EARLY POLIOMYELITIS Figure 3-16 EARLY POLIOMYELITIS CNS histology shows hypercellularity due to microgliosis (circled). More about this image found in EARLY POLIOMYELITIS CNS histology shows hypercellularity due to microglios...

ADENOVIRUS INFECTION Figure 4-17 ADENOVIRUS INFECTION Lung histology shows necrotizing bronchiolitis (A) and confirmatory positive immunohistochemistry (B,C). (Courtesy of the CDC IDPB) More about this image found in ADENOVIRUS INFECTION Lung histology shows necrotizing bronchiolitis (A) an...

PARVOVIRUS B19 Figure 8-3 PARVOVIRUS B19 Bone marrow histology shows a hypercellular appearance, with intranuclear parvovirus B19 inclusions affecting erythroid precursors (A, center and B, bottom). More about this image found in PARVOVIRUS B19 Bone marrow histology shows a hypercellular appearance, wit...

HISTOLOGY OF MENINGOCOCCEMIA Figure 11-9 HISTOLOGY OF MENINGOCOCCEMIA A: Adrenal gland with prominent hemorrhage and focal necrosis. B: Lung showing mild interstitial edema and early intra-alveolar hemorrhage. C: Heart with myocarditis demonstrating striking neutrophil infiltration. (All: court... More about this image found in HISTOLOGY OF MENINGOCOCCEMIA A: Adrenal gland with prominent hemorrhage an...

ROCKY MOUNTAIN SPOTTED FEVER Figure 14-36 ROCKY MOUNTAIN SPOTTED FEVER Skin histology showing scant perivascular inflammation on H&E stain (A), with a Rickettsia immunohistochemical stain (B) illustrating striking positivity in relation to a small dermal blood vessel from a skin biopsy. (Courtesy of the CDC IDPB) More about this image found in ROCKY MOUNTAIN SPOTTED FEVER Skin histology showing scant perivascular inf...

BURULI ULCER HISTOLOGY Figure 15-28 BURULI ULCER HISTOLOGY Ulcer edge showing epidermal hyperplasia (A), underlying granuloma formation (B), and the presence of occasional clusters of acid-fast bacilli (C). (Courtesy of the CDC IDPB) More about this image found in BURULI ULCER HISTOLOGY Ulcer edge showing epidermal hyperplasia (A), under...

GRANULOMA INGUINALE SKIN HISTOLOGY Figure 18-19 GRANULOMA INGUINALE SKIN HISTOLOGY Areas of early acanthosis and mixed dermal inflammation. More about this image found in GRANULOMA INGUINALE SKIN HISTOLOGY Areas of early acanthosis and mixed der...

PAROTID GLAND MYCOSIS Figure 21-33 PAROTID GLAND MYCOSIS Hyaline septate fungal hyphae are seen on histology (stained with H&E [A] and GMS [B]). Microbiologic culture grew Candida albicans. More about this image found in PAROTID GLAND MYCOSIS Hyaline septate fungal hyphae are seen on histology ...

CENTRAL NERVOUS SYSTEM TOXOPLASMOSIS Figure 25-3 CENTRAL NERVOUS SYSTEM TOXOPLASMOSIS A: Brain histology shows necrosis and prominent mononuclear inflammation. B: An autopsy case shows prominent necrosis with minimal inflammation. More about this image found in CENTRAL NERVOUS SYSTEM TOXOPLASMOSIS A: Brain histology shows necrosis and...

CHOLERA Figure 13-20 CHOLERA A,B: Documented histologic changes of cholera in small intestinal mucosa are mild and nonspecific, like some other toxin-associated intestinal bacterial infections, and include mild villous shortening and broadening, congestion, and lamina propria mononuclear inflamma... More about this image found in CHOLERA A,B: Documented histologic changes of cholera in small intestinal ...

HISTOLOGIC DETECTION OF H. PYLORI Figure 13-32 HISTOLOGIC DETECTION OF H. PYLORI A: Many basophilic H. pylori bacilli are easily identified on a routine hematoxylin and eosin (H&E) stain in the mucin adjacent to this gastric biopsy. B: A methylene blue stain is an example of a monochromatic stain, which can be used to highlight the organisms. C: A silver-based Warthin-Starry stain shows numerous small curved H. pylori bacilli, clearly visible against a counterstained background. D: An H. pylori immunoperoxidase stain confirms abundant organisms adjacent to the superficial gastric epithelium. More about this image found in HISTOLOGIC DETECTION OF H. PYLORI A: Many basophilic

HISTOLOGIC DIFFERENTIAL DIAGNOSIS OF WHIPPLE DISEASE Figure 13-41 HISTOLOGIC DIFFERENTIAL DIAGNOSIS OF WHIPPLE DISEASE A: Mycobacterium avium intracellulare complex (MAC) infection may mimic Whipple disease on endoscopic biopsy. B,C: MAC bacilli, however, show weaker PAS staining (B) and are acid fast (C, Ziehl-Neelsen stain). More about this image found in HISTOLOGIC DIFFERENTIAL DIAGNOSIS OF WHIPPLE DISEASE A: Mycobacter...

MIMICS OF FUNGAL ORGANISMS Figure 19-5 MIMICS OF FUNGAL ORGANISMS A,B: Air bubble artefacts in histologic sections are frequently large and irregular, and appear superimposed on the tissue. C,D: Suspected broad fungal hyphae on a skin biopsy (C), which turned out to be an incompletely sectioned Demodex spp mite on deeper levels (D). E,F: Extraneous and plant material on cytology smears and preparates can be confused with fungal hyphae (E) or yeasts (F) by the unwary. These deposits are usually larger, more irregular in outline, and poorly defined, and often appear in a different plane to the cellular material. G: The multipolar bud-like appearance can mimic Paracoccidioides spp. More about this image found in MIMICS OF FUNGAL ORGANISMS A,B: Air bubble artefacts in histologic section...

MIMICS OF FUNGAL ORGANISMS Figure 19-5 MIMICS OF FUNGAL ORGANISMS A,B: Air bubble artefacts in histologic sections are frequently large and irregular, and appear superimposed on the tissue. C,D: Suspected broad fungal hyphae on a skin biopsy (C), which turned out to be an incompletely sectioned Demodex spp mite on deeper levels (D). E,F: Extraneous and plant material on cytology smears and preparates can be confused with fungal hyphae (E) or yeasts (F) by the unwary. These deposits are usually larger, more irregular in outline, and poorly defined, and often appear in a different plane to the cellular material. G: The multipolar bud-like appearance can mimic Paracoccidioides spp. More about this image found in MIMICS OF FUNGAL ORGANISMS A,B: Air bubble artefacts in histologic section...

PNEUMOCYSTIS PNEUMONIA Figure 21-22 PNEUMOCYSTIS PNEUMONIA A: Unusual histologic patterns in Pneumocystis lung involvement include necrotizing granulomatous inflammation, which may raise the differential diagnosis of tuberculosis. B: GMS highlights the typical collapsed (helmet-shaped) cysts. More about this image found in PNEUMOCYSTIS PNEUMONIA A: Unusual histologic patterns in ...

SMALL INTESTINAL MICROSPORIDIOSIS Figure 22-13 SMALL INTESTINAL MICROSPORIDIOSIS Mild and nonspecific histologic findings, including villous blunting and scattered intraepithelial lymphocytes, are seen. (Courtesy of Dr. R. Yantiss, Weill-Cornell Medicine, New York, NY) More about this image found in SMALL INTESTINAL MICROSPORIDIOSIS Mild and nonspecific histologic findings...

GRANULOMATOUS AMEBIC ENCEPHALITIS Figure 25-15 GRANULOMATOUS AMEBIC ENCEPHALITIS Histologically, there is necrosis with associated mononuclear inflammation (A), as well as typical protozoan trophozoites and cysts (B,D, Acanthamoeba; C,E, Balamuthia). (Courtesy of the CDC Infectious Disease Pathology Branch [IDPB]) More about this image found in GRANULOMATOUS AMEBIC ENCEPHALITIS Histologically, there is necrosis with a...

DUODENAL CYSTOISOSPORIASIS Figure 26-33 DUODENAL CYSTOISOSPORIASIS Associated nonspecific histologic features: villous attenuation, an increase in lamina propria chronic inflammatory cells, and focal superficial epithelial disarray (A,B). More about this image found in DUODENAL CYSTOISOSPORIASIS Associated nonspecific histologic features: vil...

SMALL INTESTINAL CYCLOSPORIASIS Figure 26-40 SMALL INTESTINAL CYCLOSPORIASIS The nonspecific histologic findings include villous blunting and an increase in lamina propria chronic inflammatory cells. (Courtesy of Dr. J. Greenson, University of Michigan, Ann Arbor, MI) More about this image found in SMALL INTESTINAL CYCLOSPORIASIS The nonspecific histologic findings includ...

PEDIATRIC ENTEROTOXIGENIC E. COLI (ETEC) INFECTION Figure 13-6 PEDIATRIC ENTEROTOXIGENIC E. COLI (ETEC) INFECTION A,B: Endoscopic biopsy histology shows normal/near normal colon mucosa with nonspecific histologic alterations, including mild goblet cell depletion, focal lamina propria edema, and a mild increase in superficial mucosal mononuclear cells. More about this image found in PEDIATRIC ENTEROTOXIGENIC E. COLI (ETEC) INFECTION A,B: E...