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Figure 4-21
Published: 01 June 2025
HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ORAL DYSPLASIA Figure 4-21 HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ORAL DYSPLASIA A: Compact, eosinophilic parakeratin overlying epithelium shows full-thickness dysplasia. B: Numerous karyorrhectic cells (black arrows) and apoptotic cells (blue arrows). C More about this image found in HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED ORAL DYSPLASIA A: Compact, eosinophi...
Images
Figure 7-22
Published: 01 June 2025
METASTATIC CILIATED HUMAN PAPILLOMAVIRUS(HPV)-ASSOCIATED SQUAMOUS CELL CARCINOMA Figure 7-22 METASTATIC CILIATED HUMAN PAPILLOMAVIRUS(HPV)-ASSOCIATED SQUAMOUS CELL CARCINOMA Metastasis to a cervical lymph node showing a thin lining epithelium with smooth surface and scattered ciliated cells. More about this image found in METASTATIC CILIATED HUMAN PAPILLOMAVIRUS(HPV)-ASSOCIATED SQUAMOUS CELL CARC...
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Figure 2-5
Published: 01 June 2025
CYSTIC METASTASIS Figure 2-5 CYSTIC METASTASIS Axial view computerized tomography (CT) scan of the neck shows cystic metastases (asterisks) from a human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (SCC). More about this image found in CYSTIC METASTASIS Axial view computerized tomography (CT) scan of the neck...
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Figure 6-48
Published: 01 June 2025
NONKERATINIZING SQUAMOUS CELL CARCINOMA Figure 6-48 NONKERATINIZING SQUAMOUS CELL CARCINOMA An uncommon nonkeratinizing SCC of the larynx recapitulates many of the features of oropharyngeal SCC. These do not share the same strong correlation with high risk human papillomavirus or the clear More about this image found in NONKERATINIZING SQUAMOUS CELL CARCINOMA An uncommon nonkeratinizing SCC of...
Images
Figure 1-19
Published: 01 June 2025
secondary to irritation. Most cases harbor low-risk human papillomavirus (HPV) as demonstrated by RNA in situ hybridization (inset). More about this image found in EXOPHYTIC SINONASAL PAPILLOMA A: Koilocytic changes, i.e., nuclear enlarge...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-2
ISBN: 978-1-933477-61-9
...EMBRYOLOGY, ANATOMY, AND HISTOLOGY The oropharynx, more than any other area of the anatomically complex head and neck, has shaped pathology in the past 50 years through the influence of high-risk human papillomavirus (HPV). The unique anatomy makes the oropharynx particularly suited for HPV...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... is a benign, papillomatous neoplasm of squamous epithelium arising in the larynx, trachea, oropharynx, and oral cavity, and occasionally in the other head and neck mucosal sites, that is usually related to low-risk human papillomavirus (HPV) ( 49 – 52 ). General Features. Squamous papillomas arise...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
... with human immunodeficiency virus (HIV) disease, and bone marrow and solid organ transplant is also strongly linked to both cutaneous SCC and OSCC ( 3 , 13 ). A family history of head and neck cancer and some inherited genetic mutations are associated with a higher risk of oral cancer development including...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... entity but rather distinct neoplasms is now supported by emerging molecular data: OSP harbors KRAS mutations, ISP usually harbors EGFR mutations, and ESP is strongly associated with low-risk human papillomavirus (HPV) infection ( 37 – 39 ). The etiology of sinonasal papillomas...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
...EMBRYOLOGY, HISTOLOGY, AND ANATOMY The neck is a complex, vital structure with numerous tissue types including skin, muscle, bone, vasculature, nerves, and organs, making it one of the most complex anatomic sites in the human body ( 1 ). It is critical for movement, metabolism, breathing...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-3
ISBN: 978-1-933477-61-9
..., particularly of the nonkeratinizing type, are positive for high-risk human papillomavirus (HPV), especially in nonendemic areas, but further studies are needed to define the precise role of HPV in this disease ( 48 , 49 ). Clinical Features. In nonendemic areas, NPC tends to show a bimodal distribution...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
... of the endolymphatic sac and duct in relationship to the cochlear and semicircular canals. For the ear and temporal bone as a whole, between the fourth and sixth weeks of human embryonic development, the paired branchial arches appear as ridges on each side of the future head and neck region. The arches have...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... is not the result of human papillomavirus (HPV) infection ( 53 , 54 ). Verrucous carcinoma can also arise in these cysts ( 55 ). Immunohistochemical Findings. Since PIOCs arise from odontogenic epithelium, CK19 is a sensitive marker for odontogenic origin, although malignant tumors may lose some reactivity ( 56...
Images
Figure 1-3
Published: 01 December 2024
PRIMORDIA OF ADRENAL GLAND Figure 1-3 PRIMORDIA OF ADRENAL GLAND Schematic cross section of human embryo shows primordia of adrenal glands, which are located lateral to the base of the dorsal mesentery, separated from the gonadal primordium by the adrenal groove. (Fig. 1-3 from Lack EE More about this image found in PRIMORDIA OF ADRENAL GLAND Schematic cross section of human embryo shows p...
Images
Figure 1-9
Published: 01 December 2024
MEDIAL ASPECT OF DEVELOPING ADRENAL GLAND IN HUMAN FETUS Figure 1-9 MEDIAL ASPECT OF DEVELOPING ADRENAL GLAND IN HUMAN FETUS Coronal section of fetal adrenal gland shows close association with developing sympathetic plexus (on far left). Small nests of primitive sympathetic cells (white arrows More about this image found in MEDIAL ASPECT OF DEVELOPING ADRENAL GLAND IN HUMAN FETUS Coronal section o...
Images
Figure 9-2
Published: 01 December 2024
from these plexuses. (Illustration by Henry Vandyke Carter, fig. 847 from Gray H. Anatomy of the human body. Lea and Febiger; 1918:965.) More about this image found in ABDOMINAL PORTION OF THE PREAORTIC SYMPATHETIC TRUNK, WITH THE CELIAC AND H...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... hydroxylase and phenylethanolamine N-methyltransferase ( 6 ). Catecholamines regulate steroidogenesis by several mechanisms ( 7 ). In humans and other mammals, corticomedullary interactions are facilitated by the complete envelopment of the medulla by the cortex. In contrast, birds and reptiles achieve...
Images
Figure 6-1
Published: 01 September 2024
HUMAN HERPESVIRUS Figure 6-1 HUMAN HERPESVIRUS Electron microscopy of negative stain of human herpesvirus (HHV) and schematic of viral components. (Courtesy of the Centers for Disease Control and Prevention [CDC] Public Health Image Library [PHIL]) More about this image found in HUMAN HERPESVIRUS Electron microscopy of negative stain of human herpesvir...
Images
Figure 6-7
Published: 01 September 2024
DIAGNOSING HUMAN HERPESVIRUS INFECTION Figure 6-7 DIAGNOSING HUMAN HERPESVIRUS INFECTION Human herpesvirus infection can be diagnosed using direct immunofluorescence (A) as well as a Tzanck preparation (B). (Courtesy of the CDC PHIL) More about this image found in DIAGNOSING HUMAN HERPESVIRUS INFECTION Human herpesvirus infection can be ...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... a pivotal role in aldosterone synthesis ( fig. 5-51 ), while cytochrome P450 11B1 (CYP11B1) and cytochrome P450 17A1 (CYP17) are involved in cortisol synthesis in normal human adrenal glands. Interestingly, detailed data on their expression in aldosterone-secreting adenomas clearly show a marked...