tumors shown in (A) and (B). More about this image found in KI-67 IN ADRENAL CORTICAL CARCINOMA The Ki-67 proliferative index is highl...
Images
PHEOCHROMOCYTOMA: KI-67 LABELING  The Ki-67 labeling <span class="search-highlight">index</span> is 12.7 percent ...
Published: 01 December 2024
PHEOCHROMOCYTOMA: KI-67 LABELING Figure 8-42 PHEOCHROMOCYTOMA: KI-67 LABELING The Ki-67 labeling index is 12.7 percent as determined by an automated image analysis algorithm. More about this image found in PHEOCHROMOCYTOMA: KI-67 LABELING The Ki-67 labeling index is 12.7 percent ...
Images
PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTI...
Published: 01 December 2024
PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Figure 4-33 PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTISOL OVERSECRETION Low Ki-67 index (hot spot area). More about this image found in PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE ASSOCIATED WITH CORTI...
Images
“BLACK” ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME  Tumor cells express s...
Published: 01 December 2024
“BLACK” ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Figure 5-44 “BLACK” ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Tumor cells express steroidogenic factor 1 (SF1, A), Melan-A (red, B), and a low Ki-67 labeling index (red, C). More about this image found in “BLACK” ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Tumor cells express s...
Images
PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN  The tumor diffusely expressed SF1...
Published: 01 December 2024
PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Figure 6-43 PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN The tumor diffusely expressed SF1 (A). Ki-67 index (B) was 5 percent, whereas p53 was expressed in rare nuclei (C). (Same case as figs. 6-40 and 6-41 .) More about this image found in PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN The tumor diffusely expressed SF1...
Images
PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN  A–C: The tumor is shown at progre...
Published: 01 December 2024
PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Figure 6-41 PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN A–C: The tumor is shown at progressively higher magnification. It lacks necrosis and signs of invasion and showed low mitotic and proliferation indexes. Final Wieneke score was 0. (Same case as fig. 6-4... More about this image found in PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN A–C: The tumor is shown at progre...
Images
ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOM...
Published: 01 December 2024
ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOMA AND CARCINOMA Figure 5-31 ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOMA AND CARCINOMA A diagnosis of adrenal cortical carcinoma was suspected because of the presence of predominant oncocyti... More about this image found in ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOM...
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COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MP...
Published: 01 December 2024
COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) Figure 8-58 COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) This tumor is composed of an admixture of pheochromocytoma with a highly cellular nerve sheath tumor (A–D). The pheochromocyt... More about this image found in COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MP...
Images
COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MP...
Published: 01 December 2024
COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) Figure 8-58 COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) This tumor is composed of an admixture of pheochromocytoma with a highly cellular nerve sheath tumor (A–D). The pheochromocyt... More about this image found in COMPOSITE PHEOCHROMOCYTOMA WITH MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MP...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... derived from preoperative contrast-enhanced CT images have been reported to predict the Ki-67 index in the corresponding surgical samples of patients with ACC ( 115 ). GROSS FINDINGS The macroscopy of ACC reflects its high heterogeneity, in terms of both variable degrees of propensity to invade...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...Index ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... proliferation as in other neuroendocrine neoplasms ( fig. 8-42 ). There is evidence that a higher labeling index portends a worse prognosis, but the literature on this is limited ( 58 – 61 ). PHEOCHROMOCYTOMA: KI-67 LABELING Figure 8-42 PHEOCHROMOCYTOMA: KI-67 LABELING The Ki-67 labeling index is 12.7...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... pseudoinclusions, occur, but in isolated cells or small clusters ( figs. 5-23 , 5-24 ). Hyaline globules are rarely encountered ( fig. 5-25 ). The mitotic index is much less than 1 in 10 mm2 and atypical mitoses are absent. ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-23 ADRENAL...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...) is associated with longer duration of hypertension, smaller mean nodule size, lower lateralization index (a ratio indicating the level of asymmetry of aldosterone production from the adrenal glands), higher aldosterone-to-renin ratio after surgery, and higher serum potassium concentrations compared to classic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
.... However, the WHO does recommend determination of Ki-67 labeling index in paragangliomas as in other neuroendocrine neoplasms. There is evidence that a high labeling index portends a worse prognosis in terms of progression-free survival or metastasis, but the data are limited and standardized thresholds...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... by extensive invasion (vascular, capsular, and extra-adrenal) and high mitotic index. LI-FRAUMENI SYNDROME Li-Fraumeni syndrome is an autosomal dominant disease caused by germline mutations in the TP53 gene ( 71 ). It is characterized by a strong familial aggregation of malignant neoplasms...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... in the pathology report is the mitosis karyorrhexis index (MKI). This is a combination of all mitoses and all karyorrhectic figures in 5,000 tumor cells and has been described in the INPC ( 50 ). This combination has been chosen on purpose to reduce the inter- and intraobserver variation in the identification...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-19
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... with fungal infection, which should always prompt the performance of appropriate special stains. Fungal organisms are often observed on routine hematoxylin and eosin (H&E) staining, however. A high index of suspicion is required in the immunocompromised, where mycoses frequently lack any granulomatous...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-15
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... the earlobe (even if no lesions are observed here). The frequency of positive results varies depending on the type of leprosy. As emphasized above, tissue and cytology samples require staining with a modified acid-fast technique for detection of lepra bacilli ( fig. 15-24 ). A bacterial index (bacilli counted...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-05
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... of the histologic evaluation of fibrosis. Detailed schemes include the Knodell histology activity index (HAI), the Ishak modification of HAI, and the METAVIR French cooperative group scheme. The reader is referred to current reference works on liver pathology for a comprehensive description of these classifications...