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histology

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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch03
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... Figure 3-9 SINUS NODE Top: The node (outlined) can be readily identified histologically by the abundant collagen and the sinus nodal artery running through the middle of it (black asterisk). Bottom: Nodal myocytes are accompanied by abundant collagen. (Both: Masson trichrome.) ATRIOVENTRICULAR (AV...
Images
DYSPLASTIC NEVUS  A: Multiple pigmented lesions are present on the back. Th...
Published: 01 February 2024
DYSPLASTIC NEVUS Figure 4-2 DYSPLASTIC NEVUS A: Multiple pigmented lesions are present on the back. The lesion, which was biopsied and histologically confirmed, is highlighted. B: The lesion displays some asymmetry, has an irregular peripheral border, and has some variation in pigmentation, with... More about this image found in DYSPLASTIC NEVUS A: Multiple pigmented lesions are present on the back. Th...
Images
MYOEPITHELIAL CELLS: MYRIAD <span class="search-highlight">HISTOLOGIC</span> APPEARANCES  A: Myoepithelial cells ...
Published: 01 January 2024
MYOEPITHELIAL CELLS: MYRIAD HISTOLOGIC APPEARANCES Figure 1-5 MYOEPITHELIAL CELLS: MYRIAD HISTOLOGIC APPEARANCES A: Myoepithelial cells with more attenuated spindled cells. B: Myoid myoepithelial cells (see also fig. 1-4 : clear myoepithelial cells). More about this image found in MYOEPITHELIAL CELLS: MYRIAD HISTOLOGIC APPEARANCES A: Myoepithelial cells ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... ( 15 ), but with a few additional unusual findings ( Table 5-1 ). Table 5-1 CLINICAL AND PATHOLOGIC FEATURES OF ATYPICAL NEVI BY ANATOMIC SITE Anatomic Site Clinical Findings of Atypical Nevi Histologic Features of Atypical Nevi Acral Small, circumscribed with even color Parallel furrow...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... borders may develop. Histologically, these show increased pigmentation of the basilar keratinocytes and increased number of junctional single or rarely binucleated melanocytes, occasionally angulated with nuclear hyperchromasia ( 22 ). A few cytologically bland melanocytes may be present in the spinous...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... features . Histopathology   2002 ; 40 : 187 - 95 . 5. Eyden   B , Pandit   D , Banerjee   SS . Malignant melanoma with neuroendocrine differentiation: clinical, histological, immunohistochemical and ultrastructural features of three cases . Histopathology   2005 ; 47 : 402 - 9 . 6...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... for prognostic and therapeutic reasons. Some histologic features favor a primary over a metastatic tumor or vice versa, but on occasion, it is impossible to determine on histopathologic grounds alone whether a melanoma is a primary neoplasm or a metastasis. In such cases, clinical information is essential...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... nodules of large epithelioid melanocytes often, but not always, lack nuclear expression of BAP1. When loss of BAP1 is documented by immunohistochemistry, the lesions are classified as BAP1-deficient or BAP1-inactivated. If the histologic findings suggest a benign lesion, the term combined BAP1...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... for nodular melanoma when their invasive tumor cells have extended in the horizontal plane to or beyond the edge of the melanoma in situ. Accordingly, nodular melanoma does not represent a unique melanoma variant with a distinct histology or molecular pathway. Rather, it represents a shared microscopic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... and atypia and Clark nevus, although the latter term is not entirely synonymous because its historic microscopic definition does not require cytologic atypia. While there is consensus that dysplastic nevi are significant as clinical and histologic simulants of melanoma, their biology and prognostic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-23
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with an increased risk for local recurrence, particularly if the surgical margins are positive or narrow ( 10 ). In such instances, radiotherapy may reduce the incidence of local recurrence. Regression. Regression refers to observations that the body’s immune system can attack and destroy tumor. Histologic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-02
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of bland epithelioid melanocytes. C: The melanocytes in the nodule and the background CMN homogeneously express H3K27me3. If a CMN has the appearance of a nevus spilus, the corresponding histologic feature of the background patch is that of basal layer hyperpigmentation, often accompanied by increased...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-01
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of the conjunctival mucosa in the absence of an associated melanocytic neoplasm. It is the conjunctival equivalent of a melanotic macule/lentigo. REFERENCES REFERENCES 1. Elgart   GW . Seborrheic keratoses, solar lentigines, and lichenoid keratoses. Dermatoscopic features and correlation to histology...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... context. Immunohistochemistry may be necessary for the diagnosis, if it is difficult to assess the density or growth pattern of junctional melanocytes due to suboptimal histology (e.g., cautery or drying artifacts, frozen sections, blurring of the dermoepidermal junction by heavy inflammation). While...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... in clinical practice. These melanocytic nevi are usually readily recognized clinically and histologically as a benign melanocytic proliferation. Melanocytic nevi are classified histopathologically by which microanatomic compartments of the skin they involve. A junctional melanocytic nevus is limited...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... coexisting mutations or genomic aberrations are found or the histologic appearance is unquestionably malignant. For Spitz tumors in which the distinction between a benign neoplasm and a melanoma is challenging, cytogenetic analysis by comparative genomic hybridization, single nucleotide polymorphism (SNP...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... VERSUS SPITZ MELANOMA Spitzoid Melanoma Spitz Melanoma Spitzoid Histology Spitzoid Histology Immunohistochemical Findings: Immunohistochemical Findings:  May be positive for BRAF V600E  Negative for BRAF V600E  May be positive for ALK, NTRK1, ROS1 Molecular Genetic Aberrations...
Images
ROUTINE SECTIONS FOR <span class="search-highlight">HISTOLOGY</span>  Left: Short-axis slice, as viewed from apex...
Published: 15 November 2023
ROUTINE SECTIONS FOR HISTOLOGY Figure 3-1 ROUTINE SECTIONS FOR HISTOLOGY Left: Short-axis slice, as viewed from apex toward base for photographic purposes. Right: Short-axis slice, as viewed from base toward apex, for taking sections for microscopy, with six transmural sections (including both m... More about this image found in ROUTINE SECTIONS FOR HISTOLOGY Left: Short-axis slice, as viewed from apex...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... , Hempel   H , McKee   PH , Calonje   E . Deep penetrating naevus: clinicopathological study of 31 cases with further delineation of histological features allowing distinction from other pigmented benign melanocytic lesions and melanoma . Histopathology   2003 ; 43 : 529 - 37 . 4. Luzar...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-11
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...: a molecular and histologic analysis of 16 cases . Am J Surg Pathol   2019 ; 43 : 480 - 8 . 10. Goto   K , Pissaloux   D , Paindavoine   S , Tirode   F , de la Fouchardière   A . CYSLTR2-mutant cutaneous melanocytic neoplasms frequently simulate “pigmented epithelioid melanocytoma...