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hormone
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Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PHEOCHROMOCYTOMA PRODUCING GROWTH HORMONE-RELEASING HORMONE (GHRH) AND CAUSING ACROMEGALY Figure 8-41 PHEOCHROMOCYTOMA PRODUCING GROWTH HORMONE-RELEASING HORMONE (GHRH) AND CAUSING ACROMEGALY The presentation of this patient with acromegaly prompted staining of the tumor for GHRH; the tumor is di... More about this image found in PHEOCHROMOCYTOMA PRODUCING GROWTH HORMONE-RELEASING HORMONE (GHRH) AND CAUS...
Images
in Pheochromocytoma and Adrenal Medullary Hyperplasia
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
PHEOCHROMOCYTOMA PRODUCING ADRENOCORTICOTROPIC HORMONE (ACTH) AND CAUSING CUSHING SYNDROME Figure 8-40 PHEOCHROMOCYTOMA PRODUCING ADRENOCORTICOTROPIC HORMONE (ACTH) AND CAUSING CUSHING SYNDROME A: The adrenal cortex is markedly thickened and lipid depleted. B: The tumor is a highly vascular pheo... More about this image found in PHEOCHROMOCYTOMA PRODUCING ADRENOCORTICOTROPIC HORMONE (ACTH) AND CAUSING C...
Images
in Congenital Disorders of the Adrenal Gland
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
CONGENITAL ADRENAL HYPERPLASIA Figure 2-11 CONGENITAL ADRENAL HYPERPLASIA Autopsy of an infant who died of the severe salt-losing form of 21-hydroxylase deficiency shows enlargement of both adrenal glands (arrows). The glands have a convoluted or cerebriform surface and are darker than normal due... More about this image found in CONGENITAL ADRENAL HYPERPLASIA Autopsy of an infant who died of the severe...
Images
in Clinicopathologic Features of the Adrenal Cortex
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
CUSHING SYNDROME Figure 3-1 CUSHING SYNDROME The clinical features of this disorder (left) can be caused by pituitary adrenocorticotropic hormone (ACTH) excess (top right), ectopic ACTH causing massive adrenal hyperplasia (right middle), or primary adrenal disease (bottom right). (From Netter FH.... More about this image found in CUSHING SYNDROME The clinical features of this disorder (left) can be caus...
Images
in Hereditary Predisposition to Adrenal Cortical Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA IN A YOUNG PATIENT WITH LI-FRAUMENI SYNDROME Figure 7-8 ADRENAL CORTICAL CARCINOMA IN A YOUNG PATIENT WITH LI-FRAUMENI SYNDROME Nine-month-old boy with 8-cm right adrenal tumor. No signs of hormonal overproduction. Resection specimen shows nuclear pleomorphism and incre... More about this image found in ADRENAL CORTICAL CARCINOMA IN A YOUNG PATIENT WITH LI-FRAUMENI SYNDROME Ni...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Because the adrenal cortex is the site of synthesis of several hormones, adrenal cortical tumors can be associated with endocrine syndromes that vary depending on the function of the hormone(s) released. The main hormones produced by the adrenal cortex are glucocorticoids, mineralocorticoids...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Adrenal cortical adenoma is a benign neoplasm composed of adrenal cortical steroid hormone-producing cells. EPIDEMIOLOGY Adrenal cortical adenomas are not rare, however, the calculation of their real incidence is biased by the use of the term “nodular hyperplasia” for the entity now...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... presentations. Among the incidental lesions, 33.34 percent had a mean delay in diagnosis of 22.95 months (4 to 120 months). Among those with symptoms, patients were younger and more often female, had larger tumors, and had higher preoperative hormone levels. Those with a genetic predisposition were the youngest...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... prevalence of hormone-secreting tumors and a younger age at diagnosis ( 5 ). The reasons for the increased prevalence of ACC in females is not clearly understood but it has been postulated that the predominance may reflect the sexual dimorphism in the adrenal cortex and the influence of gonadal hormones...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... classes of steroid hormones: glucocorticoids, mineralocorticoids, and sex hormones ( 4 , 5 ). Their respective biosynthetic pathways are illustrated in figure 1-1 . In the adult cortex, the hormone produced in the largest quantity is cortisol. In contrast, the predominant products of the fetal cortex...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Congenital adrenal gland abnormalities may manifest anatomically, hormonally, or as a combination of the two, and thus present challenges to pathologists and clinicians. A common occurrence is the need to distinguish ectopic cortical tissue from tumor in cancer staging, abdominal surgery...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... with adrenocorticotropic hormone (ACTH)-independent cortisol secretion represent a heterogeneous group of diseases. They are divided into two subgroups: primary bilateral micronodular adrenal cortical disease and primary bilateral macronodular adrenal cortical disease. They do not constitute two different stages...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... cortical nodular diseases is covered in chapter 7 . Adrenal cortical proliferations, usually without clinical or biochemical evidence of hormone hypersecretion, have been described in the context of Carney triad ( 3 ). This is the combination of gastric gastrointestinal stromal tumor (GIST), pulmonary...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., with no pheochromocytoma detected. It differs from panic attacks and related conditions in that the episodes are not overtly triggered by fear or anxiety ( 6 ). Pseudo-Cushing is defined by mild to moderate adrenocorticotropic hormone (ACTH)-dependent hypersecretion of cortisol that can be caused by various neural...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... effect (abdominal distension) or pain. Hypertension may develop due to hormonal overproduction or local compression of the renal artery through tumor growth, but appears limited to a minority (4 percent) of patients ( 32 ). In case of (extensive) metastasis, infants and children may show constitutional...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... risk but that high scores have little predictive value in the absence of adjunctive markers ( 116 ). These may include a combination of immunohistochemical markers such as Ki-67 (already included in GAPP), SDHB, and emerging markers such as ATRX ( 116 ), together with hormonal profile, genotype...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-07
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... failure. Viruses known to cause myocarditis frequently also cause respiratory or gastrointestinal infections that are not associated with myocarditis. Host factors most likely determine an individual’s susceptibility to myocarditis and include pregnancy, sex hormone administration, age, exercise...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-02
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... Presents spontaneously in people >60 years a CJD = Creutzfeldt-Jakob disease. Acquired human disease can be transmitted via numerous routes, including ingestion, which has been linked to outbreaks of kuru and variant CJD, tissue transplantation, blood transfusion, injection of growth hormone...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-21
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... overridingly affects men, with a male to female ratio of 22 to 1 for chronic disease and 1.7 to 1 for acute/subacute disease. This gender predilection is due to the protective effect conferred by estrogen in women, since the hormone inhibits transformation of the fungus from its conidial/mycelial form to its...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
..., including hormonal factors, dietary factors, and lifestyle-related factors. Hormonal, or reproductive risk factors, include early age at menarche, nulliparity, older age at first birth, and late menopause. Pregnancy is considered a long-term protective factor, but in the short term, there is an elevation...
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