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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...-3 ACRAL MELANOMA Dermoscopically, hyperpigmentation is seen in the ridge area (arrow). This pattern is referred to as “parallel ridge pattern.” Subungual melanomas typically present as a subungual pigmented patch or linear band (longitudinal melanonychia) ( 18 ). The index of suspicion...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... labeling would be unexpected for a melanoma and a high labeling index would favor melanoma, for most diagnostically challenging cases, the Ki-67 labeling index is usually just slightly increased and does not provide decisive diagnostic evidence. We have found immunohistochemistry for PRAME (preferentially...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... is variable and tends to be restricted to junctional or superficial dermal melanocytes, with a gradient of diminished to absent labeling from the papillary to the reticular dermis ( 11 ). The Ki-67 labeling index tends to be low (less than 2 percent) in most cases. Immunoreactivity for p16 is variable, from...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-17
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... index favor melanoma, but the sensitivity and specificity of these parameters for detecting nevoid melanomas is very limited. Immunohistochemistry for p16 may also be used as a guide. Complete lack of staining is worrisome for, but not proof of, melanoma as some benign melanocytic nevi lack...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... more densely cellular aggregates in the midst or near the base of a lesion ( fig. 10-6 ). Rare mitotic figures may be seen. The Ki-67 labeling index is often slightly increased. This nevus has also been termed clonal or inverted type A nevus and melanocytic nevus with focal...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... the papillary to the reticular dermis ( 20 ). The Ki-67 labeling index tends to be low (less than 2 percent) in most case, but there are exceptions, such as in actively growing nevi. Immunoreactvity for p16 is variable, from homogeneous to partial or rare absent labeling ( 21 ). Most ordinary nevi are negative...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... expression of BAP1. Loss of nuclear labeling of BAP1 in an otherwise common BN-like tumor suggests probable metastatic melanoma. Furthermore, a common BN usually does not label for Ki-67, while metastatic melanoma usually is associated with an increased Ki-67 labeling index. Sclerosing Blue Nevus versus...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-12
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... cells or null-type cells, and are CD30 positive and ALK negative by immunohistochemistry. Findings in the implant capsule itself may be subtle, as the cellularity is often low in tissue sections compared with cytologic preparations. A high index of suspicion is important when examining implant capsules...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-14
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... artifactually displaced epithelium from metastatic carcinoma. Keratin immunostains are not of value. If critical to patient management it may be possible to use the biomarker profile of the index carcinoma to support interpretation as tumor cells or benign epithelium, which is helpful if the cells are proven...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-03
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... bridges or arcades that may be present also have an attenuated quality, with the cells arrayed parallel to the long axis of the bridges ( fig. 3-11 ). Rarely, UDH has foci of necrosis ( fig. 3-12 ); while this should raise the index of suspicion for DCIS, in the appropriate cytomorphologic setting...
Images
RELATIONSHIP OF APICAL DIRECTION TO BODY HABITUS  Anterior views.  Left: Mo...
Published: 15 November 2023
RELATIONSHIP OF APICAL DIRECTION TO BODY HABITUS Figure 1-5 RELATIONSHIP OF APICAL DIRECTION TO BODY HABITUS Anterior views. Left: More downwardly directed apex in a tall slender adult with a body mass index (BMI) of 21.0 kg/m2. Above: More horizontally directed apex in an obese adult with a BMI of 39.0 kg/m2. Also, for both hearts, pericardial reflections are indicated (yellow arrow). More about this image found in RELATIONSHIP OF APICAL DIRECTION TO BODY HABITUS Anterior views. Left: Mo...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-11
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... tumors of the breast: a review . Semin Diagn Pathol   2009 ; 26 : 141 - 9 . 54. Leon-Castillo   A , Chrisinger   JS , Panse   G , et al . Index report of cutaneous angiosarcomas with strong positivity for tyrosinase mimicking melanoma with further evaluation of melanocytic markers...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... patients into the different molecular subtypes discussed below propelled Ki67 to the fore, as some groups proposed that a low versus high index helped separate luminal A-like tumors from luminal B-like tumors ( 62 ). In 2011, the St. Gallen group endorsed a threshold of 14 percent to categorize a tumor...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-15
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... pleomorphism can be a clue Prominent eosinophilic nucleoli Melanin pigment MART-1 and HMB-45 positive Epithelioid angiosarcoma Prior history of breast cancer and radiation (for secondary angiosarcoma) Presence of blood lakes Clinical findings and high index of suspicion prevent misdiagnosis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-07
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
.... PAPILLARY LESIONS AND CORE NEEDLE BIOPSY Core needle biopsy specimens are often the index specimen in which papillary lesions are encountered. Given the myriad forms of papillary tumors of the breast, diagnosis on core needle biopsy presents particular problems for this category of lesion and caution...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-appendix01
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... Formalin-Fixed Specimens, as a Function of Body Height in 392 Women and 373 Men, 20 to 99 Years Old Appendix 5 . Proposed Normal Heart Weights, Independent of Age, Body Weight, Body Length (Height), or Body Mass Index (BMI), Based on 212 Fresh (Unfixed) Specimens from Young Adults in Three Studies...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch50
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... sarcoma, which may be relatively paucicellular and have a variable inflammatory background. In contrast to IMT, most intimal sarcomas occur in adults and in the left atrium. Histologically, there are usually areas with increased mitotic activity and a high proliferative index. Intimal sarcomas generally...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch53
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... about the distinction between UPS and malignant fibrous histiocytoma. It has been recommended to substitute MIB-1 (Ki-67) proliferative index for the mitotic count to improve reproducibility ( 11 – 13 ). In this scheme, a proliferative index of 9 percent or less is a substitute for a mitotic rate of 0...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch29
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... al . An obesity paradox: an inverse correlation between body mass index and atherosclerosis of the aorta . Cardiovasc Pathol   2016 ; 25 : 515 - 20 . 5. Suh   B , Song   YS , Shin   DW , et al . Incidentally detected atherosclerosis in the abdominal aorta or its major branches...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch21
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... implications . Nat Clin Pract Cardiovasc Med   2007 ; 4 : 480 - 90 . 23. Khan   SS , Ning   H , Wilkins   JT , et al . Association of body mass index with lifetime risk of cardiovascular disease and compression of morbidity . JAMA Cardiol   2018 ; 3 : 280 - 7 . 24. Ren   J , Wu...